ATE419242T1 - Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren - Google Patents
Pyrrolidinylharnstoffderivate als angiogeneseinhibitorenInfo
- Publication number
- ATE419242T1 ATE419242T1 AT04785388T AT04785388T ATE419242T1 AT E419242 T1 ATE419242 T1 AT E419242T1 AT 04785388 T AT04785388 T AT 04785388T AT 04785388 T AT04785388 T AT 04785388T AT E419242 T1 ATE419242 T1 AT E419242T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidinylurea
- derivatives
- angiogenesis inhibitors
- compounds
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US68249703A | 2003-10-09 | 2003-10-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE419242T1 true ATE419242T1 (de) | 2009-01-15 |
Family
ID=34435386
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT04785388T ATE419242T1 (de) | 2003-10-09 | 2004-10-08 | Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren |
Country Status (6)
Country | Link |
---|---|
EP (1) | EP1680415B1 (de) |
AT (1) | ATE419242T1 (de) |
CA (1) | CA2540868A1 (de) |
DE (1) | DE602004018811D1 (de) |
ES (1) | ES2318343T3 (de) |
WO (1) | WO2005035524A1 (de) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7745427B2 (en) | 2004-10-22 | 2010-06-29 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
SG10201913986YA (en) | 2015-10-16 | 2020-03-30 | Abbvie Inc | PROCESSES FOR THE PREPARATION OF (3S,4R)-3-ETHYL-4-(3H-IMIDAZO[1,2-a]PYRROLO[2,3-e]-PYRAZIN-8-YL)-N-(2,2,2-TRIFLUOROETHYL)PYRROLIDINE-1-CARBOXAMIDE AND SOLID STATE FORMS THEREOF |
JOP20190254A1 (ar) | 2017-04-27 | 2019-10-27 | Pharma Mar Sa | مركبات مضادة للأورام |
WO2018228934A1 (en) * | 2017-06-12 | 2018-12-20 | Boehringer Ingelheim International Gmbh | Heteroaromatic compounds as vanin inhibitors |
PE20210478A1 (es) | 2018-08-28 | 2021-03-11 | Boehringer Ingelheim Int | Compuestos heteroaromaticos como inhibidores de vanina |
JP7130873B2 (ja) | 2018-12-03 | 2022-09-05 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | バニン阻害剤としてのヘテロ芳香族化合物 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1999061406A2 (en) * | 1998-05-22 | 1999-12-02 | Abbott Laboratories | Antiangiogenic drug to treat cancer, arthritis and retinopathy |
US20030216396A1 (en) * | 2002-02-11 | 2003-11-20 | Bayer Corporation | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors |
US20030195192A1 (en) * | 2002-04-05 | 2003-10-16 | Fortuna Haviv | Nicotinamides having antiangiogenic activity |
-
2004
- 2004-10-08 WO PCT/US2004/033169 patent/WO2005035524A1/en active Application Filing
- 2004-10-08 DE DE602004018811T patent/DE602004018811D1/de not_active Expired - Fee Related
- 2004-10-08 CA CA002540868A patent/CA2540868A1/en not_active Abandoned
- 2004-10-08 EP EP04785388A patent/EP1680415B1/de not_active Not-in-force
- 2004-10-08 AT AT04785388T patent/ATE419242T1/de not_active IP Right Cessation
- 2004-10-08 ES ES04785388T patent/ES2318343T3/es active Active
Also Published As
Publication number | Publication date |
---|---|
ES2318343T3 (es) | 2009-05-01 |
EP1680415A1 (de) | 2006-07-19 |
CA2540868A1 (en) | 2005-04-21 |
DE602004018811D1 (de) | 2009-02-12 |
WO2005035524A1 (en) | 2005-04-21 |
EP1680415B1 (de) | 2008-12-31 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
ATE433447T1 (de) | Pyrimiidinverbindungen | |
EA200501928A1 (ru) | Пирролодигидроизохинолины как ингибиторы pde10 | |
DE60313472D1 (de) | Pyrrolidindion-substituierte piperidin-phthalazone als pde4-inhibitoren | |
DE60230890D1 (de) | Indolizine als kinaseproteinhemmer | |
NO20044995L (no) | Heterosykliske forbindelser | |
ATE484508T1 (de) | Furylverbindungen | |
NO20061317L (no) | Imidazopyridinderivater som induserbare NO-syntaseinhibatorer | |
NO20043016L (no) | 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav | |
ATE542796T1 (de) | N-sulfonylcarboximidamidverbindungen als apoptosepromotoren | |
NO20044526L (no) | Hemisterlinderivater og anvendelser derav | |
ATE368040T1 (de) | Substituierte tetrazyklische pyprolochinolonderivate als phosphodiesterase- inhibitoren | |
DE60316984D1 (de) | Benzoylsulfonamide als antitumor-mittel | |
SE0103710D0 (sv) | Compounds | |
ATE498600T1 (de) | Inden derivate als pharmazeutika | |
NO20061316L (no) | Imidazopyndinderivater som induserbare NO-syntaseinhibitorer | |
NO20061344L (no) | Imidazopyridinderivater som induserbare NO-syntaseoinhibitorer | |
ATE419242T1 (de) | Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren | |
BR0318521A (pt) | arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados | |
EA200600100A1 (ru) | Производные никотинамида, полезные в качестве ингибиторов pde4 | |
ATE359283T1 (de) | Substituierte pyrazinonverbindungen zur behandlung von entzündungen | |
DE60329326D1 (de) | Tace inhibitoren | |
DE60316128D1 (de) | N-sulfonylurea-apoptosis-förderer | |
EA200600601A1 (ru) | Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы | |
DK1521752T3 (da) | Makrocykliske forbindelser til behandling af cancer | |
DE60328621D1 (de) | Cyclooct-(en-)yl-derivate zur verwendung als duftstoffe |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |