ATE423772T1 - Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin - Google Patents

Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin

Info

Publication number
ATE423772T1
ATE423772T1 AT04811091T AT04811091T ATE423772T1 AT E423772 T1 ATE423772 T1 AT E423772T1 AT 04811091 T AT04811091 T AT 04811091T AT 04811091 T AT04811091 T AT 04811091T AT E423772 T1 ATE423772 T1 AT E423772T1
Authority
AT
Austria
Prior art keywords
norepinephrine
inhibitors
reupstruction
morpholine derivatives
morpholine
Prior art date
Application number
AT04811091T
Other languages
English (en)
Inventor
Peter Thaddeus Gallagher
Carlos Lilly S A Lamas-Peteira
Francisco Javier Agejas-Chicharro
Original Assignee
Lilly Co Eli
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lilly Co Eli filed Critical Lilly Co Eli
Application granted granted Critical
Publication of ATE423772T1 publication Critical patent/ATE423772T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D265/00—Heterocyclic compounds containing six-membered rings having one nitrogen atom and one oxygen atom as the only ring hetero atoms
    • C07D265/28—1,4-Oxazines; Hydrogenated 1,4-oxazines
    • C07D265/30—1,4-Oxazines; Hydrogenated 1,4-oxazines not condensed with other rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/02—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements
    • C07D295/027—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms containing only hydrogen and carbon atoms in addition to the ring hetero elements containing only one hetero ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
    • C07D295/182—Radicals derived from carboxylic acids
    • C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
AT04811091T 2003-12-23 2004-12-10 Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin ATE423772T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP03380306 2003-12-23
US54751904P 2004-02-25 2004-02-25

Publications (1)

Publication Number Publication Date
ATE423772T1 true ATE423772T1 (de) 2009-03-15

Family

ID=34751683

Family Applications (1)

Application Number Title Priority Date Filing Date
AT04811091T ATE423772T1 (de) 2003-12-23 2004-12-10 Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin

Country Status (5)

Country Link
US (1) US7595315B2 (de)
EP (1) EP1716126B1 (de)
AT (1) ATE423772T1 (de)
DE (1) DE602004019698D1 (de)
WO (1) WO2005066144A1 (de)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0219687D0 (en) * 2002-08-23 2002-10-02 Lilly Co Eli Benzyl morpholine derivatives
MXPA06012505A (es) 2004-04-30 2006-12-15 Warner Lambert Co Compuestos de morfolina sustituida para el tratamiento de trastornos del sistema nervioso central.
US8604031B2 (en) * 2006-05-18 2013-12-10 Mannkind Corporation Intracellular kinase inhibitors
CN102320984B (zh) * 2011-07-25 2014-04-02 江苏恩华药业股份有限公司 (r)-3-(3-甲氧基苯基)-n,n,2-三甲基戊-3-烯-1-胺的制备方法
CN106607066B (zh) * 2015-10-23 2019-10-18 上海浦景化工技术股份有限公司 一种用于加氢制乙醛的催化剂及其制备方法和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1660108A (zh) 1999-07-01 2005-08-31 法玛西雅厄普约翰美国公司 高度选择性去甲肾上腺素再摄取抑制剂及其用途
GB0219687D0 (en) * 2002-08-23 2002-10-02 Lilly Co Eli Benzyl morpholine derivatives
DE60324685D1 (de) * 2002-08-23 2008-12-24 Lilly Co Eli 2-(phenylthiomethyl)- morpholin-derivate zur verwendung als selektive norepinephrin-wiederaufnahme-inhibitoren

Also Published As

Publication number Publication date
US20070060585A1 (en) 2007-03-15
US7595315B2 (en) 2009-09-29
WO2005066144A1 (en) 2005-07-21
EP1716126A1 (de) 2006-11-02
DE602004019698D1 (de) 2009-04-09
EP1716126B1 (de) 2009-02-25

Similar Documents

Publication Publication Date Title
CY1116754T1 (el) Παραγωγα νιτροκατεχολης ως αναστολεις της comt
NO20060402L (no) 3-amino choman og 2-aminotetralinderivater
ATE433447T1 (de) Pyrimiidinverbindungen
DK1474406T3 (da) Disubstituerede thiazolylcarboxanilider samt deres anvendelse som mikrobicider
NO20055208L (no) 4-(2-fenylsulfanyl-fenyl)-piperidinderivater som serotonin-reopptaksinhibitorer
NO20061317L (no) Imidazopyridinderivater som induserbare NO-syntaseinhibatorer
DK1506185T3 (da) Forbindelser og deres anvendelse som 5-HT-inhibitorer
EA201000494A1 (ru) Новые гидрокси-8-гетероарилфенантридины и их применение в качестве ингибиторов pde4
EA201270630A1 (ru) Гетероциклические сетр ингибиторы
EA200801120A1 (ru) Нафтильные производные в качестве ингибиторов агрегирования бета-амилоида
NO20055205L (no) 4-(2-fcnylsulfanyl-fenyl)-1,2,3,6-tydropyridinderivater som serotoniniopptaksinhibitorer
NO20061344L (no) Imidazopyridinderivater som induserbare NO-syntaseoinhibitorer
ATE359283T1 (de) Substituierte pyrazinonverbindungen zur behandlung von entzündungen
WO2004052858A3 (en) Inhibitors of monoamine uptake
DE60317098D1 (de) Carbostyril-derivate mit selektiven serotonin-aufnahme inhibitoren, zur behandlung von gemütskrankheiten
DE602004006118D1 (de) 2,3,4,5-TETRAHYDROBENZOiFöi1,4öOXAZEPIN-5-CARBONSÄUREAMID DERIVATE ALS GAMMA-SECRETASE INHIBITOREN ZUR BEHANDLUNG VON ALZHEIMER
EA200600601A1 (ru) Производные аминопиридина в качестве ингибиторов индуцируемой no-синтазы
UA94054C2 (en) Nitrocatechol derivatives as comt inhibitors
ATE471320T1 (de) 4-aminopiperidinderivate als inhibitoren der monoamin-aufnahme
ATE419242T1 (de) Pyrrolidinylharnstoffderivate als angiogeneseinhibitoren
ATE423772T1 (de) Morpholinderivate als inhibitoren der wiederaufnahme von norepinephrin
PL1978959T3 (pl) Pochodne piperydyny i piperazyny
NO20062700L (no) Morfolinderivater som norepinefrin reopptaksinhibitorer
ATE412633T1 (de) Piperazinderivate von alkyloxindolen
NO20054289D0 (no) Imiciazo[4,5-b]kinolinderivater og dem anvendelse som NO-syntaseinhibitorer

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties