MX2012004780A - Inhibidores de akt. - Google Patents
Inhibidores de akt.Info
- Publication number
- MX2012004780A MX2012004780A MX2012004780A MX2012004780A MX2012004780A MX 2012004780 A MX2012004780 A MX 2012004780A MX 2012004780 A MX2012004780 A MX 2012004780A MX 2012004780 A MX2012004780 A MX 2012004780A MX 2012004780 A MX2012004780 A MX 2012004780A
- Authority
- MX
- Mexico
- Prior art keywords
- formula
- akt inhibitors
- compounds
- present
- provides
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
La presente invención proporciona inhibidores de AKT de la Fórmula I. la presente invención también proporciona composiciones farmacéuticas que comprenden compuestos de la Fórmula I, usos de los compuestos de la Fórmula I y un método para utilizar los compuestos de la Fórmula I.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US25430809P | 2009-10-23 | 2009-10-23 | |
PCT/US2010/053295 WO2011050016A1 (en) | 2009-10-23 | 2010-10-20 | Akt inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2012004780A true MX2012004780A (es) | 2012-08-23 |
Family
ID=43467018
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012004780A MX2012004780A (es) | 2009-10-23 | 2010-10-20 | Inhibidores de akt. |
Country Status (12)
Country | Link |
---|---|
US (1) | US8436002B2 (es) |
EP (1) | EP2491032B1 (es) |
JP (1) | JP5581390B2 (es) |
KR (1) | KR101398268B1 (es) |
CN (1) | CN102574852B (es) |
AU (1) | AU2010310786B2 (es) |
BR (1) | BR112012011328A2 (es) |
CA (1) | CA2778291C (es) |
EA (1) | EA020151B1 (es) |
ES (1) | ES2465094T3 (es) |
MX (1) | MX2012004780A (es) |
WO (1) | WO2011050016A1 (es) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN104471070B (zh) | 2012-05-17 | 2018-09-25 | 基因泰克公司 | 制备羟基化环戊并嘧啶化合物和其盐的方法 |
RU2643146C2 (ru) | 2012-05-17 | 2018-01-31 | Дженентек, Инк. | Способ получения аминокислотных соединений |
DK2858989T3 (da) | 2012-05-17 | 2020-06-02 | Genentech Inc | Amorf form af en AKT-hæmmende pyrimidinyl-cyclopentan-forbindelse, sammensætninger deraf og fremgangsmåder dertil |
JP6284928B2 (ja) | 2012-05-17 | 2018-02-28 | アレイ バイオファーマ、インコーポレイテッド | ヒドロキシル化シクロペンチルピリミジン化合物を作製するためのプロセス |
WO2013173736A1 (en) | 2012-05-17 | 2013-11-21 | Array Biopharma Inc. | Process for making hydroxylated cyclopentylpyrimidine compounds |
JP6280130B2 (ja) * | 2012-11-16 | 2018-02-14 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングMerck Patent Gesellschaft mit beschraenkter Haftung | キナーゼ活性のモジュレーターとしての新規イミダゾール−ピペリジニル誘導体 |
WO2014143612A1 (en) * | 2013-03-11 | 2014-09-18 | Merck Patent Gmbh | 6-[4-(1 h-imidazol-2-yl)piperidin-1 -yl]pyrimidin-4-amine derivatives as modulators of kinase activity |
KR20160099081A (ko) | 2013-07-26 | 2016-08-19 | 업데이트 파마 인코포레이트 | 비산트렌의 치료 효과 개선용 조합 방법 |
CA3206628A1 (en) | 2013-09-12 | 2015-03-19 | Dana-Farber Cancer Institute, Inc. | Methods for evaluating and treating waldenstrom's macroglobulinemia |
GB201401198D0 (en) | 2014-01-24 | 2014-03-12 | Bial Portela & Ca Sa | Process for the syntheis of substituted urea compounds |
WO2015130585A1 (en) | 2014-02-28 | 2015-09-03 | Merck Sharp & Dohme Corp. | Method for treating cancer |
TWI732187B (zh) * | 2016-05-20 | 2021-07-01 | 日商大鵬藥品工業股份有限公司 | 新穎5H-吡咯并[2, 3-d]嘧啶-6(7H)-酮衍生物 |
WO2020156437A1 (zh) * | 2019-01-29 | 2020-08-06 | 南京正大天晴制药有限公司 | Akt抑制剂 |
WO2021228223A1 (zh) * | 2020-05-15 | 2021-11-18 | 南京正大天晴制药有限公司 | 氘代akt激酶抑制剂 |
WO2022017446A1 (zh) * | 2020-07-22 | 2022-01-27 | 南京正大天晴制药有限公司 | Akt抑制剂的单位剂量组合物 |
JP7472391B2 (ja) | 2020-07-22 | 2024-04-22 | 南京正大天晴制薬有限公司 | ジヒドロピリド[2,3-d]ピリミジノン誘導体の塩及び結晶形 |
WO2022017449A1 (zh) * | 2020-07-22 | 2022-01-27 | 南京正大天晴制药有限公司 | 一种二氢吡啶并[2,3-d]嘧啶酮衍生物的盐、其制备方法及用途 |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU4128089A (en) | 1988-09-15 | 1990-03-22 | Rorer International (Overseas) Inc. | Monoclonal antibodies specific to human epidermal growth factor receptor and therapeutic methods employing same |
AU661533B2 (en) | 1992-01-20 | 1995-07-27 | Astrazeneca Ab | Quinazoline derivatives |
GB9221220D0 (en) | 1992-10-09 | 1992-11-25 | Sandoz Ag | Organic componds |
US5362718A (en) | 1994-04-18 | 1994-11-08 | American Home Products Corporation | Rapamycin hydroxyesters |
NL1004346C2 (nl) | 1996-10-23 | 1998-04-24 | Dsm Nv | Werkwijze voor het scheiden van een mengsel van enantiomeren in een geschikt oplosmiddel. |
US20030220297A1 (en) | 2002-02-01 | 2003-11-27 | Berstein David L. | Phosphorus-containing compounds and uses thereof |
US7563748B2 (en) | 2003-06-23 | 2009-07-21 | Cognis Ip Management Gmbh | Alcohol alkoxylate carriers for pesticide active ingredients |
WO2005117909A2 (en) | 2004-04-23 | 2005-12-15 | Exelixis, Inc. | Kinase modulators and methods of use |
RU2346996C2 (ru) | 2004-06-29 | 2009-02-20 | ЮРОПИЭН НИКЕЛЬ ПиЭлСи | Усовершенствованное выщелачивание основных металлов |
MY179032A (en) | 2004-10-25 | 2020-10-26 | Cancer Research Tech Ltd | Ortho-condensed pyridine and pyrimidine derivatives (e.g.purines) as protein kinase inhibitors |
US7767687B2 (en) * | 2004-12-13 | 2010-08-03 | Biogen Idec Ma Inc. | Pyrido pyrimidinones, dihydro pyrimido pyrimidinones and pteridinones useful as RAF kinase inhibitors |
CA2590961C (en) | 2004-12-28 | 2013-11-26 | Exelixis, Inc. | [1h-pyrazolo[3,4-d]pyrimidin-4-yl]-piperidine or -piperazine compounds as serine-threonine kinase modulators (p70s6k, atk1 and atk2) for the treatment of immunological, inflammatory and proliferative diseases |
CN101227857B (zh) | 2005-06-29 | 2011-10-19 | 电脑医师有限公司 | 具有导电桥的传感器组件 |
JP5606734B2 (ja) | 2006-04-25 | 2014-10-15 | アステックス、セラピューティックス、リミテッド | 医薬化合物 |
WO2007125325A1 (en) * | 2006-04-25 | 2007-11-08 | Astex Therapeutics Limited | Pharmaceutical compounds |
TW200801513A (en) | 2006-06-29 | 2008-01-01 | Fermiscan Australia Pty Ltd | Improved process |
AR064416A1 (es) * | 2006-12-21 | 2009-04-01 | Cancer Rec Tech Ltd | Derivados de purina, piridina y pirimidina condensadas con heterociclos, moduladores de pka y/o pkb, composiciones farmaceuticas que los contienen, y usos para el tratamiento de enfermedades hiperproliferativas. |
UA99284C2 (ru) * | 2007-05-11 | 2012-08-10 | Елі Ліллі Енд Компані | ИНГИБИТОРЫ р70 S6-КИНАЗЫ |
AR074072A1 (es) | 2008-11-11 | 2010-12-22 | Lilly Co Eli | Compuesto de imidazol -piperidin -pirrol-pirimidin-6-ona, composicion farmaceutica que lo comprende y su uso para preparar un medicamento util para tratar el glioblastoma multiforme |
-
2010
- 2010-10-20 EA EA201270590A patent/EA020151B1/ru not_active IP Right Cessation
- 2010-10-20 EP EP10774072.2A patent/EP2491032B1/en not_active Not-in-force
- 2010-10-20 AU AU2010310786A patent/AU2010310786B2/en not_active Ceased
- 2010-10-20 ES ES10774072.2T patent/ES2465094T3/es active Active
- 2010-10-20 CN CN201080046941.9A patent/CN102574852B/zh not_active Expired - Fee Related
- 2010-10-20 WO PCT/US2010/053295 patent/WO2011050016A1/en active Application Filing
- 2010-10-20 US US13/391,895 patent/US8436002B2/en not_active Expired - Fee Related
- 2010-10-20 BR BR112012011328A patent/BR112012011328A2/pt not_active IP Right Cessation
- 2010-10-20 CA CA2778291A patent/CA2778291C/en not_active Expired - Fee Related
- 2010-10-20 MX MX2012004780A patent/MX2012004780A/es active IP Right Grant
- 2010-10-20 KR KR1020127010282A patent/KR101398268B1/ko not_active IP Right Cessation
- 2010-10-20 JP JP2012535319A patent/JP5581390B2/ja not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
EA020151B1 (ru) | 2014-09-30 |
ES2465094T3 (es) | 2014-06-05 |
CN102574852B (zh) | 2014-06-25 |
WO2011050016A1 (en) | 2011-04-28 |
CN102574852A (zh) | 2012-07-11 |
JP5581390B2 (ja) | 2014-08-27 |
EA201270590A1 (ru) | 2012-09-28 |
KR101398268B1 (ko) | 2014-05-23 |
EP2491032B1 (en) | 2014-04-16 |
AU2010310786A1 (en) | 2012-04-19 |
CA2778291A1 (en) | 2011-04-28 |
EP2491032A1 (en) | 2012-08-29 |
AU2010310786B2 (en) | 2014-03-27 |
JP2013508382A (ja) | 2013-03-07 |
BR112012011328A2 (pt) | 2016-11-22 |
US20120149684A1 (en) | 2012-06-14 |
KR20120068941A (ko) | 2012-06-27 |
US8436002B2 (en) | 2013-05-07 |
CA2778291C (en) | 2014-02-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
MX2012004780A (es) | Inhibidores de akt. | |
SG179085A1 (en) | Pi3 kinase inhibitors and uses thereof | |
MY153915A (en) | Organic compounds | |
IN2012DN03883A (es) | ||
MX341825B (es) | Compuestos de heteroarilo y usos de los mismos. | |
MY161461A (en) | Akt and p70 s6 kinase inhibitors | |
MY181898A (en) | Heterocyclic compounds and uses thereof | |
TN2011000673A1 (en) | Bace inhibitors | |
PH12015501484A1 (en) | Heteroaryl compounds and uses thereof | |
TW201713640A (en) | Bruton's tyrosine kinase inhibitors | |
MA33803B1 (fr) | Inhibiteur de bromodomaine de benzodiazépine | |
UA104885C2 (uk) | Ізотіазолілоксифеніламідини та їх застосування як фунгіцидів | |
WO2011153157A3 (en) | Benzoquinolone inhibitors of vmat2 | |
PT2470546E (pt) | Compostos de hexa-hidrooxazinopteridina para serem utilizados como inibidores de mtor | |
MX2009000884A (es) | Derivados de piridizinona. | |
MY150542A (en) | Cmet inhibitors | |
UA99284C2 (ru) | ИНГИБИТОРЫ р70 S6-КИНАЗЫ | |
WO2010048358A3 (en) | Ethoxyphenylmethyl inhibitors of sglt2 | |
MX2011014019A (es) | Derivados de diazahomoadamantano y sus metodos de uso. | |
GEP20156242B (en) | 2-arylimidazole derivatives as pde10a enzyme inhibitors | |
WO2010077730A3 (en) | Indanone inhibitors of acetylcholinesterase | |
WO2010059639A3 (en) | Hydroxyadamantyl inhibitors of dipeptidylpeptidase iv | |
MX2011010046A (es) | Derivados de diaminopteridina. | |
MX2012004282A (es) | Composiciones farmaceuticas. | |
TN2010000583A1 (en) | Organic compounds |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant or registration |