NO20056192L - Kapaseinhibitorer og anvendelse derav - Google Patents

Kapaseinhibitorer og anvendelse derav

Info

Publication number
NO20056192L
NO20056192L NO20056192A NO20056192A NO20056192L NO 20056192 L NO20056192 L NO 20056192L NO 20056192 A NO20056192 A NO 20056192A NO 20056192 A NO20056192 A NO 20056192A NO 20056192 L NO20056192 L NO 20056192L
Authority
NO
Norway
Prior art keywords
capase
inhibitors
methods
compositions
caspase
Prior art date
Application number
NO20056192A
Other languages
English (en)
Inventor
Jean-Damien Charrier
Ronald Knegtel
Guy Brenchley
Michael Mortimore
Steven Durrant
John R Studley
Original Assignee
Vertex Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Vertex Pharma filed Critical Vertex Pharma
Publication of NO20056192L publication Critical patent/NO20056192L/no

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links

Abstract

Forbindelse med formel I: hvor R1, R2, R3, R4 og R5 har betydningene som angis heri. Dessuten farmasøytiske sammensetninger og fremgangsmåter ved anvendelse av slike sammensetninger for behandling av kaspase-medierte sykdomer, og fremgangsmåter for fremstilling av forbindelsene.
NO20056192A 2003-05-27 2005-12-27 Kapaseinhibitorer og anvendelse derav NO20056192L (no)

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PCT/US2004/016706 WO2004106304A2 (en) 2003-05-27 2004-05-27 3 - [2- (3-amino-2-oxo-2h-pyridin-1-yl) - acetylamino] - 4- oxo-pentanoic acid derivatives and their use as caspase inhibitors

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US20090093416A1 (en) 2009-04-09
MXPA05012837A (es) 2006-02-13
US7960415B2 (en) 2011-06-14
BRPI0410669A (pt) 2006-06-20
TW201038534A (en) 2010-11-01
UY28333A1 (es) 2004-12-31
IL172159A0 (en) 2006-04-10
RU2372335C2 (ru) 2009-11-10
EP2412707A2 (en) 2012-02-01
AU2004243308A1 (en) 2004-12-09
NZ575857A (en) 2010-11-26
EP1631549A2 (en) 2006-03-08
CN101775012A (zh) 2010-07-14
IL172159A (en) 2012-03-29
US20040242494A1 (en) 2004-12-02
AU2004243308B9 (en) 2012-02-09
NZ544156A (en) 2009-05-31
AR044770A1 (es) 2005-10-05
WO2004106304A2 (en) 2004-12-09
JP2012021019A (ja) 2012-02-02
JP2012036206A (ja) 2012-02-23
CA2526749A1 (en) 2004-12-09
CN1812972A (zh) 2006-08-02
WO2004106304A3 (en) 2005-11-03
EP2412707A3 (en) 2012-06-13
JP2007506803A (ja) 2007-03-22
CN1812972B (zh) 2010-04-28
TW200510317A (en) 2005-03-16
JP4791365B2 (ja) 2011-10-12
ZA200509700B (en) 2007-03-28
AU2004243308B2 (en) 2011-09-29
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