ATE419242T1 - Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren - Google Patents
Pyrrolidinylharnstoffderivate als angiogeneseinhibitorenInfo
- Publication number
- ATE419242T1 ATE419242T1 AT04785388T AT04785388T ATE419242T1 AT E419242 T1 ATE419242 T1 AT E419242T1 AT 04785388 T AT04785388 T AT 04785388T AT 04785388 T AT04785388 T AT 04785388T AT E419242 T1 ATE419242 T1 AT E419242T1
- Authority
- AT
- Austria
- Prior art keywords
- pyrrolidinylurea
- derivatives
- angiogenesis inhibitors
- compounds
- methods
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/08—Bridged systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Detergent Compositions (AREA)
- Fats And Perfumes (AREA)
- Pyrrole Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68249703A | 2003-10-09 | 2003-10-09 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE419242T1 true ATE419242T1 (de) | 2009-01-15 |
Family
ID=34435386
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04785388T ATE419242T1 (de) | 2003-10-09 | 2004-10-08 | Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren |
Country Status (6)
| Country | Link |
|---|---|
| EP (1) | EP1680415B1 (de) |
| AT (1) | ATE419242T1 (de) |
| CA (1) | CA2540868A1 (de) |
| DE (1) | DE602004018811D1 (de) |
| ES (1) | ES2318343T3 (de) |
| WO (1) | WO2005035524A1 (de) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2005299852B2 (en) * | 2004-10-22 | 2011-08-04 | Merck Sharp & Dohme Corp. | CGRP receptor antagonists |
| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| KR20250010141A (ko) | 2015-10-16 | 2025-01-20 | 애브비 인코포레이티드 | (3S,4R)-3-에틸-4-(3H-이미다조[1,2-a]피롤로[2,3-e]-피라진-8-일)-N-(2,2,2-트리플루오로에틸)피롤리딘-1-카복스아미드및 이의 고체상 형태의 제조 방법 |
| US11512092B2 (en) | 2015-10-16 | 2022-11-29 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US12365689B2 (en) | 2015-10-16 | 2025-07-22 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
| US11524964B2 (en) | 2015-10-16 | 2022-12-13 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| TWI807411B (zh) | 2017-04-27 | 2023-07-01 | 西班牙商瑪製藥股份有限公司 | 抗腫瘤化合物 |
| PE20200340A1 (es) * | 2017-06-12 | 2020-02-14 | Boehringer Ingelheim Int | Compuestos heteroaromaticos como inhibidores de vanina |
| JOP20210034A1 (ar) | 2018-08-28 | 2021-02-25 | Boehringer Ingelheim Int | مركبات عطرية غير متجانسة كمثبطات Vanin |
| BR112021007915A2 (pt) | 2018-12-03 | 2021-07-27 | Boehringer Ingelheim International Gmbh | compostos heteroaromáticos utilizados como inibidores de vanina |
| JP7080405B2 (ja) | 2018-12-03 | 2022-06-03 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | バニン阻害剤としての複素芳香族化合物 |
| EA202191478A1 (ru) | 2018-12-03 | 2021-10-26 | Бёрингер Ингельхайм Интернациональ Гмбх | Гетероароматические соединения в качестве ингибиторов ванина |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK1080070T3 (da) * | 1998-05-22 | 2007-02-26 | Abbott Lab | Antiangiogent lægemiddel til behandling af cancer, artritis og retinopati |
| US20030216396A1 (en) * | 2002-02-11 | 2003-11-20 | Bayer Corporation | Pyridine, quinoline, and isoquinoline N-oxides as kinase inhibitors |
| US20030195192A1 (en) * | 2002-04-05 | 2003-10-16 | Fortuna Haviv | Nicotinamides having antiangiogenic activity |
-
2004
- 2004-10-08 DE DE602004018811T patent/DE602004018811D1/de not_active Expired - Fee Related
- 2004-10-08 ES ES04785388T patent/ES2318343T3/es not_active Expired - Lifetime
- 2004-10-08 WO PCT/US2004/033169 patent/WO2005035524A1/en not_active Ceased
- 2004-10-08 CA CA002540868A patent/CA2540868A1/en not_active Abandoned
- 2004-10-08 AT AT04785388T patent/ATE419242T1/de not_active IP Right Cessation
- 2004-10-08 EP EP04785388A patent/EP1680415B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| EP1680415A1 (de) | 2006-07-19 |
| DE602004018811D1 (de) | 2009-02-12 |
| EP1680415B1 (de) | 2008-12-31 |
| WO2005035524A1 (en) | 2005-04-21 |
| ES2318343T3 (es) | 2009-05-01 |
| CA2540868A1 (en) | 2005-04-21 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| ATE360627T1 (de) | Pyrrolidindion-substituierte piperidin- phthalazone als pde4-inhibitoren | |
| ATE433447T1 (de) | Pyrimiidinverbindungen | |
| PL363168A1 (pl) | Cyklopentanole, kompozycje zawierające takie związki i sposoby leczenia | |
| EA200501928A1 (ru) | Пирролодигидроизохинолины как ингибиторы pde10 | |
| DE60230890D1 (de) | Indolizine als kinaseproteinhemmer | |
| NO20044995L (no) | Heterosykliske forbindelser | |
| ATE484508T1 (de) | Furylverbindungen | |
| NO20043016L (no) | 6-aminomorfinan-derivater, fremgangsmate for fremstilling og anvendelse derav | |
| NO20044526L (no) | Hemisterlinderivater og anvendelser derav | |
| ATE419242T1 (de) | Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren | |
| ATE368040T1 (de) | Substituierte tetrazyklische pyprolochinolonderivate als phosphodiesterase- inhibitoren | |
| DE60316984D1 (de) | Benzoylsulfonamide als antitumor-mittel | |
| SE0103710D0 (sv) | Compounds | |
| ATE498600T1 (de) | Inden derivate als pharmazeutika | |
| ATE359283T1 (de) | Substituierte pyrazinonverbindungen zur behandlung von entzündungen | |
| NO20061317L (no) | Imidazopyridinderivater som induserbare NO-syntaseinhibatorer | |
| EA200600100A1 (ru) | Производные никотинамида, полезные в качестве ингибиторов pde4 | |
| ATE443044T1 (de) | Tace inhibitoren | |
| BR0318521A (pt) | arilindenopiridinas e arilindenopirimidinas e métodos terapêuticos e profiláticos relacionados | |
| DE60316128D1 (de) | N-sulfonylurea-apoptosis-förderer | |
| EA200600601A1 (ru) | Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы | |
| ATE542796T1 (de) | N-sulfonylcarboximidamidverbindungen als apoptosepromotoren | |
| NO20061316L (no) | Imidazopyndinderivater som induserbare NO-syntaseinhibitorer | |
| NO20061344L (no) | Imidazopyridinderivater som induserbare NO-syntaseoinhibitorer | |
| DK1521752T3 (da) | Makrocykliske forbindelser til behandling af cancer |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |