JO3030B1 - مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات - Google Patents
مركب جديد مفيد لمعالجة الامراض التنكسية والالتهاباتInfo
- Publication number
- JO3030B1 JO3030B1 JOP/2010/0179A JOP20100179A JO3030B1 JO 3030 B1 JO3030 B1 JO 3030B1 JO P20100179 A JOP20100179 A JO P20100179A JO 3030 B1 JO3030 B1 JO 3030B1
- Authority
- JO
- Jordan
- Prior art keywords
- treatment
- degenerative
- inflammatory diseases
- diseases
- novel compound
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Transplantation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Abstract
يتم الإفصاح عن أي مركب يحتوي على الصيغة التي يمثلها على النحو التالي: يمكن تحضير المركب الحالي كتوليفة صيدلانية ويمكن إستخدامه للوقاية والعلاج من الحالات المختلفة في الثدييات بما فيها البشر والمشتملة على أمثلة غير مقصورة على حالات الإلتهابات أو أمراض المناعة الذاتية أو أمراض التكاثري أو رفض الزراعة أو الأمراض المشتملة على تلف دوران الغضروف أو تشوهات الغضروف الخلقي و/أو الأمراض المصاحبة لفَرْطُ إِفْراز IL6.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US22068509P | 2009-06-26 | 2009-06-26 | |
US29818810P | 2010-01-25 | 2010-01-25 |
Publications (1)
Publication Number | Publication Date |
---|---|
JO3030B1 true JO3030B1 (ar) | 2016-09-05 |
Family
ID=42340530
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JOP/2010/0179A JO3030B1 (ar) | 2009-06-26 | 2010-05-31 | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
Country Status (38)
Country | Link |
---|---|
US (2) | US8796457B2 (ar) |
EP (2) | EP2445912B1 (ar) |
JP (1) | JP5486084B2 (ar) |
KR (1) | KR101712561B1 (ar) |
CN (1) | CN102459261B (ar) |
AR (1) | AR077221A1 (ar) |
AU (1) | AU2010264635B2 (ar) |
BR (1) | BRPI1014759A2 (ar) |
CA (1) | CA2765988C (ar) |
CL (1) | CL2011003276A1 (ar) |
CO (1) | CO6491039A2 (ar) |
CR (1) | CR20110673A (ar) |
CY (1) | CY1119711T1 (ar) |
DK (2) | DK2792677T3 (ar) |
DO (1) | DOP2011000378A (ar) |
EA (1) | EA020111B1 (ar) |
ES (2) | ES2519170T3 (ar) |
HK (2) | HK1202537A1 (ar) |
HR (2) | HRP20141057T1 (ar) |
HU (1) | HUE034205T2 (ar) |
IL (1) | IL216618A (ar) |
JO (1) | JO3030B1 (ar) |
LT (1) | LT2792677T (ar) |
MA (1) | MA33447B1 (ar) |
ME (1) | ME01916B (ar) |
MX (1) | MX2011013451A (ar) |
NZ (1) | NZ596836A (ar) |
PE (1) | PE20120494A1 (ar) |
PL (2) | PL2792677T3 (ar) |
PT (2) | PT2445912E (ar) |
RS (1) | RS53617B1 (ar) |
SG (1) | SG177359A1 (ar) |
SI (2) | SI2445912T1 (ar) |
SM (1) | SMT201400169B (ar) |
TW (1) | TWI469981B (ar) |
UY (1) | UY32741A (ar) |
WO (1) | WO2010149771A1 (ar) |
ZA (1) | ZA201109502B (ar) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JO3041B1 (ar) | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
JO3417B1 (ar) | 2010-01-08 | 2019-10-20 | Regeneron Pharma | الصيغ المستقرة التي تحتوي على الأجسام المضادة لمضاد مستقبل( interleukin-6 (il-6r |
CA2832611C (en) | 2011-04-12 | 2019-05-14 | Rigel Pharmaceuticals, Inc. | Methods for inhibiting allograft rejection |
TWI589299B (zh) | 2011-10-11 | 2017-07-01 | 再生元醫藥公司 | 用於治療類風濕性關節炎之組成物及其使用方法 |
SG10201914052TA (en) * | 2011-10-11 | 2020-03-30 | Sanofi Biotechnology | Compositions for the treatment of rheumatoid arthritis and methods of using same |
SG10201700125VA (en) * | 2012-06-22 | 2017-02-27 | Galapagos Nv | Aminotriazolopyridine For Use In The Treatment Of Inflammation, And Pharmaceutical Compositions Thereof |
MX2016002764A (es) | 2013-09-05 | 2016-05-26 | Hoffmann La Roche | Compuestos de triazolopiridina, composiciones y metodos de uso de los mismos. |
GB201402070D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Pharmaceutical compositions for the treatment of inflammatory disorders |
GB201402071D0 (en) | 2014-02-07 | 2014-03-26 | Galapagos Nv | Novel salts and pharmaceutical compositions thereof for the treatment of inflammatory disorders |
EA037911B1 (ru) * | 2015-04-13 | 2021-06-04 | Галапагос Нв | Способы лечения сердечно-сосудистых заболеваний |
US11279699B2 (en) | 2016-07-26 | 2022-03-22 | Suzhou Longbiotech Pharmaceuticals Co., Ltd. | Compound as selective JAK inhibitor, and salt and therapeutic use thereof |
US11427581B2 (en) | 2018-01-31 | 2022-08-30 | Zhuhai United Laboratories Co., Ltd. | JAK inhibitor and use thereof |
CA3110891A1 (en) | 2018-08-29 | 2020-03-05 | Regeneron Pharmaceuticals, Inc. | Methods and compositions for treating subjects having rheumatoid arthritis |
US11498969B2 (en) | 2019-01-31 | 2022-11-15 | Sanofi Biotechnology | Compositions and methods for treating juvenile idiopathic arthritis |
CN111072655B (zh) * | 2019-12-30 | 2021-12-10 | 深圳市坤健创新药物研究院 | 一种三氮唑并吡啶类化合物及其制备方法和药用组合物与应用 |
EP4153564A4 (en) | 2020-05-19 | 2024-06-19 | Cybin IRL Limited | DEUTERATED TRYPTAMINE DERIVATIVES AND METHODS OF USE |
US11596612B1 (en) | 2022-03-08 | 2023-03-07 | PTC Innovations, LLC | Topical anesthetics |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP4058243B2 (ja) | 1999-01-29 | 2008-03-05 | 中外製薬株式会社 | 軟骨形成促進剤およびインドリン−2−オン誘導体 |
US20040138285A1 (en) | 2001-04-27 | 2004-07-15 | Makoto Okazaki | Chondrogenesis promoters |
US6514989B1 (en) * | 2001-07-20 | 2003-02-04 | Hoffmann-La Roche Inc. | Aromatic and heteroaromatic substituted 1,2,4-triazolo pyridine derivatives |
AU2003231880A1 (en) * | 2002-05-30 | 2003-12-19 | Vertex Pharmaceuticals Incorporated | Inhibitors of jak and cdk2 protein kinases |
DE602004001676T2 (de) | 2003-02-14 | 2007-08-30 | Pfizer Products Inc., Groton | Triazolo-Pyridine als entzündungshemmende Verbindungen |
US20050222171A1 (en) * | 2004-01-22 | 2005-10-06 | Guido Bold | Organic compounds |
ES2427136T3 (es) | 2004-06-21 | 2013-10-29 | Galapagos N.V. | Métodos y medios para el tratamiento de la osteoartritis |
JP2008509987A (ja) | 2004-08-18 | 2008-04-03 | ファルマシア アンド アップジョン カンパニー リミテッド ライアビリティ カンパニー | トリアゾロピリジン化合物 |
JP2008515874A (ja) | 2004-10-07 | 2008-05-15 | ワーナー−ランバート カンパニー リミテッド ライアビリティー カンパニー | 抗菌薬 |
GB0515026D0 (en) | 2005-07-21 | 2005-08-31 | Novartis Ag | Organic compounds |
BRPI0716239A2 (pt) * | 2006-08-30 | 2013-08-13 | Cellzome Ltd | derivados de triazol como inibidores de cinase |
CL2008001626A1 (es) | 2007-06-05 | 2009-06-05 | Takeda Pharmaceuticals Co | Compuestos derivados de heterociclos fusionados, agente farmaceutico que los comprende y su uso en la profilaxis y tratamiento del cancer. |
CN101801966A (zh) | 2007-07-18 | 2010-08-11 | 诺瓦提斯公司 | 双环杂芳基化合物和它们作为激酶抑制剂的用途 |
WO2009017954A1 (en) * | 2007-08-01 | 2009-02-05 | Phenomix Corporation | Inhibitors of jak2 kinase |
EP2181112A1 (en) | 2007-08-31 | 2010-05-05 | Merck Serono S.A. | Triazolopyridine compounds and their use as ask inhibitors |
GB0719803D0 (en) * | 2007-10-10 | 2007-11-21 | Cancer Rec Tech Ltd | Therapeutic compounds and their use |
US20090217316A1 (en) * | 2008-02-22 | 2009-08-27 | Binita Gupta | Systems and Methods for Advertising Insertion Notification in a Real-Time Streaming Media Service |
JP5595389B2 (ja) | 2008-06-20 | 2014-09-24 | ジェネンテック, インコーポレイテッド | トリアゾロピリジンjak阻害剤化合物と方法 |
JO3041B1 (ar) * | 2008-07-25 | 2016-09-05 | Galapagos Nv | مركبات جديدة مفيدة لمعالجة الأمراض التنكسية والالتهابية |
WO2010010187A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
WO2010010188A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases. |
WO2010010186A1 (en) * | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
WO2010010189A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | Novel compounds useful for the treatment of degenerative and inflammatory diseases |
WO2010010184A1 (en) | 2008-07-25 | 2010-01-28 | Galapagos Nv | [1, 2, 4] triazolo [1, 5-a] pyridines as jak inhibitors |
EP2438066A2 (en) | 2009-06-05 | 2012-04-11 | Cephalon, Inc. | PREPARATION AND USES OF 1,2,4-TRIAZOLO [1,5a]PYRIDINE DERIVATIVES |
JO3030B1 (ar) | 2009-06-26 | 2016-09-05 | Galapagos Nv | مركب جديد مفيد لمعالجة الامراض التنكسية والالتهابات |
TWI462920B (zh) | 2009-06-26 | 2014-12-01 | 葛萊伯格有限公司 | 用於治療退化性及發炎疾病之新穎化合物 |
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2010
- 2010-05-31 JO JOP/2010/0179A patent/JO3030B1/ar active
- 2010-06-23 TW TW99120587A patent/TWI469981B/zh not_active IP Right Cessation
- 2010-06-24 AR ARP100102236A patent/AR077221A1/es active IP Right Grant
- 2010-06-25 PT PT107286486T patent/PT2445912E/pt unknown
- 2010-06-25 EA EA201270076A patent/EA020111B1/ru not_active IP Right Cessation
- 2010-06-25 HU HUE14175887A patent/HUE034205T2/en unknown
- 2010-06-25 SI SI201030775T patent/SI2445912T1/sl unknown
- 2010-06-25 ME MEP-2014-132A patent/ME01916B/me unknown
- 2010-06-25 WO PCT/EP2010/059067 patent/WO2010149771A1/en active Application Filing
- 2010-06-25 NZ NZ596836A patent/NZ596836A/xx not_active IP Right Cessation
- 2010-06-25 UY UY0001032741A patent/UY32741A/es not_active Application Discontinuation
- 2010-06-25 PL PL14175887T patent/PL2792677T3/pl unknown
- 2010-06-25 EP EP10728648.6A patent/EP2445912B1/en active Active
- 2010-06-25 US US12/823,682 patent/US8796457B2/en active Active
- 2010-06-25 SI SI201031494T patent/SI2792677T1/sl unknown
- 2010-06-25 PE PE2011002144A patent/PE20120494A1/es active IP Right Grant
- 2010-06-25 CN CN201080028413.0A patent/CN102459261B/zh active Active
- 2010-06-25 CA CA2765988A patent/CA2765988C/en not_active Expired - Fee Related
- 2010-06-25 EP EP14175887.0A patent/EP2792677B1/en active Active
- 2010-06-25 RS RS20140614A patent/RS53617B1/en unknown
- 2010-06-25 PL PL10728648T patent/PL2445912T3/pl unknown
- 2010-06-25 ES ES10728648.6T patent/ES2519170T3/es active Active
- 2010-06-25 KR KR1020127002060A patent/KR101712561B1/ko active IP Right Grant
- 2010-06-25 JP JP2012516762A patent/JP5486084B2/ja active Active
- 2010-06-25 LT LTEP14175887.0T patent/LT2792677T/lt unknown
- 2010-06-25 SG SG2011096179A patent/SG177359A1/en unknown
- 2010-06-25 ES ES14175887.0T patent/ES2634325T3/es active Active
- 2010-06-25 DK DK14175887.0T patent/DK2792677T3/en active
- 2010-06-25 PT PT141758870T patent/PT2792677T/pt unknown
- 2010-06-25 MA MA34555A patent/MA33447B1/ar unknown
- 2010-06-25 AU AU2010264635A patent/AU2010264635B2/en not_active Ceased
- 2010-06-25 BR BRPI1014759A patent/BRPI1014759A2/pt active Search and Examination
- 2010-06-25 MX MX2011013451A patent/MX2011013451A/es active IP Right Grant
- 2010-06-25 DK DK10728648.6T patent/DK2445912T3/da active
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2011
- 2011-11-27 IL IL216618A patent/IL216618A/en not_active IP Right Cessation
- 2011-12-06 DO DO2011000378A patent/DOP2011000378A/es unknown
- 2011-12-14 CR CR20110673A patent/CR20110673A/es unknown
- 2011-12-22 CL CL2011003276A patent/CL2011003276A1/es unknown
- 2011-12-22 ZA ZA2011/09502A patent/ZA201109502B/en unknown
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2012
- 2012-01-16 CO CO12005375A patent/CO6491039A2/es active IP Right Grant
- 2012-09-11 HK HK15103046.1A patent/HK1202537A1/xx not_active IP Right Cessation
- 2012-09-11 HK HK12108855.3A patent/HK1168098A1/xx not_active IP Right Cessation
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2014
- 2014-08-04 US US14/451,127 patent/US9505754B2/en active Active
- 2014-11-03 HR HRP20141057AT patent/HRP20141057T1/hr unknown
- 2014-11-10 SM SM201400169T patent/SMT201400169B/xx unknown
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2017
- 2017-07-04 HR HRP20171024TT patent/HRP20171024T1/hr unknown
- 2017-07-24 CY CY20171100784T patent/CY1119711T1/el unknown
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