KR840001949A - 신규 펩티드 화합물의 제법 - Google Patents

신규 펩티드 화합물의 제법 Download PDF

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Publication number
KR840001949A
KR840001949A KR1019820004769A KR820004769A KR840001949A KR 840001949 A KR840001949 A KR 840001949A KR 1019820004769 A KR1019820004769 A KR 1019820004769A KR 820004769 A KR820004769 A KR 820004769A KR 840001949 A KR840001949 A KR 840001949A
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KR
South Korea
Prior art keywords
alkoxy
substituted
lower alkyl
hydrogen
acyl
Prior art date
Application number
KR1019820004769A
Other languages
English (en)
Other versions
KR900002560B1 (ko
Inventor
진우에몬 고니시
Original Assignee
진우에몬 고니시
니혼 소오끼 세이야꾸 가부시기가이샤
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56172515A external-priority patent/JPS5872549A/ja
Priority claimed from JP57160138A external-priority patent/JPS5951249A/ja
Application filed by 진우에몬 고니시, 니혼 소오끼 세이야꾸 가부시기가이샤 filed Critical 진우에몬 고니시
Publication of KR840001949A publication Critical patent/KR840001949A/ko
Application granted granted Critical
Publication of KR900002560B1 publication Critical patent/KR900002560B1/ko

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/02—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation
    • C07C5/10—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of aromatic six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Abstract

내용 없음

Description

신규 펩티드 화합물의 제법
본 내용은 요부공개 건이므로 전문내용을 수록하지 않았음

Claims (1)

  1. 일반식(Ⅰ)
    [식중, A는 보호기를 보유하여도 좋은 아미노산 잔기,
    R1은 수소, 저급 알킬, 아실, 알콕시카보닐, 또는 아릴킬옥시카보닐(할로겐. 알콕시, 니트로로서 치환되어있어도 좋다),
    R2는 히드록시, 알콕시, 아릴옥시, 아랄킬옥시 또는 아미노(저급알킬로서 치환되어있어도 좋다),
    R3은 수소, 저급 알킬, 아실, 또는 아랄킬,
    R4는 수소, 트실, 트리틸, 아랄킬 또는 아랄킬옥시카보닐(할로겐, 알콕시, 니트로로서 치환되어있어도 좋다),
    R5는 수소, 저급알킬,아실, 트실, 알콕시카보닐, 또는 아랄킬옥시카보닐(할로겐, 알콕시, 니트로로서 치환되어있어도 좋다을 표시한다.]
    로서 표시되는 펩티드화합물을 구성할 수 있는 부분 펩티드 또는 아미노산과 그 나머지부분을 축합시키며 필요에 따라 보호기를 이탈시키는 것을 특징으로 하는 일반식(Ⅰ)로서 표시되는 신규펩티드 화합물의 제법.
    ※ 참고사항 : 최초출원 내용에 의하여 공개하는 것임.
KR828204769A 1981-10-28 1982-10-25 신규 펩티드 화합물의 제법 KR900002560B1 (ko)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP172515 1981-10-28
JP56172515A JPS5872549A (ja) 1981-10-28 1981-10-28 新規ペプチド類
JP160138 1982-09-14
JP57160138A JPS5951249A (ja) 1982-09-14 1982-09-14 新規ペプチド化合物、その製法及び該化合物を含有する医薬組成物

Publications (2)

Publication Number Publication Date
KR840001949A true KR840001949A (ko) 1984-06-07
KR900002560B1 KR900002560B1 (ko) 1990-04-20

Family

ID=26486725

Family Applications (1)

Application Number Title Priority Date Filing Date
KR828204769A KR900002560B1 (ko) 1981-10-28 1982-10-25 신규 펩티드 화합물의 제법

Country Status (11)

Country Link
US (1) US4461724A (ko)
EP (1) EP0078228B1 (ko)
KR (1) KR900002560B1 (ko)
AU (1) AU558454B2 (ko)
BR (1) BR8206268A (ko)
CA (1) CA1248699A (ko)
DE (1) DE3275297D1 (ko)
DK (1) DK476682A (ko)
ES (1) ES516866A0 (ko)
IL (1) IL67085A (ko)
NZ (1) NZ202297A (ko)

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US5120831A (en) * 1985-02-08 1992-06-09 Procyte Corporation Metal-peptide compositions
US5177061A (en) * 1985-02-08 1993-01-05 Procyte Corporation Method for stimulating hair growth using GHL-Cu complexes
US4810693A (en) * 1985-02-08 1989-03-07 Procyte Corporation Method for inducing biological coverings in wounds
ZA877535B (en) * 1986-10-09 1988-04-11 F. Hoffmann-La Roche & Co. Aktiengesellschaft Factor ix-peptides
US5145838A (en) * 1989-08-30 1992-09-08 Procyte Corporation Methods and compositions for healing ulcers
US5023237A (en) * 1989-08-30 1991-06-11 Procyte Corporation Methods and compositions for healing ulcers
US5059588A (en) * 1989-10-13 1991-10-22 Procyte Corporation, Incorporated Methods and compositions for healing bone using gly his lys: copper
US5118665A (en) * 1990-02-09 1992-06-02 Procyte Corporation Anti-oxidative and anti-inflammatory metal:peptide complexes and uses thereof
US5164367A (en) * 1990-03-26 1992-11-17 Procyte Corporation Method of using copper(ii) containing compounds to accelerate wound healing
US5776892A (en) * 1990-12-21 1998-07-07 Curative Health Services, Inc. Anti-inflammatory peptides
ATE192646T1 (de) * 1992-01-21 2000-05-15 Howard Alliger Verwendung eines stoffgemisches enthaltend alpha hydroxy organische säure zur herstellung eines arzneimittels zur behandlung von kleinen mundgeschwüren
US5382431A (en) * 1992-09-29 1995-01-17 Skin Biology, Inc. Tissue protective and regenerative compositions
US5888522A (en) * 1996-08-23 1999-03-30 Skin Biology, Inc. Tissue protective and regenerative compositions
KR20110049875A (ko) 1999-10-01 2011-05-12 디엠아이 바이오사이언시스, 인크 금속 결합 화합물 및 그의 용도
US7592304B2 (en) 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US20030130185A1 (en) * 2000-09-29 2003-07-10 David Bar-Or Metal-binding compounds and uses therefor
US7632803B2 (en) * 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US20030158111A1 (en) * 1999-10-01 2003-08-21 David Bar-Or Methods and products for oral care
US20030055003A1 (en) * 2001-07-19 2003-03-20 David Bar-Or Use of copper chelators to inhibit the inactivation of protein C
EP1482960A4 (en) * 2001-11-20 2009-04-08 Dmi Biosciences Inc PROCESSES AND PRODUCTS FOR THE MOUTH CARE
PL375076A1 (en) * 2002-06-19 2005-11-14 N.V.Nutricia Method and composition for treating or preventing catabolism or stimulating anabolism in a mammal undergoing metabolic stress
WO2004089297A2 (en) * 2003-04-02 2004-10-21 Suntory Pharmaceutical Research Laboratories, Llc Compounds and methods for treatment of thrombosis
KR20060015588A (ko) * 2003-05-07 2006-02-17 디엠아이 바이오사이언시스, 인크 구강 케어 방법 및 제품
WO2005079463A2 (en) * 2004-02-17 2005-09-01 Dynamis Therapeutics, Inc. Fructoseamine 3 kinase and the formation of collagen and elastin
US8562965B2 (en) 2004-05-03 2013-10-22 Nektar Therapeutics Polymer derivatives comprising an acetal or ketal branching point
WO2010033240A2 (en) 2008-09-19 2010-03-25 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof
WO2010033220A2 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Modified therapeutics peptides, methods of their preparation and use

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4171299A (en) * 1975-04-04 1979-10-16 The Regents Of The University Of California Polypeptide agents for blocking the human allergic response

Also Published As

Publication number Publication date
DK476682A (da) 1983-04-29
IL67085A (en) 1986-04-29
DE3275297D1 (en) 1987-03-05
US4461724A (en) 1984-07-24
IL67085A0 (en) 1983-02-23
CA1248699A (en) 1989-01-10
NZ202297A (en) 1985-08-30
ES8402559A1 (es) 1984-02-01
AU558454B2 (en) 1987-01-29
ES516866A0 (es) 1984-02-01
KR900002560B1 (ko) 1990-04-20
EP0078228B1 (en) 1987-01-28
AU8979082A (en) 1983-05-05
BR8206268A (pt) 1983-09-20
EP0078228A1 (en) 1983-05-04

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