DE69916488D1 - Substituierte caprolactam-derivate, diese enthaltende pharmazeutische zubereitungen sowie ihre verwendung zur behandlung von tumoren - Google Patents

Substituierte caprolactam-derivate, diese enthaltende pharmazeutische zubereitungen sowie ihre verwendung zur behandlung von tumoren

Info

Publication number
DE69916488D1
DE69916488D1 DE69916488T DE69916488T DE69916488D1 DE 69916488 D1 DE69916488 D1 DE 69916488D1 DE 69916488 T DE69916488 T DE 69916488T DE 69916488 T DE69916488 T DE 69916488T DE 69916488 D1 DE69916488 D1 DE 69916488D1
Authority
DE
Germany
Prior art keywords
tumors
treatment
pharmaceutical preparations
preparations containing
substituted caprolactam
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69916488T
Other languages
English (en)
Other versions
DE69916488T2 (de
Inventor
Frederick Ray Kinder Jr
Kenneth Walter Bair
Christopher Turchik Jagoe
Richard William Versace
Sompong Wattanasin
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Publication of DE69916488D1 publication Critical patent/DE69916488D1/de
Application granted granted Critical
Publication of DE69916488T2 publication Critical patent/DE69916488T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
    • C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
    • C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D223/08—Oxygen atoms
    • C07D223/10—Oxygen atoms attached in position 2
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
DE69916488T 1998-11-17 1999-11-15 Substituierte caprolactam-derivate, diese enthaltende pharmazeutische zubereitungen sowie ihre verwendung zur behandlung von tumoren Expired - Lifetime DE69916488T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US19335498A 1998-11-17 1998-11-17
PCT/EP1999/008767 WO2000029382A1 (en) 1998-11-17 1999-11-15 Certain substituted caprolactams, pharmaceutical compositions containing them and their use in treating tumors
US193354 2002-07-11

Publications (2)

Publication Number Publication Date
DE69916488D1 true DE69916488D1 (de) 2004-05-19
DE69916488T2 DE69916488T2 (de) 2005-03-24

Family

ID=22713307

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69916488T Expired - Lifetime DE69916488T2 (de) 1998-11-17 1999-11-15 Substituierte caprolactam-derivate, diese enthaltende pharmazeutische zubereitungen sowie ihre verwendung zur behandlung von tumoren

Country Status (25)

Country Link
EP (1) EP1131297B1 (de)
JP (1) JP3550545B2 (de)
KR (1) KR20010080461A (de)
CN (1) CN1187333C (de)
AR (1) AR023914A1 (de)
AT (1) ATE264309T1 (de)
AU (1) AU748016B2 (de)
BR (1) BR9915436A (de)
CA (1) CA2347773C (de)
CO (1) CO5140099A1 (de)
CZ (1) CZ20011707A3 (de)
DE (1) DE69916488T2 (de)
ES (1) ES2221463T3 (de)
HU (1) HUP0104224A3 (de)
ID (1) ID28343A (de)
IL (1) IL142701A0 (de)
NO (1) NO20012428L (de)
PE (1) PE20001241A1 (de)
PL (1) PL347633A1 (de)
PT (1) PT1131297E (de)
SK (1) SK6692001A3 (de)
TR (1) TR200101366T2 (de)
UY (2) UY25807A1 (de)
WO (1) WO2000029382A1 (de)
ZA (1) ZA200103419B (de)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60132324T2 (de) * 2000-05-11 2008-12-24 Novartis Ag Substituierte caprolactam carbonate und ether sowie deren verwendung als anti-tumor wirkstoffe
WO2002072555A1 (en) * 2001-03-12 2002-09-19 Novartis Ag Process for preparing certain substituted caprolactams
AU2004263287B2 (en) * 2003-07-25 2009-02-12 Novartis Ag Substituted lactams and their use as anti-cancer agents
DE10349669B3 (de) * 2003-10-24 2005-05-25 Aventis Pharma Deutschland Gmbh Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung
US7153846B2 (en) 2003-10-24 2006-12-26 Sanofi-Aventis Deutschland Gmbh Bengamide derivatives, process for preparing them, and their use
FR2878528B1 (fr) * 2004-11-29 2008-05-16 Aventis Pharma Sa 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation
FR2878525B1 (fr) 2004-11-29 2007-02-23 Aventis Pharma Sa Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation
FR2901554B1 (fr) 2006-05-24 2011-04-01 Sanofi Aventis 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation
FR2901555A1 (fr) 2006-05-24 2007-11-30 Sanofi Aventis Sa 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzothiazepine, leur preparation, compositions les contenant et utilisation
FR2901556A1 (fr) * 2006-05-24 2007-11-30 Sanofi Aventis Sa Derives de 2-alcoxy-3,4,5-trihydroxy-alkylamide, leur preparation, compositions les contenant et utilisation
WO2011157787A1 (en) 2010-06-17 2011-12-22 Novartis Ag Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives
CN102947275A (zh) 2010-06-17 2013-02-27 诺瓦提斯公司 哌啶基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9411841D0 (en) * 1994-06-14 1994-08-03 Pharma Mar Sa New antitumoral compounds from jaspis sponge

Also Published As

Publication number Publication date
AU748016B2 (en) 2002-05-30
AU1506000A (en) 2000-06-05
IL142701A0 (en) 2002-03-10
UY25807A1 (es) 2001-08-27
CZ20011707A3 (cs) 2001-08-15
PL347633A1 (en) 2002-04-22
CA2347773A1 (en) 2000-05-25
HUP0104224A2 (hu) 2002-03-28
ID28343A (id) 2001-05-17
JP3550545B2 (ja) 2004-08-04
AR023914A1 (es) 2002-09-04
ATE264309T1 (de) 2004-04-15
EP1131297B1 (de) 2004-04-14
JP2002529536A (ja) 2002-09-10
SK6692001A3 (en) 2001-10-08
KR20010080461A (ko) 2001-08-22
CO5140099A1 (es) 2002-03-22
DE69916488T2 (de) 2005-03-24
NO20012428L (no) 2001-07-17
WO2000029382A1 (en) 2000-05-25
CN1326445A (zh) 2001-12-12
EP1131297A1 (de) 2001-09-12
UY26036A1 (es) 2001-06-29
CA2347773C (en) 2009-03-10
NO20012428D0 (no) 2001-05-16
ZA200103419B (en) 2002-06-26
CN1187333C (zh) 2005-02-02
PE20001241A1 (es) 2000-11-24
ES2221463T3 (es) 2004-12-16
HUP0104224A3 (en) 2002-04-29
PT1131297E (pt) 2004-08-31
BR9915436A (pt) 2001-08-07
TR200101366T2 (tr) 2001-10-22

Similar Documents

Publication Publication Date Title
ATE447947T1 (de) Pharmazeutische zubereitungen zur behandlung von insulinresitenz
DE69710095T2 (de) Pharmazeutische zubereitung zur behandlung von diabetes
ATE256463T1 (de) Pharmazeutische zubereitung zur verwendung in der behandlung von diabetes
ATE204754T1 (de) Pharmazeutische zusammensetzung von metformin und fibrat, und ihre verwendung zur behandlung von hyperglykämie
DE69929996D1 (de) Pharmazeutisches mittel zur behandlung von diabetes
ATE527022T1 (de) Verwendung von cyclooxygenase-2-inhibitoren zur behandlung und vorbeugung von tumoren, von tumor- abhängigen erkrankungen und kachexie
ATE235481T1 (de) Substituierte benzopyranderivate zur behandlung von entzündungen
DE60019556D1 (de) 2-amino-benzoxazinonderivate zur behandlung von fettleibigkeit
DE69836752D1 (de) Prostaglandinagoniste und deren verwendung zur behandlung von knochenerkrankungen
ATE276245T1 (de) Indolderivate und deren verwendung zur behandlung von u.a. osteoporosis
DE60019555D1 (de) 2-oxy-benzoxazinonderivate zur behandlung von fettleibigkeit
DE60032795D1 (de) Nordihydroguaiaretinsäurederivate zur behandlung von tumoren
DE69804659D1 (de) 21-hydro-6,19-oxidoprogesterone (21oh-60p) und deren verwendung als arzneimittel zur behandlung von glukokortikoidüberschuss
DE50010284D1 (de) Arzneimittel zur behandlung von bluthochdruck
ATE316529T1 (de) Substituierte pyridylmethylpiperazin- und piperidinderivate, deren herstellung und deren verwendung in der behandlung von erkrankungen des zentralnervensystems (zns)
DE69916488D1 (de) Substituierte caprolactam-derivate, diese enthaltende pharmazeutische zubereitungen sowie ihre verwendung zur behandlung von tumoren
EE03771B1 (et) Tetrahüdropüridoühendid, neid sisaldav ravim ja nende kasutamine
DE69912670D1 (de) Substituierte tricyclische Verbindungen und deren Verwendung zur Behandlung von sPLA2-bedingten Erkrankungen
DE69420229T2 (de) Pharmazeutische Zusammensetzung zur Behandlung von AIDS
ATE418552T1 (de) Substituierte amino-furan-2-yl-essigsaure- und amino-thien-2-yl-essigsaure-derivate und ihre verwendung zur behandlung von migraine bzw. schmerz
ATE252096T1 (de) Prolylendopeptidase-inhibitoren, ihre herstellung und ihre pharmazeutische verwendung
ATE247466T1 (de) Pharmazeutische zubereitungen enthaltend ibuprofen und domperidon zur behandlung von migräne
DE69738320D1 (de) Verwendung von pyrolidin-derivaten zur herstellung von arzneimitteln zur behandlung von drogenmissbrauch
DE59708511D1 (de) Verwendung von 7-(1-aminomethyl-2-oxa-7-aza-bicyclo 3.3.0]oct-7-yl)-chinoloncarbonsäure- und -naphthyridoncarbonsäure-derivaten zur therapie von helicobacter-pylori-infektionen und den damit assoziierten gastroduodenalen erkrankungen
ATE261965T1 (de) Bispidin-derivate zur behandlung von herzarrhythmien

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: KROHER, STROBEL RECHTS- UND PATENTANWAELTE, 80336

8328 Change in the person/name/address of the agent

Representative=s name: DR. SCHOEN & PARTNER, 80336 MUENCHEN