EA200801291A1 - Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ - Google Patents

Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ

Info

Publication number
EA200801291A1
EA200801291A1 EA200801291A EA200801291A EA200801291A1 EA 200801291 A1 EA200801291 A1 EA 200801291A1 EA 200801291 A EA200801291 A EA 200801291A EA 200801291 A EA200801291 A EA 200801291A EA 200801291 A1 EA200801291 A1 EA 200801291A1
Authority
EA
Eurasian Patent Office
Prior art keywords
carbonylaminopyrropyrazoles
efficient
inhibitors
kinaz
compounds
Prior art date
Application number
EA200801291A
Other languages
English (en)
Other versions
EA015513B1 (ru
Inventor
Лиминг Донг
Чангксинг Гуо
Юфенг Хонг
Мэри Кэтрин Джонсон
Сьюзан Элизабет Кепхарт
Хайтао Ли
Индрон Джеймс Макэлпин
Джайяшри Гириш Тике
Энл Йанг
Джунху Жанг
Original Assignee
Пфайзер Продактс Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Продактс Инк. filed Critical Пфайзер Продактс Инк.
Publication of EA200801291A1 publication Critical patent/EA200801291A1/ru
Publication of EA015513B1 publication Critical patent/EA015513B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/415—1,2-Diazoles
    • A61K31/4162—1,2-Diazoles condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/08—Drugs for disorders of the urinary system of the prostate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

Предложены карбониламинопирролопиразольные соединения формулы I, композиции, содержащие эти соединения, и способы их применения. Предпочтительные соединения формулы I обладают активностью в качестве ингибиторов протеинкиназ, в том числе в качестве ингибиторов PAK4.
EA200801291A 2005-12-21 2006-12-12 Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ EA015513B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US75334905P 2005-12-21 2005-12-21
US86493206P 2006-11-08 2006-11-08
PCT/IB2006/003646 WO2007072153A2 (en) 2005-12-21 2006-12-12 Carbonylamino pyrrolopyrazoles, potent kinase inhibitors

Publications (2)

Publication Number Publication Date
EA200801291A1 true EA200801291A1 (ru) 2008-12-30
EA015513B1 EA015513B1 (ru) 2011-08-30

Family

ID=38189022

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801291A EA015513B1 (ru) 2005-12-21 2006-12-12 Карбониламинопирролопиразолы в качестве эффективных ингибиторов киназ

Country Status (27)

Country Link
US (1) US7884117B2 (ru)
EP (1) EP1979356B1 (ru)
JP (1) JP4635089B2 (ru)
KR (1) KR101029167B1 (ru)
AP (1) AP2369A (ru)
AU (1) AU2006327866B2 (ru)
BR (1) BRPI0620354A2 (ru)
CA (1) CA2634381C (ru)
CR (1) CR10094A (ru)
CU (1) CU23751B7 (ru)
DK (1) DK1979356T3 (ru)
EA (1) EA015513B1 (ru)
EC (1) ECSP088558A (ru)
ES (1) ES2435405T3 (ru)
GE (1) GEP20104974B (ru)
HK (1) HK1128290A1 (ru)
HR (1) HRP20130976T1 (ru)
IL (1) IL191776A (ru)
MA (1) MA30076B1 (ru)
ME (1) ME00006B (ru)
MY (1) MY151455A (ru)
NO (1) NO20082482L (ru)
NZ (1) NZ568692A (ru)
PL (1) PL1979356T3 (ru)
PT (1) PT1979356E (ru)
RS (2) RS53029B (ru)
WO (1) WO2007072153A2 (ru)

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KR101881596B1 (ko) 2008-12-02 2018-07-24 웨이브 라이프 사이언시스 재팬 인코포레이티드 인 원자 변형된 핵산의 합성 방법
IN2012DN00720A (ru) 2009-07-06 2015-06-19 Ontorii Inc
US9180127B2 (en) 2009-12-29 2015-11-10 Dana-Farber Cancer Institute, Inc. Type II Raf kinase inhibitors
US10428019B2 (en) * 2010-09-24 2019-10-01 Wave Life Sciences Ltd. Chiral auxiliaries
KR20130121122A (ko) 2010-11-17 2013-11-05 에프. 호프만-라 로슈 아게 종양의 치료 방법
US8771682B2 (en) 2011-04-26 2014-07-08 Technische Universtität Dresden Methods and compositions for reducing interleukin-4 or interleukin-13 signaling
BR112014001244A2 (pt) 2011-07-19 2017-02-21 Wave Life Sciences Pte Ltd métodos para a síntese de ácidos nucléicos funcionalizados
US9382239B2 (en) 2011-11-17 2016-07-05 Dana-Farber Cancer Institute, Inc. Inhibitors of c-Jun-N-terminal kinase (JNK)
BR112014020173A8 (pt) 2012-03-16 2017-07-11 Hoffmann La Roche Métodos para o tratamento de um melanoma, utilizações de um inibidor, composições, conjunto, método de inibição, método de identificação, método de ajuste do tratamento e invenção
EP2873674B1 (en) 2012-07-13 2020-05-06 Shin Nippon Biomedical Laboratories, Ltd. Chiral nucleic acid adjuvant
EP2872147B1 (en) 2012-07-13 2022-12-21 Wave Life Sciences Ltd. Method for making chiral oligonucleotides
BR112015000784A8 (pt) 2012-07-13 2018-04-03 Wave Life Sciences Japan Grupo auxiliar assimétrico
WO2014063068A1 (en) 2012-10-18 2014-04-24 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (cdk7)
US10000483B2 (en) 2012-10-19 2018-06-19 Dana-Farber Cancer Institute, Inc. Bone marrow on X chromosome kinase (BMX) inhibitors and uses thereof
USRE48175E1 (en) 2012-10-19 2020-08-25 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged small molecules as inducers of protein degradation
EP3057955B1 (en) 2013-10-18 2018-04-11 Syros Pharmaceuticals, Inc. Heteroaromatic compounds useful for the treatment of prolferative diseases
US10047070B2 (en) 2013-10-18 2018-08-14 Dana-Farber Cancer Institute, Inc. Polycyclic inhibitors of cyclin-dependent kinase 7 (CDK7)
JPWO2015108048A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
WO2015108047A1 (ja) 2014-01-15 2015-07-23 株式会社新日本科学 免疫誘導活性を有するキラル核酸アジュバンド及び免疫誘導活性剤
JPWO2015108046A1 (ja) 2014-01-15 2017-03-23 株式会社新日本科学 抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
KR20230152178A (ko) 2014-01-16 2023-11-02 웨이브 라이프 사이언시스 리미티드 키랄 디자인
WO2015164614A1 (en) 2014-04-23 2015-10-29 Dana-Farber Cancer Institute, Inc. Janus kinase inhibitors and uses thereof
US9862688B2 (en) 2014-04-23 2018-01-09 Dana-Farber Cancer Institute, Inc. Hydrophobically tagged janus kinase inhibitors and uses thereof
AU2015337607B2 (en) 2014-10-31 2020-04-09 Ube Corporation Substituted dihydropyrrolopyrazole compound
AU2015371251B2 (en) * 2014-12-23 2020-06-11 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 (CDK7)
WO2016160617A2 (en) 2015-03-27 2016-10-06 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
EP3307728A4 (en) 2015-06-12 2019-07-17 Dana Farber Cancer Institute, Inc. ASSOCIATION THERAPY USING TRANSCRIPTION INHIBITORS AND KINASE INHIBITORS
KR102588426B1 (ko) 2015-06-15 2023-10-13 유비이 가부시키가이샤 치환 디히드로피롤로피라졸 유도체
CA2996978A1 (en) 2015-09-09 2017-03-16 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinases
WO2017144546A1 (en) 2016-02-23 2017-08-31 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical compositions for the treatment of nasopharyngeal carcinoma
JPWO2020100944A1 (ja) 2018-11-14 2021-10-07 宇部興産株式会社 ジヒドロピロロピラゾール誘導体
WO2020140098A1 (en) * 2018-12-28 2020-07-02 Dana-Farber Cancer Institute, Inc. Inhibitors of cyclin-dependent kinase 7 and uses thereof
US20220220480A1 (en) 2019-04-17 2022-07-14 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of nlrp3 inflammasome mediated il-1beta dependent disorders
WO2021198511A1 (en) 2020-04-03 2021-10-07 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and compositions for treatment of sars-cov-2 infection
WO2022008597A1 (en) 2020-07-08 2022-01-13 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods and pharmaceutical composition for the treatment of infectious diseases

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PL213199B1 (pl) * 2000-08-10 2013-01-31 Pharmacia Italia Spa Zwiazek bicyklo-pirazolowy, sposób wytwarzania go, jego kompozycja farmaceutyczna, oraz kombinatoryczna biblioteka chemiczna
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UA81790C2 (ru) * 2002-12-19 2008-02-11 Фармация Италия С.П.А. Замещенные пиролопиразольные производные как ингибиторы киназы
AU2004276341B2 (en) * 2003-09-23 2011-04-14 Vertex Pharmaceuticals Incorporated Pyrazolopyrrole derivatives as protein kinase inhibitors
JP4250195B2 (ja) 2005-01-10 2009-04-08 ファイザー・インク ピロロピラゾール類、強力なキナーゼ阻害剤

Also Published As

Publication number Publication date
WO2007072153A8 (en) 2008-08-14
RS53029B (en) 2014-04-30
CU23751B7 (es) 2012-01-31
JP4635089B2 (ja) 2011-02-16
AP2369A (en) 2012-02-29
MY151455A (en) 2014-05-30
ECSP088558A (es) 2008-07-30
PL1979356T3 (pl) 2014-01-31
JP2009520805A (ja) 2009-05-28
ES2435405T3 (es) 2013-12-19
NZ568692A (en) 2011-07-29
US20090318440A1 (en) 2009-12-24
MA30076B1 (fr) 2008-12-01
KR101029167B1 (ko) 2011-04-12
BRPI0620354A2 (pt) 2011-11-08
US7884117B2 (en) 2011-02-08
EP1979356B1 (en) 2013-09-18
CU20080115A7 (es) 2010-08-30
CA2634381A1 (en) 2007-06-28
WO2007072153A2 (en) 2007-06-28
WO2007072153A3 (en) 2007-10-25
AU2006327866A1 (en) 2007-06-28
MEP0808A (xx) 2010-02-10
HRP20130976T1 (hr) 2013-11-22
PT1979356E (pt) 2013-11-21
HK1128290A1 (en) 2009-10-23
CA2634381C (en) 2011-03-08
IL191776A (en) 2013-03-24
NO20082482L (no) 2008-07-02
DK1979356T3 (da) 2013-11-18
AP2008004506A0 (en) 2008-06-30
CR10094A (es) 2008-08-01
EP1979356A2 (en) 2008-10-15
IL191776A0 (en) 2008-12-29
GEP20104974B (en) 2010-04-26
AU2006327866B2 (en) 2012-06-14
RS20080281A (en) 2009-09-08
ME00006B (me) 2010-02-10
KR20080080567A (ko) 2008-09-04
EA015513B1 (ru) 2011-08-30

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU