EA200801145A1 - Спироциклические производные хиназолина в качестве ингибиторов pde7 - Google Patents

Спироциклические производные хиназолина в качестве ингибиторов pde7

Info

Publication number
EA200801145A1
EA200801145A1 EA200801145A EA200801145A EA200801145A1 EA 200801145 A1 EA200801145 A1 EA 200801145A1 EA 200801145 A EA200801145 A EA 200801145A EA 200801145 A EA200801145 A EA 200801145A EA 200801145 A1 EA200801145 A1 EA 200801145A1
Authority
EA
Eurasian Patent Office
Prior art keywords
spyrocyclic
hinazolin
derivatives
pde7 inhibitors
pde7
Prior art date
Application number
EA200801145A
Other languages
English (en)
Inventor
Дэвид Джеймс Роусон
Найджел Элан Суэйн
Original Assignee
Пфайзер Лимитед
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Пфайзер Лимитед filed Critical Пфайзер Лимитед
Publication of EA200801145A1 publication Critical patent/EA200801145A1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/78—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 2
    • C07D239/80—Oxygen atoms

Abstract

В данном изобретении предложены соединения формулы (I)
EA200801145A 2005-12-02 2006-11-23 Спироциклические производные хиназолина в качестве ингибиторов pde7 EA200801145A1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US74185405P 2005-12-02 2005-12-02
US79118606P 2006-04-10 2006-04-10
PCT/IB2006/003388 WO2007063391A2 (en) 2005-12-02 2006-11-23 Spirocyclic quinazoline derivatives as pde7 inhibitors

Publications (1)

Publication Number Publication Date
EA200801145A1 true EA200801145A1 (ru) 2008-10-30

Family

ID=37882213

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200801145A EA200801145A1 (ru) 2005-12-02 2006-11-23 Спироциклические производные хиназолина в качестве ингибиторов pde7

Country Status (22)

Country Link
US (1) US7507742B2 (ru)
EP (1) EP1957467A2 (ru)
JP (1) JP2009517453A (ru)
KR (1) KR101009554B1 (ru)
AP (1) AP2008004470A0 (ru)
AR (1) AR058266A1 (ru)
AU (1) AU2006321349A1 (ru)
BR (1) BRPI0619126A2 (ru)
CA (1) CA2631535C (ru)
CR (1) CR10039A (ru)
EA (1) EA200801145A1 (ru)
EC (1) ECSP088484A (ru)
GT (1) GT200600494A (ru)
MA (1) MA30014B1 (ru)
ME (1) MEP0408A (ru)
NL (1) NL2000336C2 (ru)
NO (1) NO20082077L (ru)
PE (1) PE20071087A1 (ru)
RS (1) RS20080233A (ru)
TW (1) TW200732307A (ru)
UY (1) UY29979A1 (ru)
WO (1) WO2007063391A2 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ332762A (en) 1996-07-24 2000-09-29 Warner Lambert Co Isobutylgaba and its derivatives for the treatment of pain
WO2006114707A1 (en) * 2005-04-28 2006-11-02 Pfizer Limited Amino acid derivatives
EP2139475B1 (en) * 2007-03-27 2014-12-17 Omeros Corporation PDE7 inhibitors for use in the treatment of movement disorders
US8637528B2 (en) 2007-03-27 2014-01-28 Omeros Corporation Use of PDE7 inhibitors for the treatment of movement disorders
JP2010527986A (ja) * 2007-05-24 2010-08-19 ファイザー・リミテッド スピロ環状キナゾリン誘導体およびｐｄｅ７阻害剤としてのその使用
SG176464A1 (en) * 2008-05-09 2011-12-29 Agency Science Tech & Res Diagnosis and treatment of kawasaki disease
US20100298255A1 (en) * 2009-05-19 2010-11-25 Vivia Biotech S.L. Methods for providing personalized medicine test ex vivo for hematological neoplasms
US9220715B2 (en) 2010-11-08 2015-12-29 Omeros Corporation Treatment of addiction and impulse-control disorders using PDE7 inhibitors
KR20160105948A (ko) 2010-11-08 2016-09-07 오메로스 코포레이션 Pde7 억제제를 사용한 중독 및 충동-조절 장애의 치료
CU24152B1 (es) 2010-12-20 2016-02-29 Irm Llc 1,2 oxazol-8-azabiciclo[3,2,1]octano 8 il como moduladores de fxr
MX2020000295A (es) * 2017-07-12 2020-07-22 Dart Neuroscience Llc Compuestos de benzoxazol y benzofurano sustituidos como inhibidores de pde7.
WO2024038090A1 (en) 2022-08-18 2024-02-22 Mitodicure Gmbh Use of substituted benzoxazole and benzofuran compounds for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138815A1 (en) 2000-04-28 2003-07-24 Franz-Werner Kluxen Splice variant of camp phosphodiesterase type7(pde7a3)
AP1699A (en) 2001-03-21 2006-12-26 Warner Lambert Co New spirotricyclic derivatives and their use as phosphodiesterase-7 inhibitors
EP1400244A1 (en) 2002-09-17 2004-03-24 Warner-Lambert Company LLC New spirocondensed quinazolinones and their use as phosphodiesterase inhibitors
WO2006092692A1 (en) * 2005-03-01 2006-09-08 Pfizer Limited Use of combinations of pde7 inhibitors and alpha-2-delty ligands for the treatment of neuropathic pain
KR20070107099A (ko) * 2005-03-01 2007-11-06 화이자 리미티드 신경병증성 통증의 치료를 위한 ｐｄｅ7 억제제의 용도

Also Published As

Publication number Publication date
AU2006321349A1 (en) 2007-06-07
GT200600494A (es) 2007-07-06
CA2631535C (en) 2010-07-27
EP1957467A2 (en) 2008-08-20
RS20080233A (en) 2009-07-15
BRPI0619126A2 (pt) 2011-09-13
NL2000336C2 (nl) 2007-08-07
AR058266A1 (es) 2008-01-30
PE20071087A1 (es) 2007-12-29
WO2007063391A2 (en) 2007-06-07
MEP0408A (xx) 2010-02-10
NO20082077L (no) 2008-06-04
KR101009554B1 (ko) 2011-01-18
WO2007063391A3 (en) 2007-09-13
KR20080059338A (ko) 2008-06-26
CA2631535A1 (en) 2007-06-07
ECSP088484A (es) 2008-06-30
JP2009517453A (ja) 2009-04-30
NL2000336A1 (nl) 2007-06-05
MA30014B1 (fr) 2008-12-01
AP2008004470A0 (en) 2008-06-30
UY29979A1 (es) 2007-06-29
CR10039A (es) 2008-07-10
US7507742B2 (en) 2009-03-24
US20070129388A1 (en) 2007-06-07
TW200732307A (en) 2007-09-01

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