AR081069A1 - Formas solidas del acido 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico - Google Patents

Formas solidas del acido 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico

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Publication number
AR081069A1
AR081069A1 ARP110101170A ARP110101170A AR081069A1 AR 081069 A1 AR081069 A1 AR 081069A1 AR P110101170 A ARP110101170 A AR P110101170A AR P110101170 A ARP110101170 A AR P110101170A AR 081069 A1 AR081069 A1 AR 081069A1
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Argentina
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degrees
compound
dioxol
hcl
benzoic
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ARP110101170A
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Vertex Pharma
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Publication of AR081069A1 publication Critical patent/AR081069A1/es

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Abstract

Procedimientos para preparar dichas formas, con composiciones farmacéuticas de éstas y con métodos de tratamiento con las mismas. Reivindicacion 1: Una forma solida del ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-il)ciclopropanocarboxamido)-3-metilpiridin-2-il)benzoico (Compuesto 1), caracterizada como Compuesto 1, Forma de Solvato A, o Compuesto 1, Forma de Sal HCl A. Reivindicacion 5: Compuesto 1, Forma de Solvato A, de la reivindicacion 1, 2 o 3, caracterizado por uno o más picos a 21,5 a 21,9 grados, 8,8 a 9,2 grados, 10,8 a 11,2 grados, 18,0 a 18,4 grados y 22,9 a 23,3 grados en una difraccion en polvo de rayos X obtenida usando radiacion Cu K a. Reivindicacion 22: Compuesto 1, Forma de Solvato A, de la reivindicacion 2, donde el punto de fusion es de 185sC a 190sC. Reivindicacion 25: Compuesto 1, Forma de Sal HCl A, de la reivindicacion 1, caracterizado por uno o más picos a 8,8 a 9,2 grados, 17,3 a 17,7 grados, 18,2 a 18,6 grados, 10,1 a 10,5 grados y 15,8 a 16,2 grados en una difraccion en polvo de rayos X obtenida usando radiacion Cu K a. Reivindicacion 23: Compuesto 1, Forma de Solvato A, de la reivindicacion 2, que tiene un grupo espacial P21/n y las siguientes dimensiones de celda unitaria: a = 16,5235 (10) L a = 90s; b = 12,7425 (8) L b = 103,736 (4)s; c = 20,5512 (13) L g = 90s. Reivindicacion 39: Compuesto 1, Forma de Sal HCl A, de la reivindicacion 1, que tiene un grupo espacial P-1 y las siguientes dimensiones de celda unitaria: a = 10,2702 (2) L, b = 10,8782 (2) L, c = 12,4821 (3) L, a = 67,0270 (10)s, b = 66,1810 (10)s y g = 72,4760 (10)s.
ARP110101170A 2010-04-07 2011-04-07 Formas solidas del acido 3-(6-(1-(2,2-difluorbenzo[d][1,3]dioxol-5-il)ciclopropancarboxamido)-3-metilpiridin-2-il)benzoico AR081069A1 (es)

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AR081069A1 true AR081069A1 (es) 2012-06-06

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CA2853299A1 (en) 2011-11-02 2013-05-10 Vertex Pharmaceuticals Incorporated Use of (n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide) for treating cftr mediated diseases
CA2852991C (en) 2011-11-08 2019-12-31 Vertex Pharmaceuticals Incorporated Modulators of atp-binding cassette transporters
ES2742277T3 (es) 2012-01-25 2020-02-13 Vertex Pharma Composiciones farmacéuticas de ácido 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-ilo) ciclopropano carboxamido)-3metilpiridin-2-ilo)benzoico y su administración
CA2865519C (en) 2012-02-27 2018-01-02 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions comprising a solid dispersion of n-[2,4-bis(1,1-dimethylethyl0-5-hydroxyphenyl-1]-1,4-dihydro-4-oxoquinolone-3-carboxamide for treating cystic fibrosis
US8674108B2 (en) 2012-04-20 2014-03-18 Vertex Pharmaceuticals Incorporated Solid forms of N-[2,4-bis(1,1-dimethylethy)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
WO2013185112A1 (en) 2012-06-08 2013-12-12 Vertex Pharmaceuticals Incorporated Pharmaceuticl compositions for the treatment of cftr -mediated disorders
US9012496B2 (en) 2012-07-16 2015-04-21 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions of (R)-1-(2,2-difluorobenzo[D][1,3]dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide and administration thereof
HUE039864T2 (hu) 2012-11-02 2019-02-28 Vertex Pharma Gyógyászati készítmények CFTR-közvetítette betegségek kezelésére
US20140221424A1 (en) 2013-01-30 2014-08-07 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for use in the treatment of cystic fibrosis

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CN105037334A (zh) 2015-11-11
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