EA200700185A1 - Производные хиназолиндиона в качестве ингибиторов parp - Google Patents

Производные хиназолиндиона в качестве ингибиторов parp

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Publication number
EA200700185A1
EA200700185A1 EA200700185A EA200700185A EA200700185A1 EA 200700185 A1 EA200700185 A1 EA 200700185A1 EA 200700185 A EA200700185 A EA 200700185A EA 200700185 A EA200700185 A EA 200700185A EA 200700185 A1 EA200700185 A1 EA 200700185A1
Authority
EA
Eurasian Patent Office
Prior art keywords
hinazolindion
derivatives
parp inhibitors
formula
compounds
Prior art date
Application number
EA200700185A
Other languages
English (en)
Other versions
EA011552B1 (ru
Inventor
Людо Эдмон Жозефин Кенни
Йозефус Каролус Мертенс
Якобус Альфонсус Йозефус Ван Дюн
Мария Викторина Франциска Сомерс
Вальтер Баудевейн Леопольд Ваутерс
Original Assignee
Янссен Фармацевтика Н.В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н.В. filed Critical Янссен Фармацевтика Н.В.
Publication of EA200700185A1 publication Critical patent/EA200700185A1/ru
Publication of EA011552B1 publication Critical patent/EA011552B1/ru

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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

В настоящем изобретении предлагаются соединения формулы (I), их применение в качестве ингибиторов PARP, а также фармацевтические композиции, содержащие указанные соединения формулы (I), где R, L, L, X, Y и Z имеют указанные значения.
EA200700185A 2004-06-30 2005-06-28 Производные хиназолиндиона в качестве ингибиторов parp EA011552B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP04076885 2004-06-30
PCT/EP2005/053031 WO2006003148A1 (en) 2004-06-30 2005-06-28 Quinazolinedione derivatives as parp inhibitors

Publications (2)

Publication Number Publication Date
EA200700185A1 true EA200700185A1 (ru) 2007-06-29
EA011552B1 EA011552B1 (ru) 2009-04-28

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EA200700185A EA011552B1 (ru) 2004-06-30 2005-06-28 Производные хиназолиндиона в качестве ингибиторов parp

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US (4) US8080557B2 (ru)
EP (1) EP1763523B1 (ru)
JP (1) JP5100376B2 (ru)
CN (1) CN1980913B (ru)
AR (1) AR049540A1 (ru)
AU (1) AU2005259190B2 (ru)
BR (1) BRPI0512938A (ru)
CA (1) CA2569827C (ru)
EA (1) EA011552B1 (ru)
EG (1) EG25942A (ru)
ES (1) ES2415771T3 (ru)
HK (1) HK1105957A1 (ru)
IL (1) IL180409A0 (ru)
MX (1) MXPA06014541A (ru)
NO (2) NO20070529L (ru)
NZ (1) NZ551801A (ru)
SG (1) SG154432A1 (ru)
TW (1) TWI359142B (ru)
UA (1) UA88012C2 (ru)
WO (1) WO2006003148A1 (ru)
ZA (1) ZA200610771B (ru)

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US20080039480A1 (en) 2008-02-14
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