ATE359283T1 - Substituierte pyrazinonverbindungen zur behandlung von entzündungen - Google Patents
Substituierte pyrazinonverbindungen zur behandlung von entzündungenInfo
- Publication number
- ATE359283T1 ATE359283T1 AT04769554T AT04769554T ATE359283T1 AT E359283 T1 ATE359283 T1 AT E359283T1 AT 04769554 T AT04769554 T AT 04769554T AT 04769554 T AT04769554 T AT 04769554T AT E359283 T1 ATE359283 T1 AT E359283T1
- Authority
- AT
- Austria
- Prior art keywords
- inflammation
- treatment
- sup
- substituted pyrazinone
- pyrazinone compounds
- Prior art date
Links
- HUTNOYOBQPAKIA-UHFFFAOYSA-N 1h-pyrazin-2-one Chemical class OC1=CN=CC=N1 HUTNOYOBQPAKIA-UHFFFAOYSA-N 0.000 title 1
- 206010061218 Inflammation Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- 229940043355 kinase inhibitor Drugs 0.000 abstract 1
- 239000003757 phosphotransferase inhibitor Substances 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D241/20—Nitrogen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Public Health (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Neurology (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Vascular Medicine (AREA)
- Biomedical Technology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Neurosurgery (AREA)
- Heart & Thoracic Surgery (AREA)
- Dermatology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US51087003P | 2003-10-14 | 2003-10-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE359283T1 true ATE359283T1 (de) | 2007-05-15 |
Family
ID=34435133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT04769554T ATE359283T1 (de) | 2003-10-14 | 2004-10-04 | Substituierte pyrazinonverbindungen zur behandlung von entzündungen |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US20070225291A1 (de) |
| EP (1) | EP1678164B1 (de) |
| JP (1) | JP3962425B2 (de) |
| AT (1) | ATE359283T1 (de) |
| BR (1) | BRPI0415390A (de) |
| CA (1) | CA2541667A1 (de) |
| DE (1) | DE602004005881T2 (de) |
| ES (1) | ES2284054T3 (de) |
| MX (1) | MXPA06003746A (de) |
| WO (1) | WO2005035527A1 (de) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2007514759A (ja) | 2003-12-19 | 2007-06-07 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| TW200616967A (en) | 2004-06-24 | 2006-06-01 | Smithkline Beecham Corp | Novel indazole carboxamides and their use |
| JP2008510734A (ja) | 2004-08-18 | 2008-04-10 | タケダ サン ディエゴ インコーポレイテッド | キナーゼ阻害剤 |
| DE602005023333D1 (de) | 2004-10-15 | 2010-10-14 | Takeda Pharmaceutical | Kinaseinhibitoren |
| US8063071B2 (en) | 2007-10-31 | 2011-11-22 | GlaxoSmithKline, LLC | Chemical compounds |
| UA99699C2 (ru) | 2005-06-30 | 2012-09-25 | Смитклайн Бичам Корпорейшн | Производные индолкарбоксамида и фармацевтическая композиция, которая их содержит |
| US8119655B2 (en) | 2005-10-07 | 2012-02-21 | Takeda Pharmaceutical Company Limited | Kinase inhibitors |
| US20090186907A1 (en) * | 2006-06-21 | 2009-07-23 | E.I. Dupont De Nemours And Company | Pyrazinones As Cellular Proliferation Inhibitors |
| BRPI0719883A2 (pt) | 2006-10-09 | 2015-05-05 | Takeda Pharmaceutical | Inibidores de quinase |
| PE20081889A1 (es) | 2007-03-23 | 2009-03-05 | Smithkline Beecham Corp | Indol carboxamidas como inhibidores de ikk2 |
| BRPI0813244B8 (pt) | 2007-06-27 | 2021-05-25 | Astrazeneca Ab | compostos derivados de pirazinona, composições compreendendo ditos compostos, uso dos compostos no tratamento de doenças de pulmão e composto intermediário |
| PT2300459E (pt) * | 2008-07-02 | 2013-07-04 | Hoffmann La Roche | Novas fenilpirazinonas utilizadas como inibidores de cinase |
| JP2012520257A (ja) | 2009-03-10 | 2012-09-06 | グラクソ グループ リミテッド | Ｉｋｋ２阻害剤としてのインドール誘導体 |
| WO2011146732A1 (en) * | 2010-05-19 | 2011-11-24 | Beth Israel Deaconess Medical Center | Methods for treating inflammatory autoimmune disorders |
| WO2013185284A1 (en) | 2012-06-12 | 2013-12-19 | Abbott Laboratories | Pyridinone and pyridazinone derivatives |
| WO2014145314A2 (en) | 2013-03-15 | 2014-09-18 | Cancer Research Technology, Llc | Methods and compositions for gamma-glutamyl cycle modulation |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5260293A (en) * | 1988-01-30 | 1993-11-09 | Merck Sharp & Dohme Limited | Pyrazines, pyrimidines and pyridazines useful in the treatment of senile dementia |
| GB0003154D0 (en) * | 2000-02-12 | 2000-04-05 | Astrazeneca Uk Ltd | Novel compounds |
| JP2002193938A (ja) * | 2000-12-01 | 2002-07-10 | Bayer Ag | ４−アリールピリジン誘導体 |
| RU2308455C2 (ru) * | 2001-11-07 | 2007-10-20 | Ф.Хоффманн-Ля Рош Аг | Аминопиримидины и пиридины |
-
2004
- 2004-10-04 BR BRPI0415390-1A patent/BRPI0415390A/pt not_active IP Right Cessation
- 2004-10-04 AT AT04769554T patent/ATE359283T1/de not_active IP Right Cessation
- 2004-10-04 JP JP2006534847A patent/JP3962425B2/ja not_active Expired - Fee Related
- 2004-10-04 ES ES04769554T patent/ES2284054T3/es not_active Expired - Lifetime
- 2004-10-04 MX MXPA06003746A patent/MXPA06003746A/es not_active Application Discontinuation
- 2004-10-04 DE DE602004005881T patent/DE602004005881T2/de not_active Expired - Fee Related
- 2004-10-04 CA CA002541667A patent/CA2541667A1/en not_active Abandoned
- 2004-10-04 US US10/583,782 patent/US20070225291A1/en not_active Abandoned
- 2004-10-04 WO PCT/IB2004/003238 patent/WO2005035527A1/en not_active Ceased
- 2004-10-04 EP EP04769554A patent/EP1678164B1/de not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE602004005881T2 (de) | 2008-01-17 |
| CA2541667A1 (en) | 2005-04-21 |
| US20070225291A1 (en) | 2007-09-27 |
| BRPI0415390A (pt) | 2006-12-12 |
| DE602004005881D1 (de) | 2007-05-24 |
| MXPA06003746A (es) | 2006-06-14 |
| JP3962425B2 (ja) | 2007-08-22 |
| EP1678164B1 (de) | 2007-04-11 |
| ES2284054T3 (es) | 2007-11-01 |
| JP2007508366A (ja) | 2007-04-05 |
| WO2005035527A1 (en) | 2005-04-21 |
| EP1678164A1 (de) | 2006-07-12 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |