ES8607278A1 - Acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(3-oxo-1- piperazinil)-3-quinolin-carboxilicos - Google Patents

Acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(3-oxo-1- piperazinil)-3-quinolin-carboxilicos

Info

Publication number
ES8607278A1
ES8607278A1 ES543837A ES543837A ES8607278A1 ES 8607278 A1 ES8607278 A1 ES 8607278A1 ES 543837 A ES543837 A ES 543837A ES 543837 A ES543837 A ES 543837A ES 8607278 A1 ES8607278 A1 ES 8607278A1
Authority
ES
Spain
Prior art keywords
oxo
piperazinyl
cyclopropyl
dihydro
fluoro
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES543837A
Other languages
English (en)
Other versions
ES543837A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bayer AG
Original Assignee
Bayer AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bayer AG filed Critical Bayer AG
Publication of ES8607278A1 publication Critical patent/ES8607278A1/es
Publication of ES543837A0 publication Critical patent/ES543837A0/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Fodder In General (AREA)
  • Quinoline Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE ACIDOS 1-CICLOPROPIL-6-FLUOR-1,4-DIHIDRO-4-OXO-7-(3-OXO-1-PIPERAZINIL)-3-QUINOLIN-CARBOXILICOS, DE FORMULA (I), EN LA QUE R1 REPRESENTA HIDROGENO, METILO O ETILO; Y R2 PUEDE SER HIDROGENO O FLUOR. COMPRENDE LA REACCION DE UN COMPUESTO DE FORMULA (II), CON UNA 2-PIPERAZINONA, DE FORMULA (III), EN LAS QUE X REPRESENTA CLORO, BROMO O FLUOR Y R1 Y R2 TIENEN LOS MISMOS SIGNIFICADOS QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN UN DISOLVENTE INERTE, A UNA TEMPERATURA COMPRENDIDA ENTRE 20JC Y 200JC. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SUS EFECTOS ANTIBACTERIANOS.
ES543837A 1984-06-04 1985-06-03 Acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(3-oxo-1- piperazinil)-3-quinolin-carboxilicos Expired ES8607278A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE19843420770 DE3420770A1 (de) 1984-06-04 1984-06-04 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-(3-oxo-1-piperazinyl)-3-chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Publications (2)

Publication Number Publication Date
ES8607278A1 true ES8607278A1 (es) 1986-06-01
ES543837A0 ES543837A0 (es) 1986-06-01

Family

ID=6237581

Family Applications (1)

Application Number Title Priority Date Filing Date
ES543837A Expired ES8607278A1 (es) 1984-06-04 1985-06-03 Acidos 1-ciclopropil-6-fluor-1,4-dihidro-4-oxo-7-(3-oxo-1- piperazinil)-3-quinolin-carboxilicos

Country Status (11)

Country Link
US (1) US4588726A (es)
EP (1) EP0166939B1 (es)
JP (1) JPS611682A (es)
KR (1) KR860000279A (es)
AT (1) ATE35264T1 (es)
CA (1) CA1248953A (es)
DE (2) DE3420770A1 (es)
DK (1) DK249385A (es)
ES (1) ES8607278A1 (es)
IL (1) IL75367A (es)
ZA (1) ZA854164B (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3420116A1 (de) * 1984-05-30 1985-12-05 Bayer Ag, 5090 Leverkusen Immunstimulierende mittel
DE3509546A1 (de) * 1985-03-16 1986-09-25 Bayer Ag, 5090 Leverkusen 7-amino-1-(subst.cyclopropyl)-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3705621C2 (de) * 1986-02-25 1997-01-09 Otsuka Pharma Co Ltd Heterocyclisch substituierte Chinoloncarbonsäurederivate
US5563138A (en) * 1987-04-16 1996-10-08 Otsuka Pharmaceutical Company, Limited Benzoheterocyclic compounds
US5262417A (en) * 1988-12-06 1993-11-16 The Upjohn Company Antibacterial quinolone compounds
US4992449A (en) * 1990-02-01 1991-02-12 American Cyanamid Company 7-(substituted)cycloalkylamino-1-(substituted)-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acids
JP2613139B2 (ja) * 1990-07-19 1997-05-21 エスエス製薬 株式会社 キノロンカルボン酸誘導体
DE4301247A1 (de) * 1993-01-19 1994-07-21 Bayer Ag Verfahren zur Herstellung mehrfach halogenierter Benzotrichloride und Benzoylchloride sowie neue Trihalogenbenzotrichloride und -benzoylchloride
MX9700497A (es) * 1994-07-18 1997-04-30 Ube Industries Derivado de acido trifluorometilquinolinocarboxilico.
DE19503471A1 (de) * 1995-02-03 1996-08-08 Bayer Ag Verfahren zur Herstellung von kernhalogenierten Benzoylchloriden
IN186245B (es) 1997-09-19 2001-07-14 Ranbaxy Lab Ltd
CN101851164A (zh) * 2010-05-28 2010-10-06 南京大唐医药科技有限公司 取代的含氟,氮类苯甲酰乙酸乙酯的合成方法

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5845426B2 (ja) * 1978-09-29 1983-10-08 杏林製薬株式会社 置換キノリンカルボン酸誘導体
DE3033157A1 (de) * 1980-09-03 1982-04-01 Bayer Ag, 5090 Leverkusen 7-amino-1-cyclopropyl-4-oxo-1,4-dihydro-naphthyridin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
SE440354B (sv) * 1981-02-19 1985-07-29 Kyorin Seiyaku Kk Kinolinkarboxylsyraderivat
DE3248506A1 (de) * 1982-12-29 1984-07-05 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7(alkyl-1-piperazinyl)-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
DE3306771A1 (de) * 1983-02-25 1984-08-30 Bayer Ag, 5090 Leverkusen Chinoloncarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel

Also Published As

Publication number Publication date
EP0166939B1 (de) 1988-06-22
US4588726A (en) 1986-05-13
IL75367A (en) 1988-09-30
ZA854164B (en) 1986-01-29
EP0166939A1 (de) 1986-01-08
DE3420770A1 (de) 1985-12-05
ATE35264T1 (de) 1988-07-15
DK249385A (da) 1985-12-05
IL75367A0 (en) 1985-09-29
CA1248953A (en) 1989-01-17
JPS611682A (ja) 1986-01-07
ES543837A0 (es) 1986-06-01
KR860000279A (ko) 1986-01-27
DK249385D0 (da) 1985-06-03
DE3563441D1 (en) 1988-07-28

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