UY26036A1 - Procedimiento para preparar ciertas caprolactamas sustituidas - Google Patents
Procedimiento para preparar ciertas caprolactamas sustituidasInfo
- Publication number
- UY26036A1 UY26036A1 UY26036A UY26036A UY26036A1 UY 26036 A1 UY26036 A1 UY 26036A1 UY 26036 A UY26036 A UY 26036A UY 26036 A UY26036 A UY 26036A UY 26036 A1 UY26036 A1 UY 26036A1
- Authority
- UY
- Uruguay
- Prior art keywords
- compound
- formula
- cycloalkyl
- procedure
- alkyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
Proceso para la preparación de un compuesto de caprolactama, de fórmula (I), sustituida, en donde: R1 es alquilo o cicloaqluilo; R2 es hidrógeno o alquilo; X es alquileno, alquenileno o alquinileno; m es 0 o 1; y R3 es cicloalquilo, o un sistema de anillos aromáticos seleccionado a partir de II, III. IV y V (ver figuras), o una sal de adición de ácido farmacéuticamente aceptable del mismo, cuando sea posible, cuyo proceso comprende, en un primer paso, acilar un compuesto de aminocaprolactama de la fórmula VI, o con un compuesto de lactona de fórmula VII, en presencia de un solvente orgánico polar, para obtener un compuesto de diamida de la de la fórmula VIII, en donde cada uno de R1, R2, X, m y R3 es como se define anteriormente, y en un segundo paso, hidrolizar el compuesto de diamida obtenido en el primer paso, mediante su disolución en una mezcla de solventes, para obtener el compuesto de caprolactama deseado de la fórmula (I). Por ejemplo: (2R,3R,4S,5R,6E)-3,4,5-trihidroxi-2-metoxi-8,8-dimetil-N-((3S,6R)-hexahidro-2-oxo-6-(cicloheptilcarbonil)oxi-2H-azepin-3-il)non-6-enamida. Estos compuestos son útiles para el tratamiento de tumores.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19335498A | 1998-11-17 | 1998-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UY26036A1 true UY26036A1 (es) | 2001-06-29 |
Family
ID=22713307
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25807A UY25807A1 (es) | 1998-11-17 | 1999-11-17 | Caprolactamas sustituidas, composiciones farmacéuticas que las contienen, y su uso en el tratamiento de tumores. |
| UY26036A UY26036A1 (es) | 1998-11-17 | 2000-02-25 | Procedimiento para preparar ciertas caprolactamas sustituidas |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UY25807A UY25807A1 (es) | 1998-11-17 | 1999-11-17 | Caprolactamas sustituidas, composiciones farmacéuticas que las contienen, y su uso en el tratamiento de tumores. |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1131297B1 (es) |
| JP (1) | JP3550545B2 (es) |
| KR (1) | KR20010080461A (es) |
| CN (1) | CN1187333C (es) |
| AR (1) | AR023914A1 (es) |
| AT (1) | ATE264309T1 (es) |
| AU (1) | AU748016B2 (es) |
| BR (1) | BR9915436A (es) |
| CA (1) | CA2347773C (es) |
| CO (1) | CO5140099A1 (es) |
| CZ (1) | CZ20011707A3 (es) |
| DE (1) | DE69916488T2 (es) |
| ES (1) | ES2221463T3 (es) |
| HU (1) | HUP0104224A3 (es) |
| ID (1) | ID28343A (es) |
| IL (1) | IL142701A0 (es) |
| NO (1) | NO20012428L (es) |
| PE (1) | PE20001241A1 (es) |
| PL (1) | PL347633A1 (es) |
| PT (1) | PT1131297E (es) |
| SK (1) | SK6692001A3 (es) |
| TR (1) | TR200101366T2 (es) |
| UY (2) | UY25807A1 (es) |
| WO (1) | WO2000029382A1 (es) |
| ZA (1) | ZA200103419B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2003532711A (ja) * | 2000-05-11 | 2003-11-05 | ノバルティス アクチエンゲゼルシャフト | 置換カプロラクタム炭酸エステルおよびカプロラクタムエーテル、およびそれらの抗腫瘍薬としての使用 |
| WO2002072555A1 (en) * | 2001-03-12 | 2002-09-19 | Novartis Ag | Process for preparing certain substituted caprolactams |
| CN1856486A (zh) * | 2003-07-25 | 2006-11-01 | 诺瓦提斯公司 | 取代的内酰胺和它们作为抗癌剂的用途 |
| DE10349669B3 (de) * | 2003-10-24 | 2005-05-25 | Aventis Pharma Deutschland Gmbh | Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US7153846B2 (en) | 2003-10-24 | 2006-12-26 | Sanofi-Aventis Deutschland Gmbh | Bengamide derivatives, process for preparing them, and their use |
| FR2878525B1 (fr) | 2004-11-29 | 2007-02-23 | Aventis Pharma Sa | Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation |
| FR2878528B1 (fr) | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
| FR2901555A1 (fr) | 2006-05-24 | 2007-11-30 | Sanofi Aventis Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzothiazepine, leur preparation, compositions les contenant et utilisation |
| FR2901556A1 (fr) * | 2006-05-24 | 2007-11-30 | Sanofi Aventis Sa | Derives de 2-alcoxy-3,4,5-trihydroxy-alkylamide, leur preparation, compositions les contenant et utilisation |
| FR2901554B1 (fr) | 2006-05-24 | 2011-04-01 | Sanofi Aventis | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation |
| EP2582680A1 (en) | 2010-06-17 | 2013-04-24 | Novartis AG | Biphenyl substituted 1,3-dihydro-benzoimidazol-2-ylideneamine derivatives |
| JP2013532149A (ja) | 2010-06-17 | 2013-08-15 | ノバルティス アーゲー | ピペリジニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9411841D0 (en) * | 1994-06-14 | 1994-08-03 | Pharma Mar Sa | New antitumoral compounds from jaspis sponge |
-
1999
- 1999-11-04 CO CO99069674A patent/CO5140099A1/es unknown
- 1999-11-15 CN CNB998134104A patent/CN1187333C/zh not_active Expired - Fee Related
- 1999-11-15 AU AU15060/00A patent/AU748016B2/en not_active Ceased
- 1999-11-15 CA CA002347773A patent/CA2347773C/en not_active Expired - Fee Related
- 1999-11-15 PL PL99347633A patent/PL347633A1/xx unknown
- 1999-11-15 KR KR1020017006152A patent/KR20010080461A/ko not_active Application Discontinuation
- 1999-11-15 ES ES99957309T patent/ES2221463T3/es not_active Expired - Lifetime
- 1999-11-15 IL IL14270199A patent/IL142701A0/xx unknown
- 1999-11-15 BR BR9915436-6A patent/BR9915436A/pt not_active Application Discontinuation
- 1999-11-15 PE PE1999001155A patent/PE20001241A1/es not_active Application Discontinuation
- 1999-11-15 AR ARP990105796A patent/AR023914A1/es unknown
- 1999-11-15 HU HU0104224A patent/HUP0104224A3/hu unknown
- 1999-11-15 AT AT99957309T patent/ATE264309T1/de not_active IP Right Cessation
- 1999-11-15 CZ CZ20011707A patent/CZ20011707A3/cs unknown
- 1999-11-15 PT PT99957309T patent/PT1131297E/pt unknown
- 1999-11-15 ID IDW00200100966A patent/ID28343A/id unknown
- 1999-11-15 EP EP99957309A patent/EP1131297B1/en not_active Expired - Lifetime
- 1999-11-15 JP JP2000582369A patent/JP3550545B2/ja not_active Expired - Fee Related
- 1999-11-15 SK SK669-2001A patent/SK6692001A3/sk unknown
- 1999-11-15 DE DE69916488T patent/DE69916488T2/de not_active Expired - Lifetime
- 1999-11-15 WO PCT/EP1999/008767 patent/WO2000029382A1/en active IP Right Grant
- 1999-11-15 TR TR2001/01366T patent/TR200101366T2/xx unknown
- 1999-11-17 UY UY25807A patent/UY25807A1/es unknown
-
2000
- 2000-02-25 UY UY26036A patent/UY26036A1/es unknown
-
2001
- 2001-04-26 ZA ZA200103419A patent/ZA200103419B/en unknown
- 2001-05-16 NO NO20012428A patent/NO20012428L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| PT1131297E (pt) | 2004-08-31 |
| BR9915436A (pt) | 2001-08-07 |
| CA2347773A1 (en) | 2000-05-25 |
| PL347633A1 (en) | 2002-04-22 |
| NO20012428L (no) | 2001-07-17 |
| CO5140099A1 (es) | 2002-03-22 |
| EP1131297B1 (en) | 2004-04-14 |
| DE69916488D1 (de) | 2004-05-19 |
| CZ20011707A3 (cs) | 2001-08-15 |
| PE20001241A1 (es) | 2000-11-24 |
| AU1506000A (en) | 2000-06-05 |
| CN1187333C (zh) | 2005-02-02 |
| AR023914A1 (es) | 2002-09-04 |
| NO20012428D0 (no) | 2001-05-16 |
| UY25807A1 (es) | 2001-08-27 |
| SK6692001A3 (en) | 2001-10-08 |
| JP2002529536A (ja) | 2002-09-10 |
| ES2221463T3 (es) | 2004-12-16 |
| JP3550545B2 (ja) | 2004-08-04 |
| WO2000029382A1 (en) | 2000-05-25 |
| KR20010080461A (ko) | 2001-08-22 |
| TR200101366T2 (tr) | 2001-10-22 |
| ATE264309T1 (de) | 2004-04-15 |
| ZA200103419B (en) | 2002-06-26 |
| ID28343A (id) | 2001-05-17 |
| DE69916488T2 (de) | 2005-03-24 |
| AU748016B2 (en) | 2002-05-30 |
| CN1326445A (zh) | 2001-12-12 |
| EP1131297A1 (en) | 2001-09-12 |
| IL142701A0 (en) | 2002-03-10 |
| HUP0104224A3 (en) | 2002-04-29 |
| CA2347773C (en) | 2009-03-10 |
| HUP0104224A2 (hu) | 2002-03-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| ABAN | Application deemed to be withdrawn (no publication fee paid) |
Effective date: 20090205 |