GB1081093A - Improvements in or relating to 6-[d(-)-alpha-(amino-phenylacetamido)]-penicillanic acid derivatives - Google Patents
Improvements in or relating to 6-[d(-)-alpha-(amino-phenylacetamido)]-penicillanic acid derivativesInfo
- Publication number
- GB1081093A GB1081093A GB11240/64A GB1124064A GB1081093A GB 1081093 A GB1081093 A GB 1081093A GB 11240/64 A GB11240/64 A GB 11240/64A GB 1124064 A GB1124064 A GB 1124064A GB 1081093 A GB1081093 A GB 1081093A
- Authority
- GB
- United Kingdom
- Prior art keywords
- alpha
- phenylacetamido
- penicillanic acid
- amino
- penicillins
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D499/00—Heterocyclic compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula:, e.g. penicillins, penems; Such ring systems being further condensed, e.g. 2,3-condensed with an oxygen-, nitrogen- or sulfur-containing hetero ring
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D1/00—Evaporating
- B01D1/0082—Regulation; Control
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The invention relates to penicillins of general Formula I <FORM:1081093/C2/1> in which R is H, a straight or branched chain alkyl containing 1 to 12 C atoms, or a substituted or unsubstituted aryl radical, or an aralkyl radical; and non-toxic salts thereof with metals, ammonium, amines and tetracyclines aminomethylated at the 2-amido group. A penicillin of general Formula I or a salt thereof, is prepared by reacting 6-[D(-)alpha-(aminophenylacetamido)] penicillanic acid or a salt thereof in water (salts) or an organic solvent (free acid) with an aldehyde of formula <FORM:1081093/C2/2> where R has the above meaning. Typical compounds are 6-[D(-)alpha-(methylene amino phenylacetamido)] penicillanic acid, 6-[D(-) alpha - (benzylidene amino phenylacetamido)]-penicillanic acid and 6-[D(-)alpha-(salicylidene amino phenylacetamido)] penicillanic acid, The penicillins are effective against penicillinase-producing bacteria. They are used in therapeutic compositions for human or veterinary use.
Priority Applications (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB11240/64A GB1081093A (en) | 1964-03-17 | 1964-03-17 | Improvements in or relating to 6-[d(-)-alpha-(amino-phenylacetamido)]-penicillanic acid derivatives |
FR984A FR87141E (en) | 1964-03-17 | 1965-03-12 | Improvements to the regulation of multiple effect evaporation plants |
CH363165A CH446338A (en) | 1964-03-17 | 1965-03-16 | Process for the preparation of 6- (D (-) - alpha- (amino-phenylacetamido)) - penicillanic acid derivatives and its salts |
BE661232D BE661232A (en) | 1964-03-17 | 1965-03-17 |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB11240/64A GB1081093A (en) | 1964-03-17 | 1964-03-17 | Improvements in or relating to 6-[d(-)-alpha-(amino-phenylacetamido)]-penicillanic acid derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
GB1081093A true GB1081093A (en) | 1967-08-31 |
Family
ID=9982576
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
GB11240/64A Expired GB1081093A (en) | 1964-03-17 | 1964-03-17 | Improvements in or relating to 6-[d(-)-alpha-(amino-phenylacetamido)]-penicillanic acid derivatives |
Country Status (4)
Country | Link |
---|---|
BE (1) | BE661232A (en) |
CH (1) | CH446338A (en) |
FR (1) | FR87141E (en) |
GB (1) | GB1081093A (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2162198A1 (en) * | 1971-12-03 | 1973-07-13 | Bristol Myers Co | |
EP0076066A1 (en) * | 1981-09-22 | 1983-04-06 | Kureha Kagaku Kogyo Kabushiki Kaisha | Penicillin derivatives |
EP0405316A2 (en) * | 1989-06-20 | 1991-01-02 | Yeong Sul Kim | 1,1-dioxopenicillanoyloxymethyl D-6-[alpha(methyleneamino)-phenyl-acetamidol]-penicillanate and a process for the preparation thereof |
US5049384A (en) * | 1988-07-08 | 1991-09-17 | Kim Young S | Antibacterial composition for medical use and a process for the preparation thereof |
EP0606506A1 (en) | 1993-01-12 | 1994-07-20 | Yeong Sul Kim | Beta-lactamase resistant antibacterial composition |
-
1964
- 1964-03-17 GB GB11240/64A patent/GB1081093A/en not_active Expired
-
1965
- 1965-03-12 FR FR984A patent/FR87141E/en not_active Expired
- 1965-03-16 CH CH363165A patent/CH446338A/en unknown
- 1965-03-17 BE BE661232D patent/BE661232A/xx unknown
Cited By (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2162198A1 (en) * | 1971-12-03 | 1973-07-13 | Bristol Myers Co | |
EP0076066A1 (en) * | 1981-09-22 | 1983-04-06 | Kureha Kagaku Kogyo Kabushiki Kaisha | Penicillin derivatives |
US4540689A (en) * | 1981-09-22 | 1985-09-10 | Kureha Kagaku Kogyo Kabushiki Kaisha | Penicillin derivative |
US5049384A (en) * | 1988-07-08 | 1991-09-17 | Kim Young S | Antibacterial composition for medical use and a process for the preparation thereof |
EP0405316A2 (en) * | 1989-06-20 | 1991-01-02 | Yeong Sul Kim | 1,1-dioxopenicillanoyloxymethyl D-6-[alpha(methyleneamino)-phenyl-acetamidol]-penicillanate and a process for the preparation thereof |
EP0405316A3 (en) * | 1989-06-20 | 1991-01-23 | Yeong Sul Kim | 1,1-dioxopenicillanoyloxymethyl d-6-(alpha(methyleneamino)-phenyl-acetamidol)-penicillanate and a process for the preparation thereof |
US5004738A (en) * | 1989-06-20 | 1991-04-02 | Young Sul Kim | 1,1-dioxopenicillanoyl oxymethyl D-6-(α-(methyleneamino) phenylacetamido)-penicillanate and a process for the preparation thereof |
EP0606506A1 (en) | 1993-01-12 | 1994-07-20 | Yeong Sul Kim | Beta-lactamase resistant antibacterial composition |
Also Published As
Publication number | Publication date |
---|---|
FR4325M (en) | 1966-08-01 |
FR87141E (en) | 1966-06-17 |
CH446338A (en) | 1967-11-15 |
BE661232A (en) | 1965-07-16 |
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