ES8402559A1 - Un procedimiento para preparar nuevos compuestos peptidicos. - Google Patents

Un procedimiento para preparar nuevos compuestos peptidicos.

Info

Publication number
ES8402559A1
ES8402559A1 ES82516866A ES516866A ES8402559A1 ES 8402559 A1 ES8402559 A1 ES 8402559A1 ES 82516866 A ES82516866 A ES 82516866A ES 516866 A ES516866 A ES 516866A ES 8402559 A1 ES8402559 A1 ES 8402559A1
Authority
ES
Spain
Prior art keywords
group
optionally
substituted
lower alkyl
hydrogen atom
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES82516866A
Other languages
English (en)
Other versions
ES516866A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Nippon Zoki Pharmaceutical Co Ltd
Original Assignee
Nippon Zoki Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP56172515A external-priority patent/JPS5872549A/ja
Priority claimed from JP57160138A external-priority patent/JPS5951249A/ja
Application filed by Nippon Zoki Pharmaceutical Co Ltd filed Critical Nippon Zoki Pharmaceutical Co Ltd
Publication of ES8402559A1 publication Critical patent/ES8402559A1/es
Publication of ES516866A0 publication Critical patent/ES516866A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C5/00—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms
    • C07C5/02—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation
    • C07C5/10—Preparation of hydrocarbons from hydrocarbons containing the same number of carbon atoms by hydrogenation of aromatic six-membered rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/02—Halogenated hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/08—Tripeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1008—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atoms, i.e. Gly, Ala
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1016—Tetrapeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1024—Tetrapeptides with the first amino acid being heterocyclic
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE COMPUESTOS PEPTIDICOS, ASI COMO DE SUS SALES DE ADICION DE ACIDO Y COMPLETO METALICOS, DE FORMULA (I), EN LA QUE A ES UN RESTO AMINOACIDO; Y R1, R2, R3, R4 Y R5 PUEDEN SER VARIOS TIPOS DE RADICALES.CONSISTE EN EFECTUAR REACCIONES DE COPULACION SUCESIVAS DE COMPUESTOS DE FORMULAS LYS(R5)-R2 Y R1-HIS(R4), R1-SER(R3) Y R1-A, EN FASE LIQUIDA O SOLIDA, CON RESINA CLOROMETILADA O AMINOMETILADA. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, EN PRESENCIA DE UN AGENTE DE CONDENSACION, CON AGITACION, A UNA TEMPERATURA COMPRENDIDA ENTRE C20JCY LA AMBIENTE.ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO DE LA ULCERA Y LA TROMBOSIS.
ES82516866A 1981-10-28 1982-10-27 Un procedimiento para preparar nuevos compuestos peptidicos. Granted ES516866A0 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP56172515A JPS5872549A (ja) 1981-10-28 1981-10-28 新規ペプチド類
JP57160138A JPS5951249A (ja) 1982-09-14 1982-09-14 新規ペプチド化合物、その製法及び該化合物を含有する医薬組成物

Publications (2)

Publication Number Publication Date
ES8402559A1 true ES8402559A1 (es) 1984-02-01
ES516866A0 ES516866A0 (es) 1984-02-01

Family

ID=26486725

Family Applications (1)

Application Number Title Priority Date Filing Date
ES82516866A Granted ES516866A0 (es) 1981-10-28 1982-10-27 Un procedimiento para preparar nuevos compuestos peptidicos.

Country Status (11)

Country Link
US (1) US4461724A (es)
EP (1) EP0078228B1 (es)
KR (1) KR900002560B1 (es)
AU (1) AU558454B2 (es)
BR (1) BR8206268A (es)
CA (1) CA1248699A (es)
DE (1) DE3275297D1 (es)
DK (1) DK476682A (es)
ES (1) ES516866A0 (es)
IL (1) IL67085A (es)
NZ (1) NZ202297A (es)

Families Citing this family (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4810693A (en) * 1985-02-08 1989-03-07 Procyte Corporation Method for inducing biological coverings in wounds
US5120831A (en) * 1985-02-08 1992-06-09 Procyte Corporation Metal-peptide compositions
US5177061A (en) * 1985-02-08 1993-01-05 Procyte Corporation Method for stimulating hair growth using GHL-Cu complexes
ZA877535B (en) * 1986-10-09 1988-04-11 F. Hoffmann-La Roche & Co. Aktiengesellschaft Factor ix-peptides
US5145838A (en) * 1989-08-30 1992-09-08 Procyte Corporation Methods and compositions for healing ulcers
US5023237A (en) * 1989-08-30 1991-06-11 Procyte Corporation Methods and compositions for healing ulcers
US5059588A (en) * 1989-10-13 1991-10-22 Procyte Corporation, Incorporated Methods and compositions for healing bone using gly his lys: copper
US5118665A (en) * 1990-02-09 1992-06-02 Procyte Corporation Anti-oxidative and anti-inflammatory metal:peptide complexes and uses thereof
US5164367A (en) * 1990-03-26 1992-11-17 Procyte Corporation Method of using copper(ii) containing compounds to accelerate wound healing
US5776892A (en) * 1990-12-21 1998-07-07 Curative Health Services, Inc. Anti-inflammatory peptides
ATE192646T1 (de) * 1992-01-21 2000-05-15 Howard Alliger Verwendung eines stoffgemisches enthaltend alpha hydroxy organische säure zur herstellung eines arzneimittels zur behandlung von kleinen mundgeschwüren
US5382431A (en) * 1992-09-29 1995-01-17 Skin Biology, Inc. Tissue protective and regenerative compositions
US5888522A (en) * 1996-08-23 1999-03-30 Skin Biology, Inc. Tissue protective and regenerative compositions
KR20100075503A (ko) 1999-10-01 2010-07-02 디엠아이 바이오사이언시스, 인크 금속 결합 화합물 및 그의 용도
US20030158111A1 (en) * 1999-10-01 2003-08-21 David Bar-Or Methods and products for oral care
US7632803B2 (en) 1999-10-01 2009-12-15 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
US20030130185A1 (en) * 2000-09-29 2003-07-10 David Bar-Or Metal-binding compounds and uses therefor
US7592304B2 (en) * 1999-10-01 2009-09-22 Dmi Life Sciences, Inc. Metal-binding compounds and uses therefor
WO2003007686A2 (en) * 2001-07-19 2003-01-30 Dmi Biosciences, Inc. Use of copper chelators to inhibit the inactivation of protein c
EP1482960A4 (en) * 2001-11-20 2009-04-08 Dmi Biosciences Inc PROCESSES AND PRODUCTS FOR THE MOUTH CARE
EP3184107A1 (en) * 2002-06-19 2017-06-28 N.V. Nutricia Method and preparation for treating metabolic stress
US7217794B2 (en) * 2003-04-02 2007-05-15 Daiamed, Inc. Compounds and methods for treatment of thrombosis
EP1620066A4 (en) * 2003-05-07 2010-11-03 Dmi Biosciences Inc ORAL CARE PROCESSES AND PRODUCTS
EP1753861A4 (en) * 2004-02-17 2010-03-10 Dynamis Therapeutics Inc FRUCTOSAMINE-3-KINASE AND THE FORMATION OF COLLAGEN AND ELASTIN
US8562965B2 (en) 2004-05-03 2013-10-22 Nektar Therapeutics Polymer derivatives comprising an acetal or ketal branching point
WO2010033220A2 (en) * 2008-09-19 2010-03-25 Nektar Therapeutics Modified therapeutics peptides, methods of their preparation and use
US8680263B2 (en) 2008-09-19 2014-03-25 Nektar Therapeutics Carbohydrate-based drug delivery polymers and conjugates thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4171299A (en) * 1975-04-04 1979-10-16 The Regents Of The University Of California Polypeptide agents for blocking the human allergic response

Also Published As

Publication number Publication date
CA1248699A (en) 1989-01-10
KR900002560B1 (ko) 1990-04-20
AU8979082A (en) 1983-05-05
DE3275297D1 (en) 1987-03-05
AU558454B2 (en) 1987-01-29
IL67085A0 (en) 1983-02-23
NZ202297A (en) 1985-08-30
ES516866A0 (es) 1984-02-01
EP0078228A1 (en) 1983-05-04
DK476682A (da) 1983-04-29
IL67085A (en) 1986-04-29
BR8206268A (pt) 1983-09-20
KR840001949A (ko) 1984-06-07
US4461724A (en) 1984-07-24
EP0078228B1 (en) 1987-01-28

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19981201