UA118010C2 - Інгібітори реплікації вірусів грипу - Google Patents

Інгібітори реплікації вірусів грипу

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Publication number
UA118010C2
UA118010C2 UAA201402082A UAA201402082A UA118010C2 UA 118010 C2 UA118010 C2 UA 118010C2 UA A201402082 A UAA201402082 A UA A201402082A UA A201402082 A UAA201402082 A UA A201402082A UA 118010 C2 UA118010 C2 UA 118010C2
Authority
UA
Ukraine
Prior art keywords
patient
pharmaceutically acceptable
structural formula
biological sample
acceptable salt
Prior art date
Application number
UAA201402082A
Other languages
English (en)
Inventor
Пол С. Чаріфсон
Майкл П. Кларк
Упул К. Бандарадже
Ренді С. Бетіл
Майкл Дж. Бойд
Іоана Дейвіс
Хунбо Ден
Джон П. Даффі
Люк Дж. Фармер
Хуай Гао
Веньсінь Гу
Джозеф М. Кеннеді
Брайан Ледфорд
Марк В. Ледебур
Франсуа Мальте
Емануеле Перола
Тяньшен Ван
Original Assignee
Вертекс Фармасьютікалз Інкорпорейтед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46650922&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=UA118010(C2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Вертекс Фармасьютікалз Інкорпорейтед filed Critical Вертекс Фармасьютікалз Інкорпорейтед
Publication of UA118010C2 publication Critical patent/UA118010C2/uk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/351—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom not condensed with another ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings

Abstract

Способи інгібування реплікації вірусу грипу в біологічному зразку або у пацієнта, зменшення кількості вірусу грипу в біологічному зразку або в пацієнта і лікування грипу у пацієнта включають введення у вказаний біологічний зразок або пацієнту ефективної кількості сполуки, що відповідає структурній формулі (І): EMBED ISISServer , (I) або її фармацевтично прийнятної солі, де змінні структурної формули (І) є такими, як розкрито в даному описі. Сполука відповідає структурній формулі (І) або структурній формулі її фармацевтично прийнятної солі, де змінні структурної формули (І) є такими, як розкрито в даному описі. Фармацевтична композиція містить ефективну кількість такої сполуки або її фармацевтично прийнятної солі і фармацевтично прийнятний носій, ад'ювант або наповнювач.
UAA201402082A 2011-08-01 2012-01-08 Інгібітори реплікації вірусів грипу UA118010C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201161513793P 2011-08-01 2011-08-01
PCT/US2012/049097 WO2013019828A1 (en) 2011-08-01 2012-08-01 Inhibitors of influenza viruses replication

Publications (1)

Publication Number Publication Date
UA118010C2 true UA118010C2 (uk) 2018-11-12

Family

ID=46650922

Family Applications (2)

Application Number Title Priority Date Filing Date
UAA201402082A UA118010C2 (uk) 2011-08-01 2012-01-08 Інгібітори реплікації вірусів грипу
UAA201807026A UA122808C2 (uk) 2011-08-01 2012-08-01 Інгібітори реплікації вірусів грипу

Family Applications After (1)

Application Number Title Priority Date Filing Date
UAA201807026A UA122808C2 (uk) 2011-08-01 2012-08-01 Інгібітори реплікації вірусів грипу

Country Status (36)

Country Link
US (5) US9051319B2 (uk)
EP (2) EP2739623B1 (uk)
JP (3) JP5917692B2 (uk)
KR (1) KR101967172B1 (uk)
CN (3) CN105503862B (uk)
AP (1) AP3867A (uk)
AR (1) AR087418A1 (uk)
AU (2) AU2012290127B2 (uk)
CA (1) CA2844054C (uk)
CL (1) CL2014000245A1 (uk)
CO (1) CO6940412A2 (uk)
CY (1) CY1118726T1 (uk)
DK (1) DK2739623T3 (uk)
EA (3) EA037372B1 (uk)
EC (1) ECSP14013189A (uk)
ES (2) ES2763535T3 (uk)
GE (2) GEP201706698B (uk)
HK (3) HK1194736A1 (uk)
HR (1) HRP20170421T1 (uk)
HU (1) HUE033752T2 (uk)
IL (2) IL230618A (uk)
IN (1) IN2014CN00562A (uk)
LT (1) LT2739623T (uk)
ME (1) ME02638B (uk)
MX (1) MX339149B (uk)
PE (1) PE20141209A1 (uk)
PL (1) PL2739623T3 (uk)
PT (1) PT2739623T (uk)
RS (1) RS55858B1 (uk)
SG (2) SG10201503835TA (uk)
SI (1) SI2739623T1 (uk)
TW (3) TWI537268B (uk)
UA (2) UA118010C2 (uk)
UY (1) UY34234A (uk)
WO (1) WO2013019828A1 (uk)
ZA (2) ZA201400604B (uk)

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