KR850006938A - 폴루로뮤티린 유도체의 제조방법 - Google Patents

폴루로뮤티린 유도체의 제조방법 Download PDF

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Publication number
KR850006938A
KR850006938A KR1019850000904A KR850000904A KR850006938A KR 850006938 A KR850006938 A KR 850006938A KR 1019850000904 A KR1019850000904 A KR 1019850000904A KR 850000904 A KR850000904 A KR 850000904A KR 850006938 A KR850006938 A KR 850006938A
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KR
South Korea
Prior art keywords
polyurilmutilin
derivatives
preparing
formula
protected
Prior art date
Application number
KR1019850000904A
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English (en)
Other versions
KR920001990B1 (ko
Inventor
베르네르 하인츠 (외 1)
Original Assignee
예안 크라메르 · 한스 루돌프 하우스
산도즈 리미티드
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19843405632 external-priority patent/DE3405632A1/de
Priority claimed from DE19843413708 external-priority patent/DE3413708A1/de
Application filed by 예안 크라메르 · 한스 루돌프 하우스, 산도즈 리미티드 filed Critical 예안 크라메르 · 한스 루돌프 하우스
Publication of KR850006938A publication Critical patent/KR850006938A/ko
Application granted granted Critical
Publication of KR920001990B1 publication Critical patent/KR920001990B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/04—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D277/06—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms

Abstract

내용 없음

Description

폴루로뮤티린 유도체의 제조방법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (2)

  1. 하기식(Ⅱ)의 화합물을 하기식(Ⅲ)의 반응성 에스테트와 반응시키고 모든 보호된 아미노기를 탈보호화하고 유리형태 또는 산부가염 또는 4차염의 형태로 얻어지는 화합물을 회수하는 단계로 구성되는 하기식(Ⅰ)의 화합물과 그것의 산부가엽 또는 4차염의 제조방법.
    상기식에서, R1은 에틸 또는 비닐이며, R2는 5원소로 된 포화헤테로사이클이나 하이드록시에 의해 알킬부가 치환되거나 치환되지 않은 아미노 알킬이며, R2′는 모든 아미노기가 보호되어 있는 것을 제외하고는 상기의 R2와 같다.
  2. 본 출원의 명성서와 청구범위에서 지적한 상기 공정 또는 특징의 각각 혹은 둘 또는 그 이상의 조합으로 언급된 공정단계와 특징적인 조성물.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR1019850000904A 1984-02-17 1985-02-14 플루로뮤터린 유도체의 제조방법 KR920001990B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE19843405632 DE3405632A1 (de) 1984-02-17 1984-02-17 Neue pleuromutilinderivate, verfahren zu ihrer herstellung und ihre verwendung
DE3405632.7 1984-02-17
DE3413708.4 1984-04-12
DE19843413708 DE3413708A1 (de) 1984-04-12 1984-04-12 Neue pleuromutilinderivate, verfahren zu ihrer herstellung und ihre verwendung

Publications (2)

Publication Number Publication Date
KR850006938A true KR850006938A (ko) 1985-10-25
KR920001990B1 KR920001990B1 (ko) 1992-03-09

Family

ID=25818547

Family Applications (1)

Application Number Title Priority Date Filing Date
KR1019850000904A KR920001990B1 (ko) 1984-02-17 1985-02-14 플루로뮤터린 유도체의 제조방법

Country Status (21)

Country Link
US (1) US4675330A (ko)
EP (1) EP0153277B1 (ko)
JP (1) JPH068278B2 (ko)
KR (1) KR920001990B1 (ko)
AU (1) AU585209B2 (ko)
CA (1) CA1249281A (ko)
CY (1) CY1565A (ko)
DE (1) DE3560511D1 (ko)
DK (1) DK164664C (ko)
ES (1) ES8606262A1 (ko)
FI (1) FI90414C (ko)
GR (1) GR850415B (ko)
HK (1) HK103690A (ko)
HU (1) HU194819B (ko)
IE (1) IE58232B1 (ko)
IL (1) IL74355A (ko)
MY (1) MY102919A (ko)
NZ (1) NZ211131A (ko)
PH (1) PH21588A (ko)
PL (1) PL145848B1 (ko)
SG (1) SG69290G (ko)

Families Citing this family (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AT392272B (de) * 1989-10-03 1991-02-25 Biochemie Gmbh Verfahren zur herstellung eines pleuromutilinderivats und seiner saeureadditionssalze
HU208115B (en) * 1989-10-03 1993-08-30 Biochemie Gmbh New process for producting pleuromutilin derivatives
AT400674B (de) * 1991-07-24 1996-02-26 Biochemie Gmbh Pharmazeutische pleuromutilin-zubereitung
AT397654B (de) * 1992-05-04 1994-06-27 Biochemie Gmbh Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
KR100516418B1 (ko) * 1996-07-04 2005-12-20 바이오케미 게젤샤프트 엠베하 플루로뮤틸린유도체의수의학적용도
GB9614017D0 (en) * 1996-07-04 1996-09-04 Biochemie Gmbh Organic compounds
NO331772B1 (no) * 1996-07-04 2012-03-26 Biochemie Gmbh Veterinaermedisinsk anvendelse av et pleuromutilinderivat
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
TWI260220B (en) * 1999-11-22 2006-08-21 Novartis Ag A pharmaceutical composition for the transdermal treatment of bacterial infections in animals
GB0017031D0 (en) * 2000-07-11 2000-08-30 Biochemie Gmbh Antimicrobials
PE20020676A1 (es) * 2000-09-13 2002-08-27 Biochemie Gmbh Compuestos de mutilina como antibacterianos
CO5390081A1 (es) 2001-11-28 2004-04-30 Novartis Ag Compuestos organicos
US20040116510A1 (en) * 2002-03-05 2004-06-17 Nichtberger Steven A. Antihypertensive agent and cholesterol absorption inhibitor combination therapy
GB0209262D0 (en) * 2002-04-23 2002-06-05 Biochemie Gmbh Organic compounds
GB0308114D0 (en) * 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
EP1686115A1 (de) * 2005-01-26 2006-08-02 Novartis AG Organische Säureadditionssalze von Valnemulin
GB0504314D0 (en) * 2005-03-02 2005-04-06 Glaxo Group Ltd Novel polymorph
CN101880252B (zh) * 2010-06-29 2013-01-23 金河生物科技股份有限公司 盐酸沃尼妙林的制备方法
CN102229580B (zh) * 2011-05-12 2014-02-26 南通大学 新型截短侧耳素衍生物、其制备方法及其医药用途
CN102344397B (zh) * 2011-08-23 2013-09-04 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的提纯方法
CN102424660B (zh) * 2011-08-25 2013-11-27 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的低温起泡干燥法及其干燥品
CN102675173B (zh) * 2012-04-28 2013-12-11 武汉回盛生物科技有限公司 一种盐酸沃尼妙林的化学合成方法
CN103193692A (zh) * 2013-04-23 2013-07-10 河北科技大学 一种沃尼妙林及其盐酸盐的制备
CN104311464A (zh) * 2014-09-15 2015-01-28 河北威远动物药业有限公司 一种兽用沃尼妙林的制备方法

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4060542A (en) * 1969-07-25 1977-11-29 Biochemie Gesellschaft M.B.H. 14-Desoxy-14 thiocyanato-acetoxy-mutilin
US3919290A (en) * 1972-10-03 1975-11-11 Sandoz Ltd Substituted 14-desoxy-mutilins
US4086359A (en) * 1975-09-30 1978-04-25 E. R. Squibb & Sons, Inc. Derivatives of pleuromutilin and compositions
CH619450A5 (ko) * 1976-01-15 1980-09-30 Sandoz Ag
JPS54160358A (en) * 1978-06-06 1979-12-19 Sandoz Ag Improvement for organic compound
GB2072012B (en) * 1980-03-14 1984-07-25 Squibb & Sons Inc Veterinary compositions containing pleuromutilin derivatives
FR2526019A1 (fr) * 1982-04-28 1983-11-04 Sandoz Sa Nouveaux derives de la pleuromutiline, leur preparation et leur utilisation comme medicaments

Also Published As

Publication number Publication date
IL74355A0 (en) 1985-05-31
HUT39155A (en) 1986-08-28
DK72885D0 (da) 1985-02-15
EP0153277B1 (de) 1987-08-26
IL74355A (en) 1988-04-29
PL145848B1 (en) 1988-11-30
MY102919A (en) 1993-03-31
CA1249281A (en) 1989-01-24
ES8606262A1 (es) 1986-04-16
IE850375L (en) 1985-08-17
HK103690A (en) 1990-12-21
PL251972A1 (en) 1985-12-03
US4675330A (en) 1987-06-23
KR920001990B1 (ko) 1992-03-09
EP0153277A2 (de) 1985-08-28
NZ211131A (en) 1988-08-30
FI90414C (fi) 1994-02-10
FI90414B (fi) 1993-10-29
GR850415B (ko) 1985-06-18
PH21588A (en) 1987-12-11
DK164664C (da) 1992-12-21
JPS60199870A (ja) 1985-10-09
ES540464A0 (es) 1986-04-16
JPH068278B2 (ja) 1994-02-02
FI850654L (fi) 1985-08-18
DE3560511D1 (en) 1987-10-01
IE58232B1 (en) 1993-08-11
DK72885A (da) 1985-08-18
DK164664B (da) 1992-07-27
EP0153277A3 (en) 1985-09-25
AU3877385A (en) 1985-09-12
FI850654A0 (fi) 1985-02-15
SG69290G (en) 1990-11-23
CY1565A (en) 1991-05-17
AU585209B2 (en) 1989-06-15
HU194819B (en) 1988-03-28

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