DK96286A - 6-amidino-2-naphthyl-4-amino-benzoat-derivater og farmaceutisk acceptable syreadditionssalte deraf - Google Patents
6-amidino-2-naphthyl-4-amino-benzoat-derivater og farmaceutisk acceptable syreadditionssalte deraf Download PDFInfo
- Publication number
- DK96286A DK96286A DK96286A DK96286A DK96286A DK 96286 A DK96286 A DK 96286A DK 96286 A DK96286 A DK 96286A DK 96286 A DK96286 A DK 96286A DK 96286 A DK96286 A DK 96286A
- Authority
- DK
- Denmark
- Prior art keywords
- carbon atoms
- straight
- chain
- acid addition
- addition salts
- Prior art date
Links
- 239000002253 acid Substances 0.000 title abstract 2
- 150000003839 salts Chemical class 0.000 title abstract 2
- UETMUSOZOUFSDX-UHFFFAOYSA-N 4-amino-2-(6-carbamimidoylnaphthalen-2-yl)benzoic acid Chemical class C1=CC2=C(C=CC(=C2)C(=N)N)C=C1C3=C(C=CC(=C3)N)C(=O)O UETMUSOZOUFSDX-UHFFFAOYSA-N 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 4
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 101710081722 Antitrypsin Proteins 0.000 abstract 1
- -1 amidine compounds Chemical class 0.000 abstract 1
- 230000002391 anti-complement effect Effects 0.000 abstract 1
- 230000000288 anti-kallikrein effect Effects 0.000 abstract 1
- 230000001475 anti-trypsic effect Effects 0.000 abstract 1
- 108010008730 anticomplement Proteins 0.000 abstract 1
- 239000004019 antithrombin Substances 0.000 abstract 1
- 239000003795 chemical substances by application Substances 0.000 abstract 1
- 229940012957 plasmin Drugs 0.000 abstract 1
- 125000001424 substituent group Chemical group 0.000 abstract 1
- 239000002753 trypsin inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C277/00—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C277/08—Preparation of guanidine or its derivatives, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups of substituted guanidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C279/00—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups
- C07C279/18—Derivatives of guanidine, i.e. compounds containing the group, the singly-bound nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of guanidine groups bound to carbon atoms of six-membered aromatic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/04—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
- C07D233/28—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/44—Nitrogen atoms not forming part of a nitro radical
- C07D233/50—Nitrogen atoms not forming part of a nitro radical with carbocyclic radicals directly attached to said nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
- C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
- C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
- C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
- C07D235/30—Nitrogen atoms not forming part of a nitro radical
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP15504584 | 1984-07-25 | ||
| JP15504584A JPS6133173A (ja) | 1984-07-25 | 1984-07-25 | アミジン化合物 |
| PCT/JP1985/000392 WO1986000893A1 (fr) | 1984-07-25 | 1985-07-12 | Nouveaux composes d'amidine |
| JP8500392 | 1985-07-12 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| DK96286D0 DK96286D0 (da) | 1986-03-03 |
| DK96286A true DK96286A (da) | 1986-03-03 |
| DK169069B1 DK169069B1 (da) | 1994-08-08 |
Family
ID=15597463
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK096286A DK169069B1 (da) | 1984-07-25 | 1986-03-03 | 6-Amidino-2-naphthyl-4-amino-benzoat-derivater og farmaceutisk acceptable syreadditionssalte deraf |
Country Status (19)
| Country | Link |
|---|---|
| US (2) | US4777182A (da) |
| EP (1) | EP0190356B1 (da) |
| JP (1) | JPS6133173A (da) |
| KR (2) | KR870001087B1 (da) |
| AU (1) | AU567039B2 (da) |
| CA (1) | CA1254205A (da) |
| CS (1) | CS255891B2 (da) |
| DD (1) | DD235637A5 (da) |
| DE (1) | DE3582057D1 (da) |
| DK (1) | DK169069B1 (da) |
| ES (1) | ES8607218A1 (da) |
| FI (1) | FI78461C (da) |
| HU (1) | HU195769B (da) |
| MX (1) | MX160912A (da) |
| NO (1) | NO163954C (da) |
| PH (1) | PH20585A (da) |
| SU (1) | SU1456008A3 (da) |
| WO (1) | WO1986000893A1 (da) |
| ZA (1) | ZA855552B (da) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3824236C1 (da) * | 1988-07-16 | 1989-12-28 | Heidelberger Druckmaschinen Ag, 6900 Heidelberg, De | |
| CA2032420A1 (en) * | 1989-12-22 | 1991-06-23 | Akira Okuyama | Guanidinobenzene derivatives |
| US5238964A (en) * | 1990-04-05 | 1993-08-24 | Torii & Co., Ltd. | Agent for treatment of cerebrovascular contraction |
| US5652237A (en) * | 1994-09-09 | 1997-07-29 | Warner-Lambert Company | 2-substituted-4H-3, 1-benzoxazin-4-ones and benzthiazin-4-ones as inhibitors of complement C1r protease for the treatment of inflammatory processes |
| AU707215B2 (en) * | 1995-01-05 | 1999-07-08 | Torii Pharmaceutical Co., Ltd. | Thrombolytic agents |
| ATE222583T1 (de) * | 1995-01-05 | 2002-09-15 | Torii Pharmaceutical Co Ltd | Derivate substituierter amidinonaphthylester |
| EP1063973B1 (en) | 1998-03-19 | 2016-11-16 | Bristol-Myers Squibb Company | Biphasic controlled release delivery system for high solubility pharmaceuticals and method |
| WO2001077082A1 (en) * | 1999-06-02 | 2001-10-18 | Torii Pharmaceutical Co., Ltd. | Naphthalene derivatives |
| WO2001094299A1 (en) * | 2000-06-08 | 2001-12-13 | Shizuoka Coffein Co., Ltd. | Benzene derivatives |
| EP1884237B1 (en) | 2005-05-17 | 2010-12-08 | Santen Pharmaceutical Co., Ltd. | Amidino derivatives for use in the prevention or treatment of glaucoma |
| EP2119439A3 (en) * | 2005-05-17 | 2010-01-27 | Santen Pharmaceutical Co., Ltd. | Angiogenesis inhibitor for treating macular degeneration |
| WO2008058167A2 (en) * | 2006-11-07 | 2008-05-15 | Case Western Reserve University | Method for treating disorders associated with complement activation |
| CN107080846A (zh) | 2010-07-09 | 2017-08-22 | 詹姆斯.特林卡.格林 | 用于包括瑞格列净的短半衰期药物的组合立即/延迟释放递送系统 |
| JP6252991B2 (ja) * | 2012-07-04 | 2017-12-27 | 味の素株式会社 | ナファモスタットメシル酸塩の製造方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4292429A (en) * | 1978-03-08 | 1981-09-29 | Ciba-Geigy Corporation | Imidazole urea and amido compounds |
| AU527371B2 (en) * | 1980-09-16 | 1983-03-03 | Torii & Co., Ltd. | Amidine |
| JPS57179146A (en) * | 1981-04-28 | 1982-11-04 | Torii Yakuhin Kk | Amidine compound |
| JPS60130561A (ja) * | 1983-12-16 | 1985-07-12 | Torii Yakuhin Kk | アミジン誘導体およびそれを含む強心剤 |
-
1984
- 1984-07-25 JP JP15504584A patent/JPS6133173A/ja active Granted
-
1985
- 1985-07-12 DE DE8585903394T patent/DE3582057D1/de not_active Expired - Fee Related
- 1985-07-12 HU HU853727A patent/HU195769B/hu not_active IP Right Cessation
- 1985-07-12 KR KR1019860700140A patent/KR870001087B1/ko not_active Expired
- 1985-07-12 WO PCT/JP1985/000392 patent/WO1986000893A1/ja not_active Ceased
- 1985-07-12 US US06/835,853 patent/US4777182A/en not_active Expired - Fee Related
- 1985-07-12 CA CA000486773A patent/CA1254205A/en not_active Expired
- 1985-07-12 EP EP85903394A patent/EP0190356B1/en not_active Expired - Lifetime
- 1985-07-12 AU AU45492/85A patent/AU567039B2/en not_active Ceased
- 1985-07-23 ZA ZA855552A patent/ZA855552B/xx unknown
- 1985-07-23 DD DD85278877A patent/DD235637A5/de not_active IP Right Cessation
- 1985-07-23 ES ES545482A patent/ES8607218A1/es not_active Expired
- 1985-07-23 PH PH32559A patent/PH20585A/en unknown
- 1985-07-24 MX MX206081A patent/MX160912A/es unknown
- 1985-07-24 CS CS855463A patent/CS255891B2/cs not_active IP Right Cessation
-
1986
- 1986-03-03 DK DK096286A patent/DK169069B1/da not_active IP Right Cessation
- 1986-03-04 FI FI860904A patent/FI78461C/fi not_active IP Right Cessation
- 1986-03-07 NO NO86860865A patent/NO163954C/no not_active IP Right Cessation
- 1986-03-10 KR KR1019860700140A patent/KR860700250A/ko active Granted
- 1986-03-24 SU SU864027333A patent/SU1456008A3/ru active
-
1988
- 1988-07-11 US US07/217,405 patent/US4820730A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| KR860700250A (ko) | 1986-08-01 |
| AU567039B2 (en) | 1987-11-05 |
| WO1986000893A1 (fr) | 1986-02-13 |
| DD235637A5 (de) | 1986-05-14 |
| EP0190356A4 (en) | 1987-12-09 |
| ES545482A0 (es) | 1986-05-16 |
| JPS6133173A (ja) | 1986-02-17 |
| ZA855552B (en) | 1986-03-26 |
| DK169069B1 (da) | 1994-08-08 |
| CS546385A2 (en) | 1987-07-16 |
| US4777182A (en) | 1988-10-11 |
| KR870001087B1 (ko) | 1987-06-04 |
| AU4549285A (en) | 1986-02-25 |
| FI78461B (fi) | 1989-04-28 |
| HUT42433A (en) | 1987-07-28 |
| FI78461C (fi) | 1989-08-10 |
| EP0190356B1 (en) | 1991-03-06 |
| DE3582057D1 (en) | 1991-04-11 |
| SU1456008A3 (ru) | 1989-01-30 |
| HU195769B (en) | 1988-07-28 |
| NO860865L (no) | 1986-04-10 |
| CS255891B2 (en) | 1988-03-15 |
| US4820730A (en) | 1989-04-11 |
| FI860904A7 (fi) | 1986-03-04 |
| MX160912A (es) | 1990-06-14 |
| NO163954C (no) | 1990-08-15 |
| JPH0461868B2 (da) | 1992-10-02 |
| ES8607218A1 (es) | 1986-05-16 |
| CA1254205A (en) | 1989-05-16 |
| PH20585A (en) | 1987-02-20 |
| FI860904A0 (fi) | 1986-03-04 |
| DK96286D0 (da) | 1986-03-03 |
| NO163954B (no) | 1990-05-07 |
| EP0190356A1 (en) | 1986-08-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| B1 | Patent granted (law 1993) | ||
| PBP | Patent lapsed |