DE69609202D1 - Stereoselektive herstellung von 2-substituierten succinatderivaten - Google Patents

Stereoselektive herstellung von 2-substituierten succinatderivaten

Info

Publication number
DE69609202D1
DE69609202D1 DE69609202T DE69609202T DE69609202D1 DE 69609202 D1 DE69609202 D1 DE 69609202D1 DE 69609202 T DE69609202 T DE 69609202T DE 69609202 T DE69609202 T DE 69609202T DE 69609202 D1 DE69609202 D1 DE 69609202D1
Authority
DE
Germany
Prior art keywords
alkyl
hydrogen
compounds
alk
thiazolyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69609202T
Other languages
English (en)
Other versions
DE69609202T2 (de
Inventor
Douglas Bailey
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim Canada Ltd
Original Assignee
Boehringer Ingelheim Canada Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Canada Ltd filed Critical Boehringer Ingelheim Canada Ltd
Application granted granted Critical
Publication of DE69609202D1 publication Critical patent/DE69609202D1/de
Publication of DE69609202T2 publication Critical patent/DE69609202T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B57/00—Separation of optically-active compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/62—Halogen-containing esters
    • C07C69/65—Halogen-containing esters of unsaturated acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/38—Radicals substituted by singly-bound nitrogen atoms having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/40—Unsubstituted amino or imino radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/62—Carboxylic acid esters
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/07—Optical isomers
DE69609202T 1995-12-22 1996-12-17 Stereoselektive herstellung von 2-substituierten succinatderivaten Expired - Lifetime DE69609202T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
CA002165996A CA2165996C (en) 1995-12-22 1995-12-22 Stereoselective preparation of 2-substituted succinic derivatives
PCT/CA1996/000852 WO1997023641A1 (en) 1995-12-22 1996-12-17 Stereoselective preparation of 2-substituted succinic derivatives

Publications (2)

Publication Number Publication Date
DE69609202D1 true DE69609202D1 (de) 2000-08-10
DE69609202T2 DE69609202T2 (de) 2001-03-01

Family

ID=4157228

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69609202T Expired - Lifetime DE69609202T2 (de) 1995-12-22 1996-12-17 Stereoselektive herstellung von 2-substituierten succinatderivaten

Country Status (12)

Country Link
US (1) US5808085A (de)
EP (1) EP0882138B1 (de)
JP (1) JP4030583B2 (de)
AT (1) ATE194388T1 (de)
CA (1) CA2165996C (de)
DE (1) DE69609202T2 (de)
DK (1) DK0882138T3 (de)
ES (1) ES2147944T3 (de)
GR (1) GR3034465T3 (de)
MX (1) MX9805061A (de)
PT (1) PT882138E (de)
WO (1) WO1997023641A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6323180B1 (en) * 1998-08-10 2001-11-27 Boehringer Ingelheim (Canada) Ltd Hepatitis C inhibitor tri-peptides
US6232958B1 (en) 1998-12-29 2001-05-15 Microsoft Corporation Input device with multiplexed switches

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5275950A (en) * 1990-05-11 1994-01-04 Abbott Laboratories Process for the preparation of a renin inhibiting compound
US5215918A (en) * 1992-06-19 1993-06-01 Bend Research, Inc. Enantiomeric enrichment of (R,S)-3-quinuclidinol
KR950703520A (ko) * 1992-09-25 1995-09-20 자크 루 레닌 억제성 N-(2-아미노-2-옥소에틸)부탄디아미드 유도체(Renin inhibiting N-(2-amino-2-oxoethyl)butanediamide derivatives)
US5420283A (en) * 1993-08-02 1995-05-30 Pfizer Inc. Resolution of (R)-2-benzylsuccinic acid 4-[4-(N-t-butoxycarbonylmethylamino)-piperidine] amide
US5508466A (en) * 1994-04-13 1996-04-16 G.D. Searle & Co. Synthesis of N-protected-α-substituted-glycine racemic esters by zinc-mediated addition of organic halide to glycine cation equivalent

Also Published As

Publication number Publication date
EP0882138A1 (de) 1998-12-09
GR3034465T3 (en) 2000-12-29
US5808085A (en) 1998-09-15
DK0882138T3 (da) 2000-11-20
ES2147944T3 (es) 2000-10-01
DE69609202T2 (de) 2001-03-01
JP2000502259A (ja) 2000-02-29
WO1997023641A1 (en) 1997-07-03
CA2165996C (en) 2002-01-29
ATE194388T1 (de) 2000-07-15
CA2165996A1 (en) 1997-06-23
MX9805061A (es) 1998-10-31
JP4030583B2 (ja) 2008-01-09
EP0882138B1 (de) 2000-07-05
PT882138E (pt) 2000-10-31

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