KR910000746A - 1, 1-디옥소페닐실리노일 옥시메틸 d-6-[x-(메틸렌 아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염 - Google Patents

1, 1-디옥소페닐실리노일 옥시메틸 d-6-[x-(메틸렌 아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염 Download PDF

Info

Publication number
KR910000746A
KR910000746A KR1019890008501A KR890008501A KR910000746A KR 910000746 A KR910000746 A KR 910000746A KR 1019890008501 A KR1019890008501 A KR 1019890008501A KR 890008501 A KR890008501 A KR 890008501A KR 910000746 A KR910000746 A KR 910000746A
Authority
KR
South Korea
Prior art keywords
dioxophenylsilinoyl
phenylanate
oxymethyl
para
phenyl
Prior art date
Application number
KR1019890008501A
Other languages
English (en)
Other versions
KR910009271B1 (ko
Inventor
김영설
Original Assignee
김영설
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 김영설 filed Critical 김영설
Priority to KR1019890008501A priority Critical patent/KR910009271B1/ko
Priority to US07/383,435 priority patent/US5004738A/en
Priority to YU01177/90A priority patent/YU117790A/xx
Priority to AU57681/90A priority patent/AU5768190A/en
Priority to PT94430A priority patent/PT94430A/pt
Priority to CA002019432A priority patent/CA2019432A1/en
Priority to HU903922A priority patent/HU205611B/hu
Priority to JP2160034A priority patent/JPH0331289A/ja
Priority to EP19900111655 priority patent/EP0405316A3/en
Publication of KR910000746A publication Critical patent/KR910000746A/ko
Application granted granted Critical
Publication of KR910009271B1 publication Critical patent/KR910009271B1/ko

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/28—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2 with modified 2-carboxyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
    • C07D499/21—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring with a nitrogen atom directly attached in position 6 and a carbon atom having three bonds to hetero atoms with at the most one bond to halogen, e.g. an ester or nitrile radical, directly attached in position 2
    • C07D499/44—Compounds with an amino radical acylated by carboxylic acids, attached in position 6
    • C07D499/48—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical
    • C07D499/58—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical
    • C07D499/64—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms
    • C07D499/68—Compounds with an amino radical acylated by carboxylic acids, attached in position 6 with a carbon chain, substituted by hetero atoms or by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, attached to the carboxamido radical substituted in alpha-position to the carboxamido radical by nitrogen atoms with aromatic rings as additional substituents on the carbon chain

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)

Abstract

내용 없음

Description

1, 1-디옥소페닐실리노일 옥시메틸 D-6-[X-(메틸렌 아미노)페닐-아세트아미노]-페니실라네이트와 그의 파라-톨루엔술폰산염
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (3)

  1. 다음 구조식(Ⅰ)의 화합물 및 그 약제학적으로 허용되는 염.
  2. 구조식(Ⅴ)의 화합물과 구조식(Ⅵ)화합물을 극성용매중에서 반응시켜 구조식(Ⅰ)의 화합물 또는 그 약학적으로 허용되는 염을 제조하는 방법.
  3. 제2항에서, 유리의 구조식(Ⅰ)의 화합물을 유기용매 존재하에 또는 유기용제와 물의 혼합용매 존재하에 유기 또는 무기산과 반응시켜 구조식(Ⅰ) 화합물의 약학적으로 허용되는 염을 제조하는 방법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019890008501A 1989-06-20 1989-06-20 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염 KR910009271B1 (ko)

Priority Applications (9)

Application Number Priority Date Filing Date Title
KR1019890008501A KR910009271B1 (ko) 1989-06-20 1989-06-20 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
US07/383,435 US5004738A (en) 1989-06-20 1989-07-24 1,1-dioxopenicillanoyl oxymethyl D-6-(α-(methyleneamino) phenylacetamido)-penicillanate and a process for the preparation thereof
YU01177/90A YU117790A (en) 1989-06-20 1990-06-15 1,1-dioxopenicillanoyloxymethyl d-6 (methylenamino) fenylacetamido/penicilanat and process for obtaining thereof
AU57681/90A AU5768190A (en) 1989-06-20 1990-06-19 1,1-dioxopenicillanoyloxymethyl d-6-(alpha-methyleneamino) phenylacetamido) penicillanate and a process for the preparation thereof
PT94430A PT94430A (pt) 1989-06-20 1990-06-20 Processo para a preparacao de d-6-{alfa-(metilenoamino)-fenilacetamido}-penicilanato de 1,1-dioxopenicilanoiloximetilo e de composicoes farmaceuticas que o contem
CA002019432A CA2019432A1 (en) 1989-06-20 1990-06-20 1,1-dioxopenicil-lanoyloxymethyl d-6-[ -(methyleneamino)phenylacetamido] penicillanate and a process for the preparation thereof
HU903922A HU205611B (en) 1989-06-20 1990-06-20 Process for producing 1,1-dioxo-penicillanoyl-oxy-methyl-d-6-/alpha-/methylen-amino/-phenyl-acetyl-amino/-penicillanate, salts and pharmaceutical compositions contaiing them as active components
JP2160034A JPH0331289A (ja) 1989-06-20 1990-06-20 １，１―ジオキソペニシラノイルオキシメチルＤ―［α―（メチレンアミノ）フェニルアセトアミド］ベニシラネートとその塩、その製造方法及びそれよりなる細菌感染症治療剤
EP19900111655 EP0405316A3 (en) 1989-06-20 1990-06-20 1,1-dioxopenicillanoyloxymethyl d-6-(alpha(methyleneamino)-phenyl-acetamidol)-penicillanate and a process for the preparation thereof

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019890008501A KR910009271B1 (ko) 1989-06-20 1989-06-20 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염

Publications (2)

Publication Number Publication Date
KR910000746A true KR910000746A (ko) 1991-01-30
KR910009271B1 KR910009271B1 (ko) 1991-11-08

Family

ID=19287265

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019890008501A KR910009271B1 (ko) 1989-06-20 1989-06-20 1,1-디옥소페닐실라노일 옥시메틸 D-6-[α-(메틸렌아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염

Country Status (9)

Country Link
US (1) US5004738A (ko)
EP (1) EP0405316A3 (ko)
JP (1) JPH0331289A (ko)
KR (1) KR910009271B1 (ko)
AU (1) AU5768190A (ko)
CA (1) CA2019432A1 (ko)
HU (1) HU205611B (ko)
PT (1) PT94430A (ko)
YU (1) YU117790A (ko)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR004510A1 (es) 1995-09-07 1998-12-16 Smithkline Beecham Plc Composiciones que comprenden amoxicilina y clavulanato, procedimientos para su preparacion y el uso de las composiciones para la fabricacion de unmedicamento
ES2161602B1 (es) * 1999-04-08 2003-02-16 Asturpharma S A Sintesis de 6-(d-alfa-(bencilidenaminofenilacetamido))penicilanato de 1,1-dioxopenicilanoiloximetilo y analogos. nuevos intermedios para la sintesis de sultamicilina.
US7250176B1 (en) * 1999-04-13 2007-07-31 Beecham Pharmaceuticals (Pte) Limited Method of treating a bacterial infection
US6756057B2 (en) 2000-10-12 2004-06-29 Beecham Pharmaceuticals (Pte) Limited Amoxicillin and potassium clavulanate dosage form
WO2002030392A2 (en) 2000-10-12 2002-04-18 Beecham Pharmaceuticals (Pte) Limited Formulation containing amoxicillin

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1081093A (en) * 1964-03-17 1967-08-31 Rech S Et D Applic Scient Et M Improvements in or relating to 6-[d(-)-alpha-(amino-phenylacetamido)]-penicillanic acid derivatives
IE49881B1 (en) * 1979-02-13 1986-01-08 Leo Pharm Prod Ltd B-lactam intermediates
US4244951A (en) * 1979-05-16 1981-01-13 Pfizer Inc. Bis-esters of methanediol with penicillins and penicillanic acid 1,1-dioxide
IL64009A (en) * 1980-10-31 1984-09-30 Rech Applications Therap Crystalline 1,1-dioxopenicillanoyloxymethyl 6-(d-alpha-amino-alpha-phenylacetamido)penicillanate tosylate hydrates,their production and pharmaceutical compositions containing them
US4419284A (en) * 1981-03-23 1983-12-06 Pfizer Inc. Preparation of halomethyl esters (and related esters) of penicillanic acid 1,1-dioxide
IN157669B (ko) * 1981-03-23 1986-05-17 Pfizer
US4393001A (en) * 1981-03-23 1983-07-12 Pfizer Inc. Intermediates for production of 1,1-dioxopenicillanoyloxymethyl 6-(2-amino-2-phenylacetamido)penicillanates
US4432987A (en) * 1982-04-23 1984-02-21 Pfizer Inc. Crystalline benzenesulfonate salts of sultamicillin
US4377590A (en) * 1982-05-10 1983-03-22 Pfizer Inc. Derivatives of ampicillin and amoxicillin with beta-lactamase inhibitors
US4503040A (en) * 1984-02-27 1985-03-05 Pfizer Inc. 6-(Aminoacyloxymethyl)penicillanic acid 1,1-dioxides as beta-lactamase inhibitors

Also Published As

Publication number Publication date
JPH0331289A (ja) 1991-02-12
HU205611B (en) 1992-05-28
EP0405316A2 (en) 1991-01-02
KR910009271B1 (ko) 1991-11-08
HUT55020A (en) 1991-04-29
PT94430A (pt) 1991-02-08
AU5768190A (en) 1991-01-03
CA2019432A1 (en) 1990-12-20
EP0405316A3 (en) 1991-01-23
US5004738A (en) 1991-04-02
HU903922D0 (en) 1990-11-28
YU117790A (en) 1992-05-28

Similar Documents

Publication Publication Date Title
KR840005083A (ko) 항고혈압제로서 유용한 아미노산유도체의 제조방법
KR830007077A (ko) 악타플라닌의 가비당체의 제조방법
KR860001110A (ko) 항균제 ⅱ의 제법
KR840001949A (ko) 신규 펩티드 화합물의 제법
KR850006938A (ko) 폴루로뮤티린 유도체의 제조방법
KR870006039A (ko) 신규 티아졸 화합물, 그 제조방법 및 이 화합물을 함유하는 약학적 조성물
KR830006198A (ko) 시클로헥산 유도체의 제조방법
KR890009962A (ko) 매뉴마이신 유도체, 이의 제조방법 및 용도
KR910000746A (ko) 1, 1-디옥소페닐실리노일 옥시메틸 d-6-[x-(메틸렌 아미노)페닐-아세트아미도]-페니실라네이트와 그의 파라-톨루엔술폰산염
KR870006024A (ko) 니자티딘의 제조방법
KR870002151A (ko) 3,7-이치환된 -3- 세펨 화합물의 제조방법
KR870006083A (ko) 벤질아스파르탐의 제조 방법
KR840000482A (ko) 시스틴 유도체의 제조방법
KR900018123A (ko) 광학적 활성인 d-2-n-펜아세틸아미노-4-메틸 포스피노부티르산의 라세미화 방법
KR870003064A (ko) 아미디노 우레아 유도체의 제조방법
KR870001236A (ko) N-보호된-L-α-아스파틸-L-페닐알라닌의 제조 방법
KR910000602A (ko) N-2'-카르복실페닐-4-클로로안트라닐산의 신규 제조방법
KR860006483A (ko) 시타라빈 유도체의 제조방법
KR860006459A (ko) 신규의 수용성 벤조티아진 디옥사이드 염의 제조방법
KR880003926A (ko) 구아디노 티아졸 화합물의 제조방법
KR870003089A (ko) 1-카바페넴 및 1-카바세펨 제조중간체의 제조방법
KR910004586A (ko) 6-메틸-3,4-디하이드로-1,2,3-옥사티아진-4-온-2,2-디옥사이드 칼륨염의 제조방법
KR890001977A (ko) 피로글루타미드 유도체
KR880000453A (ko) 세팔로스포린 유도체 및 그의 산부가염의 제조방법
KR880007560A (ko) α-L-아스파틸-L-페닐알라닌 알킬에스테르의 제조방법

Legal Events

Date Code Title Description
A201 Request for examination
E902 Notification of reason for refusal
G160 Decision to publish patent application
E701 Decision to grant or registration of patent right
GRNT Written decision to grant
FPAY Annual fee payment

Payment date: 20061107

Year of fee payment: 16

LAPS Lapse due to unpaid annual fee