MX346497B - Compuestos para la diferenciacion de celulas madre mejorada en hepatocitos. - Google Patents

Compuestos para la diferenciacion de celulas madre mejorada en hepatocitos.

Info

Publication number
MX346497B
MX346497B MX2015011505A MX2015011505A MX346497B MX 346497 B MX346497 B MX 346497B MX 2015011505 A MX2015011505 A MX 2015011505A MX 2015011505 A MX2015011505 A MX 2015011505A MX 346497 B MX346497 B MX 346497B
Authority
MX
Mexico
Prior art keywords
compounds
hepatocytes
stem cell
cell differentiation
formula
Prior art date
Application number
MX2015011505A
Other languages
English (en)
Other versions
MX2015011505A (es
Inventor
Michael Hamilton Matthew
Chiao Eric
Kameoka Sei
Leonard Brian
Triyatni Miriam
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2015011505A publication Critical patent/MX2015011505A/es
Publication of MX346497B publication Critical patent/MX346497B/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/067—Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/20—Antivirals for DNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/30—Organic components
    • C12N2500/46—Amines, e.g. putrescine
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2503/00—Use of cells in diagnostics
    • C12N2503/02—Drug screening
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/45—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from artificially induced pluripotent stem cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Biochemistry (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a compuestos de fórmula I y sales farmacéuticamente aceptables y ésteres del mismo, donde R1 - R11 son como se definen en la descripción indicaciones. Además, la presente invención se relaciona con los métodos de fabricación y utiliza compuestos de fórmula I así como composiciones farmacéuticas que contengan dichos compuestos. Los compuestos de formula I son útiles para diferenciar células madre de células más adultas como hepatocitos para usarse en plataformas de selección de fármacos y en aplicaciones de modelado de la enfermedad.
MX2015011505A 2013-03-15 2014-03-12 Compuestos para la diferenciacion de celulas madre mejorada en hepatocitos. MX346497B (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361792019P 2013-03-15 2013-03-15
US201361811155P 2013-05-22 2013-05-22
PCT/EP2014/054763 WO2014140058A1 (en) 2013-03-15 2014-03-12 Compounds for improved stem cell differentiation into hepatocytes

Publications (2)

Publication Number Publication Date
MX2015011505A MX2015011505A (es) 2016-01-22
MX346497B true MX346497B (es) 2017-03-22

Family

ID=50272618

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015011505A MX346497B (es) 2013-03-15 2014-03-12 Compuestos para la diferenciacion de celulas madre mejorada en hepatocitos.

Country Status (11)

Country Link
US (2) US9334480B2 (es)
EP (1) EP2970178B1 (es)
JP (1) JP6129360B2 (es)
KR (1) KR101767802B1 (es)
CN (1) CN105051023B (es)
BR (1) BR112015023185A2 (es)
CA (1) CA2900690A1 (es)
HK (1) HK1217199A1 (es)
MX (1) MX346497B (es)
RU (1) RU2662954C2 (es)
WO (1) WO2014140058A1 (es)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112105359B (zh) 2017-12-04 2023-12-01 豪夫迈·罗氏有限公司 作为cccDNA抑制剂用于治疗乙型肝炎病毒(HBV)感染的吡咯并[2,3-b]吡嗪化合物
KR20230010625A (ko) 2020-03-11 2023-01-19 비트 바이오 리미티드 간 세포 생성 방법

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7498171B2 (en) * 2002-04-12 2009-03-03 Anthrogenesis Corporation Modulation of stem and progenitor cell differentiation, assays, and uses thereof
WO2005024004A1 (ja) * 2003-08-27 2005-03-17 Renomedix Institute Inc. 間葉系幹細胞の肝細胞への分化方法及び人工ヒト肝臓細胞
EA016633B1 (ru) * 2006-05-23 2012-06-29 Общество С Ограниченной Ответственностью "Инновационная Фармацевтика" Замещенные индолы, способ их получения и применения
WO2012141038A1 (ja) * 2011-04-15 2012-10-18 国立大学法人鳥取大学 ヒト間葉系幹細胞を肝細胞へ分化誘導する新規化合物の合成と解析

Also Published As

Publication number Publication date
CN105051023A (zh) 2015-11-11
EP2970178A1 (en) 2016-01-20
CN105051023B (zh) 2017-08-22
RU2015140469A (ru) 2017-04-21
KR101767802B1 (ko) 2017-08-11
MX2015011505A (es) 2016-01-22
RU2662954C2 (ru) 2018-07-31
US9334480B2 (en) 2016-05-10
CA2900690A1 (en) 2014-09-18
JP6129360B2 (ja) 2017-05-17
JP2016511276A (ja) 2016-04-14
HK1217199A1 (zh) 2016-12-30
US20150158840A1 (en) 2015-06-11
US20150197726A1 (en) 2015-07-16
US9181218B2 (en) 2015-11-10
KR20150119342A (ko) 2015-10-23
EP2970178B1 (en) 2017-06-14
WO2014140058A1 (en) 2014-09-18
BR112015023185A2 (pt) 2017-07-18

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