EA200401202A1 - Сульфонилпроизводные в качестве новых ингибиторов гистон-деацетилазы - Google Patents

Сульфонилпроизводные в качестве новых ингибиторов гистон-деацетилазы

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Publication number
EA200401202A1
EA200401202A1 EA200401202A EA200401202A EA200401202A1 EA 200401202 A1 EA200401202 A1 EA 200401202A1 EA 200401202 A EA200401202 A EA 200401202A EA 200401202 A EA200401202 A EA 200401202A EA 200401202 A1 EA200401202 A1 EA 200401202A1
Authority
EA
Eurasian Patent Office
Prior art keywords
histon
new
deacetylase inhibitors
sulphinyl
derivatives
Prior art date
Application number
EA200401202A
Other languages
English (en)
Other versions
EA006707B1 (ru
Inventor
Кристоф Ван Эмелен
Янине Артс
Лео Якобус Йозеф Бакс
Ханс Луи Йос Де Винтер
Свен Францискус Анна Ван Брандт
Марк Густаф Селин Вердонк
Ливен Мерпул
Изабелль Ноэлль Констанс Пилатт
Виржини Софи Понселе
Алексей Борисович Дяткин
Original Assignee
Янссен Фармацевтика Н. В.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Янссен Фармацевтика Н. В. filed Critical Янссен Фармацевтика Н. В.
Publication of EA200401202A1 publication Critical patent/EA200401202A1/ru
Publication of EA006707B1 publication Critical patent/EA006707B1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/402—1-aryl substituted, e.g. piretanide
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Abstract

Данное изобретение включает в себя новые соединения формулы (I), где n, m, t, R, R, R, R, L, Q, X, Y, Z имеют определенные значения, ингибирующие ферментную активность гистон-деацетилазы; их получение, содержащие их композиции и их применение в качестве лекарственного препарата.Международная заявка была опубликована вместе с отчетом о международном поиске.
EA200401202A 2002-03-13 2003-03-11 Сульфонилпроизводные в качестве новых ингибиторов гистон-деацетилазы EA006707B1 (ru)

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PCT/EP2003/002516 WO2003076422A1 (en) 2002-03-13 2003-03-11 Sulfonyl-derivatives as novel inhibitors of histone deacetylase

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