AT397654B - Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung - Google Patents

Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung

Info

Publication number
AT397654B
AT397654B AT0089792A AT89792A AT397654B AT 397654 B AT397654 B AT 397654B AT 0089792 A AT0089792 A AT 0089792A AT 89792 A AT89792 A AT 89792A AT 397654 B AT397654 B AT 397654B
Authority
AT
Austria
Prior art keywords
pct
pleuromutil
derivatives
new
production
Prior art date
Application number
AT0089792A
Other languages
English (en)
Other versions
ATA89792A (de
Inventor
Ingolf Dr Macher
Original Assignee
Biochemie Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AT0089792A priority Critical patent/AT397654B/de
Application filed by Biochemie Gmbh filed Critical Biochemie Gmbh
Priority to AT93909858T priority patent/ATE184277T1/de
Priority to PCT/EP1993/001033 priority patent/WO1993022288A1/en
Priority to JP5518915A priority patent/JP2718829B2/ja
Priority to DE69326302T priority patent/DE69326302T2/de
Priority to US08/178,317 priority patent/US5545654A/en
Priority to EP93909858A priority patent/EP0592643B1/de
Priority to ES93909858T priority patent/ES2138623T3/es
Priority to CA002103072A priority patent/CA2103072C/en
Priority to SG1996009469A priority patent/SG76479A1/en
Publication of ATA89792A publication Critical patent/ATA89792A/de
Application granted granted Critical
Publication of AT397654B publication Critical patent/AT397654B/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Oncology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT0089792A 1992-05-04 1992-05-04 Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung AT397654B (de)

Priority Applications (10)

Application Number Priority Date Filing Date Title
AT0089792A AT397654B (de) 1992-05-04 1992-05-04 Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
PCT/EP1993/001033 WO1993022288A1 (en) 1992-05-04 1993-04-29 Pleuromutilin derivatives
JP5518915A JP2718829B2 (ja) 1992-05-04 1993-04-29 プレウロムチリン誘導体
DE69326302T DE69326302T2 (de) 1992-05-04 1993-04-29 Pleuromutilin-derivate
AT93909858T ATE184277T1 (de) 1992-05-04 1993-04-29 Pleuromutilin-derivate
US08/178,317 US5545654A (en) 1992-05-04 1993-04-29 Pleuromutilin derivatives
EP93909858A EP0592643B1 (de) 1992-05-04 1993-04-29 Pleuromutilin-derivate
ES93909858T ES2138623T3 (es) 1992-05-04 1993-04-29 Derivados de pleuromutilina.
CA002103072A CA2103072C (en) 1992-05-04 1993-04-29 Pleuromutilin derivatives
SG1996009469A SG76479A1 (en) 1992-05-04 1993-04-29 Pleuromutilin derivatives

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
AT0089792A AT397654B (de) 1992-05-04 1992-05-04 Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung

Publications (2)

Publication Number Publication Date
ATA89792A ATA89792A (de) 1993-10-15
AT397654B true AT397654B (de) 1994-06-27

Family

ID=3502346

Family Applications (2)

Application Number Title Priority Date Filing Date
AT0089792A AT397654B (de) 1992-05-04 1992-05-04 Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
AT93909858T ATE184277T1 (de) 1992-05-04 1993-04-29 Pleuromutilin-derivate

Family Applications After (1)

Application Number Title Priority Date Filing Date
AT93909858T ATE184277T1 (de) 1992-05-04 1993-04-29 Pleuromutilin-derivate

Country Status (9)

Country Link
US (1) US5545654A (de)
EP (1) EP0592643B1 (de)
JP (1) JP2718829B2 (de)
AT (2) AT397654B (de)
CA (1) CA2103072C (de)
DE (1) DE69326302T2 (de)
ES (1) ES2138623T3 (de)
SG (1) SG76479A1 (de)
WO (1) WO1993022288A1 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
GB9918037D0 (en) * 1999-07-30 1999-09-29 Biochemie Gmbh Organic compounds
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
US6988990B2 (en) * 2003-05-29 2006-01-24 General Electric Company Automatic annotation filler system and method for use in ultrasound imaging
ES2335284T3 (es) * 2003-09-03 2010-03-24 Glaxo Group Limited Nuevo procedimiento para preparar derivados de pleuromutilina.
EP1686115A1 (de) * 2005-01-26 2006-08-02 Novartis AG Organische Säureadditionssalze von Valnemulin
CN101456833B (zh) * 2008-12-12 2012-10-03 湖北龙翔药业有限公司 一种纯化截短侧耳素类化合物盐酸盐的方法
CN101597248B (zh) * 2009-07-10 2012-08-22 河北远征药业有限公司 沃尼妙林及其盐酸盐的制备方法
CN102070499A (zh) * 2010-12-01 2011-05-25 安徽省皖北药业股份有限公司 一种延胡索酸泰妙菌素的精制方法
CN102344397B (zh) * 2011-08-23 2013-09-04 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的提纯方法
CN102424660B (zh) * 2011-08-25 2013-11-27 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的低温起泡干燥法及其干燥品
CN103288694B (zh) * 2013-06-28 2015-06-17 宁夏泰瑞制药股份有限公司 一种截短侧耳素类合成衍生物盐的晶体制备方法
CN104311509A (zh) * 2014-09-15 2015-01-28 中国农业科学院兰州畜牧与兽药研究所 截短侧耳素类衍生物及其制备方法、应用
CN106496085B (zh) * 2016-09-21 2018-01-26 盐城市舜宝化工有限公司 合成盐酸沃尼妙林的中间体化合物以及盐酸沃尼妙林的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CY1353A (en) * 1979-01-12 1987-04-24 Sandoz Ag New pleuromutilin derivatives, their production and use
DE3560511D1 (en) * 1984-02-17 1987-10-01 Sandoz Ag Pleuromutilin derivatives, process for their preparation and their use
HU208115B (en) * 1989-10-03 1993-08-30 Biochemie Gmbh New process for producting pleuromutilin derivatives

Also Published As

Publication number Publication date
DE69326302D1 (de) 1999-10-14
CA2103072A1 (en) 1993-11-05
CA2103072C (en) 2004-07-27
DE69326302T2 (de) 2000-01-27
EP0592643B1 (de) 1999-09-08
ATA89792A (de) 1993-10-15
EP0592643A1 (de) 1994-04-20
JPH06508853A (ja) 1994-10-06
JP2718829B2 (ja) 1998-02-25
WO1993022288A1 (en) 1993-11-11
ATE184277T1 (de) 1999-09-15
SG76479A1 (en) 2000-11-21
US5545654A (en) 1996-08-13
ES2138623T3 (es) 2000-01-16

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Effective date: 20120504