AR023914A1 - Caprolactamas sustituidas, un proceso para su preparacion, composiciones farmaceuticas que las contienen, y su uso para la preparacion de composicionesfarmaceuticas en el tratamiento de tumores - Google Patents
Caprolactamas sustituidas, un proceso para su preparacion, composiciones farmaceuticas que las contienen, y su uso para la preparacion de composicionesfarmaceuticas en el tratamiento de tumoresInfo
- Publication number
- AR023914A1 AR023914A1 ARP990105796A ARP990105796A AR023914A1 AR 023914 A1 AR023914 A1 AR 023914A1 AR P990105796 A ARP990105796 A AR P990105796A AR P990105796 A ARP990105796 A AR P990105796A AR 023914 A1 AR023914 A1 AR 023914A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- pharmaceutical compositions
- caprolactamas
- replaced
- compositions containing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D223/00—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
- C07D223/02—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings
- C07D223/06—Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom not condensed with other rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D223/08—Oxygen atoms
- C07D223/10—Oxygen atoms attached in position 2
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
Abstract
La presente se refiere a caprolactamas sustituidas, que comprende un compuesto de la formula (1) en donde: R1 es alquilo C1-6 o cicloalquilo C3-6; R2 eshidrogeno o alquilo C1-6; X es alquileno C1-12, alquenileno C2-12 o alquinileno C2-12; m es 0 o1; y R3 es cicloalquilo C3-8; o un sistema de anillo aromáticoseleccionado a partir de las formulas (2) a (5), en donde: R4 es hidrogeno, cloro, o metoxilo; R5 es hidrogeno, cloro, alquilo C1-18, o alcoxilo C1-18; y Z esoxígeno, azufre, N-H, oN-CH3; o una sal de adicion de ácido farmacéuticamente aceptable del mismo, cuando sea posible; caprolactama sustituida a composicionesfarmacéuticas que contienen estos compuestos, o al uso de estos compuestos para la preparacion de un medicamentosen el tra tamiento de tumores, y a un procesopara fabricar estos compuestos.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US19335498A | 1998-11-17 | 1998-11-17 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR023914A1 true AR023914A1 (es) | 2002-09-04 |
Family
ID=22713307
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990105796A AR023914A1 (es) | 1998-11-17 | 1999-11-15 | Caprolactamas sustituidas, un proceso para su preparacion, composiciones farmaceuticas que las contienen, y su uso para la preparacion de composicionesfarmaceuticas en el tratamiento de tumores |
Country Status (25)
| Country | Link |
|---|---|
| EP (1) | EP1131297B1 (es) |
| JP (1) | JP3550545B2 (es) |
| KR (1) | KR20010080461A (es) |
| CN (1) | CN1187333C (es) |
| AR (1) | AR023914A1 (es) |
| AT (1) | ATE264309T1 (es) |
| AU (1) | AU748016B2 (es) |
| BR (1) | BR9915436A (es) |
| CA (1) | CA2347773C (es) |
| CO (1) | CO5140099A1 (es) |
| CZ (1) | CZ20011707A3 (es) |
| DE (1) | DE69916488T2 (es) |
| ES (1) | ES2221463T3 (es) |
| HU (1) | HUP0104224A3 (es) |
| ID (1) | ID28343A (es) |
| IL (1) | IL142701A0 (es) |
| NO (1) | NO20012428L (es) |
| PE (1) | PE20001241A1 (es) |
| PL (1) | PL347633A1 (es) |
| PT (1) | PT1131297E (es) |
| SK (1) | SK6692001A3 (es) |
| TR (1) | TR200101366T2 (es) |
| UY (2) | UY25807A1 (es) |
| WO (1) | WO2000029382A1 (es) |
| ZA (1) | ZA200103419B (es) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1191237C (zh) * | 2000-05-11 | 2005-03-02 | 诺瓦提斯公司 | 取代的己内酰胺碳酸酯与醚和它们作为抗肿瘤剂的用途 |
| US6545148B2 (en) | 2001-03-12 | 2003-04-08 | Novartis Ag | Process for preparing certain substituted caprolactams |
| JP2006528611A (ja) * | 2003-07-25 | 2006-12-21 | ノバルティス アクチエンゲゼルシャフト | 置換ラクタムおよびそれらの抗がん剤としての使用 |
| DE10349669B3 (de) * | 2003-10-24 | 2005-05-25 | Aventis Pharma Deutschland Gmbh | Bengamide-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung |
| US7153846B2 (en) | 2003-10-24 | 2006-12-26 | Sanofi-Aventis Deutschland Gmbh | Bengamide derivatives, process for preparing them, and their use |
| FR2878525B1 (fr) * | 2004-11-29 | 2007-02-23 | Aventis Pharma Sa | Bengamides possedant un cycle caprolactame substitue, procede de preparation, compositions les contenant et utilisation |
| FR2878528B1 (fr) * | 2004-11-29 | 2008-05-16 | Aventis Pharma Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamides, leur preparation, compositions les contenant et utilisation |
| FR2901556A1 (fr) * | 2006-05-24 | 2007-11-30 | Sanofi Aventis Sa | Derives de 2-alcoxy-3,4,5-trihydroxy-alkylamide, leur preparation, compositions les contenant et utilisation |
| FR2901554B1 (fr) | 2006-05-24 | 2011-04-01 | Sanofi Aventis | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzazepine, leur preparation, compositions les contenant et utilisation |
| FR2901555A1 (fr) | 2006-05-24 | 2007-11-30 | Sanofi Aventis Sa | 2-alcoxy-3,4,5-trihydroxy-alkylamide-benzothiazepine, leur preparation, compositions les contenant et utilisation |
| JP2013528635A (ja) | 2010-06-17 | 2013-07-11 | ノバルティス アーゲー | ビフェニル置換１，３−ジヒドロ−ベンゾイミダゾール−２−イリデンアミン誘導体 |
| CN102947275A (zh) | 2010-06-17 | 2013-02-27 | 诺瓦提斯公司 | 哌啶基取代的1,3-二氢-苯并咪唑-2-亚基胺衍生物 |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9411841D0 (en) * | 1994-06-14 | 1994-08-03 | Pharma Mar Sa | New antitumoral compounds from jaspis sponge |
-
1999
- 1999-11-04 CO CO99069674A patent/CO5140099A1/es unknown
- 1999-11-15 CN CNB998134104A patent/CN1187333C/zh not_active Expired - Fee Related
- 1999-11-15 EP EP99957309A patent/EP1131297B1/en not_active Expired - Lifetime
- 1999-11-15 ID IDW00200100966A patent/ID28343A/id unknown
- 1999-11-15 ES ES99957309T patent/ES2221463T3/es not_active Expired - Lifetime
- 1999-11-15 IL IL14270199A patent/IL142701A0/xx unknown
- 1999-11-15 KR KR1020017006152A patent/KR20010080461A/ko not_active Application Discontinuation
- 1999-11-15 CA CA002347773A patent/CA2347773C/en not_active Expired - Fee Related
- 1999-11-15 SK SK669-2001A patent/SK6692001A3/sk unknown
- 1999-11-15 BR BR9915436-6A patent/BR9915436A/pt not_active Application Discontinuation
- 1999-11-15 AT AT99957309T patent/ATE264309T1/de not_active IP Right Cessation
- 1999-11-15 WO PCT/EP1999/008767 patent/WO2000029382A1/en active IP Right Grant
- 1999-11-15 AU AU15060/00A patent/AU748016B2/en not_active Ceased
- 1999-11-15 PL PL99347633A patent/PL347633A1/xx unknown
- 1999-11-15 JP JP2000582369A patent/JP3550545B2/ja not_active Expired - Fee Related
- 1999-11-15 CZ CZ20011707A patent/CZ20011707A3/cs unknown
- 1999-11-15 HU HU0104224A patent/HUP0104224A3/hu unknown
- 1999-11-15 PT PT99957309T patent/PT1131297E/pt unknown
- 1999-11-15 PE PE1999001155A patent/PE20001241A1/es not_active Application Discontinuation
- 1999-11-15 TR TR2001/01366T patent/TR200101366T2/xx unknown
- 1999-11-15 DE DE69916488T patent/DE69916488T2/de not_active Expired - Lifetime
- 1999-11-15 AR ARP990105796A patent/AR023914A1/es unknown
- 1999-11-17 UY UY25807A patent/UY25807A1/es unknown
-
2000
- 2000-02-25 UY UY26036A patent/UY26036A1/es unknown
-
2001
- 2001-04-26 ZA ZA200103419A patent/ZA200103419B/en unknown
- 2001-05-16 NO NO20012428A patent/NO20012428L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| CZ20011707A3 (cs) | 2001-08-15 |
| EP1131297A1 (en) | 2001-09-12 |
| HUP0104224A2 (hu) | 2002-03-28 |
| JP3550545B2 (ja) | 2004-08-04 |
| ID28343A (id) | 2001-05-17 |
| PE20001241A1 (es) | 2000-11-24 |
| SK6692001A3 (en) | 2001-10-08 |
| PT1131297E (pt) | 2004-08-31 |
| HUP0104224A3 (en) | 2002-04-29 |
| BR9915436A (pt) | 2001-08-07 |
| AU748016B2 (en) | 2002-05-30 |
| UY26036A1 (es) | 2001-06-29 |
| PL347633A1 (en) | 2002-04-22 |
| JP2002529536A (ja) | 2002-09-10 |
| CA2347773A1 (en) | 2000-05-25 |
| NO20012428L (no) | 2001-07-17 |
| WO2000029382A1 (en) | 2000-05-25 |
| ES2221463T3 (es) | 2004-12-16 |
| NO20012428D0 (no) | 2001-05-16 |
| IL142701A0 (en) | 2002-03-10 |
| UY25807A1 (es) | 2001-08-27 |
| ZA200103419B (en) | 2002-06-26 |
| TR200101366T2 (tr) | 2001-10-22 |
| CO5140099A1 (es) | 2002-03-22 |
| CN1187333C (zh) | 2005-02-02 |
| DE69916488D1 (de) | 2004-05-19 |
| CN1326445A (zh) | 2001-12-12 |
| KR20010080461A (ko) | 2001-08-22 |
| ATE264309T1 (de) | 2004-04-15 |
| CA2347773C (en) | 2009-03-10 |
| EP1131297B1 (en) | 2004-04-14 |
| AU1506000A (en) | 2000-06-05 |
| DE69916488T2 (de) | 2005-03-24 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60119894D1 (de) | Piperidinverbindungen und diese enthaltenden medikamente | |
| DK633088A (da) | Kollagenaseinhibitorer | |
| SE0000772D0 (sv) | Chemical compounds | |
| MXPA00006605A (es) | Compuestos de carbonil-indol biciclicos como agentes antiinflamatorios/analgesicos. | |
| ATE28565T1 (de) | Spiro(4.(3+n))-2-aza-alkan-3-carbonsaeurederivate, verfahren zu ihrer herstellung, diese enthaltende mittel und ihre verwendung. | |
| AR023914A1 (es) | Caprolactamas sustituidas, un proceso para su preparacion, composiciones farmaceuticas que las contienen, y su uso para la preparacion de composicionesfarmaceuticas en el tratamiento de tumores | |
| ATE220402T1 (de) | Basisch substituierte vinylpyrrolidin- cephalosporine | |
| DE69429570D1 (de) | Galanthamin Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Medikamente | |
| DE68926981D1 (de) | Cephemverbindungen und Verfahren zu ihrer Herstellung | |
| FI101301B1 (fi) | Menetelmä terapeuttisesti käyttökelpoisten, N-substituoitujen heksahydroatsepiinijohdannaisten valmistamiseksi | |
| PT80670B (de) | Neue 8-alkylthio-2-piperazino-pyrimido<5,4d>pyrimidine ihre herstellung und diese verbindungen enthaltende arzneimittel | |
| ID964B (id) | SENYAWA 4-(5,6,7,8-TETRAHIDROIMIDAZO[1,5-a]PIRIDIN-5-IL)HEMIHIDRAT | |
| PT732332E (pt) | Benzotienilpiperazinas substituidas sua utilizacao como medicamentos e processos para a sua preparacao | |
| CA2374643A1 (en) | 1-trifluoromethyl-4-hydroxy-7-piperidinylaminomethylchroman derivatives as substance p antagonists | |
| HUP0302820A2 (hu) | CNS rendellenességek kezelésében hasznos indolszármazékok és ezeket tartalmazó gyógyszerkészítmények | |
| EP1057829A4 (en) | Condensed pyrimidine derivatives and pharmaceutical compositions containing them | |
| KR910004632A (ko) | 신규한 1-옥사-2-옥소-8-아자스피로[4,5]데칸 유도체와 그들을 포함하는 약제학적 조성물 및 그 제조방법 | |
| ATE22081T1 (de) | Substituierte thienobenzodiazepinone, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel. | |
| ATE4541T1 (de) | Alkyl- und cycloalkylsubstituierte 2-(2-(2hydroxy-3-tert.-butylamino-propoxy)-5-acylamino phenyl)-1,3,4-oxadiazole, verfahren zu ihrer herstellung und diese verbindungen enthaltende pharmazeutische zubereitungen. | |
| TH52462A (th) | ออกซาโซลิดิโนน ซึ่งได้มาจากซัลแทมและซัลโทน | |
| IT1317886B1 (it) | Procedimento per la preparazione di 9,10-diidro-pirrolo (2,1-b)(1,3)benzotiazepine 9-ammino sostituite. |