MA49752A - Procédés de préparation de composés de pyrrolidine - Google Patents

Procédés de préparation de composés de pyrrolidine

Info

Publication number
MA49752A
MA49752A MA049752A MA49752A MA49752A MA 49752 A MA49752 A MA 49752A MA 049752 A MA049752 A MA 049752A MA 49752 A MA49752 A MA 49752A MA 49752 A MA49752 A MA 49752A
Authority
MA
Morocco
Prior art keywords
processes
preparation
pyrrolidine compounds
pyrrolidine
compounds
Prior art date
Application number
MA049752A
Other languages
English (en)
Inventor
Paul T Angell
Robert M Hughes
Berenice Lewandowski
Benjamin J Littler
William A Nugent
David Smith
John Studley
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of MA49752A publication Critical patent/MA49752A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/06—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with radicals, containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4015—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/263—2-Pyrrolidones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Pyrrole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
MA049752A 2017-08-02 2018-08-02 Procédés de préparation de composés de pyrrolidine MA49752A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201762540395P 2017-08-02 2017-08-02

Publications (1)

Publication Number Publication Date
MA49752A true MA49752A (fr) 2021-04-21

Family

ID=63209720

Family Applications (1)

Application Number Title Priority Date Filing Date
MA049752A MA49752A (fr) 2017-08-02 2018-08-02 Procédés de préparation de composés de pyrrolidine

Country Status (15)

Country Link
US (1) US11434201B2 (fr)
EP (1) EP3661915B1 (fr)
JP (1) JP7121794B2 (fr)
KR (1) KR102606188B1 (fr)
CN (1) CN111051280B (fr)
AR (1) AR112467A1 (fr)
AU (1) AU2018309043B2 (fr)
CA (1) CA3071278A1 (fr)
ES (1) ES2912657T3 (fr)
IL (1) IL272384B (fr)
MA (1) MA49752A (fr)
MX (1) MX2020001302A (fr)
NZ (1) NZ761391A (fr)
TW (1) TWI799435B (fr)
WO (1) WO2019028228A1 (fr)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN112250627B (zh) 2014-10-06 2024-02-02 弗特克斯药品有限公司 囊性纤维化跨膜转导调节因子调节剂
RS62670B1 (sr) 2016-09-30 2021-12-31 Vertex Pharma Modulator transmembranskog regulatora provodnosti cistične fibroze, farmaceutske kompozicije, metode lečenja i proces izrade modulatora
MX2019006637A (es) 2016-12-09 2019-08-21 Vertex Pharma Modulador del regulador de conductancia transmembrana de fibrosis quistica composiciones farmaceuticas metodos de tratamiento y proceso para producir el modulador.
AU2018279646B2 (en) 2017-06-08 2023-04-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
MA49631A (fr) 2017-07-17 2020-05-27 Vertex Pharma Méthodes de traitement de la fibrose kystique
CA3071278A1 (fr) 2017-08-02 2019-02-07 Vertex Pharmaceuticals Incorporated Procedes de preparation de composes de pyrrolidine
CA3078893A1 (fr) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated Formes cristallines et compositions de modulateurs de cftr
MX2020005753A (es) 2017-12-08 2020-08-20 Vertex Pharma Procesos para producir moduladores de regulador de conductancia transmembranal de fibrosis quistica.
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
US11066417B2 (en) 2018-02-15 2021-07-20 Vertex Pharmaceuticals Incorporated Modulators of cystic fibrosis transmembrane conductance regulator, pharmaceutical compositions, methods of treatment, and process for making the modulators
WO2019200246A1 (fr) 2018-04-13 2019-10-17 Alexander Russell Abela Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur
MX2022001828A (es) 2019-08-14 2022-06-08 Vertex Pharma Formas cristalinas de moduladores del regulador de conductancia transmembrana de la fibrosis quistica (cftr).
TW202120517A (zh) 2019-08-14 2021-06-01 美商維泰克斯製藥公司 製備cftr調節劑之方法
TW202115092A (zh) 2019-08-14 2021-04-16 美商維泰克斯製藥公司 囊腫纖維化跨膜傳導調節蛋白之調節劑

Family Cites Families (213)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB967177A (en) * 1959-10-13 1964-08-19 Rohm & Haas A method for preparing pyrrolidinones and piperidinones
EP0194599A3 (fr) 1985-03-14 1988-01-20 Nissan Chemical Industries Ltd. Dérivés de benzamide, leur procédé de préparation et fongicides pour le sol les contenant
GB9122590D0 (en) 1991-10-24 1991-12-04 Lilly Industries Ltd Pharmaceutical compounds
DE4410453A1 (de) 1994-03-25 1995-09-28 Hoechst Ag Substituierte heterocyclische Carbonsäureamidester, ihre Herstellung und ihre Verwendung als Arzneimittel
GB9514160D0 (en) 1994-07-25 1995-09-13 Zeneca Ltd Aromatic compounds
EP0804077A1 (fr) 1995-01-19 1997-11-05 Novartis AG Composition herbicide
WO1997018712A1 (fr) 1995-11-23 1997-05-29 Novartis Ag Composition herbicide
EP0873311A1 (fr) 1995-12-15 1998-10-28 Merck Frosst Canada Inc. Derives d'ethane tri-aryle utilises comme inhibiteurs de pde iv
JPH10114654A (ja) 1996-10-09 1998-05-06 Fujisawa Pharmaceut Co Ltd 新規用途
AU6209098A (en) 1997-01-15 1998-08-07 Novartis Ag Herbicidal agent
GB9716657D0 (en) 1997-08-07 1997-10-15 Zeneca Ltd Chemical compounds
DE19742951A1 (de) 1997-09-29 1999-04-15 Hoechst Schering Agrevo Gmbh Acylsulfamoylbenzoesäureamide, diese enthaltende nutzpflanzenschützende Mittel und Verfahren zu ihrer Herstellung
DE19802697A1 (de) 1998-01-24 1999-07-29 Bayer Ag Selektive Herbizide auf Basis von N-Aryl-triazolin(thi)onen und N-Arylsulfonylamino(thio)carbonyltriazolin(thi)onen
CA2320217C (fr) 1998-02-13 2005-01-11 Kureha Kagaku Kogyo Kabushiki Kaisha Derives de n-(pnenylsulfonyle) picolinamide, procede de production de ces derniers et herbicide
BR9909440A (pt) 1998-04-06 2000-12-26 Fujisawa Pharmaceutical Co Derivados de indol
EA004405B1 (ru) 1999-06-10 2004-04-29 Уорнер-Ламберт Компани Способ ингибирования агрегации амилоидных белков и визуализации амилоидных отложений с использованием производных изоиндолина
DE19936438A1 (de) 1999-08-03 2001-02-08 Aventis Cropscience Gmbh Kombinationen von Herbiziden und Safenern
DE19940860A1 (de) 1999-08-27 2001-03-01 Bayer Ag Selektive Herbizide auf Basis eines substituierten Phenylsulfonyl aminocarbonyltriazolinons und Safenern II
DE19958381A1 (de) 1999-12-03 2001-06-07 Bayer Ag Herbizide auf Basis von N-Aryl-uracilen
AU2001286557A1 (en) 2000-08-23 2002-03-04 Merck Frosst Canada And Co. Method of treating or preventing urinary incontinence using prostanoid ep1 receptor antagonists
AR031130A1 (es) 2000-09-20 2003-09-10 Abbott Lab N-acilsulfonamidas promotoras de la apoptosis
US20020055631A1 (en) 2000-09-20 2002-05-09 Augeri David J. N-acylsulfonamide apoptosis promoters
US6720338B2 (en) 2000-09-20 2004-04-13 Abbott Laboratories N-acylsulfonamide apoptosis promoters
WO2002030895A1 (fr) 2000-10-10 2002-04-18 Smithkline Beecham Corporation Indoles substituees, compositions pharmaceutiques contenant ces indoles et leur utilisation comme agent de fixation de ppar-$g(g)
US20100074949A1 (en) 2008-08-13 2010-03-25 William Rowe Pharmaceutical composition and administration thereof
DE10119721A1 (de) 2001-04-21 2002-10-31 Bayer Cropscience Gmbh Herbizide Mittel enthaltend Benzoylcyclohexandione und Safener
DK1395566T3 (da) 2001-05-31 2008-01-07 Vicore Pharma Ab Tricycliske forbindelser, der er nyttige som angiotensin Il-agonister
CN1880304B (zh) 2001-06-28 2010-11-24 辉瑞产品公司 三酰胺取代的吲哚、苯并呋喃及苯并噻吩
DE10145019A1 (de) 2001-09-13 2003-04-03 Bayer Cropscience Gmbh Kombinationen aus Herbiziden und Safenern
DE10146873A1 (de) 2001-09-24 2003-04-17 Bayer Cropscience Gmbh Heterocyclische Amide und -Iminderivate, Verfahren zu ihrer Herstellung, sie enthaltende Mittel und ihre Verwendung als Schädlingsbekämpfungsmittel
US20060100195A1 (en) 2001-11-19 2006-05-11 Takayuki Maruyama Remedies for urinary frequency
DE10157545A1 (de) 2001-11-23 2003-06-12 Bayer Cropscience Gmbh Herbizide Mittel enthaltend Benzoylpyrazole und Safener
US7247748B2 (en) 2002-03-27 2007-07-24 Smithkline Corporation Amide compounds and methods of using the same
GB0212785D0 (en) 2002-05-31 2002-07-10 Glaxo Group Ltd Compounds
WO2003103394A2 (fr) 2002-06-08 2003-12-18 Bayer Cropscience Gmbh Combinaisons d'acides carboxyliques aromatiques herbicides et de phytoprotecteurs
DE10237461A1 (de) 2002-08-16 2004-02-26 Bayer Cropscience Gmbh Herbizide Mittel enthaltend Benzoylpyrazole und Safener
AU2003288901A1 (en) 2002-09-06 2004-03-29 Merck And Co., Inc. Treatment of rheumatoid arthritis by inhibition of pde4
CA2503063A1 (fr) 2002-10-22 2004-05-06 Merck Frosst Canada & Co./Merck Frosst Canada & Cie Inhibiteurs selectifs de la cyclo-oxygenase-2 liberant de l'oxyde nitrique
GB0225548D0 (en) 2002-11-01 2002-12-11 Glaxo Group Ltd Compounds
WO2004046141A1 (fr) 2002-11-21 2004-06-03 Vicore Pharma Ab Nouveaux agonistes tricycliques de l'angiotensine ii
EP1581499A1 (fr) 2002-12-20 2005-10-05 Pfizer Products Inc. Inhibiteurs de proteine de transfert de triglyceride microsomale
WO2004056777A1 (fr) 2002-12-20 2004-07-08 Pfizer Products Inc. Inhibiteurs de proteine microsomale de transfert de triglyceride
JP2006519258A (ja) 2003-02-28 2006-08-24 エンサイシブ・ファーマシューティカルズ・インコーポレイテッド ピリジン、ピリミジン、キノリン、キナゾリンおよびナフタレン系のウロテンシン−ｉｉ受容体拮抗薬
AU2003219291A1 (en) 2003-03-24 2004-10-18 Vicore Pharma Ab Bicyclic compounds useful as angiotensin ii agonists
DE602004022819D1 (de) 2003-06-06 2009-10-08 Vertex Pharma Von atp-bindende kassette transportern
ES2328824T3 (es) 2003-11-14 2009-11-18 Vertex Pharmaceuticals Incorporated Tiazoles y oxazoles utiles como moduladores de transportadores de tipo casete de union a atp.
GB0328024D0 (en) 2003-12-03 2004-01-07 Glaxo Group Ltd Compounds
AU2005207037A1 (en) 2004-01-22 2005-08-04 Nitromed, Inc. Nitrosated and/or nitrosylated compounds, compositions and methods of use
WO2005075435A1 (fr) 2004-01-30 2005-08-18 Vertex Pharmaceuticals Incorporated Modulateurs de transporteurs de type cassette de liaison a l'atp
US7977322B2 (en) 2004-08-20 2011-07-12 Vertex Pharmaceuticals Incorporated Modulators of ATP-binding cassette transporters
EA010369B1 (ru) 2004-02-04 2008-08-29 Пфайзер Продактс Инк. Замещенные хинолиновые соединения
WO2005082414A2 (fr) 2004-03-02 2005-09-09 Astellas Pharma Inc. Médicaments associés
SI1731512T1 (sl) 2004-03-05 2015-01-30 Nissan Chemical Industries, Ltd. Z izoksazolinom substituirana benzamidna spojina in sredstvo za uravnavanje škodljivih organizmov
WO2005099705A2 (fr) 2004-03-24 2005-10-27 Bayer Pharmaceuticals Corporation Preparation de derives imidazoles et leurs procedes d'utilisation
GB0410121D0 (en) 2004-05-06 2004-06-09 Glaxo Group Ltd Compounds
US8354427B2 (en) 2004-06-24 2013-01-15 Vertex Pharmaceutical Incorporated Modulators of ATP-binding cassette transporters
ES2656017T3 (es) 2004-06-24 2018-02-22 Vertex Pharmaceuticals Incorporated Moduladores de transportadores del casete de unión a ATP
EP1790638B1 (fr) 2004-09-15 2013-04-03 Shionogi Co., Ltd. Dérivé de carbamoylpyridone ayant une activité d'inhibition de la vih intégrase
KR20070064356A (ko) 2004-09-29 2007-06-20 포톨라 파마슈티컬스, 인코포레이티드 치환된 2ｈ-1,3-벤족사진-4(3ｈ)온
US20080287399A1 (en) 2004-12-14 2008-11-20 Astrazeneca Ab Substituted Aminopyridines and Uses Thereof
GB0428173D0 (en) 2004-12-23 2005-01-26 Astrazeneca Ab Compounds
AU2005318372A1 (en) 2004-12-23 2006-06-29 Glaxo Group Limited Pyridine compounds for the treatment of prostaglandin mediated diseases
EP1891018B1 (fr) 2005-05-24 2011-11-16 Vertex Pharmaceuticals, Inc. Modulateurs des transporteurs de cassette de liaison a l'atp
WO2007019397A2 (fr) 2005-08-05 2007-02-15 Genelabs Technologies, Inc. Derives d'aryle et heteroaryle a 6 membres pour le traitement de virus
KR20080053297A (ko) 2005-08-11 2008-06-12 버텍스 파마슈티칼스 인코포레이티드 낭포성 섬유종 트랜스막 전도도 조정자의 조절자
WO2007053641A2 (fr) 2005-11-01 2007-05-10 Mars, Incorporated Procyanidines de type a et inflammation
CA2635214A1 (fr) 2005-12-27 2007-07-05 Vertex Pharmaceuticals Incorporated Composes utiles dans les bio-essais cftr et leurs procedes
DK3219705T3 (da) 2005-12-28 2020-04-14 Vertex Pharma Farmaceutiske sammensætninger af den amorfe form af n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinolin-3-carboxamid
US7671221B2 (en) 2005-12-28 2010-03-02 Vertex Pharmaceuticals Incorporated Modulators of ATP-Binding Cassette transporters
EP2016065B1 (fr) 2005-12-28 2012-09-19 Vertex Pharmaceuticals Incorporated Dérivés de la 1-(benzo[d][1,3]dioxol-5-yl)-n-(phenyl)cyclopropane-carboxamide et composés similaires en tant que modulateurs des transporteurs de cassettes de liaison de l'atp pour le traitement de la fibrose cystique
CN101415698A (zh) 2006-04-05 2009-04-22 拜尔农科股份有限公司 杀真菌剂n-环丙基-磺酰胺衍生物
CA2869945C (fr) 2006-04-07 2018-01-23 Vertex Pharmaceuticals Incorporated Modulateurs des transporteurs de cassettes de liaison de l'atp
ES2377840T3 (es) 2006-05-12 2012-04-02 Vertex Pharmaceuticals, Inc. Composiciones de N-[2,4-bis(1,1-dimetiletil)-5-hidroxifenil]-1,4-dihidro-4-oxoquinolina-3-carboxamida
ES2431466T3 (es) 2006-06-30 2013-11-26 Sunesis Pharmaceuticals, Inc. Inhibidores de piridinonil pdk1
ES2646175T3 (es) 2006-11-03 2017-12-12 Vertex Pharmaceuticals Incorporated Derivados de azaindol como moduladores de CFTR
US7754739B2 (en) 2007-05-09 2010-07-13 Vertex Pharmaceuticals Incorporated Modulators of CFTR
US20090047246A1 (en) 2007-02-12 2009-02-19 Intermune, Inc. Novel inhibitors of hepatitis c virus replication
WO2008141385A1 (fr) 2007-05-21 2008-11-27 Biota Scientific Management Pty Ltd Inhibiteurs de polymérases virales
US8058299B2 (en) 2007-05-22 2011-11-15 Via Pharmaceuticals, Inc. Diacylglycerol acyltransferase inhibitors
MX2009012608A (es) 2007-05-25 2009-12-07 Amgen Inc Compuestos de hidroxietil amina substituidos como moduladores de beta-secretasa y metodos de uso.
GB0716532D0 (en) 2007-08-24 2007-10-03 Angeletti P Ist Richerche Bio Therapeutic compounds
EP2197842B1 (fr) 2007-08-29 2012-05-23 Schering Corporation Dérivés d'indole substitués en 2 et 3 pour traiter des infections virales
CA2699292A1 (fr) 2007-09-14 2009-03-26 Vertex Pharmaceuticals Incorporated Solid forms of n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
AU2013231151B2 (en) 2007-11-16 2015-06-25 Vertex Pharmaceuticals Incorporated Isoquinoline modulators of ATP-Binding Cassette transporters
JP5249344B2 (ja) 2007-11-16 2013-07-31 メルク・シャープ・アンド・ドーム・コーポレーション ヘテロ環の３位が置換されたインドール誘導体およびその使用
GB0723794D0 (en) 2007-12-05 2008-01-16 Lectus Therapeutics Ltd Potassium ion channel modulators and uses thereof
EP3683218B1 (fr) 2007-12-07 2024-09-18 Vertex Pharmaceuticals Incorporated Formes solides d'acide benzoïque 3-(6- (1- (2,2-difluorobenzo [d] [1,3] dioxol-5-yl) cyclopropanecarboxamido) -3-methylpyridin-2-yl)
NZ612635A (en) 2007-12-07 2015-06-26 Vertex Pharma Processes for producing cycloalkylcarboxamido-pyridine benzoic acids
AU2013270464B2 (en) 2008-03-31 2016-05-26 Vertex Pharmaceuticals Incorporated Pyridyl derivatives as CFTR modulators
CN102036952A (zh) 2008-04-16 2011-04-27 比奥里波克斯公司 用作药物的双芳基化合物
US20110112193A1 (en) 2008-05-14 2011-05-12 Peter Nilsson Bis-aryl compounds for use as medicaments
EP2145537A1 (fr) 2008-07-09 2010-01-20 Bayer CropScience AG Régulateur de croissance végétale
UY31982A (es) 2008-07-16 2010-02-26 Boehringer Ingelheim Int Derivados de 1,2-dihidropiridin-3-carboxamidas n-sustituidas
ME03019B (fr) 2008-08-13 2018-10-20 Vertex Pharma Composition pharmaceutique de n-[2,4-bis(1,1-dimethylethyl)-5-hydroxyphenyl]-1,4-dihydro-4- oxoquinoline-3-carboxamide et son administration
US20110160227A1 (en) 2008-08-21 2011-06-30 Antony Shaw Prolyl Hydroxylase Inhibitors
WO2010027875A2 (fr) 2008-08-27 2010-03-11 Calcimedica Inc. Composés qui modulent le calcium intracellulaire
NZ592694A (en) 2008-11-06 2013-05-31 Vertex Pharma ATP-Binding Cassette (ABC) transporters as modulators of CFTR activity
UA104876C2 (uk) 2008-11-06 2014-03-25 Вертекс Фармасьютікалз Інкорпорейтед Модулятори atф-зв'язувальних касетних транспортерів
UA108193C2 (uk) 2008-12-04 2015-04-10 Апоптозіндукуючий засіб для лікування раку і імунних і аутоімунних захворювань
US20100160322A1 (en) 2008-12-04 2010-06-24 Abbott Laboratories Apoptosis-inducing agents for the treatment of cancer and immune and autoimmune diseases
ES2536090T3 (es) 2009-01-19 2015-05-20 Abbvie Inc. Agentes inductores de la apoptosis para el tratamiento del cáncer y enfermedades inmunitarias y autoinmunitarias
MX2011009188A (es) 2009-03-11 2011-09-26 Bayer Cropscience Ag Cetoenoles sustituidos con haloalquilmetilenoxi-fenilo.
EP3330255B1 (fr) 2009-03-20 2020-12-09 Vertex Pharmaceuticals Incorporated Procédé de fabrication de modulateurs de régulateur de conductance transmembranaire de la fibrose kystique
WO2010110231A1 (fr) 2009-03-26 2010-09-30 塩野義製薬株式会社 Dérivé de 3-hydroxy-4-pyridone substitué
WO2010123822A1 (fr) 2009-04-20 2010-10-28 Institute For Oneworld Health Composés, compositions et méthodes comprenant des dérivés de pyridazine sulfonamide
PL2435432T6 (pl) 2009-05-26 2024-02-12 Abbvie Ireland Unlimited Company Środki wywołujące apoptozę do leczenia raka oraz chorób immunologicznych i autoimmunologicznych
AU2010336355A1 (en) 2009-12-24 2012-07-05 Vertex Pharmaceuticals Incorporated Analogues for the treatment or prevention of flavivirus infections
WO2011102514A1 (fr) 2010-02-22 2011-08-25 武田薬品工業株式会社 Composé cyclique aromatique
WO2011116397A1 (fr) 2010-03-19 2011-09-22 Vertex Pharmaceuticals Incorporated Formes solides de n-[2,4-bis(1,1-diméthyléthyl)-5-hydroxyphényl]-1,4-dihydro-4-oxoquinoline-3-carboxamide
HUE062892T2 (hu) 2010-03-25 2023-12-28 Vertex Pharma (R)-1(2,2-difluorbenzo[d][1,3]dioxol-5-il)-N-(1-(2,3-dihidroxipropil)-6-fluor-2-(1-hidroxi- 2-metilpropán-2-il)-1H-indol-5-il)ciklopropánkarboxamid elõállítása és köztitermékei
HRP20211752T1 (hr) 2010-04-07 2022-02-18 Vertex Pharmaceuticals Incorporated Farmaceutski pripravci 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioksol-5-il)ciklopropankarboksamido)-3-metilpiridin-2-il)benzojeve kiseline i njihova primjena
MX2012011655A (es) 2010-04-07 2012-11-23 Vertex Pharma Formas solidas de acido 3-(6-(1-(2,2-difluorobenzo [d][1-3]dioxol-5-il]ciclopropanocarboxamido)-3-metilpiridin-2-il) benzoico.
US8344137B2 (en) 2010-04-14 2013-01-01 Hoffman-La Roche Inc. 3,3-dimethyl tetrahydroquinoline derivatives
AU2011242452A1 (en) 2010-04-22 2012-11-08 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions and administrations thereof
ES2858351T3 (es) 2010-04-22 2021-09-30 Vertex Pharma Compuesto intermedio para proceso de producción de compuestos de cicloalquilcaraboxamido-indol
TWI520960B (zh) 2010-05-26 2016-02-11 艾伯維有限公司 用於治療癌症及免疫及自體免疫疾病之細胞凋亡誘導劑
US8563593B2 (en) 2010-06-08 2013-10-22 Vertex Pharmaceuticals Incorporated Formulations of (R)-1-(2,2-difluorobenzo[D] [1,3] dioxol-5-yl)-N-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1H-indol-5-yl)cyclopropanecarboxamide
JP2013536231A (ja) 2010-08-23 2013-09-19 バーテックス ファーマシューティカルズ インコーポレイテッド （ｒ）−１−（２，２−ジフルオロベンゾ［ｄ］［１，３］ジオキソール−５−イル）−ｎ−（１−（２，３−ジヒドロキシプロピル）−６−フルオロ−２−（１−ヒドロキシ−２−メチルプロパン−２−イル）−１ｈ−インドール−５−イル）シクロプロパンカルボキサミドを含む医薬組成物およびその投与
JP2013536251A (ja) 2010-08-27 2013-09-19 バーテックス ファーマシューティカルズ インコーポレイテッド 薬学的組成物およびその投与
US9394290B2 (en) 2010-10-21 2016-07-19 Universitaet Des Saarlandes Campus Saarbruecken Selective CYP11B1 inhibitors for the treatment of cortisol dependent diseases
CA2815179A1 (fr) 2010-11-10 2012-05-18 Actelion Pharmaceuticals Ltd Derives de lactame utiles en tant qu'antagonistes du recepteur de l'orexine
WO2012087938A1 (fr) 2010-12-20 2012-06-28 Glaxosmithkline Llc Dérivés de quinazolinone en tant qu'agents antiviraux
EP2471363A1 (fr) 2010-12-30 2012-07-04 Bayer CropScience AG Utilisation d'acides aryl-, hétéroaryl- et benzylsulfonaminés, d'esters d'acide aminé, d'amides d'acide aminé et carbonitrile ou leurs sels pour l'augmentation de la tolérance au stress dans des plantes
CA2825746A1 (fr) 2011-01-26 2012-08-02 Kyorin Pharmaceutical Co. Ltd. Derive de pyrazolopyridine ou sel de qualite pharmacologique de celui-ci
WO2012110518A1 (fr) 2011-02-17 2012-08-23 Bayer Pharma Aktiengesellschaft 3-(biphenyl-3-yl)-8,8-difluoro-4-hydroxy-l-azaspiro[4.5]déc-3-en-2-one substitués utilisés à des fins thérapeutiques
WO2012116960A1 (fr) 2011-03-01 2012-09-07 Bayer Cropscience Ag 2-acyloxy-pyrrolin-4-ones
AR085585A1 (es) 2011-04-15 2013-10-09 Bayer Cropscience Ag Vinil- y alquinilciclohexanoles sustituidos como principios activos contra estres abiotico de plantas
WO2012166415A1 (fr) 2011-05-27 2012-12-06 Amira Pharmaceuticals, Inc. Inhibiteurs hétérocycliques d'autotaxine et leurs utilisations
CA2842183A1 (fr) 2011-07-18 2013-01-24 Adolor Corporation Procedes de preparation de composes antagonistes des opioides peripheriques et des intermediaires de ceux-ci
SG2014011654A (en) 2011-08-30 2014-08-28 Chdi Foundation Inc Kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
UA115971C2 (uk) 2011-09-16 2018-01-25 Байєр Інтеллектуал Проперті Гмбх Застосування ацилсульфонамідів для покращення врожайності рослин
WO2013038373A1 (fr) 2011-09-16 2013-03-21 Novartis Ag Dérivés pyrimidinamides
BR112014006940A2 (pt) 2011-09-23 2017-04-04 Bayer Ip Gmbh uso de derivados de ácido 1-fenilpirazol-3-carboxílico 4-substituído como agentes contra estresse abiótico em plantas
CA2852991C (fr) 2011-11-08 2019-12-31 Vertex Pharmaceuticals Incorporated Modulateurs de transporteurs de cassette de liaison a l'atp
US8426450B1 (en) 2011-11-29 2013-04-23 Helsinn Healthcare Sa Substituted 4-phenyl pyridines having anti-emetic effect
SG10201606135TA (en) 2012-01-25 2016-09-29 Vertex Pharma Formulations of 3-(6-(1-(2,2-difluorobenzo[d][1,3]dioxol-5-yl) cyclopropanecarboxamido)-3-methylpyridin-2-yl)benzoic acid
JP2015083542A (ja) 2012-02-08 2015-04-30 大日本住友製薬株式会社 ３位置換プロリン誘導体
AU2013226076B2 (en) 2012-02-27 2017-11-16 Vertex Pharmaceuticals Incorporated Pharmaceutical composition and administration thereof
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
EP2838882A1 (fr) 2012-04-20 2015-02-25 Vertex Pharmaceuticals Incorporated Formes solides de n-[2,4-bis(1,1-diméthyléthyle)-5-hydroxyphényle]-1,4-dihydro-4-oxoquinoline-3-carboxamide
EA026393B1 (ru) 2012-05-22 2017-04-28 Дженентек, Инк. N-замещенные бензамиды и их применение в лечении боли
AU2013270681A1 (en) 2012-06-08 2014-12-18 Vertex Pharmaceuticals Incorporated Pharmaceutical compositions for the treatment of CFTR -mediated disorders
WO2013185202A1 (fr) 2012-06-14 2013-12-19 Beta Pharma Canada Inc Inducteurs d'apoptose
WO2014008458A2 (fr) 2012-07-06 2014-01-09 Genentech, Inc. Benzamides n-substitués et leurs procédés d'utilisation
EP2872122A1 (fr) 2012-07-16 2015-05-20 Vertex Pharmaceuticals Incorporated Compositions pharmaceutiques de (r)-1-(2,2-diflurorbenzo[d][1,3]dioxol-5-yl)-n-(1-(2,3-dihydroxypropyl)-6-fluoro-2-(1-hydroxy-2-methylpropan-2-yl)-1h-indol-5-yl) cyclopropanecarboxamide et son administration
JP2015178458A (ja) 2012-07-25 2015-10-08 杏林製薬株式会社 ベンゼン環縮合含窒素５員複素環式化合物、またはその薬理学的に許容される塩
ES2677480T3 (es) 2012-08-13 2018-08-02 Abbvie Inc. Agentes que inducen apoptosis
DK2888251T3 (da) 2012-08-21 2019-07-29 Peter Maccallum Cancer Inst Perforinhæmmende benzensulfonamidforbindelser, fremstilling og anvendelser deraf
AU2013312477B2 (en) 2012-09-06 2018-05-31 Plexxikon Inc. Compounds and methods for kinase modulation, and indications therefor
US10093640B2 (en) 2012-09-21 2018-10-09 Vanderbilt University Substituted benzofuran, benzothiophene and indole MCL-1 inhibitors
US9567301B2 (en) 2012-11-02 2017-02-14 Dana-Farber Cancer Institute, Inc. Pyrrol-1-yl benzoic acid derivatives useful as myc inhibitors
SI2914248T2 (sl) 2012-11-02 2023-12-29 Vertex Pharmaceuticals Incorporated, Farmacevtski sestavki za zdravljenje bolezni, pri katerih posreduje CFTR
EP2914265A4 (fr) 2012-11-05 2016-04-13 Nant Holdings Ip Llc Dérivés indol-5-ole substitués et leurs applications thérapeutiques
WO2014086751A1 (fr) 2012-12-05 2014-06-12 Bayer Cropscience Ag Utilisation de 1-(aryléthinyl)-cyclohexanols, 1-(hétéroaryléthinyl)-cyclohexanols, 1-(hétérocyclyléthinyl)-cyclohexanols et 1-(cyloalcényléthinyl)-cyclohexanols substitués comme principes actifs contre le stress abiotique des plantes
WO2014086723A1 (fr) 2012-12-05 2014-06-12 Bayer Cropscience Ag Utilisation de 1-(aryléthinyl)-bicycloalcanols, 1-(hétéroaryléthinyl)-bicycloalcanols, 1-(hétérocyclyléthinyl)-bicycloalcanols et 1-(cyloalcényléthinyl)-bicycloalcanols substitués comme principes actifs contre le stress abiotique des plantes
UA115576C2 (uk) 2012-12-06 2017-11-27 Байєр Фарма Акцієнгезелльшафт Похідні бензимідазолу як антагоністи ер4
GB201223265D0 (en) 2012-12-21 2013-02-06 Selvita Sa Novel benzimidazole derivatives as kinase inhibitors
WO2014109858A1 (fr) 2013-01-14 2014-07-17 Amgen Inc. Méthodes d'utilisation d'inhibiteurs de cycle cellulaire pour moduler une ou plusieurs propriétés d'une culture cellulaire
ES2705247T3 (es) 2013-03-14 2019-03-22 Univ Columbia 4-fenilpiperidinas, su preparación y uso
ES2700541T3 (es) 2013-03-14 2019-02-18 Univ Columbia Octahidrociclopentapirroles, su preparación y uso
RS59981B1 (sr) 2013-03-15 2020-03-31 Cyclerion Therapeutics Inc Sgc stimulatori
MY184218A (en) 2013-03-29 2021-03-26 Takeda Pharmaceuticals Co 6-(5-hydroxy-1h-pyrazol-1-yl)nicotinamide derivatives and their use as phd inhibitors
CA2911453C (fr) 2013-05-07 2021-08-03 Galapagos Nv Nouveaux composes et leurs compositions pharmaceutiques pour le traitement de la mucoviscidose.
WO2014181287A1 (fr) 2013-05-09 2014-11-13 Piramal Enterprises Limited Composés hétérocyclyliques et leurs utilisations
WO2014190199A1 (fr) 2013-05-24 2014-11-27 The California Institute For Biomedical Research Composés pour le traitement de la tuberculose résistante aux médicaments et persistante
WO2015010832A1 (fr) 2013-07-22 2015-01-29 Syngenta Participations Ag Dérivés hétérocycliques microbiocides
WO2015031608A1 (fr) 2013-08-28 2015-03-05 Vanderbilt University Inhibiteurs de mcl-1 de type indole substitué
WO2015051043A1 (fr) 2013-10-01 2015-04-09 Amgen Inc. Composés d'acylsulfonamide de biaryle en tant qu'inhibiteurs des canaux sodiques
WO2015069287A1 (fr) 2013-11-08 2015-05-14 Allergan, Inc. Composés à utiliser en tant que modulateurs des tyrosine kinases
US10231932B2 (en) 2013-11-12 2019-03-19 Vertex Pharmaceuticals Incorporated Process of preparing pharmaceutical compositions for the treatment of CFTR mediated diseases
RU2744460C2 (ru) 2014-04-15 2021-03-09 Вертекс Фармасьютикалз Инкорпорейтед Фармацевтические композиции для лечения заболеваний, опосредованных муковисцидозным трансмембранным регулятором проводимости
CN112250627B (zh) 2014-10-06 2024-02-02 弗特克斯药品有限公司 囊性纤维化跨膜转导调节因子调节剂
JP6746569B2 (ja) 2014-10-07 2020-08-26 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ 嚢胞性線維症膜貫通コンダクタンス制御因子のモジュレーターの共結晶
SG11201703963QA (en) 2014-11-18 2017-06-29 Vertex Pharma Process of conducting high throughput testing high performance liquid chromatography
MA41253A (fr) 2014-12-23 2017-10-31 Proteostasis Therapeutics Inc Composés, compositions et procédés pour augmenter l'activité du cftr
US10738011B2 (en) 2014-12-23 2020-08-11 Proteostasis Therapeutics, Inc. Derivatives of 5-(hetero)arylpyrazol-3-carboxylic amide or 1-(hetero)aryltriazol-4-carboxylic amide useful for the treatment of inter alia cystic fibrosis
EP3256463B1 (fr) 2015-02-15 2019-10-09 F. Hoffmann-La Roche AG Dérivés de 1-(het)arylsulfonyl-(pyrrolidine ou piperidine)-2-carboxamide et leur utilisation en tant qu'antagonistes de trpa1
WO2016160945A1 (fr) 2015-03-31 2016-10-06 Concert Pharmaceuticals, Inc. Vx-661 deutéré
US20180353500A1 (en) 2015-09-21 2018-12-13 Vertex Pharmaceuticals (Europe) Limited Administration of deuterated cftr potentiators
EP3854782A1 (fr) 2016-03-30 2021-07-28 Genentech, Inc. Benzamides substitués et leurs procédés d'utilisation
WO2017173274A1 (fr) 2016-03-31 2017-10-05 Vertex Pharmaceuticals Incorporated Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique
EP3440057B1 (fr) 2016-04-07 2021-09-22 Proteostasis Therapeutics, Inc. Analogues du ivacaftor conentant des atomes de silicium
CN109219602A (zh) 2016-04-26 2019-01-15 艾伯维公司 囊性纤维化跨膜传导调节物蛋白的调节剂
US10138227B2 (en) 2016-06-03 2018-11-27 Abbvie S.Á.R.L. Heteroaryl substituted pyridines and methods of use
WO2017223188A1 (fr) 2016-06-21 2017-12-28 Proteostasis Therapeutics, Inc. Composés, compositions et procédés pour augmenter l'activité du cftr
RS62670B1 (sr) 2016-09-30 2021-12-31 Vertex Pharma Modulator transmembranskog regulatora provodnosti cistične fibroze, farmaceutske kompozicije, metode lečenja i proces izrade modulatora
US10399940B2 (en) 2016-10-07 2019-09-03 Abbvie S.Á.R.L. Substituted pyrrolidines and methods of use
US9981910B2 (en) 2016-10-07 2018-05-29 Abbvie S.Á.R.L. Substituted pyrrolidines and methods of use
US20190248779A1 (en) 2016-10-26 2019-08-15 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
US20190248765A1 (en) 2016-10-26 2019-08-15 Proteostasis Therapeutics, Inc. Compounds, compositions, and methods for increasing cftr activity
US20190256474A1 (en) 2016-10-26 2019-08-22 Proteostasis Therapeutics, Inc. N-phenyl-2-(3-phenyl-6-oxo-1,6-dihydropyridazin-1-yl)acetamide derivatives for treating cystic fibrosis
EP4424311A2 (fr) 2016-11-18 2024-09-04 Cystic Fibrosis Foundation Pyrrolopyrimidines en tant que potentialisateurs de cftr
MX2019006637A (es) 2016-12-09 2019-08-21 Vertex Pharma Modulador del regulador de conductancia transmembrana de fibrosis quistica composiciones farmaceuticas metodos de tratamiento y proceso para producir el modulador.
SG10201911221RA (en) 2016-12-16 2020-02-27 Cystic Fibrosis Found Bicyclic heteroaryl derivatives as cftr potentiators
US20200123137A1 (en) 2016-12-20 2020-04-23 AbbVie S.à.r.l. Deuterated cftr modulators and methods of use
WO2018127130A1 (fr) 2017-01-07 2018-07-12 Shanghai Fochon Pharmaceutical Co., Ltd. Composés en tant qu'agents induisant l'apoptose sélective de bcl-2
TW201831471A (zh) 2017-02-24 2018-09-01 盧森堡商艾伯維公司 囊腫纖化症跨膜傳導調節蛋白的調節劑及其使用方法
US20180280349A1 (en) 2017-03-28 2018-10-04 Vertex Pharmaceuticals Incorporated Methods of treating cystic fibrosis in patients with residual function mutations
MA49061A (fr) 2017-04-28 2021-04-21 Proteostasis Therapeutics Inc Dérivés 4-sulfonylaminocarbonylquinoline pour augmenter l'activité cftr
AU2018279646B2 (en) 2017-06-08 2023-04-06 Vertex Pharmaceuticals Incorporated Methods of treatment for cystic fibrosis
US20210069174A1 (en) 2017-07-01 2021-03-11 Vertex Pharmaceuticals Incorporated Compositions and methods for treatment of cystic fibrosis
CA3069225A1 (fr) 2017-07-17 2019-01-24 Vertex Pharmaceuticals Incorporated Methodes de traitement de la fibrose kystique
MA49631A (fr) 2017-07-17 2020-05-27 Vertex Pharma Méthodes de traitement de la fibrose kystique
WO2019026075A1 (fr) 2017-07-31 2019-02-07 Technion Research & Development Foundation Limited Procédés de détection d'adn modifié et non modifié
CA3071278A1 (fr) 2017-08-02 2019-02-07 Vertex Pharmaceuticals Incorporated Procedes de preparation de composes de pyrrolidine
US10988454B2 (en) 2017-09-14 2021-04-27 Abbvie Overseas S.À.R.L. Modulators of the cystic fibrosis transmembrane conductance regulator protein and methods of use
CA3078230A1 (fr) 2017-10-06 2019-04-11 Proteostasis Therapeutics, Inc. Composes, compositions et methodes pour augmenter l'activite de cftr
CA3078893A1 (fr) 2017-10-19 2019-04-25 Vertex Pharmaceuticals Incorporated Formes cristallines et compositions de modulateurs de cftr
US20210228489A1 (en) 2017-12-04 2021-07-29 Vertex Pharmaceuticals Incorporated Compositions for treating cystic fibrosis
MX2020005753A (es) 2017-12-08 2020-08-20 Vertex Pharma Procesos para producir moduladores de regulador de conductancia transmembranal de fibrosis quistica.
TWI810243B (zh) 2018-02-05 2023-08-01 美商維泰克斯製藥公司 用於治療囊腫纖化症之醫藥組合物
WO2019191620A1 (fr) 2018-03-30 2019-10-03 Vertex Pharmaceuticals Incorporated Formes cristallines de modulateurs de cftr
WO2019200246A1 (fr) 2018-04-13 2019-10-17 Alexander Russell Abela Modulateurs du régulateur de la conductance transmembranaire de la fibrose kystique, compositions pharmaceutiques, procédés de traitement et procédé de fabrication du modulateur

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