ATE374190T1 - Tetrahydrochinazolinderivate als cfr-antagonisten - Google Patents
Tetrahydrochinazolinderivate als cfr-antagonistenInfo
- Publication number
- ATE374190T1 ATE374190T1 AT04763724T AT04763724T ATE374190T1 AT E374190 T1 ATE374190 T1 AT E374190T1 AT 04763724 T AT04763724 T AT 04763724T AT 04763724 T AT04763724 T AT 04763724T AT E374190 T1 ATE374190 T1 AT E374190T1
- Authority
- AT
- Austria
- Prior art keywords
- sup
- cfr
- antagonists
- tetrahydroquinazoline
- derivatives
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
- C07D239/72—Quinazolines; Hydrogenated quinazolines
- C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
- C07D239/94—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US49451103P | 2003-08-12 | 2003-08-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE374190T1 true ATE374190T1 (de) | 2007-10-15 |
Family
ID=34135343
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04763724T ATE374190T1 (de) | 2003-08-12 | 2004-08-03 | Tetrahydrochinazolinderivate als cfr-antagonisten |
Country Status (9)
Country | Link |
---|---|
US (1) | US7223767B2 (de) |
EP (1) | EP1656354B1 (de) |
JP (1) | JP2007501821A (de) |
CN (1) | CN100398524C (de) |
AT (1) | ATE374190T1 (de) |
CA (1) | CA2534785A1 (de) |
DE (1) | DE602004009200T2 (de) |
ES (1) | ES2293317T3 (de) |
WO (1) | WO2005014557A1 (de) |
Families Citing this family (24)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB0525068D0 (en) | 2005-12-08 | 2006-01-18 | Novartis Ag | Organic compounds |
US8063050B2 (en) | 2006-07-06 | 2011-11-22 | Array Biopharma Inc. | Hydroxylated and methoxylated pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
WO2008006039A1 (en) | 2006-07-06 | 2008-01-10 | Array Biopharma Inc. | Dihydrothieno pyrimidines as akt protein kinase inhibitors |
MY147628A (en) * | 2006-07-06 | 2012-12-31 | Array Biopharma Inc | Cyclopenta [d] pyrimidines as akt protein kinase inhibitors |
DE602007011628D1 (de) | 2006-07-06 | 2011-02-10 | Array Biopharma Inc | Dihydrofuropyrimidine als akt-proteinkinaseinhibitoren |
US8846683B2 (en) | 2007-07-05 | 2014-09-30 | Array Biopharma, Inc. | Pyrimidyl cyclopentanes as Akt protein kinase inhibitors |
CN103396409B (zh) | 2007-07-05 | 2015-03-11 | 阵列生物制药公司 | 作为akt蛋白激酶抑制剂的嘧啶基环戊烷 |
US9409886B2 (en) | 2007-07-05 | 2016-08-09 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as AKT protein kinase inhibitors |
CA2692506C (en) * | 2007-07-05 | 2015-11-24 | Array Biopharma Inc. | Pyrimidyl cyclopentanes as akt protein kinase inhibitors |
CA2711699A1 (en) * | 2008-01-09 | 2009-07-16 | Array Biopharma Inc. | Hydroxylated pyrimidyl cyclopentanes as akt protein kinase inhibitors |
EP2240455B1 (de) * | 2008-01-09 | 2012-12-26 | Array Biopharma, Inc. | Hydroxylierte pyrimidyl-cyclopentane als akt-proteinkinasehemmer |
AU2008363295B2 (en) * | 2008-10-20 | 2015-05-07 | Forschungsverbund Berlin E.V. | Low molecular weight thyroid stimulating hormone receptor (TSHR) agonists |
US8349852B2 (en) | 2009-01-13 | 2013-01-08 | Novartis Ag | Quinazolinone derivatives useful as vanilloid antagonists |
WO2011092293A2 (en) | 2010-02-01 | 2011-08-04 | Novartis Ag | Cyclohexyl amide derivatives as crf receptor antagonists |
JP2013518085A (ja) | 2010-02-01 | 2013-05-20 | ノバルティス アーゲー | CRF−1受容体アンタゴニストとしてのピラゾロ[5,1b]オキサゾール誘導体 |
JP5748777B2 (ja) | 2010-02-02 | 2015-07-15 | ノバルティス アーゲー | Crf受容体アンタゴニストとしてのシクロヘキシルアミド誘導体 |
JP5965387B2 (ja) | 2010-04-08 | 2016-08-03 | アメリカ合衆国 | Tsh受容体用のインバースアゴニストおよびニュートラルアンタゴニスト |
SG194048A1 (en) | 2011-04-01 | 2013-11-29 | Genentech Inc | Combinations of akt inhibitor compounds and chemotherapeutic agents, and methods of use |
CN103841976A (zh) | 2011-04-01 | 2014-06-04 | 基因泰克公司 | Akt和mek抑制剂化合物的组合及其使用方法 |
US8546416B2 (en) | 2011-05-27 | 2013-10-01 | Novartis Ag | 3-spirocyclic piperidine derivatives as ghrelin receptor agonists |
EA201491990A1 (ru) | 2012-05-03 | 2015-02-27 | Новартис Аг | L-малатная соль 2,7-диазаспиро[4.5]дец-7-иловых производных и их кристаллические формы в качестве агонистов грелиновых рецепторов |
KR20150047609A (ko) | 2012-08-30 | 2015-05-04 | 니뽄 신야쿠 가부시키가이샤 | 피리딘 유도체 및 의약 |
CN104262265B (zh) * | 2014-07-21 | 2016-04-13 | 湖南华腾制药有限公司 | 一种四氢喹唑啉衍生物的制备方法 |
CN106083554B (zh) * | 2016-06-12 | 2018-12-07 | 南京工业大学 | 一种一锅法制备2-乙酰基环己酮的方法 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS57203072A (en) * | 1981-06-05 | 1982-12-13 | Sankyo Co Ltd | 4-anilinopyrimidine derivative, its preparation, antidepressant comprising it as active ingredient |
JPS6270A (ja) * | 1985-03-07 | 1987-01-06 | Sankyo Co Ltd | シクロペンタ〔d〕ピリミジン誘導体 |
US5234936A (en) * | 1991-10-24 | 1993-08-10 | American Home Products Corporation | Pyrimidocycloalkanes as a ii antagonists |
TW574214B (en) | 1994-06-08 | 2004-02-01 | Pfizer | Corticotropin releasing factor antagonists |
TW477787B (en) | 1996-08-27 | 2002-03-01 | Pfizer | Pyrido six-membered nitrogen-containing cyclic ring derivatives having corticotropin releasing factor antagonist activity and pharmaceutical composition containing same |
AU7644698A (en) * | 1997-04-22 | 1998-11-13 | Janssen Pharmaceutica N.V. | Crf antagonistic quino- and quinazolines |
NL1010018C2 (nl) * | 1997-09-09 | 1999-03-10 | Duphar Int Res | Chinoline en chinazoline derivaten met corticotropine releasing factor (CRF) antagonistische werking. |
US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
CN1649848A (zh) * | 2001-04-30 | 2005-08-03 | 葛兰素集团有限公司 | 作为促肾上腺皮质激素释放因子(crf)拮抗剂的稠合嘧啶衍生物 |
-
2004
- 2004-08-03 AT AT04763724T patent/ATE374190T1/de not_active IP Right Cessation
- 2004-08-03 JP JP2006522947A patent/JP2007501821A/ja active Pending
- 2004-08-03 EP EP04763724A patent/EP1656354B1/de not_active Not-in-force
- 2004-08-03 CA CA002534785A patent/CA2534785A1/en not_active Abandoned
- 2004-08-03 WO PCT/EP2004/008661 patent/WO2005014557A1/en active IP Right Grant
- 2004-08-03 DE DE602004009200T patent/DE602004009200T2/de active Active
- 2004-08-03 ES ES04763724T patent/ES2293317T3/es active Active
- 2004-08-03 CN CNB2004800229778A patent/CN100398524C/zh not_active Expired - Fee Related
- 2004-08-11 US US10/916,582 patent/US7223767B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20050038052A1 (en) | 2005-02-17 |
DE602004009200D1 (de) | 2007-11-08 |
JP2007501821A (ja) | 2007-02-01 |
CA2534785A1 (en) | 2005-02-17 |
WO2005014557A1 (en) | 2005-02-17 |
EP1656354B1 (de) | 2007-09-26 |
CN1835931A (zh) | 2006-09-20 |
US7223767B2 (en) | 2007-05-29 |
ES2293317T3 (es) | 2008-03-16 |
EP1656354A1 (de) | 2006-05-17 |
DE602004009200T2 (de) | 2008-07-10 |
CN100398524C (zh) | 2008-07-02 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |