UA99284C2 - ИНГИБИТОРЫ р70 S6-КИНАЗЫ - Google Patents

ИНГИБИТОРЫ р70 S6-КИНАЗЫ

Info

Publication number
UA99284C2
UA99284C2 UAA200911422A UAA200911422A UA99284C2 UA 99284 C2 UA99284 C2 UA 99284C2 UA A200911422 A UAA200911422 A UA A200911422A UA A200911422 A UAA200911422 A UA A200911422A UA 99284 C2 UA99284 C2 UA 99284C2
Authority
UA
Ukraine
Prior art keywords
kinase inhibitors
formula
methods
provides
present
Prior art date
Application number
UAA200911422A
Other languages
English (en)
Ukrainian (uk)
Inventor
Роберт Дін Даллі
Цзяньпін Хуан
Саджан Джоузеф
Тімоті Алан Шеперд
Крістіан Л. Холст
Original Assignee
Елі Ліллі Енд Компані
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Елі Ліллі Енд Компані filed Critical Елі Ліллі Енд Компані
Publication of UA99284C2 publication Critical patent/UA99284C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Vascular Medicine (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Это изобретение предлагает ингибиторы р70 S 6-киназы формулы: , фармацевтические композиции, которые их содержат, и их применение.
UAA200911422A 2007-05-11 2008-01-05 ИНГИБИТОРЫ р70 S6-КИНАЗЫ UA99284C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US91733107P 2007-05-11 2007-05-11

Publications (1)

Publication Number Publication Date
UA99284C2 true UA99284C2 (ru) 2012-08-10

Family

ID=39765082

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200911422A UA99284C2 (ru) 2007-05-11 2008-01-05 ИНГИБИТОРЫ р70 S6-КИНАЗЫ

Country Status (34)

Country Link
US (2) US8093383B2 (ru)
EP (1) EP2148880B1 (ru)
JP (1) JP5503532B2 (ru)
KR (1) KR101088219B1 (ru)
CN (1) CN101679439B (ru)
AR (1) AR066344A1 (ru)
AU (1) AU2008251692B2 (ru)
BR (1) BRPI0811212A2 (ru)
CA (1) CA2687265C (ru)
CL (1) CL2008001230A1 (ru)
CO (1) CO6241109A2 (ru)
CR (1) CR11106A (ru)
DK (1) DK2148880T3 (ru)
DO (1) DOP2009000257A (ru)
EA (1) EA016445B1 (ru)
EC (1) ECSP099721A (ru)
ES (1) ES2483726T3 (ru)
GT (1) GT200900292A (ru)
HK (1) HK1140767A1 (ru)
HR (1) HRP20140611T1 (ru)
IL (1) IL201564A (ru)
MA (1) MA31433B1 (ru)
MX (1) MX2009012075A (ru)
MY (1) MY154898A (ru)
NZ (1) NZ580423A (ru)
PE (1) PE20090887A1 (ru)
PL (1) PL2148880T3 (ru)
PT (1) PT2148880E (ru)
RS (1) RS53451B (ru)
SI (1) SI2148880T1 (ru)
TN (1) TN2009000446A1 (ru)
TW (1) TWI423805B (ru)
UA (1) UA99284C2 (ru)
WO (1) WO2008140947A1 (ru)

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UA110113C2 (xx) 2010-07-29 2015-11-25 Біциклічні азагетероциклічні карбоксаміди
US9586938B2 (en) 2010-07-29 2017-03-07 Merck Patent Gmbh Cyclic amine azaheterocyclic carboxamides
HUE028967T2 (en) 2010-11-24 2017-01-30 Merck Patent Gmbh Kinozalin carboxamide azetidines
HUE034979T2 (en) 2011-09-12 2018-05-02 Merck Patent Gmbh Aminopyrimidine derivatives for use as modulators of kinase activity
KR101995605B1 (ko) * 2011-09-12 2019-07-02 메르크 파텐트 게엠베하 키나아제 활성의 조절 인자로서 새로운 이미다졸 아민
JP6318156B2 (ja) 2012-09-06 2018-04-25 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼをモジュレートするための化合物および方法、ならびにその指標
AU2013203714B2 (en) 2012-10-18 2015-12-03 Signal Pharmaceuticals, Llc Inhibition of phosphorylation of PRAS40, GSK3-beta or P70S6K1 as a marker for TOR kinase inhibitory activity
EP2920178B1 (en) 2012-11-16 2016-12-21 Merck Patent GmbH Novel heterocyclic derivatives as modulators of kinase activity (p70s6 and akt)
ES2656096T3 (es) 2012-11-16 2018-02-23 Merck Patent Gmbh Nuevos derivados de imidazol-piperidinilo como moduladores de la actividad de quinasa
UA115154C2 (uk) 2012-11-29 2017-09-25 Мерк Патент Гмбх Похідні азахіназолінкарбоксаміду
KR20150124957A (ko) * 2013-03-11 2015-11-06 메르크 파텐트 게엠베하 키나아제 활성의 조절인자로서 (6-[4-1h-이미다졸-2-일)피페리딘-1-일]피리미딘-4-아민 유도체
SG10201708111YA (en) 2013-04-17 2017-11-29 Signal Pharm Llc Combination therapy comprising a dihydropyrazino-pyrazine compound and an androgen receptor antagonist for treating prostate cancer
AU2014254059B2 (en) 2013-04-17 2019-06-06 Signal Pharmaceuticals, Llc Combination therapy comprising a TOR kinase inhibitor and a cytidine analog for treating cancer
US9358232B2 (en) 2013-04-17 2016-06-07 Signal Pharmaceuticals, Llc Methods for treating cancer using TOR kinase inhibitor combination therapy
JP6382945B2 (ja) 2013-04-17 2018-08-29 シグナル ファーマシューティカルズ，エルエルシー ジヒドロピラジノ−ピラジンによる癌治療
MX2015014590A (es) 2013-04-17 2016-03-03 Signal Pharm Llc Tratamiento de cancer con dihidropirazino-pirazinas.
CA2909625C (en) 2013-04-17 2021-06-01 Signal Pharmaceuticals, Llc Combination therapy comprising a tor kinase inhibitor and a 5-substituted quinazolinone compound for treating cancer
KR102459285B1 (ko) 2013-04-17 2022-10-27 시그날 파마소티칼 엘엘씨 1-에틸-7-(2-메틸-6-(1H-1,2,4-트리아졸-3-일)피리딘-3-일)-3,4-디하이드로피라지노[2,3-b]피라진-2(1H)-온에 관한 약학 제제, 제조방법, 고체 형태 및 사용 방법
CN113831345A (zh) 2013-05-29 2021-12-24 西格诺药品有限公司 二氢吡嗪并吡嗪化合物的药物组合物、其固体形式和它们的用途
WO2015134536A1 (en) * 2014-03-04 2015-09-11 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
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EP3131551A4 (en) 2014-04-16 2017-09-20 Signal Pharmaceuticals, LLC SOLID FORMS COMPRISING 1-ETHYL-7-(2-METHYL-6-(1H-1,2,4-TRIAZOL-3-YL) PYRIDIN-3-YL)-3,4-DIHYDROPYRAZINO(2,3-b)PYRAZIN-2(1H)-ONE, AND A COFORMER, COMPOSITIONS AND METHODS OF USE THEREOF
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CN106187899B (zh) * 2016-06-28 2019-07-16 绍兴文理学院 一种氟代氮杂芳烃的合成方法
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IL302951A (en) 2020-11-16 2023-07-01 Merck Patent Gmbh Kinase inhibitor combinations for cancer treatment

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UA99284C2 (ru) * 2007-05-11 2012-08-10 Елі Ліллі Енд Компані ИНГИБИТОРЫ р70 S6-КИНАЗЫ

Also Published As

Publication number Publication date
IL201564A (en) 2014-08-31
PL2148880T3 (pl) 2014-10-31
CA2687265C (en) 2012-12-04
WO2008140947A1 (en) 2008-11-20
PT2148880E (pt) 2014-08-28
DOP2009000257A (es) 2010-03-31
CN101679439B (zh) 2013-09-11
KR20100005710A (ko) 2010-01-15
CN101679439A (zh) 2010-03-24
DK2148880T3 (da) 2014-06-16
EA016445B1 (ru) 2012-05-30
AU2008251692B2 (en) 2012-10-11
HK1140767A1 (en) 2010-10-22
AU2008251692A1 (en) 2008-11-20
CL2008001230A1 (es) 2009-05-22
MY154898A (en) 2015-08-28
JP2010526814A (ja) 2010-08-05
ES2483726T3 (es) 2014-08-07
US20120071490A1 (en) 2012-03-22
KR101088219B1 (ko) 2011-11-30
EP2148880B1 (en) 2014-05-28
CR11106A (es) 2010-04-12
GT200900292A (es) 2011-06-24
US8093383B2 (en) 2012-01-10
MA31433B1 (fr) 2010-06-01
MX2009012075A (es) 2009-11-19
RS53451B (en) 2014-12-31
CA2687265A1 (en) 2008-11-20
US20090163714A1 (en) 2009-06-25
HRP20140611T1 (hr) 2014-08-15
PE20090887A1 (es) 2009-07-13
IL201564A0 (en) 2010-05-31
SI2148880T1 (sl) 2014-07-31
TWI423805B (zh) 2014-01-21
BRPI0811212A2 (pt) 2014-10-29
NZ580423A (en) 2012-02-24
TW200848053A (en) 2008-12-16
ECSP099721A (es) 2009-12-28
CO6241109A2 (es) 2011-01-20
TN2009000446A1 (en) 2011-03-31
AR066344A1 (es) 2009-08-12
EP2148880A1 (en) 2010-02-03
JP5503532B2 (ja) 2014-05-28
EA200971051A1 (ru) 2010-06-30

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