ES8607218A1 - Un procedimiento para preparar compuestos de amidina - Google Patents

Un procedimiento para preparar compuestos de amidina

Info

Publication number
ES8607218A1
ES8607218A1 ES545482A ES545482A ES8607218A1 ES 8607218 A1 ES8607218 A1 ES 8607218A1 ES 545482 A ES545482 A ES 545482A ES 545482 A ES545482 A ES 545482A ES 8607218 A1 ES8607218 A1 ES 8607218A1
Authority
ES
Spain
Prior art keywords
pct
amidine compounds
formula
image
date feb
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES545482A
Other languages
English (en)
Other versions
ES545482A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Torii and Co Ltd
Original Assignee
Torii and Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Torii and Co Ltd filed Critical Torii and Co Ltd
Publication of ES545482A0 publication Critical patent/ES545482A0/es
Publication of ES8607218A1 publication Critical patent/ES8607218A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
    • C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/44—Nitrogen atoms not forming part of a nitro radical
    • C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D233/88—Nitrogen atoms, e.g. allantoin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical

Abstract

PROCEDIMIENTO PARA PREPARAR COMPUESTOS DE AMIDINA. COMPRENDE: A) DISOLVER O SUSPENDER UN COMPUESTO DE FORMULA (II) DE ACIDO CARBOXILICO EN UN DISOLVENTE ORGANICO TAL COMO DIMETILFORMAMIDA, PIRIDINA O SIMILAR, DEJANDO LUEGO QUE EL COMPUESTO (II) REACCIONE CON UN ACTIVADOR DE ACIDOS CARBOXILICOS, TAL COMO DICICLOHEXILCARBODIIMIDA (DCC), ETC; Y B) AÑADIR AL PRODUCTO DE REACCION EL COMPUESTO DE FORMULA (III), AGITAR LA MEZCLA A UNA TEMPERATURA ENTRE C30JC Y 80JC, DURANTE 3 A 5 HORAS, PARA OBTENER EL COMPUESTO DE FORMULA (I). SIENDO: R1 Y R2, H O UN GRUPO ALQUILO DE C 1 A 6; R3, GRUPO ALQUILO DE C 1 A 6 O UN GRUPO DE FORMULA R4-B-(CH2)N; R4, H, R5-CO; R5, GRUPO ALQUILO DE C 1 A 15; B, -O- O -NH-; Y N, ES 1 A 2. SE UTILIZAN COMO AGENTES ANTITRIPSINA, ANTIPLASMINA, ANTICALICREINA, ANTITROMBINA Y ANTICOMPLEMENTO.
ES545482A 1984-07-25 1985-07-23 Un procedimiento para preparar compuestos de amidina Expired ES8607218A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP15504584A JPS6133173A (ja) 1984-07-25 1984-07-25 アミジン化合物

Publications (2)

Publication Number Publication Date
ES545482A0 ES545482A0 (es) 1986-05-16
ES8607218A1 true ES8607218A1 (es) 1986-05-16

Family

ID=15597463

Family Applications (1)

Application Number Title Priority Date Filing Date
ES545482A Expired ES8607218A1 (es) 1984-07-25 1985-07-23 Un procedimiento para preparar compuestos de amidina

Country Status (19)

Country Link
US (2) US4777182A (es)
EP (1) EP0190356B1 (es)
JP (1) JPS6133173A (es)
KR (2) KR870001087B1 (es)
AU (1) AU567039B2 (es)
CA (1) CA1254205A (es)
CS (1) CS255891B2 (es)
DD (1) DD235637A5 (es)
DE (1) DE3582057D1 (es)
DK (1) DK169069B1 (es)
ES (1) ES8607218A1 (es)
FI (1) FI78461C (es)
HU (1) HU195769B (es)
MX (1) MX160912A (es)
NO (1) NO163954C (es)
PH (1) PH20585A (es)
SU (1) SU1456008A3 (es)
WO (1) WO1986000893A1 (es)
ZA (1) ZA855552B (es)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3824236C1 (es) * 1988-07-16 1989-12-28 Heidelberger Druckmaschinen Ag, 6900 Heidelberg, De
CA2032420A1 (en) * 1989-12-22 1991-06-23 Akira Okuyama Guanidinobenzene derivatives
US5238964A (en) * 1990-04-05 1993-08-24 Torii & Co., Ltd. Agent for treatment of cerebrovascular contraction
US5652237A (en) * 1994-09-09 1997-07-29 Warner-Lambert Company 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes
AU686104B2 (en) * 1995-01-05 1998-02-05 Torii Pharmaceutical Co., Ltd. Substituted amidinonaphthyl ester derivatives
KR100254095B1 (ko) * 1995-01-05 2000-07-01 쓰까다 후미끼 혈전용해약
CA2320900C (en) 1998-03-19 2009-10-27 Bristol-Myers Squibb Company Biphasic controlled release delivery system for high solubility pharmaceuticals and method
WO2001077082A1 (fr) * 1999-06-02 2001-10-18 Torii Pharmaceutical Co., Ltd. Derives de naphtalene
AU2000252458A1 (en) * 2000-06-08 2001-12-17 Shizuoka Coffein Co., Ltd. Benzene derivatives
EP2143431A1 (en) 2005-05-17 2010-01-13 Santen Pharmaceutical Co., Ltd. Protective agent for neurocyte comprising amidino derivative as active ingredient
EP1884236B1 (en) * 2005-05-17 2011-03-02 Santen Pharmaceutical Co., Ltd. Angiogenesis inhibitor containing amine derivative as active ingredient
WO2008058167A2 (en) * 2006-11-07 2008-05-15 Case Western Reserve University Method for treating disorders associated with complement activation
KR101942590B1 (ko) 2010-07-09 2019-01-25 비에이치브이 파르마, 인크. 레모글리플로진을 포함하는 짧은 반감기 약제용의 즉시/지연 조합 방출 전달 시스템
JP6252991B2 (ja) * 2012-07-04 2017-12-27 味の素株式会社 ナファモスタットメシル酸塩の製造方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4292429A (en) * 1978-03-08 1981-09-29 Ciba-Geigy Corporation Imidazole urea and amido compounds
JPS57179146A (en) * 1981-04-28 1982-11-04 Torii Yakuhin Kk Amidine compound
AU527371B2 (en) * 1980-09-16 1983-03-03 Torii & Co., Ltd. Amidine
JPS60130561A (ja) * 1983-12-16 1985-07-12 Torii Yakuhin Kk アミジン誘導体およびそれを含む強心剤

Also Published As

Publication number Publication date
AU567039B2 (en) 1987-11-05
US4820730A (en) 1989-04-11
EP0190356A1 (en) 1986-08-13
AU4549285A (en) 1986-02-25
DK96286A (da) 1986-03-03
KR870001087B1 (ko) 1987-06-04
KR860700250A (ko) 1986-08-01
JPS6133173A (ja) 1986-02-17
ZA855552B (en) 1986-03-26
NO860865L (no) 1986-04-10
DK169069B1 (da) 1994-08-08
DK96286D0 (da) 1986-03-03
CA1254205A (en) 1989-05-16
FI860904A (fi) 1986-03-04
NO163954B (no) 1990-05-07
US4777182A (en) 1988-10-11
HU195769B (en) 1988-07-28
FI78461B (fi) 1989-04-28
NO163954C (no) 1990-08-15
HUT42433A (en) 1987-07-28
CS546385A2 (en) 1987-07-16
EP0190356B1 (en) 1991-03-06
SU1456008A3 (ru) 1989-01-30
PH20585A (en) 1987-02-20
DE3582057D1 (en) 1991-04-11
WO1986000893A1 (en) 1986-02-13
ES545482A0 (es) 1986-05-16
CS255891B2 (en) 1988-03-15
DD235637A5 (de) 1986-05-14
JPH0461868B2 (es) 1992-10-02
EP0190356A4 (en) 1987-12-09
MX160912A (es) 1990-06-14
FI860904A0 (fi) 1986-03-04
FI78461C (fi) 1989-08-10

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