PE20140572A1 - Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar - Google Patents
Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de pparInfo
- Publication number
- PE20140572A1 PE20140572A1 PE2013002163A PE2013002163A PE20140572A1 PE 20140572 A1 PE20140572 A1 PE 20140572A1 PE 2013002163 A PE2013002163 A PE 2013002163A PE 2013002163 A PE2013002163 A PE 2013002163A PE 20140572 A1 PE20140572 A1 PE 20140572A1
- Authority
- PE
- Peru
- Prior art keywords
- phenyl
- pyrrolidinyl
- benzamide
- piperazinyl
- acetyl
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
- A61K31/215—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids
- A61K31/216—Esters, e.g. nitroglycerine, selenocyanates of carboxylic acids of acids having aromatic rings, e.g. benactizyne, clofibrate
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/18—Drugs for disorders of the alimentary tract or the digestive system for pancreatic disorders, e.g. pancreatic enzymes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/10—Anti-acne agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D295/00—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
- C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
- C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
- C07D295/182—Radicals derived from carboxylic acids
- C07D295/192—Radicals derived from carboxylic acids from aromatic carboxylic acids
Abstract
SE REFIERE A UNA COMBINACION FARMACEUTICA QUE COMPRENDE: A) UN AGONISTA DE RECEPTORES ACTIVADOS POR PROLIFERADORES DE PEROXISOMA (PPAR) EN PARTICULAR PPAR-a TAL COMO UN FENOFIBRATO; Y B) UN INHIBIDOR DE ACIL CoA DIACILGLICEROL ACILTRANSFERASA (DGAT) TAL COMO 4-[4-[[2-CLORO-4-(1-PIRROLIDINILMETIL)FENILO]ACETIL]-1-PIPERAZINIL]-N-[3-(1-PIRROLIDINIL)FENIL]-BENZAMIDA; 4-[4-[[2,6-DICLORO-4-(1-PIRROLIDINILMETIL)FENIL]ACETIL]-1-PIPERAZINIL]-N-[3-(1-PIRROLIDINIL)FENIL]-BENZAMIDA; 4-[4-[[2,6-DICLORO-4-[[4-(METILSULFONIL)-1-PIPERAZINIL]METIL]FENIL]ACETIL]-1-PIPERAZINIL]-N-[3-(1-PIRROLIDINIL)FENIL]-BENZAMIDA; ENTRE OTROS. DICHA COMBINACION ES UTIL PARA EL TRATAMIENTO DE OBESIDAD, HIPERCOLESTEROLEMIA, HIPERLIPIDEMIA, DIABETES TIPO 2, HIGADO GRASO
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PCT/EP2008/057008 WO2008148849A2 (en) | 2007-06-08 | 2008-06-05 | Piperidine/piperazine derivatives |
PCT/EP2008/057011 WO2008148851A1 (en) | 2007-06-08 | 2008-06-05 | Piperidine/piperazine derivatives |
PCT/EP2008/056983 WO2008148840A1 (en) | 2007-06-08 | 2008-06-05 | Piperidine/piperazine derivatives |
PCT/EP2008/057060 WO2008148868A1 (en) | 2007-06-08 | 2008-06-06 | Piperidine/piperazine derivatives |
EP08170780 | 2008-12-05 |
Publications (1)
Publication Number | Publication Date |
---|---|
PE20140572A1 true PE20140572A1 (es) | 2014-05-16 |
Family
ID=40640200
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000769A PE20100083A1 (es) | 2008-06-05 | 2009-06-03 | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar |
PE2013002163A PE20140572A1 (es) | 2008-06-05 | 2009-06-03 | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PE2009000769A PE20100083A1 (es) | 2008-06-05 | 2009-06-03 | Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar |
Country Status (11)
Country | Link |
---|---|
US (3) | US9107946B2 (es) |
EP (1) | EP2296659B1 (es) |
JP (1) | JP5579170B2 (es) |
AR (1) | AR073450A1 (es) |
AU (1) | AU2009253892B2 (es) |
CA (1) | CA2725933C (es) |
ES (1) | ES2617619T3 (es) |
PE (2) | PE20100083A1 (es) |
TW (1) | TWI460175B (es) |
UY (1) | UY31863A (es) |
WO (1) | WO2009147170A2 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2002060446A1 (en) | 2001-01-29 | 2002-08-08 | Shionogi & Co., Ltd. | Medicinal preparation containing 5-methyl-1-phenyl-2-(1h)-pyridone as active ingredient |
ES2649564T3 (es) | 2006-03-31 | 2018-01-12 | Novartis Ag | Inhibidores de DGAT |
JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
EP2152271B1 (en) | 2007-06-08 | 2015-10-21 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
AR066911A1 (es) | 2007-06-08 | 2009-09-23 | Janssen Pharmaceutica Nv | Derivados de piperidina / piperazina |
JP5464709B2 (ja) | 2007-06-08 | 2014-04-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペリジン/ピペラジン誘導体 |
AR066169A1 (es) | 2007-09-28 | 2009-07-29 | Novartis Ag | Derivados de benzo-imidazoles, utiles para trastornos asociados con la actividad de dgat |
EP2296659B1 (en) | 2008-06-05 | 2016-12-21 | Janssen Pharmaceutica, N.V. | Drug combinations comprising a DGAT inhibitor and a PPAR-agonist |
WO2011002067A1 (ja) * | 2009-07-02 | 2011-01-06 | 武田薬品工業株式会社 | 複素環化合物およびその用途 |
EP2709609B1 (en) | 2011-05-17 | 2017-10-04 | Shionogi & Co., Ltd. | Heterocyclic compounds |
WO2013049621A1 (en) * | 2011-09-29 | 2013-04-04 | The Board Of Regents Of The University Of Oklahoma | Ophthalmic compositions comprising ppar-alpha agonists and methods of production and use thereof |
AR091858A1 (es) | 2012-07-25 | 2015-03-04 | Sova Pharmaceuticals Inc | INHIBIDORES DE CISTATIONIN-g-LIASA (CSE) |
CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
FR3050112B1 (fr) | 2016-04-15 | 2020-09-04 | Soc Civ Immobiliere Gecinq | Utilisation de l'acide fenofibrique dans le traitement des maladies hepatiques |
ES2781309T3 (es) * | 2016-05-27 | 2020-09-01 | Bristol Myers Squibb Co | Triazolonas y tetrazolonas como inhibidores de ROCK |
EP3558992A4 (en) * | 2016-12-15 | 2020-12-02 | ONO Pharmaceutical Co., Ltd. | ACTIVATOR OF TREK (TWIK-ASSOCIATED K + CHANNELS) CHANNELS |
EA201991731A1 (ru) * | 2017-01-27 | 2019-12-30 | Женфит | Модуляторы ror–гамма и их применение |
CN106957280B (zh) * | 2017-03-13 | 2019-02-15 | 洛阳师范学院 | 醚类芳基哌嗪衍生物及其盐、制备方法以及在制备治疗抗肿瘤药物中的用途 |
TWI820077B (zh) * | 2018-01-05 | 2023-11-01 | 美商斯布雷克薩一號公司 | 治療涉及酸性或缺氧性患病組織之疾病之化合物、組合物及方法 |
Family Cites Families (83)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1383906A (en) | 1971-02-22 | 1974-02-12 | Bdh Pharmaceuticals Ltd | Pyridazinones |
JPS5692887A (en) | 1979-12-05 | 1981-07-27 | Sumitomo Chem Co Ltd | N-substituted imidazole derivative |
DE3338846A1 (de) | 1982-10-29 | 1984-05-03 | Toyama Chemical Co. Ltd., Tokyo | Neue 4-oxo-1,4-dihydronicotinsaeurederivate und salze derselben, verfahren zu ihrer herstellung und antibakterielle mittel mit einem gehalt derselben |
GB8729083D0 (en) | 1987-12-12 | 1988-01-27 | Pfizer Ltd | Triazole antifungal agents |
JP2969359B2 (ja) | 1989-01-13 | 1999-11-02 | 武田薬品工業株式会社 | 環状アミン化合物 |
DE4317093A1 (de) | 1993-05-21 | 1994-11-24 | Basf Ag | Niedermolekulare und polymere flüssigkristalline Benztriazole und deren Verwendung |
TW286317B (es) | 1993-12-13 | 1996-09-21 | Hoffmann La Roche | |
US5639754A (en) | 1994-07-12 | 1997-06-17 | Janssen Pharmaceutica N.V. | Urea and thiourea derivatives of azolones |
FR2722788B1 (fr) | 1994-07-20 | 1996-10-04 | Pf Medicament | Nouvelles piperazides derivees d'aryl piperazine, leurs procedes de preparation, leur utilisation a titre de medicament et les compositions pharmaceutiques les comprenant |
KR100233202B1 (ko) | 1994-09-30 | 1999-12-01 | 가나이 쓰도무 | 고속재생모드를 갖는 자기기록 재생장치 |
AU699619B2 (en) | 1995-01-11 | 1998-12-10 | Samjin Pharmaceutical Co., Ltd. | New piperazine derivatives and methods for the preparation thereof and compositions containing the same |
ATE235239T1 (de) | 1995-08-10 | 2003-04-15 | Merck & Co Inc | 2-substituierte aryl-pyrrolen, zusammensetzungen solche verbindungen enthaltend und deren verwendung |
EP0871444A4 (en) | 1995-08-10 | 1999-01-13 | Merck & Co Inc | 2.5 SUBSTITUTED ARYL PYRROL, THE COMPOSITIONS THAT CONTAIN AND THE USE THEREOF |
GB9702213D0 (en) | 1996-02-24 | 1997-03-26 | Zeneca Ltd | Chemical compounds |
HN1997000027A (es) | 1996-12-06 | 1997-06-05 | Pfizer Prod Inc | Derivados de 6-fenil piridil - 2 amina |
JPH11139969A (ja) | 1997-08-07 | 1999-05-25 | Tanabe Seiyaku Co Ltd | 医薬組成物 |
DE19743435A1 (de) | 1997-10-01 | 1999-04-08 | Merck Patent Gmbh | Benzamidinderivate |
PL345283A1 (en) | 1998-07-20 | 2001-12-03 | Merck Patent Gmbh | Biphenyl derivatives |
GB9826412D0 (en) | 1998-12-03 | 1999-01-27 | Glaxo Group Ltd | Chemical compounds |
AUPP999799A0 (en) | 1999-04-27 | 1999-05-20 | Fujisawa Pharmaceutical Co., Ltd. | New compound |
AP2001002326A0 (en) | 1999-05-21 | 2001-12-31 | Pfizer Prod Inc | New pharmaceuticals combinations for nos inhibitors. |
CN1167686C (zh) | 1999-06-22 | 2004-09-22 | 神经研究公司 | 苯并咪唑衍生物和包括这些化合物的药物组合物 |
MXPA02007719A (es) | 2000-02-10 | 2002-10-11 | Upjohn Co | Tioamidas de oxazolidinona con sustituyentes de piperazina y amida. |
GB0013378D0 (en) * | 2000-06-01 | 2000-07-26 | Glaxo Group Ltd | Use of therapeutic benzamide derivatives |
WO2001095856A2 (en) | 2000-06-15 | 2001-12-20 | Chaconne Nsi Co., Ltd. | Urea derivative useful as an anti-cancer agent and process for preparing same |
US20030060472A1 (en) | 2000-06-21 | 2003-03-27 | Learmonth David Alexander | Novel substituted nitrocatechols, their use in the treatment of some central and peripheral nervous system disorders and pharmaceutical compositions containing them |
GB2363792A (en) | 2000-06-21 | 2002-01-09 | Portela & Ca Sa | Nitrocatechols |
JO2654B1 (en) | 2000-09-04 | 2012-06-17 | شركة جانسين فارماسوتيكا ان. في | Multiple aryl caroxa amides are useful as lipid - lowering agents |
US7186683B2 (en) | 2000-09-18 | 2007-03-06 | Sanos Bioscience A/S | Use of GLP for the treatment, prevention, diagnosis, and prognosis of bone-related and nutrition-related disorders |
AUPR201600A0 (en) | 2000-12-11 | 2001-01-11 | Fujisawa Pharmaceutical Co., Ltd. | Quinazolinone derivative |
DE10063008A1 (de) | 2000-12-16 | 2002-06-20 | Merck Patent Gmbh | Carbonsäureamidderivate |
AU2002217742B2 (en) | 2001-01-16 | 2008-02-21 | Astrazeneca Ab | Therapeutic heterocyclic compounds |
JO2390B1 (en) | 2001-04-06 | 2007-06-17 | شركة جانسين فارماسوتيكا ان. في | Diphenylcarboxamides act as lipid-lowering agents |
DE10204116A1 (de) | 2002-02-01 | 2003-08-07 | Bayer Cropscience Ag | DELTA·1·-Pyrroline |
CN101450934B (zh) | 2002-03-13 | 2012-10-10 | 詹森药业有限公司 | 用作组蛋白去乙酰酶抑制剂的磺酰基衍生物 |
ES2322252T3 (es) | 2002-03-13 | 2009-06-18 | Janssen Pharmaceutica Nv | Aminoderivados como nuevos inhibidores de histona-desacetilasa. |
BR0308837A (pt) | 2002-04-01 | 2005-02-01 | Cadila Healthcare Ltd | Composto, composição, método e medicamento para o tratamento de infecções bacterianas, psorìase ou artrite em mamìferos, método e medicamento para o tratamento de toxicidade devido a quimioterapia em um paciente, composição farmacêutica, processo para a preparação de um composto e processo para a conversão dos compostos da fórmula (i) em compostos adicionais da fórmula (i) |
TWI319387B (en) | 2002-04-05 | 2010-01-11 | Astrazeneca Ab | Benzamide derivatives |
US7842693B2 (en) | 2002-06-12 | 2010-11-30 | Chemocentryx, Inc. | Substituted piperazines |
WO2004018439A1 (en) | 2002-08-22 | 2004-03-04 | Orchid Chemicals & Pharmaceuticals Ltd | Novel antibacterial agents |
JP3988830B2 (ja) | 2002-11-22 | 2007-10-10 | 日本たばこ産業株式会社 | 縮合二環式窒素含有複素環 |
ATE551324T1 (de) | 2003-02-03 | 2012-04-15 | Janssen Pharmaceutica Nv | Chinolin-amid-derivate als modulatoren von vanilloid-vr1-rezeptoren |
DE10306250A1 (de) | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
AR044152A1 (es) | 2003-05-09 | 2005-08-24 | Bayer Corp | Derivados de alquilarilo, metodo de preparacion y uso para el tratamiento de la obesidad |
WO2004110375A2 (en) | 2003-06-06 | 2004-12-23 | Merck & Co., Inc. | Combination therapy for the treatment of diabetes |
JP4920410B2 (ja) | 2003-07-14 | 2012-04-18 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 代謝モジュレーターとしての縮合アリールおよびヘテロアリール誘導体ならびに代謝に関連する障害の予防および治療 |
CA2534675C (en) | 2003-08-11 | 2013-07-23 | F. Hoffmann-La Roche Ag | Piperazine with or-substituted phenyl group and their use as glyt1 inhibitors |
JP2005206492A (ja) | 2004-01-21 | 2005-08-04 | Sankyo Co Ltd | スルホンアミド化合物 |
KR20060114376A (ko) | 2004-01-30 | 2006-11-06 | 니뽄 다바코 산교 가부시키가이샤 | 식욕 감퇴 화합물 |
JP4787529B2 (ja) | 2004-04-09 | 2011-10-05 | 大塚製薬株式会社 | 医薬組成物 |
CA2572874A1 (en) | 2004-07-02 | 2006-01-12 | Sankyo Company Limited | Urea derivative |
GT200500208A (es) | 2004-08-03 | 2006-03-02 | Indazoles ùtiles para tratar enfermedades cardiovasculares | |
CN100360525C (zh) | 2004-09-16 | 2008-01-09 | 中国科学院上海药物研究所 | 一类新的噁唑烷酮衍生物、其制备方法和用途 |
AU2005286648A1 (en) | 2004-09-20 | 2006-03-30 | Xenon Pharmaceuticals Inc. | Heterocyclic derivatives and their use as stearoyl-CoA desaturase inhibitors |
GB0421908D0 (en) | 2004-10-01 | 2004-11-03 | Angeletti P Ist Richerche Bio | New uses |
CN101087769A (zh) | 2004-10-15 | 2007-12-12 | 拜尔药品公司 | 用于治疗肥胖的联苯-4-基-羰基氨基酸衍生物的制备及用途 |
EA013250B1 (ru) | 2004-10-22 | 2010-04-30 | Янссен Фармацевтика, Н.В. | Ингибиторы c-fms киназы |
MX2007007101A (es) * | 2004-12-14 | 2007-08-21 | Astrazeneca Ab | Derivados de oxadiazol como inhibidores de acil coa:diacilglicerol aciltransferasa. |
CA2586477A1 (en) | 2004-12-22 | 2006-06-29 | Janssen Pharmaceutica N.V. | Diacylglycerol acyltransferase assay |
GT200600046A (es) * | 2005-02-09 | 2006-09-25 | Terapia de combinacion | |
GB0505084D0 (en) | 2005-03-11 | 2005-04-20 | Glaxo Group Ltd | Compounds |
JP5140577B2 (ja) * | 2005-03-31 | 2013-02-06 | タケダ カリフォルニア インコーポレイテッド | ヒドロキシステロイドデヒドロゲナーゼ阻害剤 |
EP1869052A1 (en) | 2005-04-06 | 2007-12-26 | AstraZeneca AB | Substituted heterocycles and their use as chk1, pdk1 and pak inhibitors |
KR20080000652A (ko) | 2005-04-19 | 2008-01-02 | 바이엘 파마슈티칼스 코포레이션 | 아릴 알킬산 유도체 및 그의 용도 |
JP2008543747A (ja) * | 2005-06-11 | 2008-12-04 | アストラゼネカ アクチボラグ | Dgat阻害剤としてのオキサジアゾール誘導体 |
NZ565535A (en) | 2005-06-30 | 2011-03-31 | Ipsen Pharma Sas | GLP-1 pharmaceutical compositions |
JP2007131584A (ja) | 2005-11-11 | 2007-05-31 | Sankyo Co Ltd | 新規ベンゾオキサゾール誘導体 |
EP1966183A4 (en) * | 2005-12-20 | 2010-12-29 | Merck Frosst Canada Ltd | HETEROAROMATIC COMPOUNDS AS INHIBITORS OF STEAROYL-COENZYME A-DELTA-9-DESATURASE |
WO2007071966A1 (en) | 2005-12-22 | 2007-06-28 | Astrazeneca Ab | Pyrimido- [4, 5-b] -oxazines for use as dgat inhibitors |
EP1810974A1 (en) | 2006-01-18 | 2007-07-25 | Ludwig-Maximilians-Universität München | Preparation and use of magnesium amides |
US7569561B2 (en) | 2006-02-22 | 2009-08-04 | Boehringer Ingelheim International Gmbh | 2,4-diaminopyrimidines useful for treating cell proliferation diseases |
US7728031B2 (en) | 2006-02-24 | 2010-06-01 | Abbott Laboratories | Octahydro-pyrrolo[3,4-b]pyrrole derivatives |
US20090069304A1 (en) | 2006-03-03 | 2009-03-12 | Shionogi & Co., Ltd. | Mmp-13 selective inhibitor |
EP2041132A2 (en) | 2006-07-06 | 2009-04-01 | Boehringer Ingelheim International GmbH | New compounds |
EP1918285A1 (en) * | 2006-11-03 | 2008-05-07 | Merck Sante | Diazepane-acetamide derivatives as selective 11beta-HSD1 inhibitors |
GB0706793D0 (en) * | 2007-04-05 | 2007-05-16 | Evotec Ag | Compounds |
MX2009012285A (es) | 2007-05-22 | 2009-12-15 | Via Pharmaceuticals Inc | Inhibidores de diacilglicerol aciltransferasa. |
EP2152271B1 (en) | 2007-06-08 | 2015-10-21 | Janssen Pharmaceutica, N.V. | Piperidine/piperazine derivatives |
JP5464709B2 (ja) * | 2007-06-08 | 2014-04-09 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | ピペリジン/ピペラジン誘導体 |
AR066911A1 (es) * | 2007-06-08 | 2009-09-23 | Janssen Pharmaceutica Nv | Derivados de piperidina / piperazina |
JO2972B1 (en) | 2007-06-08 | 2016-03-15 | جانسين فارماسوتيكا ان. في | Piperidine / piperazine derivatives |
EP2296659B1 (en) | 2008-06-05 | 2016-12-21 | Janssen Pharmaceutica, N.V. | Drug combinations comprising a DGAT inhibitor and a PPAR-agonist |
-
2009
- 2009-06-03 EP EP09757551.8A patent/EP2296659B1/en active Active
- 2009-06-03 ES ES09757551.8T patent/ES2617619T3/es active Active
- 2009-06-03 PE PE2009000769A patent/PE20100083A1/es not_active Application Discontinuation
- 2009-06-03 CA CA2725933A patent/CA2725933C/en active Active
- 2009-06-03 UY UY0001031863A patent/UY31863A/es unknown
- 2009-06-03 WO PCT/EP2009/056800 patent/WO2009147170A2/en active Application Filing
- 2009-06-03 AU AU2009253892A patent/AU2009253892B2/en not_active Ceased
- 2009-06-03 PE PE2013002163A patent/PE20140572A1/es not_active Application Discontinuation
- 2009-06-03 US US12/993,491 patent/US9107946B2/en active Active
- 2009-06-03 JP JP2011512112A patent/JP5579170B2/ja active Active
- 2009-06-04 TW TW098118476A patent/TWI460175B/zh not_active IP Right Cessation
- 2009-06-04 AR ARP090102006A patent/AR073450A1/es unknown
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2015
- 2015-07-08 US US14/793,896 patent/US9724418B2/en active Active
-
2017
- 2017-06-20 US US15/627,475 patent/US20180028660A1/en not_active Abandoned
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AU2009253892B2 (en) | 2015-07-30 |
TW201014846A (en) | 2010-04-16 |
UY31863A (es) | 2010-01-05 |
PE20100083A1 (es) | 2010-02-17 |
CA2725933C (en) | 2018-01-16 |
US9724418B2 (en) | 2017-08-08 |
US20150320741A1 (en) | 2015-11-12 |
US20110112111A1 (en) | 2011-05-12 |
AR073450A1 (es) | 2010-11-10 |
EP2296659A2 (en) | 2011-03-23 |
JP2011522000A (ja) | 2011-07-28 |
AU2009253892A1 (en) | 2009-12-10 |
EP2296659B1 (en) | 2016-12-21 |
CA2725933A1 (en) | 2009-12-10 |
TWI460175B (zh) | 2014-11-11 |
US9107946B2 (en) | 2015-08-18 |
WO2009147170A2 (en) | 2009-12-10 |
US20180028660A1 (en) | 2018-02-01 |
ES2617619T3 (es) | 2017-06-19 |
JP5579170B2 (ja) | 2014-08-27 |
WO2009147170A3 (en) | 2010-06-10 |
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