BRPI0507278A - moduladores dos transportadores do cassete de ligação ao atp - Google Patents
moduladores dos transportadores do cassete de ligação ao atpInfo
- Publication number
- BRPI0507278A BRPI0507278A BRPI0507278-6A BRPI0507278A BRPI0507278A BR PI0507278 A BRPI0507278 A BR PI0507278A BR PI0507278 A BRPI0507278 A BR PI0507278A BR PI0507278 A BRPI0507278 A BR PI0507278A
- Authority
- BR
- Brazil
- Prior art keywords
- ring
- modulators
- membered
- atp
- aromatic
- Prior art date
Links
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- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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Abstract
MODULADORES DOS TRANSPORTADORES DO CASSETE DE LIGAçãO AO ATP. A presente invenção refere-se aos moduladores dos transportadores de Cassete de Ligação a ATP ("ABC") ou fragmentos destes, incluindo o Regulador da Conductância da Transmembrana de Fibrose Cística ("CFTR"), suas composições e métodos também. A presente invenção também refere-se aos métodos de tratamento de doenças mediadas pelo transportador de ABC usando tais moduladores (I) ou um sal farmaceuticamente aceitável deste, em que: Ht é um anel heteroamático de 5 membros contendo de 1 a 4 heteroátomos selecioandos de O, S, N, NH, em que dito anel é opcionalmente fundido a um anel carbocíclico ou heterocíclico, aromático ou não-aromático de 6 membros ou bicíclico de 10 membros, em que Ht é opcionalmente substituído por w ocorrências de WR¬ w¬, em que w é de 0 a 5; o anel A é anel monocíclico de 3 a 7 membros tendo de 0 a 3 heteroátomos selecionados de O, S, N OU NH, em que o anel A é opcionalmente substituído por q ocorrências de QR¬ q¬, o anel B é opcionalmente fundido ao anel carbocíclico ou heterocíclico, aromático ou não aromático de 5 a 6 membros.
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Application Number | Priority Date | Filing Date | Title |
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US54056404P | 2004-01-30 | 2004-01-30 | |
US60350304P | 2004-08-20 | 2004-08-20 | |
PCT/US2005/002644 WO2005075435A1 (en) | 2004-01-30 | 2005-01-31 | Modulators of atp-binding cassette transporters |
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BRPI0507278A true BRPI0507278A (pt) | 2007-06-26 |
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BRPI0507278-6A BRPI0507278A (pt) | 2004-01-30 | 2005-01-31 | moduladores dos transportadores do cassete de ligação ao atp |
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US (1) | US8759335B2 (pt) |
EP (2) | EP3219709B1 (pt) |
JP (5) | JP4960708B2 (pt) |
CN (1) | CN1938279B (pt) |
AU (1) | AU2005210474B2 (pt) |
BR (1) | BRPI0507278A (pt) |
CA (1) | CA2554796A1 (pt) |
ES (2) | ES2631362T3 (pt) |
HK (1) | HK1104292A1 (pt) |
MX (1) | MXPA06008606A (pt) |
WO (1) | WO2005075435A1 (pt) |
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2005
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- 2005-01-31 US US11/047,366 patent/US8759335B2/en active Active
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- 2005-01-31 EP EP17166575.5A patent/EP3219709B1/en active Active
- 2005-01-31 CN CN2005800097913A patent/CN1938279B/zh not_active Expired - Fee Related
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JP5840239B2 (ja) | 2016-01-06 |
JP2014088437A (ja) | 2014-05-15 |
JP6158985B2 (ja) | 2017-07-05 |
JP2007519740A (ja) | 2007-07-19 |
ES2791303T3 (es) | 2020-11-03 |
EP3219709A1 (en) | 2017-09-20 |
JP5669319B2 (ja) | 2015-02-12 |
MXPA06008606A (es) | 2007-04-13 |
ES2631362T3 (es) | 2017-08-30 |
EP3219709B1 (en) | 2020-03-18 |
JP4960708B2 (ja) | 2012-06-27 |
US20060052358A1 (en) | 2006-03-09 |
HK1104292A1 (en) | 2008-01-11 |
CA2554796A1 (en) | 2005-08-18 |
EP1716122A1 (en) | 2006-11-02 |
JP2016153424A (ja) | 2016-08-25 |
CN1938279B (zh) | 2011-09-14 |
AU2005210474B2 (en) | 2011-07-07 |
WO2005075435A1 (en) | 2005-08-18 |
CN1938279A (zh) | 2007-03-28 |
EP1716122B1 (en) | 2017-04-19 |
AU2005210474A1 (en) | 2005-08-18 |
JP2012077094A (ja) | 2012-04-19 |
US8759335B2 (en) | 2014-06-24 |
JP2015091875A (ja) | 2015-05-14 |
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