AR039568A1 - Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa, composicion farmaceutica y procedimiento de preparacion del compuesto - Google Patents

Derivados de sulfonilo como novedosos inhibidores de la histona desacetilasa, composicion farmaceutica y procedimiento de preparacion del compuesto

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Publication number
AR039568A1
AR039568A1 ARP030100856A ARP030100856A AR039568A1 AR 039568 A1 AR039568 A1 AR 039568A1 AR P030100856 A ARP030100856 A AR P030100856A AR P030100856 A ARP030100856 A AR P030100856A AR 039568 A1 AR039568 A1 AR 039568A1
Authority
AR
Argentina
Prior art keywords
alkyl
amino
aminoalkyl
hydroxyalkyl
alkyloxy
Prior art date
Application number
ARP030100856A
Other languages
English (en)
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of AR039568A1 publication Critical patent/AR039568A1/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
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    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/402—1-aryl substituted, e.g. piretanide
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    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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Abstract

Compuestos de la fórmula (1) teniendo actividad enzimática inhibidora de la histona desacetilasa; su preparación y utilización del compuesto para la preparación de un medicamento. Estos compuestos pueden utilizarse para inhibir el crecimiento anormal de células tumorales sea en forma directa (apoptosis) o indirectamente (inhibición de la neovascularización de los tumores). Reivindicación 1: Un compuesto de formula (1), las formas N-óxido, las sales de adición farmacéuticamente aceptables, y las formas estereoquímicamente isoméricas de los mismos, en donde n vale 0,1, 2 o 3 y cuando n es 0 entonces se pretende un enlace directo; t vale 0, 1, 2, 3 ó 4 y cuando t es 0 entonces se pretende un enlace directo; cada Q es nitrógeno o carbono; cada X es nitrógeno o carbono; cada Y es nitrógeno o carbono; cada Z es nitrógeno o -CH<; R1 es -C(O)NR7R8, -NHC(O)R9, -C(O)- alcanodiil C1-6SR9, -NR10C(O)N(OH)R9, -NR10C(O)alcanodiil C1-6SR9, -NR10C(O)C=N (OH)R9 u otro grupo quelante de Zn; en donde R7 y R8 son en forma individual e independientemente seleccionados entre hidrógeno, hidroxi, alquilo C1-6, hidroxialquilo C1-6, aminoalquilo C1-6 o aminoarilo; R9 se selecciona independientemente entre hidrógeno,alquilo C1-6, alquil C1-6carbonilo, arilalquilo C1-6, alquil C1-6pirazinilo, piridinona, pirrolidinona o metilimidazolilo; R10 se selecciona independientemente entre hidrógeno o alquilo C1-6; R2 es hidrógeno, halo, hidroxi, amino, nitro, alquilo C1-6, alquiloxi C1-6, trifluorometilo, di (alquil C1-6)-amino, hidroxiamino o naftalensulfonilpirazinilo; -L- es un enlace directo o un radical bivalente seleccionado de entre alcanodiilo C1-6, amino, carbonilo o aminocarbonilo cada uno de los R3 independientemente de los demás representa un átomo de hidrógeno y un átomo de hidrógeno puede estar reemplazado con arilo; R4 es hidrógeno, hidroxilo, amino, hidroxialquilo C1-6, alquilo C1-6, alquiloxilo C1-6, arilalquilo C1-6, aminocarbonilo, hidroxicarbonilo, aminoalquilo C1-6, aminocarbonilalquilo C1-6, hidroxicarbonilalquilo C1-6, hidroxiaminocarbonilo, alquiloxi C1-6carbonilo, alquil C1-6aminoalquilo C1-6 o di (alquil C1-6)aminoalquilo C1-6 ; la parte cíclica A es un radical seleccionado entre (a-1), a (a-51) en los cuales cada s es independientemente 0,1, 2,3, 4 o 5; cada R5 y R6 son independientemente seleccionados de hidrógeno; halo; hidroxilo; amino; nitro; trihaloalquilo C1-6; trihaloalquiloxilo C1-6; alquilo C1-6; alquilo C1-6 substituido con arilo y cicloalquilo C3-10; alquiloxilo C1-6; alquiloxi C1-6alquiloxilo C1-6; alquil C1-6carbonilo; alquiloxi C1-6carbonilo; alquil C1-6sulfonilo; cianoalquilo C1-6; hidroxialquilo C1-6; hidroxialquiloxilo C1-6; hidroxialquil C1-6amino; aminoalquiloxilo C1-6; di (alquil C1-6) aminocarbonilo; di(hidroxialquil C1-6) amino; (aril) (alquil C1-6)amino; di (alquil C1-6)aminoalquiloxilo C1-6; di (alquil C1-6)aminoalquilamino C1-6; di (alquil C1-6)aminoalquilamino C1-6 alquilo C1-6; arilsulfonilo; arilsulfonilamino; ariloxilo; ariloxialquilo C1-6; arilalquenodiilo C2-6; di (alquil C1-6)amino; di (alquil C1-6)aminoalquilo C1-6; di(alquil C1-6) amino (alquil C1-6) amino; di(alquil C1-6) amino(alquil C1-6)amino alquilo C1-6; di (alquil C1-6)aminoalquil C1-6(alquil C1-6)amino; di (alquil C1-6)aminoalquil C1-6(alquil C1-6)aminoalquilo C1-6; aminosulfonilamino (alquil C1-6) amino; aminosulfonilamino(alquil C1-6) aminoalquilo C1-6; di (alquil C1-6)aminosulfonilamino(alquil C1-6) amino; di (alquil C1-6)aminosulfonilamino(alquil C1-6)aminoalquilo C1-6; ciano; tiofenilo; tiofenilo substituido con di (alquil C1-6)aminoalquil C1-6 (alquil C1-6)aminoalquilo C1-6, di (alquil C1-6)aminoalquilo C1-6, alquil C1-6piperazinilalquilo C1-6, hidroxialquil C1-6piperazinilalquilo C1-6, hidroxialquiloxi C1-6alquil C1-6piperazinilalquilo C1-6, di(alquil C1-6) aminosulfonilpiperazinilalquilo C1-6, alquiloxi C1-6piperidinilo, alquiloxi C1-6piperidinilalquilo C1-6, morfolinilalquilo C1-6, hidroxialquil C1-6(alquil C1-6)aminoalquilo C1-6, o di(hidroxialquil C1-6)aminoalquilo C1-6 ; furanilo; furanilo substituido con hidroxialquilo C1-6; benzofuranilo; imidazolilo; oxazolilo; oxazolilo substituido con arilo y alquilo C1-6; alquil C1-6triazolilo; tetrazolilo; pirrolidinilo; pirrolilo; piperidinilalquiloxilo C1-6; morfolinilo; alquil C1-6morfolinilo; morfolinilalquiloxilo C1-6; morfolinilalquilo C1-6; morfolinilalquil C1-6amino; morfolinilC1-6alquilaminoalquilo C1-6; piperazinilo; alquil C1-6piperazinilo; alquil C1-6piperazinilalquiloxilo C1-6; piperazinilalquilo C1-6; naftalenilsulfonilpiperazinilo; naftalenilsulfonilpiperidinilo; naftalenilsulfonilo; alquil C1-6piperazinilalquilo C1-6; alquil C1-6piperazinilalquil C1-6amino; alquil C1-6piperazinilalquil C1-6aminoalquilo C1-6; alquil C1-6piperazinilsulfonilo; aminosulfonilpiperazinilalquiloxilo C1-6; aminosulfonilpiperazinilo; aminosulfonilpiperazinilalquilo C1-6; di(alquilo C1-6) aminosulfonilpiperazinilo; di (alquil C1-6)aminosulfonilpiperazinilalquilo C1-6; hidroxialquil C1-6piperazinilo; hidroxialquil C1-6piperazinilalquilo C1-6; alquiloxi C1-6piperidinilo; alquiloxi C1-6piperidinilalquilo C1-6; piperidinilaminoalquil C1-6amino; piperdinilaminoalquil C1-6aminoalquilo C1-6; (alquil C1-6piperidinil)(hidroxialquil C1-6)aminoalquilamino C1-6; (alquil C1-6piperidinil)(hidroxialquilo C1-6) aminoalquilamino C1-6 alquilo C1-6; hidroxialquiloxi C1-6alquil C1-6piperazinilo; hidroxialquiloxi C1-6alquil C1-6piperazinilalquilo C1-6; (hidroxialquil C1-6) (alquil C1-6) amino; (hidroxialquil C1-6)(alquil C1-6)aminoalquilo C1-6; hidroxialquil C1-6aminoalquilo C1-6; di(hidroxialquil C1-6 aminoalquilo C1-6; pirrolidinilalquilo C1-6; pirrolidinilalquiloxilo C1-6; pirazolilo; tiopirazolilo; pirazolilo substituido con dos substituyentes seleccionados de alquilo C1-6 o trihaloalquilo C1-6; piridinilo; piridinilo substituido con alquiloxilo C1-6, ariloxilo o arilo; pirimidinilo; tetrahidropirimidinilpiperazinilo; tetrahidropirimidinilpiperazinilalquilo C1-6; quinolinilo; indol; fenilo; o fenilo substituido con uno, dos o tres substituyentes independientemente seleccionados de halo, amino, nitro, alquilo C1-6, alquiloxilo C1-6, hidroxialquilo C1-4, trifluorometilo, trifluorometiloxilo, hidroxialquiloxilo C1-4, alquil C1-4sulfonilo, alquiloxi C1-4alquiloxilo C1-4, alquiloxi C1-4carbonilo, aminoalquiloxilo C1-4, di (alquil C1-4)aminoalquiloxilo C1-4, di(alquil C1-4) amino, di (alquil C1-4) aminocarbonilo, di (alquil C1-4)aminoalquilo C1-4, di (alquil C1-4)aminoalquil C1-4aminoalquilo C1-4, di (alquil C1-4)aminoalquil C1-4(alquil C1-4)amino, di (alquil C1-4)aminoalquil C1-4(alquil C1-4) aminoalquilo C1-4; aminosulfonilamino(alquil C1-4) amino, aminosulfonilamino (alquil C1-4)aminoalquilo C1-4, di (alquil C1-4)aminosulfonilamino(alquil C1-4)amino, di (alquil C1-4)aminosulfonilamino(alquil C1-4)aminoalquilo C1-6, ciano, piperidinilalquiloxilo C1-4, pirrolidinilalquiloxilo C1-4, aminosulfonilpiperazinilo, aminosulfonilpiperazinilalquilo C1-4, di(alquil C1-4) aminosulfonilpiperazinilo, di (alquil C1-4)aminosulfonilpiperazinilalquilo C1-4, hidroxialquil C1-4piperazinilo, hidroxialquil C1-4piperazinilalquilo C1-4, alquiloxi C1-4piperidinilo, alquiloxi C1-4piperidinilalquilo C1-4, hidroxialquiloxi C1-4alquil C1-4piperazinilo, hidroxialquiloxi C1-4alquil C1-4piperaziniloalquilo C1-4, (hidroxialquil C1-4)(alquil C1-4) amino, (hidroxialquil C1-4)(alquil C1-4)aminoalquilo C1-4, di(hidroxialquil C1-4) arnino, di(hidroxialquil C1-4) aminoalquilo C1-4, furanilo, furanilo substituido con -CH=CH-CH=CH-, pirrolidinilalquilo C1-4, pirrolidiniloalquiloxilo C1-4, morfolinilo, morfolinilalquiloxilo C1-4, morfolinilalquilo C1-4, morfolinilalquil C1-4amino, morfolinilalquil C1-4amino alquilo C1-4, piperazinilo, alquil C1-4piperazinilo, alquil C1-4piperazinilalquiloxilo C1-4, piperazinilalquilo C1-4, alquil C1-4piperazinilalquilo C1-4, alquil C1-4piperazinilalquil C1-4amino, alquil C1-4piperazinilalquil C1-4aminoalquilo C1-4, tetrahidropirimidinilpiperazinilo, tetrahidropirimidinilpiperazinilalquilo C1-4, piperidinilaminoalquil C1-4amino, piperidinilaminoalquil C1-4aminoC1-4alquilo, (alquil C1-4piperidinil)(hidroxialquil C1-4)amino alquilamino C1-4, (alquil C1-4piperidinil)(hidroxialquil C1-4)aminoalquil C1-4aminoalquilo C1-4, piridinilalquiloxilo C1-4, hidroxialquil C1-4amino, (hidroxialquil C1-4)aminoalquilo C1-4, di (alquil C1-4)aminoalquil C1-4amino, aminotiadiazolilo, aminosulfonilpiperazinilalquiloxilo C1-4, o tiofenilalquil C1-4amino; la porción central (2) también puedeestar puenteada (es decir, formando una porción bicíclica) con un puente metileno, etileno o propileno; cada R5 y R6 puede estar colocado en el nitrógeno en reemplazo del hidrógeno; arilo en la anterior es fenilo, o fenilo substituido con uno o más substituyentes seleccionados cada uno independientemente de halo, alquilo C1-6, alquiloxilo C1-6, trifluorometilo, ciano o hidroxicarbonilo. Reivindicación 13: Un proceso para preparar un compuesto de acuerdo con la reivindicación 1, caracterizado porque, a) se hace reaccionar un intermediario de la fórmula (II) con un ácido apropiado, como ser por ejemplo, ácido trifluoracético, proporcionando un ácido hidroxámico de fórmula (I-a), en donde R1 es -C(O)NH(OH); b) hidrogenación catalítica de un intermediario de fórmula (VI) con hidrógeno en presencia de un catalizador, como ser, por ejemplo, paladio sobre carbón (10%), con la formación de un ácido hidroxámico de fórmula (I-a), en donde R1 es -C(O)NH(OH); c) hacer reaccionar un intermediario de fórmula (VII) con un intermediario de fórmula (VIII) en donde R' es del grupo de fórmulas (3) en presencia de N'-(etilcarbonimidoil)-N,N-dimetil-1,3propandiamina, monoclorhidrato (EDC) e hidroxibenzotriazol (HOBT), proporcionando un compuesto de fórmula (I-b) en donde R1 es del grupo de fórmulas (4).
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