EA199800522A1 - Способ получения ловастатина - Google Patents

Способ получения ловастатина

Info

Publication number
EA199800522A1
EA199800522A1 EA199800522A EA199800522A EA199800522A1 EA 199800522 A1 EA199800522 A1 EA 199800522A1 EA 199800522 A EA199800522 A EA 199800522A EA 199800522 A EA199800522 A EA 199800522A EA 199800522 A1 EA199800522 A1 EA 199800522A1
Authority
EA
Eurasian Patent Office
Prior art keywords
lovastatin
lactonized
crystallizes
antioxidant
precipitated
Prior art date
Application number
EA199800522A
Other languages
English (en)
Other versions
EA000954B1 (ru
Inventor
Димчо Иванов Димов
Георгий Асенов Грозданов
Неделчо Генов Петков
Димитра Цонева Тодорова
Албена Стефанова Димитрова
Original Assignee
Балканфарма - Разград Ад
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from BG100197A external-priority patent/BG62651B1/bg
Priority claimed from BG100316A external-priority patent/BG63011B1/bg
Application filed by Балканфарма - Разград Ад filed Critical Балканфарма - Разград Ад
Publication of EA199800522A1 publication Critical patent/EA199800522A1/ru
Publication of EA000954B1 publication Critical patent/EA000954B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/16—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D309/28—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/30—Oxygen atoms, e.g. delta-lactones
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/02—Oxygen as only ring hetero atoms
    • C12P17/06—Oxygen as only ring hetero atoms containing a six-membered hetero ring, e.g. fluorescein

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines Containing Plant Substances (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)

Abstract

Описанный способ находит применение в фармацевтической промышленности. Ловастатин получают согласно этому способу из культурального бульона фильтрованием при рН 9,5-13,0, включенный в твердую массу ловастатин осаждают из полученного фильтрата, рН 2,5-4,0, в присутствии инертного наполнителя, антиоксиданта и не смешивающегося с водой органического растворителя. Его экстрагируют и лактонизуют в среде хлорсодержащего органического растворителя. Последний концентрируют и остаток растворяют в смеси растворителей, имеющих разную полярность. После охлаждения при -10 - 30°С ловастатин кристаллизуется, его сушат и несколько раз перекристаллизуют.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA199800522A 1995-12-06 1996-10-22 Способ получения ловастатина EA000954B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
BG100197A BG62651B1 (bg) 1995-12-06 1995-12-06 Метод за изолиране и пречистване на ловастатин
BG100316A BG63011B1 (bg) 1996-01-29 1996-01-29 метод за получаване на ловастатин
PCT/BG1996/000013 WO1997020834A1 (en) 1995-12-06 1996-10-22 Method of production of lovastatin

Publications (2)

Publication Number Publication Date
EA199800522A1 true EA199800522A1 (ru) 1999-02-25
EA000954B1 EA000954B1 (ru) 2000-08-28

Family

ID=25663364

Family Applications (1)

Application Number Title Priority Date Filing Date
EA199800522A EA000954B1 (ru) 1995-12-06 1996-10-22 Способ получения ловастатина

Country Status (8)

Country Link
EP (1) EP0877742B1 (ru)
AU (1) AU7271696A (ru)
CA (1) CA2243592C (ru)
DE (2) DE69614571T2 (ru)
EA (1) EA000954B1 (ru)
ES (1) ES2131037T3 (ru)
UA (1) UA44922C2 (ru)
WO (1) WO1997020834A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI9800046A (sl) 1998-02-18 1999-08-31 LEK, tovarna farmacevtskih in kemi�nih izdelkov, d.d. Postopek za pridobivanje inhibitorjev HMG-CoA reduktaze visoke čistosti
EP1533308B1 (en) * 1998-12-10 2014-01-15 Kaneka Corporation A process for producing a simvastatin precursor
SK282679B6 (sk) * 1999-04-16 2002-11-06 Biotika, A. S. Spôsob izolácie lovastatínu z vyfermentovanej pôdy
EP1265884A4 (en) 2000-03-03 2003-05-21 Plus Chemical S A PROCESS FOR THE PURIFICATION OF LOVASTATIN AND SIMVASTATIN FOR REDUCING THE CONTENT OF DIMER IMPURITIES
IN192861B (ru) 2000-06-30 2004-05-22 Ranbaxy Lab Ltd
ES2204285B1 (es) * 2002-05-20 2005-03-01 Ercros Industrial, S.A. Procedimiento para el aislamiento y purificacion de lovastatina.
DE60327813D1 (de) * 2003-10-14 2009-07-09 Lupin Ltd Verfahren zu herstellung von lovastatin.
AU2004317826A1 (en) 2004-03-30 2005-10-13 Lupin Ltd An improved method for manufacture of 4-hydroxy pyran-2-one derivatives
WO2009013764A2 (en) * 2007-07-24 2009-01-29 Jubilant Organosys Limited Process for producing 6(r)-[2-(8'(s)-2 ',2 '-dimethylbutyryloxy-2'(s),6'(r)-dimethyl-1,2,6,7', 8',8a'(r)- hexahydronaphthyl-l'(s))ethyl]-4(r)-hydroxy-3,4,5,6- tetrahydro-2h-pyran-2-one
CN103012344B (zh) * 2011-09-28 2014-11-12 北大方正集团有限公司 从洛伐他汀结晶母液中回收洛伐他汀的方法
EP2597092A1 (en) 2011-11-24 2013-05-29 Sterling Biotech Limited A process for purification of lovastatin
CN102875505B (zh) * 2012-08-02 2015-08-05 丽珠集团新北江制药股份有限公司 一种美伐他汀的提取精制工艺
CN106083789A (zh) * 2016-06-07 2016-11-09 山东鲁抗医药股份有限公司 从发酵液中沉淀分离提取洛伐他汀的方法
CN108976190B (zh) * 2017-12-21 2020-09-04 北大方正集团有限公司 一种从洛伐他汀结晶母液中回收洛伐他汀的方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU548996B2 (en) * 1980-02-04 1986-01-09 Merck & Co., Inc. Tetrahydro-2h-pyran-2-one derivatives
HU210867B (en) * 1992-11-04 1995-10-30 Biogal Gyogyszergyar Method for extraction and purification of mevinolin from culture medium
SI9300303A (en) * 1993-06-08 1994-12-31 Krka Tovarna Zdravil Process for isolation of hypolipemic effective substance

Also Published As

Publication number Publication date
CA2243592C (en) 2001-12-25
EP0877742B1 (en) 2001-08-16
EP0877742A1 (en) 1998-11-18
EA000954B1 (ru) 2000-08-28
WO1997020834A1 (en) 1997-06-12
DE69614571T2 (de) 2002-06-27
DE877742T1 (de) 1999-07-22
UA44922C2 (uk) 2002-03-15
DE69614571D1 (de) 2001-09-20
ES2131037T3 (es) 2001-12-16
ES2131037T1 (es) 1999-07-16
AU7271696A (en) 1997-06-27
CA2243592A1 (en) 1997-06-12

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Legal Events

Date Code Title Description
MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ KZ KG TJ TM

MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): BY MD RU