ES8307760A1 - Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina. - Google Patents

Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina.

Info

Publication number
ES8307760A1
ES8307760A1 ES512880A ES512880A ES8307760A1 ES 8307760 A1 ES8307760 A1 ES 8307760A1 ES 512880 A ES512880 A ES 512880A ES 512880 A ES512880 A ES 512880A ES 8307760 A1 ES8307760 A1 ES 8307760A1
Authority
ES
Spain
Prior art keywords
group
alkyl group
together represent
preparing
different
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES512880A
Other languages
English (en)
Other versions
ES512880A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Sankyo Co Ltd
Ube Corp
Original Assignee
Sankyo Co Ltd
Ube Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sankyo Co Ltd, Ube Industries Ltd filed Critical Sankyo Co Ltd
Publication of ES8307760A1 publication Critical patent/ES8307760A1/es
Publication of ES512880A0 publication Critical patent/ES512880A0/es
Granted legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/26—Psychostimulants, e.g. nicotine, cocaine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems

Abstract

PROCEDIMIENTO PARA LA OBTENCION DE DERIVADOS DE 4-ANILINOPIRIMIDINA Y DE SUS SALES FISIOLOGICAMENTE COMPATIBLES, DE FORMULA (I), EN LA QUE R>3 ES HIDROGENO O ALQUILO C<1<-<6; R>1, R>2 Y R>4 PUEDEN SER VARIOS RADICALES, Y N VALE 0, 1 O 2. CONSISTE EN LA REACCION DE UN COMPUESTO DERIVADO DE HALOPIRIMIDINA, DE FORMULA (II), CON UN COMPUESTO DE ANILINA, DE FORMULA (III), EN LAS QUE X ES UN HALOGENO Y LOS DEMAS SIMBOLOS TIENEN EL MISMO SIGNIFICADO QUE EN LA FORMULA (I). LA REACCION SE LLEVA A CABO EN AUSENCIA DE DISOLVENTE A UNA TEMPERATURA ENTRE 100 C Y 200 C, O EN UN DISOLVENTE INERTE, A LA TEMPERATURA DE REFLUJO DE LA MISMA. ESTOS COMPUESTOS TIENEN APLICACIONES FARMACOLOGICAS POR SU ACTIVIDAD ANTIDEPRESIVA.
ES512880A 1981-06-05 1982-06-04 Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina. Granted ES512880A0 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP56086555A JPS57203072A (en) 1981-06-05 1981-06-05 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient

Publications (2)

Publication Number Publication Date
ES8307760A1 true ES8307760A1 (es) 1983-08-01
ES512880A0 ES512880A0 (es) 1983-08-01

Family

ID=13890246

Family Applications (1)

Application Number Title Priority Date Filing Date
ES512880A Granted ES512880A0 (es) 1981-06-05 1982-06-04 Un procedimiento para la preparacion de derivados de 4-anilino-pirimidina.

Country Status (10)

Country Link
US (1) US4450162A (es)
EP (1) EP0067630B1 (es)
JP (1) JPS57203072A (es)
KR (1) KR880002234B1 (es)
CA (1) CA1169861A (es)
DE (1) DE3263653D1 (es)
ES (1) ES512880A0 (es)
FI (1) FI77454C (es)
PH (1) PH20130A (es)
ZA (1) ZA823917B (es)

Families Citing this family (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK130584A (da) * 1983-04-08 1984-10-09 Ciba Geigy Ag N-(2-nitrophenyl)-4-amino-pyrimidin-derivater samt deres fremstilling og anvendelse som mikrobicider
PH21918A (en) * 1983-07-25 1988-04-08 Ciba Geigy Ag N-(2-nitrophenyl)-5-aminopyrimidine derivatives,the preparation and use thereof
GR80171B (en) * 1983-08-29 1985-01-02 Ciba Geigy Ag N-(2-nitrophenyl)-4-aminopyrimidine derivatives process for the preparation thereof and use
US4725600A (en) * 1984-07-13 1988-02-16 Fujisawa Pharmaceutical Co., Ltd. Pyrimidine compounds having activity as a cardiotonic anti-hypertensive cerebrovascular vasodilator and anti-platelet aggregation agent
JPS6270A (ja) * 1985-03-07 1987-01-06 Sankyo Co Ltd シクロペンタ〔ｄ〕ピリミジン誘導体
DE3618353A1 (de) * 1986-05-31 1987-12-03 Hoechst Ag Schaedlingsbekaempfungsmittel auf der basis von aminopyrimidin-derivaten sowie neue aminopyrimidin-verbindungen
US5037980A (en) * 1988-04-18 1991-08-06 American Cyanamid Company Phenyl imidazo[1,2-a]pyrimidines
GR900100380A (el) * 1989-05-20 1991-10-10 Fisons Plc Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
US5234936A (en) * 1991-10-24 1993-08-10 American Home Products Corporation Pyrimidocycloalkanes as a ii antagonists
CA2146333A1 (en) * 1992-10-05 1994-04-14 Tomio Kimura Pyrimidine compound
DE69943247D1 (de) * 1998-03-27 2011-04-14 Janssen Pharmaceutica Nv HIV hemmende Pyrimidin Derivate
WO1999050250A1 (en) * 1998-03-27 1999-10-07 Janssen Pharmaceutica N.V. Hiv inhibiting pyrimidine derivatives
EA005423B1 (ru) * 1999-09-24 2005-02-24 Янссен Фармацевтика Н.В. Противовирусные композиции
ATE374190T1 (de) * 2003-08-12 2007-10-15 Hoffmann La Roche Tetrahydrochinazolinderivate als cfr-antagonisten
EP1812424A4 (en) 2004-11-17 2009-07-08 Miikana Therapeutics Inc Kinase Inhibitors
WO2007041358A2 (en) * 2005-09-30 2007-04-12 Miikana Therapeutics, Inc. Substituted pyrazole compounds
US20090029992A1 (en) * 2007-06-11 2009-01-29 Agoston Gregory E Substituted pyrazole compounds
US8946239B2 (en) 2008-07-10 2015-02-03 Duquesne University Of The Holy Spirit Substituted pyrrolo, -furano, and cyclopentylpyrimidines having antimitotic and/or antitumor activity and methods of use thereof
WO2015160489A2 (en) 2014-04-03 2015-10-22 Duquesne University Of The Holy Spirit Substituted cyclopenta pyrimidine bicyclic compounds having antimitotic and/or antitumor activity and methods of use thereof
GB2578974B (en) * 2015-04-17 2020-08-19 Univ Holy Ghost Duquesne Cyclopenta[d]pyrimidines as antitubulin and antitumor agents

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2719846A (en) * 1954-05-06 1955-10-04 Searle & Co 4[n-(beta-diethylaminoethyl) anilino]-pyrimidine and acid addition salts thereof
US3321478A (en) * 1963-09-20 1967-05-23 American Cyanamid Co Aminoethoxyphenyl amine, ether, and sulfide derivatives of pyrimidine
FR2190818B1 (es) * 1972-06-28 1975-03-07 Roussel Uclaf
CH593266A5 (es) * 1973-09-20 1977-11-30 Delalande Sa
DE2626495A1 (de) * 1976-06-12 1977-12-29 Bayer Ag Quartaere reaktivverbindungen

Also Published As

Publication number Publication date
KR880002234B1 (ko) 1988-10-20
CA1169861A (en) 1984-06-26
EP0067630B1 (en) 1985-05-08
PH20130A (en) 1986-10-02
US4450162A (en) 1984-05-22
KR840000508A (ko) 1984-02-22
JPS57203072A (en) 1982-12-13
FI77454B (fi) 1988-11-30
ES512880A0 (es) 1983-08-01
FI821990A0 (fi) 1982-06-04
EP0067630A1 (en) 1982-12-22
FI77454C (fi) 1989-03-10
ZA823917B (en) 1983-04-27
JPH0440347B2 (es) 1992-07-02
DE3263653D1 (en) 1985-06-13

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Legal Events

Date Code Title Description
FD1A Patent lapsed

Effective date: 19971001