EA200501341A1 - Противобактериальные индолоноксазолидиноны, промежуточные соединения для их получения и содержащие их фармацевтические композиции - Google Patents

Противобактериальные индолоноксазолидиноны, промежуточные соединения для их получения и содержащие их фармацевтические композиции

Info

Publication number
EA200501341A1
EA200501341A1 EA200501341A EA200501341A EA200501341A1 EA 200501341 A1 EA200501341 A1 EA 200501341A1 EA 200501341 A EA200501341 A EA 200501341A EA 200501341 A EA200501341 A EA 200501341A EA 200501341 A1 EA200501341 A1 EA 200501341A1
Authority
EA
Eurasian Patent Office
Prior art keywords
indonoxozolidinones
antibacterial
receiving
pharmaceutical compositions
intermediate connections
Prior art date
Application number
EA200501341A
Other languages
English (en)
Other versions
EA009725B1 (ru
Inventor
Тони-Джо Поэл
Original Assignee
Фармация Энд Апджон Компани Ллс
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Фармация Энд Апджон Компани Ллс filed Critical Фармация Энд Апджон Компани Ллс
Publication of EA200501341A1 publication Critical patent/EA200501341A1/ru
Publication of EA009725B1 publication Critical patent/EA009725B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
    • C07D209/32—Oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Данное изобретение представляет противобактериальные агенты формулы (I) и промежуточные соединения для их получения.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200501341A 2003-02-24 2004-02-12 Противобактериальные индолоноксазолидиноны, промежуточные соединения для их получения и содержащие их фармацевтические композиции EA009725B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US44973403P 2003-02-24 2003-02-24
PCT/IB2004/000466 WO2004074282A1 (en) 2003-02-24 2004-02-12 Antibacterial indolone oxazolidinones, intermediates for their preparation and pharmaceutical compositions containing them

Publications (2)

Publication Number Publication Date
EA200501341A1 true EA200501341A1 (ru) 2006-02-24
EA009725B1 EA009725B1 (ru) 2008-02-28

Family

ID=32908714

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200501341A EA009725B1 (ru) 2003-02-24 2004-02-12 Противобактериальные индолоноксазолидиноны, промежуточные соединения для их получения и содержащие их фармацевтические композиции

Country Status (27)

Country Link
US (1) US7012088B2 (ru)
EP (1) EP1599470A1 (ru)
JP (1) JP3887396B2 (ru)
KR (1) KR100701226B1 (ru)
CN (1) CN100349892C (ru)
AP (1) AP2005003375A0 (ru)
AU (1) AU2004213246A1 (ru)
BR (1) BRPI0406824A (ru)
CA (1) CA2515984A1 (ru)
CO (1) CO5601039A2 (ru)
CR (1) CR7956A (ru)
EA (1) EA009725B1 (ru)
EC (1) ECSP055980A (ru)
GE (1) GEP20084306B (ru)
HK (1) HK1082253A1 (ru)
HR (1) HRP20050658A2 (ru)
IS (1) IS7883A (ru)
MA (1) MA27661A1 (ru)
MX (1) MXPA05008960A (ru)
NO (1) NO20052794L (ru)
OA (1) OA13032A (ru)
PL (1) PL377428A1 (ru)
RS (1) RS20050649A (ru)
TN (1) TNSN05202A1 (ru)
UA (1) UA80326C2 (ru)
WO (1) WO2004074282A1 (ru)
ZA (1) ZA200505225B (ru)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7141588B2 (en) * 2002-02-25 2006-11-28 Pfizer, Inc. N-aryl-2-oxazolidinone-5-carboxamides and their derivatives
JP2008509126A (ja) * 2004-08-06 2008-03-27 ファルマシア・アンド・アップジョン・カンパニー・エルエルシー 抗菌剤としてオキシインドールを含有するオキサゾリジノン類
WO2006106426A1 (en) * 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc An oxindole oxazolidinone as antibacterial agent
AU2006231919A1 (en) * 2005-04-06 2006-10-12 Pharmacia & Upjohn Company Llc 7-fluoro-1,3-dihydro-indol-2-one oxazolidinones as antibacterial agents
ES2600460T3 (es) 2005-05-10 2017-02-09 Intermune, Inc. Derivados de piridona-2-ona como moduladores del sistema de proteína cinasa activada por estrés
WO2007088478A1 (en) * 2006-02-01 2007-08-09 Pfizer Products Inc. Indazole oxazolidinones as antibacterial agents
JP2009526036A (ja) * 2006-02-08 2009-07-16 ファイザー・プロダクツ・インク 抗菌剤としてのオキシインドールを含有するオキサゾリジノン
CA2726588C (en) 2008-06-03 2019-04-16 Karl Kossen Compounds and methods for treating inflammatory and fibrotic disorders
FR2948940B1 (fr) * 2009-08-04 2011-07-22 Servier Lab Nouveaux derives dihydroindolones, leur procede de preparation et les compositions pharmaceutiques qui les contiennent
JP5685384B2 (ja) * 2010-03-29 2015-03-18 公益財団法人相模中央化学研究所 ３，３−ジフルオロ−２，３−ジヒドロインドール−２−オン誘導体の製造方法
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
HUE034106T2 (en) * 2012-10-17 2018-01-29 Univ Okayama Compound, tautomer and geometric isomer thereof, compound, tautomer or salt of geometric isomer, process for preparing the compound, tautomer, isomer or salt, antimicrobial agent and anti-infectious drug
CN103193794B (zh) * 2013-04-12 2016-04-06 中国药科大学 一种异吲哚酮并异噁唑类稠环化合物及其合成方法
WO2015153683A1 (en) 2014-04-02 2015-10-08 Intermune, Inc. Anti-fibrotic pyridinones
CN107151225B (zh) * 2017-06-30 2020-05-08 贵州大学 2-羟基吲哚类衍生物、其制备方法和用途
CN113773306B (zh) * 2021-10-29 2023-11-10 四川农业大学 3,3-二取代吲哚酮类化合物及其制备方法和应用

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5164510A (en) * 1988-09-15 1992-11-17 The Upjohn Company 5'Indolinyl-5β-amidomethyloxazolidin-2-ones
ES2157934T3 (es) 1988-09-15 2001-09-01 Upjohn Co Fenil-5-beta-amidometiloxazolidin-2-onas sustituidas con nitrogeno en la posicion 3.
US5225565A (en) * 1988-09-15 1993-07-06 The Upjohn Company Antibacterial 3-(fused-ring substituted)phenyl-5β-amidomethyloxazolidin-2-ones
MY115155A (en) 1993-09-09 2003-04-30 Upjohn Co Substituted oxazine and thiazine oxazolidinone antimicrobials.
DE19514313A1 (de) * 1994-08-03 1996-02-08 Bayer Ag Benzoxazolyl- und Benzothiazolyloxazolidinone
HRP960159A2 (en) * 1995-04-21 1997-08-31 Bayer Ag Benzocyclopentane oxazolidinones containing heteroatoms
DE19601627A1 (de) * 1996-01-18 1997-07-24 Bayer Ag Heteroatomhaltige Cyclopentanopyridyl-Oxazolidinone
DE19604223A1 (de) * 1996-02-06 1997-08-07 Bayer Ag Neue substituierte Oxazolidinone
DE19805117A1 (de) 1998-02-09 1999-08-12 Bayer Ag Neue Oxazolidinone mit azolhaltigen Tricyclen
CN1311787A (zh) 1998-06-05 2001-09-05 阿斯特拉曾尼卡有限公司 噁唑烷酮衍生物、其制备方法以及含有它们的药物组合物
GB9812019D0 (en) * 1998-06-05 1998-07-29 Zeneca Ltd Chemical compounds
GB9821938D0 (en) 1998-10-09 1998-12-02 Zeneca Ltd Chemical compounds
AU1045300A (en) 1998-11-17 2000-06-05 Bayer Aktiengesellschaft Novel heterocyclyl-substituted oxazolidone derivatives
DE19962924A1 (de) 1999-12-24 2001-07-05 Bayer Ag Substituierte Oxazolidinone und ihre Verwendung
PE20011124A1 (es) 2000-03-31 2001-10-28 Upjohn Co Nuevos agentes antibacterianos de benzosultam oxazolidinona
GB0009803D0 (en) 2000-04-25 2000-06-07 Astrazeneca Ab Chemical compounds
US8048386B2 (en) 2002-02-25 2011-11-01 Cepheid Fluid processing and control
PE20030044A1 (es) 2000-11-17 2003-02-09 Upjohn Co Isoxazolinonas biciclicas de formula i
EP1443930A1 (en) 2001-10-25 2004-08-11 AstraZeneca AB Isoxazoline derivatives useful as antimicrobials

Also Published As

Publication number Publication date
UA80326C2 (en) 2007-09-10
TNSN05202A1 (fr) 2007-06-11
KR100701226B1 (ko) 2007-03-29
HK1082253A1 (en) 2006-06-02
OA13032A (en) 2006-11-10
EP1599470A1 (en) 2005-11-30
NO20052794L (no) 2005-11-01
CR7956A (es) 2005-12-01
AP2005003375A0 (en) 2005-09-30
MA27661A1 (fr) 2005-12-01
CN1742008A (zh) 2006-03-01
US7012088B2 (en) 2006-03-14
ECSP055980A (es) 2006-01-16
JP3887396B2 (ja) 2007-02-28
PL377428A1 (pl) 2006-02-06
HRP20050658A2 (en) 2005-12-31
GEP20084306B (en) 2008-02-11
CN100349892C (zh) 2007-11-21
IS7883A (is) 2005-06-09
BRPI0406824A (pt) 2005-12-27
JP2006515012A (ja) 2006-05-18
ZA200505225B (en) 2006-11-29
EA009725B1 (ru) 2008-02-28
WO2004074282A1 (en) 2004-09-02
US20040176610A1 (en) 2004-09-09
CO5601039A2 (es) 2006-01-31
RS20050649A (en) 2007-11-15
CA2515984A1 (en) 2004-09-02
MXPA05008960A (es) 2005-11-04
NO20052794D0 (no) 2005-06-09
KR20050102135A (ko) 2005-10-25
AU2004213246A1 (en) 2004-09-02

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Legal Events

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MM4A Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s)

Designated state(s): AM AZ BY KZ KG MD TJ TM RU