CL2007001689A1 - Formas cristalinas sustancialmente puras de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida; composicion farmaceutica, util para tratar una enfermedad que responde a una inhibicion de la actividad de cinasa de prot - Google Patents

Formas cristalinas sustancialmente puras de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida; composicion farmaceutica, util para tratar una enfermedad que responde a una inhibicion de la actividad de cinasa de prot

Info

Publication number
CL2007001689A1
CL2007001689A1 CL200701689A CL2007001689A CL2007001689A1 CL 2007001689 A1 CL2007001689 A1 CL 2007001689A1 CL 200701689 A CL200701689 A CL 200701689A CL 2007001689 A CL2007001689 A CL 2007001689A CL 2007001689 A1 CL2007001689 A1 CL 2007001689A1
Authority
CL
Chile
Prior art keywords
methyl
substantiely
propenamide
indol
illness
Prior art date
Application number
CL200701689A
Other languages
English (en)
Inventor
Murat Bajwa Joginder Acemoglu
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=38832679&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CL2007001689(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of CL2007001689A1 publication Critical patent/CL2007001689A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/20—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C07D209/16—Tryptamines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/14—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/04—Indoles; Hydrogenated indoles
    • C07D209/10—Indoles; Hydrogenated indoles with substituted hydrocarbon radicals attached to carbon atoms of the hetero ring
    • C07D209/18—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D209/20—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals substituted additionally by nitrogen atoms, e.g. tryptophane

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Indole Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epidemiology (AREA)
CL200701689A 2006-06-12 2007-06-11 Formas cristalinas sustancialmente puras de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida; composicion farmaceutica, util para tratar una enfermedad que responde a una inhibicion de la actividad de cinasa de prot CL2007001689A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US80451706P 2006-06-12 2006-06-12
US88322407P 2007-01-03 2007-01-03

Publications (1)

Publication Number Publication Date
CL2007001689A1 true CL2007001689A1 (es) 2008-05-16

Family

ID=38832679

Family Applications (1)

Application Number Title Priority Date Filing Date
CL200701689A CL2007001689A1 (es) 2006-06-12 2007-06-11 Formas cristalinas sustancialmente puras de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida; composicion farmaceutica, util para tratar una enfermedad que responde a una inhibicion de la actividad de cinasa de prot

Country Status (29)

Country Link
US (1) US7989494B2 (es)
EP (2) EP2086930A2 (es)
JP (3) JP2009540006A (es)
KR (4) KR20150082690A (es)
CN (1) CN102584673B (es)
AR (1) AR061297A1 (es)
AU (1) AU2007257881B2 (es)
BR (1) BRPI0712993A2 (es)
CA (1) CA2650263A1 (es)
CL (1) CL2007001689A1 (es)
CR (1) CR10440A (es)
EA (1) EA017984B1 (es)
EC (1) ECSP088976A (es)
GE (1) GEP20115175B (es)
GT (1) GT200800280A (es)
IL (1) IL195015A (es)
MA (1) MA30511B1 (es)
ME (1) ME00529B (es)
MX (1) MX2008015900A (es)
MY (1) MY149337A (es)
NI (1) NI200800306A (es)
NO (1) NO20090135L (es)
PE (1) PE20080852A1 (es)
PH (1) PH12012501725A1 (es)
SM (1) SMP200900001B (es)
TN (1) TNSN08495A1 (es)
TW (2) TWI515179B (es)
UY (1) UY30406A1 (es)
WO (1) WO2007146716A2 (es)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GEP20105125B (en) * 2006-06-12 2010-11-25 Novartis Ag Salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl) ethyl] amino] methyl] phenyl]-2e-2-propenamide
RU2009130457A (ru) * 2007-01-10 2011-02-20 Новартис АГ (CH) Составы ингибиторов дезацетилазы
WO2017032281A1 (zh) * 2015-08-21 2017-03-02 苏州晶云药物科技有限公司 帕比司他乳酸盐的新晶型
CN106866491B (zh) * 2015-12-10 2021-12-10 江苏豪森药业集团有限公司 帕比司他乳酸盐晶型ⅰ及其制备方法和用途
CN106866492B (zh) * 2015-12-10 2021-11-26 江苏豪森药业集团有限公司 帕比司他乳酸盐晶型ii及其制备方法和用途
WO2018092151A1 (en) * 2016-11-21 2018-05-24 Msn Laboratories Private Limited, R&D Center Process for the preparation of 2-(e)-n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl) ethyl]amino]methyl]phenyl]-2-propenamide 2-hydroxypropanoic acid (1:1) and its polymorphs thereof
WO2018163114A1 (en) * 2017-03-10 2018-09-13 Shilpa Medicare Limited Amorphous panobinostat and its lactate salt
US10537585B2 (en) 2017-12-18 2020-01-21 Dexcel Pharma Technologies Ltd. Compositions comprising dexamethasone
CA3150303A1 (en) * 2019-08-20 2021-02-25 Ono Pharmaceutical Co., Ltd. Salt and crystal form of compound having agonistic activity to s1p5 receptor
GB201913121D0 (en) 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913124D0 (en) 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma
GB201913122D0 (en) 2019-09-11 2019-10-23 Seald As Compositions and methods for treatment of cholangiocarcinoma

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PE20020354A1 (es) * 2000-09-01 2002-06-12 Novartis Ag Compuestos de hidroxamato como inhibidores de histona-desacetilasa (hda)
NZ544689A (en) 2001-11-06 2007-08-31 Novartis Ag Cyclooxygenase-2 inhibitor/histone deacetylase inhibitor combination
US20050227300A1 (en) 2001-12-07 2005-10-13 Atadja Peter W Use of alpha-tubulin acetylation levels as a biomarker for protein deacetylase inhibitors
AU2004241729A1 (en) 2003-05-21 2004-12-02 Novartis Ag Combination of histone deacetylase inhibitors with chemotherapeutic agents
WO2005013958A1 (en) 2003-08-07 2005-02-17 Novartis Ag Histone deacetylase inhibitors as immunosuppressants
US20080085902A1 (en) 2003-09-23 2008-04-10 Guido Bold Combination Of A Vegf Receptor Inhibitor Or With A Chemotherapeutic Agent
GEP20105125B (en) 2006-06-12 2010-11-25 Novartis Ag Salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3-yl) ethyl] amino] methyl] phenyl]-2e-2-propenamide

Also Published As

Publication number Publication date
WO2007146716A3 (en) 2009-07-30
SMP200900001B (it) 2010-03-01
EP2409967A1 (en) 2012-01-25
JP2013139476A (ja) 2013-07-18
KR20140142335A (ko) 2014-12-11
CR10440A (es) 2011-08-22
CA2650263A1 (en) 2007-12-21
AU2007257881B2 (en) 2011-06-16
GEP20115175B (en) 2011-03-10
TW200815344A (en) 2008-04-01
PH12012501725A1 (en) 2015-07-06
EA017984B1 (ru) 2013-04-30
TWI453196B (zh) 2014-09-21
CN102584673A (zh) 2012-07-18
BRPI0712993A2 (pt) 2012-04-17
JP2009540006A (ja) 2009-11-19
US20090192210A1 (en) 2009-07-30
ME00529B (me) 2011-10-10
SMAP200900001A (it) 2009-01-14
EP2086930A2 (en) 2009-08-12
JP2015164968A (ja) 2015-09-17
MA30511B1 (fr) 2009-06-01
IL195015A (en) 2014-03-31
GT200800280A (es) 2015-11-24
UY30406A1 (es) 2008-01-31
WO2007146716A2 (en) 2007-12-21
NO20090135L (no) 2009-03-12
MY149337A (en) 2013-08-30
IL195015A0 (en) 2009-08-03
AR061297A1 (es) 2008-08-20
PE20080852A1 (es) 2008-08-19
ECSP088976A (es) 2009-01-30
TW201441190A (zh) 2014-11-01
AU2007257881A1 (en) 2007-12-21
KR20160032264A (ko) 2016-03-23
MX2008015900A (es) 2009-03-06
CN102584673B (zh) 2014-08-06
NI200800306A (es) 2012-02-01
TWI515179B (zh) 2016-01-01
EA200802383A1 (ru) 2010-02-26
KR20150082690A (ko) 2015-07-15
US7989494B2 (en) 2011-08-02
KR20090015968A (ko) 2009-02-12
TNSN08495A1 (en) 2010-04-14

Similar Documents

Publication Publication Date Title
CL2007001689A1 (es) Formas cristalinas sustancialmente puras de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida; composicion farmaceutica, util para tratar una enfermedad que responde a una inhibicion de la actividad de cinasa de prot
BRPI0810893A2 (pt) Uso de inibidor de tnf-alfa a um anti-histamínico para tratar rinite alérgica e conjuntivite, e composição farmacêutica compreendendo os referidos compostos.
CL2007001692A1 (es) Sal de n-hidroxi-3-[4-[[[2-(2-metil-1h-indol-3-il)etil]amino]metil]fenil]-2e-2-propenamida; composicion farmaceutica, util para tratar una enfermedad que responde a una inhibicion de la actividad de cinasa de proteina.
PE20100083A1 (es) Combinaciones de drogas que comprenden un inhibidor de dgat y un agonista de ppar
BRPI0716838A2 (pt) combinaÇÕes de inibidores de histona deacetilase especÍfica de classe i com inibidores de proteosome
CL2007002930A1 (es) Un compuesto 4-[4-({[4-cloro-3-(trifluorometil)fenil]carbamoil}amino)-3-fluorofenoxi]-n-metilpiridin-2-carboxamida monohidratado; proceso de preparacion; composicion y combinacion farmaceutica; y uso para el tratamiento de trastornos hiperproliferati
DK2332909T3 (da) Hydroxybenzamidderivater og deres anvendelse som inhibitorer af hsp90
SI2004607T1 (sl) Derivati (4-(4-(6-trifluorometil-piridin-3-ilamino)-N-vsebujoče-heteroaril)- fenil)-cikloheksil)-ocetne kisline in farmacevtske uporabe le-teh
NO20092535L (no) Fumaratsalt av (alfa S, beta R)-6-brom-alfa-[2-(dimetylamino)etyl]-2-metoksy-alfa-1-naftalenyl-beta-fenyl-3-kinolinetanol
CL2007000918A1 (es) Compuestos derivados de enfumafungina, inhibidores de (1,3)-beta-d-glucanosintetasa; composicion farmaceutica; y uso para tratar una infeccion fungica.
HK1126495A1 (en) Process for making salts of n-hydroxy-3-[4-[[[2-(2-methyl-1h-indol-3- yl)ethyl]amino]methyl]phenyl]-2e-2-propenamide n--3-[4-[[[2-(2--1h--3-)]]]]-2e-2-
SV2010003529A (es) Composicion de zibotentan que contiene manitol y/o celulosa microcristalina
CL2007002329A1 (es) Compuestos derivados de 5,6-bisaril-2-piridin carboxamida, inhibidores de urotensina ii; procedimiento de preparacion; composicion farmaceutica que comprende a dichos compuestos; y su uso para tratar y/o prevenir insuficiencia cardiaca congestiva, is
BRPI0809288A2 (pt) Formulações farmacêuticas auto-precipitação para a liberação modificada de um princípio ativo
DK2094699T3 (da) Hidtil ukendte imidazolonderivater, fremstilling deraf som lægemidler, farmaceutiske præparater og anvendelse deraf som hæmmere af proteinkinaser, især cdc7
ZA200809651B (en) Process for making salts of N-hydroxy-3[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamide
ZA200809383B (en) Salts of n-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl] amino]methyl]phenyl]-2E-2propenamide
CL2007002817A1 (es) Modificacion cristalina del compuesto 4-{[(6-cloropirid-3-il)metil](metil)amino}furano-2(5h)-ona; composicion; uso de dicho compuesto; y procedimiento para combatir insectos indeseados.
AR063895A1 (es) Utilizacion de la agomelatina para la obtencion de medicamentos destinados al tratamiento de la leucomalacia periventricular
NO20091862L (no) N-(3-bensyl) -2, 2- (bis-fenyl) - propan-1-amin derivativer som CETP inhibitorer for behandlingen av atherosclerose and cardiovaskulaere sykdommer
BRPI0924198A2 (pt) combinação de ingredientes ativos contendo um fármaco anti-inflamtório não esteroidal e um derivado de colchicosida
DK2032533T3 (da) Fremgangsmåde til fremstilling af N-hydroxy-3-[4-[[[2-(2-methyl-1H-indol-3-yl)ethyl]amino]methyl]phenyl]-2E-2-propenamid samt udgangsmaterialer dertil
CY1117493T1 (el) Αλατα του ν-υδροξυ-3-[4-[[[2-(2-μεθυλ-1η-ινδολ-3-υλ)αιθυλ]αμινο]μεθυλο]φαινυλο]-2ε-2-προπεναμιδιου
CL2007002102A1 (es) Uso de pramipexol y meloxicam para tratar el dolor; y composicion farmaceutica que los comprende.
AR057933A1 (es) Composicion farmaceutica despigmentante que comprende n-(2-((3-(4- bromofenil)- 2- propenil ) amino) etil) -5- isoquinolinsulfonamida (h89)