ES8205219A1 - Un metodo para producir un compuesto de hidrouracilo - Google Patents

Un metodo para producir un compuesto de hidrouracilo

Info

Publication number
ES8205219A1
ES8205219A1 ES505549A ES505549A ES8205219A1 ES 8205219 A1 ES8205219 A1 ES 8205219A1 ES 505549 A ES505549 A ES 505549A ES 505549 A ES505549 A ES 505549A ES 8205219 A1 ES8205219 A1 ES 8205219A1
Authority
ES
Spain
Prior art keywords
hydrouracil
compounds
ch2ch2
analgesics
methyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES505549A
Other languages
English (en)
Other versions
ES505549A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Welfide Corp
Original Assignee
Welfide Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Welfide Corp filed Critical Welfide Corp
Publication of ES505549A0 publication Critical patent/ES505549A0/es
Publication of ES8205219A1 publication Critical patent/ES8205219A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/20—Hypnotics; Sedatives

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Neurosurgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Neurology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pain & Pain Management (AREA)
  • Anesthesiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE UN COMPUESTO DE HIDROURACILO, ASI COMO DE SUS SALES DE ADICION DE ACIDO FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE A ES UN RADICAL -CH=CH-CH2- O -CH2CH2-, Y R ES HIDROGENO O METILO. CONSISTE EN LA REACCION DE UN COMPUESTO DE FORMULA (II) CON UN COMPUESTO DE FORMULA (III), EN LAS QUE A Y R TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I), E "Y" ES UN ATOMO O GRUPO REACTIVO. LA REACCION SE LLEVA A CABO EN UN DISOLVENTE ORGANICO INERTE, EN PRESENCIA DE UNA BASE Y A UNA TEMPERATURA ENTE 0 GRADOS CENTIGRADOS Y LA DE EBULLICION DEL DISOLVENTE. ALTERNATIVAMENTE SE PUEDE HACER REACCIONAR UN COMPUESTO DE FORMULA (UV), EN LA QUE A ES EL MISMO QUE EN LA FORMULA (I) Y R'' ES ALCOXI, AMINO O ALQUILAMINO INFERIOR, CON UREA, UN DERIVADO DE ACIDO CARBONICO, ACIDO ISOCIANICO O ISOCIANATO DE METILO.
ES505549A 1980-09-17 1981-09-16 Un metodo para producir un compuesto de hidrouracilo Expired ES8205219A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP55129816A JPS5753481A (en) 1980-09-17 1980-09-17 4-hydrouracil-piperidines

Publications (2)

Publication Number Publication Date
ES505549A0 ES505549A0 (es) 1982-06-01
ES8205219A1 true ES8205219A1 (es) 1982-06-01

Family

ID=15018924

Family Applications (1)

Application Number Title Priority Date Filing Date
ES505549A Expired ES8205219A1 (es) 1980-09-17 1981-09-16 Un metodo para producir un compuesto de hidrouracilo

Country Status (5)

Country Link
US (1) US4514403A (es)
EP (1) EP0047990B1 (es)
JP (1) JPS5753481A (es)
DE (1) DE3162041D1 (es)
ES (1) ES8205219A1 (es)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS60243017A (ja) * 1984-05-16 1985-12-03 Kyowa Hakko Kogyo Co Ltd 抗けいれん組成物
JPS63104923A (ja) * 1986-10-22 1988-05-10 Yoshitomi Pharmaceut Ind Ltd 抗不安薬
US4816585A (en) * 1987-03-05 1989-03-28 Olin Corporation Tetraalkylpiperidinyl substituted uracil derivatives and their use as ultraviolet light stabilizers
US4904714A (en) * 1987-10-02 1990-02-27 Olin Corporation Synthetic resin composition and its method of use
JP2807577B2 (ja) * 1990-06-15 1998-10-08 エーザイ株式会社 環状アミド誘導体

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2727469A1 (de) * 1977-06-18 1978-12-21 Hoechst Ag Neue hexahydropyrimidine, verfahren zu ihrer herstellung und arzneimittel, die diese verbindungen enthalten
JPS5524155A (en) * 1978-08-10 1980-02-21 Yoshitomi Pharmaceut Ind Ltd Piperidine derivative having heterocyclic ring at 4-position

Also Published As

Publication number Publication date
EP0047990A1 (en) 1982-03-24
ES505549A0 (es) 1982-06-01
JPS5753481A (en) 1982-03-30
DE3162041D1 (en) 1984-03-01
JPS6234036B2 (es) 1987-07-24
US4514403A (en) 1985-04-30
EP0047990B1 (en) 1984-01-25

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