MX2012000709A - Inhibidores de pirrolopiridina de cinasas. - Google Patents

Inhibidores de pirrolopiridina de cinasas.

Info

Publication number
MX2012000709A
MX2012000709A MX2012000709A MX2012000709A MX2012000709A MX 2012000709 A MX2012000709 A MX 2012000709A MX 2012000709 A MX2012000709 A MX 2012000709A MX 2012000709 A MX2012000709 A MX 2012000709A MX 2012000709 A MX2012000709 A MX 2012000709A
Authority
MX
Mexico
Prior art keywords
kinases
pyrrolopyridine
inhibitors
compounds
formula
Prior art date
Application number
MX2012000709A
Other languages
English (en)
Inventor
Yunsong Tong
Alan Florjancic
Thomas Penning
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2012000709A publication Critical patent/MX2012000709A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula (I) o sales farmacéuticas aceptables (ver fórmula (I)) en donde R1a, R1b, R1c, X, e Y se definen en la descripción. La presente invención se refiere también a composiciones que contiene los compuestos los cuales son útiles para inhibir las cinasas tal como Cdc7 y métodos para tratar enfermedades tal como el cáncer.
MX2012000709A 2009-07-15 2010-07-15 Inhibidores de pirrolopiridina de cinasas. MX2012000709A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US22574209P 2009-07-15 2009-07-15
PCT/US2010/042067 WO2011008915A1 (en) 2009-07-15 2010-07-15 Pyrrolopyridine inhibitors of kinases

Publications (1)

Publication Number Publication Date
MX2012000709A true MX2012000709A (es) 2012-03-16

Family

ID=42813135

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2012000709A MX2012000709A (es) 2009-07-15 2010-07-15 Inhibidores de pirrolopiridina de cinasas.

Country Status (8)

Country Link
US (1) US8435980B2 (es)
EP (1) EP2454257B1 (es)
JP (1) JP2012533553A (es)
CN (1) CN102471339A (es)
CA (1) CA2767089A1 (es)
ES (1) ES2432029T3 (es)
MX (1) MX2012000709A (es)
WO (1) WO2011008915A1 (es)

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JP6857617B2 (ja) 2015-05-13 2021-04-14 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ インフルエンザウイルスの複製の阻害剤
WO2016183116A1 (en) 2015-05-13 2016-11-17 Vertex Pharmaceuticals Incorporated Methods of preparing inhibitors of influenza viruses replication
CA2998493A1 (en) 2015-09-16 2017-03-23 Metacrine, Inc. Farnesoid x receptor agonists and uses thereof
KR101954369B1 (ko) * 2017-01-26 2019-03-05 한미약품 주식회사 피리미딘 화합물 및 그의 의약 용도
JP7174709B2 (ja) 2017-03-15 2022-11-17 メタクリン，インク． ファルネソイドｘ受容体アゴニストおよびその使用
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AU2019340402B2 (en) 2018-08-17 2025-04-03 Ptc Therapeutics, Inc. Method for treating pancreatic cancer
KR20250073553A (ko) 2018-09-18 2025-05-27 일라이 릴리 앤드 캄파니 파르네소이드 x 수용체 효능제 및 그의 용도
US12533353B2 (en) 2018-09-24 2026-01-27 Carna Biosciences, Inc. Methods of treatment of cancer comprising CDC7 inhibitors
PH12021551985A1 (en) 2019-02-22 2022-08-22 Hanmi Pharmaceutical Co Ltd Pharmaceutical composition comprising flt3 inhibitor and hypomethylating agent for treating acute myeloid leukemia
WO2020171649A1 (ko) * 2019-02-22 2020-08-27 한미약품 주식회사 Flt3 저해제 및 iap 길항제를 포함하는 급성 골수성 백혈병의 치료를 위한 약학적 조합물
KR20210002015A (ko) * 2019-06-27 2021-01-06 한미약품 주식회사 Flt3 저해제 및 화학치료제를 포함하는 급성 골수성 백혈병 치료용 약학적 조성물
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Also Published As

Publication number Publication date
WO2011008915A1 (en) 2011-01-20
US20110015173A1 (en) 2011-01-20
CA2767089A1 (en) 2011-01-20
JP2012533553A (ja) 2012-12-27
EP2454257B1 (en) 2013-08-21
CN102471339A (zh) 2012-05-23
US8435980B2 (en) 2013-05-07
EP2454257A1 (en) 2012-05-23
ES2432029T3 (es) 2013-11-29

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Owner name: ABBVIE INC.

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