EA200700166A1 - 4-замещённые производные хинолина, способ получения и промежуточные вещества для их приготовления и содержащие их фармацевтические композиции - Google Patents

4-замещённые производные хинолина, способ получения и промежуточные вещества для их приготовления и содержащие их фармацевтические композиции

Info

Publication number
EA200700166A1
EA200700166A1 EA200700166A EA200700166A EA200700166A1 EA 200700166 A1 EA200700166 A1 EA 200700166A1 EA 200700166 A EA200700166 A EA 200700166A EA 200700166 A EA200700166 A EA 200700166A EA 200700166 A1 EA200700166 A1 EA 200700166A1
Authority
EA
Eurasian Patent Office
Prior art keywords
preparation
pharmaceutical compositions
quinoline
obtaining
substituted derivatives
Prior art date
Application number
EA200700166A
Other languages
English (en)
Inventor
Мишель Табар
Фабрис Вивьяни
Серж Миньяни
Батист Ронан
Original Assignee
Новексель
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Новексель filed Critical Новексель
Publication of EA200700166A1 publication Critical patent/EA200700166A1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/18—Halogen atoms or nitro radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/04—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms
    • C07D215/06—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, directly attached to the ring carbon atoms having only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, attached to the ring nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)

Abstract

Настоящее изобретение относится к 4-замещенным производным хинолина общей формулы Iкоторые действуют в качестве антимикробных (антибактериальных) средств. Данное изобретение также относится к способу и промежуточным соединениям для их получения и к содержащим их фармацевтическим композициям.
EA200700166A 2004-06-29 2005-06-24 4-замещённые производные хинолина, способ получения и промежуточные вещества для их приготовления и содержащие их фармацевтические композиции EA200700166A1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FR0407124A FR2872164B1 (fr) 2004-06-29 2004-06-29 Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent
PCT/FR2005/001598 WO2006010831A1 (fr) 2004-06-29 2005-06-24 Derives de quinoleines-4-substituees, leur procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent

Publications (1)

Publication Number Publication Date
EA200700166A1 true EA200700166A1 (ru) 2007-06-29

Family

ID=34954685

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200700166A EA200700166A1 (ru) 2004-06-29 2005-06-24 4-замещённые производные хинолина, способ получения и промежуточные вещества для их приготовления и содержащие их фармацевтические композиции

Country Status (12)

Country Link
US (1) US20080032985A1 (ru)
EP (1) EP1763527A1 (ru)
JP (1) JP2008504351A (ru)
KR (1) KR20070029763A (ru)
CN (1) CN101023076A (ru)
AU (1) AU2005266218A1 (ru)
CA (1) CA2571668A1 (ru)
EA (1) EA200700166A1 (ru)
FR (1) FR2872164B1 (ru)
IL (1) IL179709A0 (ru)
TW (1) TW200609221A (ru)
WO (1) WO2006010831A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7691850B2 (en) 2004-06-15 2010-04-06 Glaxo Group Limited Antibacterial agents
MY150958A (en) 2005-06-16 2014-03-31 Astrazeneca Ab Compounds for the treatment of multi-drug resistant bacterial infections
ATE481406T1 (de) 2006-04-06 2010-10-15 Glaxo Group Ltd Pyrrolochinoxalinonderivate als antibakterielle mittel
GB0613208D0 (en) 2006-07-03 2006-08-09 Glaxo Group Ltd Compounds
EP1992628A1 (en) 2007-05-18 2008-11-19 Glaxo Group Limited Derivatives and analogs of N-ethylquinolones and N-ethylazaquinolones
CL2008001003A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
CL2008001002A1 (es) * 2007-04-11 2008-10-17 Actelion Pharmaceuticals Ltd Compuestos derivados de oxazolidinona; composicion farmaceutica que comprende a dichos compuestos; y su uso para preparar un medicamento para tratar una infeccion bacteriana.
AU2008240764C1 (en) * 2007-04-20 2011-10-20 Glaxo Group Limited Tricyclic nitrogen containing compounds as antibacterial agents
EP2080761A1 (en) 2008-01-18 2009-07-22 Glaxo Group Limited Compounds
US8012961B2 (en) 2008-04-15 2011-09-06 Actelion Pharmaceutical Ltd. Tricyclic antibiotics
JP2012505866A (ja) 2008-10-17 2012-03-08 グラクソ グループ リミテッド 抗菌剤として使用される三環式窒素化合物
JP5653935B2 (ja) 2009-01-15 2015-01-14 グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ 抗菌薬として有用なナフチリジン―２（１ｈ）−オン化合物
ES2759303T3 (es) 2014-08-22 2020-05-08 Glaxosmithkline Ip Dev Ltd Compuestos tricíclicos que contienen nitrógeno para tratar infección por Neisseria gonorrhoeae
TW201722965A (zh) 2015-08-16 2017-07-01 葛蘭素史密斯克藍智慧財產發展有限公司 用於抗菌應用之化合物

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2053340C (en) * 1990-10-18 2002-04-02 Timothy P. Burkholder Mercaptoacetylamide derivatives useful as inhibitors of enkephalinase and ace
US6103905A (en) * 1997-06-19 2000-08-15 Sepracor, Inc. Quinoline-indole antimicrobial agents, uses and compositions related thereto
JP2002505689A (ja) * 1997-06-19 2002-02-19 セプレイコー インコーポレイテッド キノリン−インドール抗菌剤、それらに関する用途及び組成物
WO2000043383A1 (en) * 1999-01-20 2000-07-27 Smithkline Beecham P.L.C. Piperidinylquinolines as protein tyrosine kinase inhibitors
CZ2003243A3 (cs) * 2000-07-26 2003-09-17 Smithkline Beecham P. L. C. Aminopiperidinové chinoliny a jejich azaisosterické analogy s antibakteriální aktivitou
FR2858619B1 (fr) * 2003-08-08 2006-12-22 Aventis Pharma Sa Derives de quinoleines-4-substituees, leurs procede et intermediaires de preparation et les compositions pharmaceutiques qui les contiennent

Also Published As

Publication number Publication date
EP1763527A1 (fr) 2007-03-21
FR2872164B1 (fr) 2006-11-17
AU2005266218A1 (en) 2006-02-02
WO2006010831A1 (fr) 2006-02-02
IL179709A0 (en) 2007-05-15
US20080032985A1 (en) 2008-02-07
KR20070029763A (ko) 2007-03-14
CN101023076A (zh) 2007-08-22
JP2008504351A (ja) 2008-02-14
FR2872164A1 (fr) 2005-12-30
AU2005266218A2 (en) 2006-02-02
CA2571668A1 (en) 2006-02-02
TW200609221A (en) 2006-03-16

Similar Documents

Publication Publication Date Title
EA200700166A1 (ru) 4-замещённые производные хинолина, способ получения и промежуточные вещества для их приготовления и содержащие их фармацевтические композиции
SE0301373D0 (sv) Novel compounds
EA200970156A1 (ru) Пиридизиноновые производные
ATE362932T1 (de) Azaindolverbindungen als kinaseinhibitoren
CY1109998T1 (el) Ενδυναμωτες υποδοχεων γλουταμινικου
EA200800540A1 (ru) Карбоксамидные производные в качестве антагонистов мускариновых рецепторов
MX2010009752A (es) Compuestos de oxadiazoantraceno para el tratamiento de diabetes.
ATE433447T1 (de) Pyrimiidinverbindungen
UA107188C2 (uk) Карбоксамідні похідні хіназолінів або хінолінів та фармацевтична композиція на їх основі
ATE517882T1 (de) Chinolinderivate
SE0101675D0 (sv) Novel composition
HRP20070076A2 (en) Pyrimidine derivatives
EA200700188A1 (ru) Производные замещенного 2-алкилхиназолинона как ингибиторы parp
EA200700099A1 (ru) Производные пиридина
EA200700185A1 (ru) Производные хиназолиндиона в качестве ингибиторов parp
HK1110588A1 (en) Novel phenylaminopyrimidine derivatives as inhibitors of bcr-abl kinase
EA200801608A1 (ru) Производные бензимидазолонкарбоновой кислоты
NO20056192L (no) Kapaseinhibitorer og anvendelse derav
EA201101334A1 (ru) Новые соединения бензотиадиазепина, способ их приготовления и фармацевтические композиции, содержащие их
NO20064344L (no) Caspaseinhibitorer og anvendelser derav
EA200702375A1 (ru) Производные мочевины, способы их получения и применения
EA201190293A1 (ru) Пролекарства триптолида
NO20073170L (no) Kaspaseinhibitorer og anvendelse derav
EA200970124A1 (ru) Производные 2-арилиндола в качестве ингибиторов npges-1
EA200600605A1 (ru) Перегруппированные пентанолы, способ их получения и их применение в качестве противовоспалительных средств