DE69326302D1 - Pleuromutilin-derivate - Google Patents

Pleuromutilin-derivate

Info

Publication number
DE69326302D1
DE69326302D1 DE69326302T DE69326302T DE69326302D1 DE 69326302 D1 DE69326302 D1 DE 69326302D1 DE 69326302 T DE69326302 T DE 69326302T DE 69326302 T DE69326302 T DE 69326302T DE 69326302 D1 DE69326302 D1 DE 69326302D1
Authority
DE
Germany
Prior art keywords
pct
sec
independently hydrogen
date
pleuromutilin derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69326302T
Other languages
English (en)
Other versions
DE69326302T2 (de
Inventor
Ingolf Macher
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sandoz GmbH
Original Assignee
Biochemie GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biochemie GmbH filed Critical Biochemie GmbH
Publication of DE69326302D1 publication Critical patent/DE69326302D1/de
Application granted granted Critical
Publication of DE69326302T2 publication Critical patent/DE69326302T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/52—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being acyclic and saturated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/30—Oxygen or sulfur atoms
    • C07D233/32—One oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2603/00—Systems containing at least three condensed rings
    • C07C2603/56—Ring systems containing bridged rings
    • C07C2603/58—Ring systems containing bridged rings containing three rings
    • C07C2603/76—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members
    • C07C2603/80—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings
    • C07C2603/82—Ring systems containing bridged rings containing three rings containing at least one ring with more than six ring members containing eight-membered rings having three condensed rings with in total fourteen carbon atoms and having a having a [5.4.3.0(1,8)] ring structure, e.g. pleuromutiline

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69326302T 1992-05-04 1993-04-29 Pleuromutilin-derivate Expired - Lifetime DE69326302T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
AT0089792A AT397654B (de) 1992-05-04 1992-05-04 Neue pleuromutilinderivate, ihre verwendung und verfahren zu ihrer herstellung
PCT/EP1993/001033 WO1993022288A1 (en) 1992-05-04 1993-04-29 Pleuromutilin derivatives

Publications (2)

Publication Number Publication Date
DE69326302D1 true DE69326302D1 (de) 1999-10-14
DE69326302T2 DE69326302T2 (de) 2000-01-27

Family

ID=3502346

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69326302T Expired - Lifetime DE69326302T2 (de) 1992-05-04 1993-04-29 Pleuromutilin-derivate

Country Status (9)

Country Link
US (1) US5545654A (de)
EP (1) EP0592643B1 (de)
JP (1) JP2718829B2 (de)
AT (2) AT397654B (de)
CA (1) CA2103072C (de)
DE (1) DE69326302T2 (de)
ES (1) ES2138623T3 (de)
SG (1) SG76479A1 (de)
WO (1) WO1993022288A1 (de)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
UY25225A1 (es) 1997-10-29 2000-12-29 Smithkline Beecham Plc Derivados de pleuromutilina utiles como agentes antimicrobianos
GB0218578D0 (en) * 2002-08-09 2002-09-18 Glaxo Group Ltd Novel method
US6988990B2 (en) * 2003-05-29 2006-01-24 General Electric Company Automatic annotation filler system and method for use in ultrasound imaging
JP5460947B2 (ja) * 2003-09-03 2014-04-02 グラクソ グループ リミテッド 新規調製方法、塩、組成物及び使用
EP1686115A1 (de) * 2005-01-26 2006-08-02 Novartis AG Organische Säureadditionssalze von Valnemulin
CN101456833B (zh) * 2008-12-12 2012-10-03 湖北龙翔药业有限公司 一种纯化截短侧耳素类化合物盐酸盐的方法
CN101597248B (zh) * 2009-07-10 2012-08-22 河北远征药业有限公司 沃尼妙林及其盐酸盐的制备方法
CN102070499A (zh) * 2010-12-01 2011-05-25 安徽省皖北药业股份有限公司 一种延胡索酸泰妙菌素的精制方法
CN102344397B (zh) * 2011-08-23 2013-09-04 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的提纯方法
CN102424660B (zh) * 2011-08-25 2013-11-27 浙江升华拜克生物股份有限公司 一种伐奈莫林盐酸盐的低温起泡干燥法及其干燥品
CN103288694B (zh) * 2013-06-28 2015-06-17 宁夏泰瑞制药股份有限公司 一种截短侧耳素类合成衍生物盐的晶体制备方法
CN104311509A (zh) * 2014-09-15 2015-01-28 中国农业科学院兰州畜牧与兽药研究所 截短侧耳素类衍生物及其制备方法、应用
CN106496085B (zh) * 2016-09-21 2018-01-26 盐城市舜宝化工有限公司 合成盐酸沃尼妙林的中间体化合物以及盐酸沃尼妙林的制备方法

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2966635D1 (en) * 1979-01-12 1984-03-08 Sandoz Ag New pleuromutilin derivatives, their production and pharmaceutical compositions containing them
DE3560511D1 (en) * 1984-02-17 1987-10-01 Sandoz Ag Pleuromutilin derivatives, process for their preparation and their use
HU208115B (en) * 1989-10-03 1993-08-30 Biochemie Gmbh New process for producting pleuromutilin derivatives

Also Published As

Publication number Publication date
WO1993022288A1 (en) 1993-11-11
SG76479A1 (en) 2000-11-21
AT397654B (de) 1994-06-27
ES2138623T3 (es) 2000-01-16
US5545654A (en) 1996-08-13
CA2103072A1 (en) 1993-11-05
ATE184277T1 (de) 1999-09-15
JP2718829B2 (ja) 1998-02-25
ATA89792A (de) 1993-10-15
JPH06508853A (ja) 1994-10-06
EP0592643A1 (de) 1994-04-20
DE69326302T2 (de) 2000-01-27
EP0592643B1 (de) 1999-09-08
CA2103072C (en) 2004-07-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8328 Change in the person/name/address of the agent

Representative=s name: PFENNING MEINIG & PARTNER GBR, 80339 MUENCHEN

8328 Change in the person/name/address of the agent

Representative=s name: MAIWALD PATENTANWALTSGESELLSCHAFT MBH, 80335 MUENC