EP0871444A4 - 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use - Google Patents

2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use

Info

Publication number
EP0871444A4
EP0871444A4 EP96928099A EP96928099A EP0871444A4 EP 0871444 A4 EP0871444 A4 EP 0871444A4 EP 96928099 A EP96928099 A EP 96928099A EP 96928099 A EP96928099 A EP 96928099A EP 0871444 A4 EP0871444 A4 EP 0871444A4
Authority
EP
European Patent Office
Prior art keywords
compounds
methods
substituted aryl
compositions containing
aryl pyrroles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96928099A
Other languages
German (de)
French (fr)
Other versions
EP0871444A1 (en
Inventor
Laszlo Stephen E De
Nathan B Mantlo
Gerald S Ponticello
Harold G Selnick
Nigel J Liverton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9607253.3A external-priority patent/GB9607253D0/en
Priority claimed from GBGB9608472.8A external-priority patent/GB9608472D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0871444A1 publication Critical patent/EP0871444A1/en
Publication of EP0871444A4 publication Critical patent/EP0871444A4/en
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
EP96928099A 1995-08-10 1996-08-06 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use Withdrawn EP0871444A4 (en)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US209495P 1995-08-10 1995-08-10
US2094 1995-08-10
US1418296P 1996-03-26 1996-03-26
US14182 1996-03-26
GB9607253 1996-04-04
GBGB9607253.3A GB9607253D0 (en) 1996-04-04 1996-04-04 2,5-Substituted aryl pyrroles, compositions containing such compounds of use
GB9608472 1996-04-25
GBGB9608472.8A GB9608472D0 (en) 1996-04-25 1996-04-25 2,5-Substituted aryl pyrroles,compositions containing such compounds and methods of use
PCT/US1996/012922 WO1997005878A1 (en) 1995-08-10 1996-08-06 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use

Publications (2)

Publication Number Publication Date
EP0871444A1 EP0871444A1 (en) 1998-10-21
EP0871444A4 true EP0871444A4 (en) 1999-01-13

Family

ID=27451430

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96928099A Withdrawn EP0871444A4 (en) 1995-08-10 1996-08-06 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use

Country Status (5)

Country Link
EP (1) EP0871444A4 (en)
JP (1) JPH11510511A (en)
AU (1) AU699148B2 (en)
CA (1) CA2228050A1 (en)
WO (1) WO1997005878A1 (en)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
US7772432B2 (en) 1991-09-19 2010-08-10 Astrazeneca Ab Amidobenzamide derivatives which are useful as cytokine inhibitors
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
BR9710352A (en) * 1996-07-11 1999-08-17 Pfizer Pyridylpyrrole compounds
AU7132998A (en) * 1997-04-24 1998-11-13 Ortho-Mcneil Corporation, Inc. Substituted pyrrolopyridines useful in the treatment of inflammatory diseases
CN100443481C (en) 1997-06-12 2008-12-17 艾文蒂斯药品有限公司 Imidazolyl-cyclic acetals
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
IL134723A0 (en) 1997-09-23 2001-04-30 Zeneca Ltd Amide derivatives for the treatment of diseases mediated by cytokines
KR100378937B1 (en) 1997-10-20 2003-05-09 에프. 호프만-라 로슈 아게 Bicyclic kinase inhibitors
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
CN1285830A (en) * 1997-11-14 2001-02-28 三共株式会社 Pyridylpyrrole derivatives
CA2307111C (en) 1997-11-19 2009-06-30 Kowa Co., Ltd. Novel pyridazine derivatives and drugs containing the same as the active ingredient
US6174901B1 (en) 1998-12-18 2001-01-16 Amgen Inc. Substituted pyridine and pyridazine compounds and methods of use
HUP0101099A3 (en) * 1997-12-19 2002-09-30 Amgen Inc Thousand Oaks Substituted pyridine and pyridazine compounds and their pharmaceutical use
EP1037639A4 (en) 1997-12-19 2002-04-17 Smithkline Beecham Corp Compounds of heteroaryl substituted imidazole, their pharmaceutical compositions and uses
PL197181B1 (en) 1998-05-15 2008-03-31 Astrazeneca Ab Benzamide derivatives for the treatment of diseases mediated by cytokines
NZ507144A (en) 1998-05-15 2002-10-25 Astrazeneca Ab Benzamide derivatives useful for the treatment of diseases mediated by cytokines
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
EP1102750A1 (en) 1998-08-04 2001-05-30 AstraZeneca AB Amide derivatives useful as inhibitors of the production of cytokines
RU2219171C2 (en) 1998-09-25 2003-12-20 Астразенека Аб Derivatives of amide, method for their preparing and pharmaceutical composition based on thereof
US6593333B1 (en) 1998-10-01 2003-07-15 Astrazeneca Ab Substituted anilino-quinazoline (or quinoline) compounds and use thereof
EP1119254A4 (en) 1998-10-07 2004-05-12 Smithkline Beecham Corp Novel treatment for stroke management
JP2002528506A (en) 1998-11-04 2002-09-03 スミスクライン・ビーチャム・コーポレイション Pyridin-4-yl or pyrimidin-4-yl substituted pyrazine
JP2000247959A (en) 1999-02-26 2000-09-12 Kowa Co Pyridazin-3-one derivative, and drug containing the same
IL145357A0 (en) 1999-03-17 2002-06-30 Astrazeneca Ab Amide derivatives
AU4315100A (en) * 1999-04-28 2000-11-17 Sankyo Company Limited Preventive or inhibitory agents for hepatopathy
DK1178981T3 (en) 1999-05-14 2003-09-29 Ortho Mcneil Pharm Inc Substituted 3-pyridyl-4-aryl pyrrols and their therapeutic and prophylactic uses
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
JP2003512467A (en) * 1999-10-27 2003-04-02 ノバルティス アクチエンゲゼルシャフト Thiazole and imidazo (4,5-b) pyridine compounds and their pharmaceutical use
US6982270B1 (en) 1999-11-23 2006-01-03 Smithkline Beecham Corporation 3,4-dihydro-(1H)quinazolin-2-one compounds as CSBP/p38 kinase inhibitors
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
EP1233951B1 (en) 1999-11-23 2005-06-01 SmithKline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p38 kinase inhibitors
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6664256B1 (en) 2000-07-10 2003-12-16 Kowa Co., Ltd. Phenylpyridazine compounds and medicines containing the same
EP1352906A4 (en) * 2001-01-18 2004-06-16 Sankyo Co Compositions for prevention or treatment of hepatopathy
WO2002057255A1 (en) * 2001-01-22 2002-07-25 Sankyo Company, Limited 4- or 5-substituted pyrrole derivatives
EG23054A (en) * 2001-01-22 2004-02-29 Sankyo Co Pyrrole derivatives their preparation and their therapeutic uses
MY130778A (en) * 2001-02-09 2007-07-31 Vertex Pharma Heterocyclic inhibitiors of erk2 and uses thereof
GB0112348D0 (en) 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
WO2003022832A1 (en) * 2001-09-05 2003-03-20 Smithkline Beecham P.L.C. Pyridylfurans and pyrroles as raf kinase inhibitors
PL376056A1 (en) * 2002-09-27 2005-12-12 Janssen Pharmaceutica N.V. 3,4-disubstituted pyrroles and their for use in treating inflammatory diseases
US7211577B2 (en) 2003-03-18 2007-05-01 Kowa Co., Ltd. Water-soluble phenylpyridazine derivative and medicine containing the same
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
CA2687912C (en) 2007-06-08 2015-11-03 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
CA2687754C (en) 2007-06-08 2015-12-08 Janssen Pharmaceutica N.V. Piperidine, piperazine derivatives for use as dgat inhibitors
US8633197B2 (en) 2007-06-08 2014-01-21 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine/Piperazine derivatives
UY31863A (en) 2008-06-05 2010-01-05 Janssen Pharmaceutica Nv DRUG COMBINATIONS UNDERSTANDING A DGAT INHIBITOR AND A PPAR AGONIST
US8088817B2 (en) * 2008-08-25 2012-01-03 Santen Pharmaceutical Co., Ltd. Pyrrole derivative having, as substituents, ureido group, aminocarbonly group and bicyclic group which may have substituent
EA025493B1 (en) * 2011-05-17 2016-12-30 Акционерное Общество "Фармасинтез" Compounds, pharmaceutical compositions and a method for the prophylaxis and treatment of the adhesion process
CN102863371B (en) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 Fluoro pyrrolin or fluoro pyrroles
CN111662239B (en) * 2019-03-06 2023-07-28 中国医学科学院药物研究所 1,2, 4-triazole compound, preparation method and pharmaceutical application thereof
CN113354616B (en) * 2020-03-05 2024-03-26 中国医学科学院药物研究所 Diaryl-1, 2, 4-triazole compound and preparation method and pharmaceutical application thereof
CN114394934B (en) * 2022-01-06 2023-06-13 苏州大学 Pyrazole benzamide compound as well as preparation method and application thereof

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016441A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016441A1 (en) * 1995-10-31 1997-05-09 Merck & Co., Inc. Substituted aryl pyrroles, compositions containing such compounds and methods of use

Non-Patent Citations (8)

* Cited by examiner, † Cited by third party
Title
CHEMICAL ABSTRACTS, vol. 124, no. 19, 6 May 1996, Columbus, Ohio, US; abstract no. 260752x, J. LEHUEDE ET AL: "Preparation of 1H-2,3,4,5-tetraarylpyrroles by oxidation of heterocyclic imine-enamines" page 1241; XP002084087 *
D. BHATTACHARJEE ET AL: "Reissert compound studies. XXXV. Acid-catalyzed condensations of the phthalazine Reissert compound and condensations of phthalazine Reissert compound salt", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 17, 1980, PROVO US, pages 1035 - 1040, XP002084079 *
D. M. PERRINE ET AL: "Four novel phenyldithienoindole isomers from the oxidative photocyclization of dithienylpyrroles", JOURNAL OF ORGANIC CHEMISTRY, vol. 52, no. 11, 1987, EASTON US, pages 2213 - 2216, XP002084077 *
H. STETTER ET AL: "Addition von Aldehyden an aktivierte Doppelbindungen. XV (1. Synthese von gamma-Diketonen mit heterocyclischen Substituenteh und deren Umsetzung zu N-Methylpyrrolen und Chinolizidin bzw. Indolizidin Systemen", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 14, 1977, PROVO US, pages 573 - 581, XP002084080 *
K. T. POTTS ET AL: "The pyrrolo(3,4-c)pyrazole system, a new 10pi-electron heteropentalene", JOURNAL OF ORGANIC CHEMISTRY, vol. 44, no. 4, 1979, EASTON US, pages 622 - 626, XP002084076 *
See also references of WO9705878A1 *
SYNTH. COMMUN., vol. 26, no. 4, 1996, pages 793 - 802 *
V. GIRIDHAR ET AL: "Base and acid-catalyzed condensation reactions of Resissert compounds with vinylpyridines", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 8, 1971, PROVO US, pages 121 - 123, XP002084078 *

Also Published As

Publication number Publication date
WO1997005878A1 (en) 1997-02-20
JPH11510511A (en) 1999-09-14
EP0871444A1 (en) 1998-10-21
AU699148B2 (en) 1998-11-26
AU6769196A (en) 1997-03-05
CA2228050A1 (en) 1997-02-20

Similar Documents

Publication Publication Date Title
EP0871444A4 (en) 2,5-substituted aryl pyrroles, compositions containing such compounds and methods of use
EP0859771A4 (en) Substituted pyridyl pyrroles, compositions containing such compounds and methods of use
AU7482396A (en) Substituted aryl pyrroles, compositions containing such compounds and methods of use
IL116455A0 (en) Imidazole compounds and pharmaceutical compositions containing them
IL117294A0 (en) Organosilicon compounds and compositions containing them
IL116957A0 (en) Substituted heterocyclic compounds their preparation and pharmaceutical compositions containing them
AU6613996A (en) Heterocyclic compounds and pharmaceutical compositions containing them
PL328771A1 (en) Derivatives of 4-aminopyrimidine, therapeutic agents containing such compounds, their application and method of obtaining such compounds
IL136937A0 (en) τ-GLUTAMYL AND β-ASPARTYL CONTAINING COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME
AP9701160A0 (en) Compounds and pharmaceutical compositions containing them
EG22151A (en) Biocidal compositions comprising mixtures of halopropynyl compounds and sulfur containing triazines
AU7529096A (en) Substituted aryl pyrroles, compositions containing such compounds and methods of use
HUP9901452A3 (en) Bicyclic-aromatic compounds and pharmaceutical compositions containing them
IL117620A0 (en) Heterocyclic compounds processes for the preparation thereof and pharmaceutical compositions containing the same
ZA961779B (en) Aromatic heterocyclic compounds pharmaceutical and cosmetic compositions containing them and uses thereof
IL118221A0 (en) Substituted cephalosporins and pharmaceutical compositions containing them
PL319163A1 (en) Inhibitors of 5 alpha-reductase
AU7961498A (en) 9a-azalides, compositions containing such compounds and methods of treatment
PL324588A1 (en) Novel compounds-substituted piperydinodiones-2,6, method of obtaining them and drug containing such compounds
AU7986098A (en) 9a-aza-3-ketolides, compositions containing such compounds and methods of treatment
GB9814269D0 (en) 9a-Aza-3-ketolides, compositions containing such compounds and methods of treatment
IL123424A0 (en) Heterocyclic compounds their preparation and pharmaceutical compositions containing them
PL326581A1 (en) Herbicidal 3,5-difluoropyridines, method of obtaining them and herbicidal composition containing such compounds
GB9608472D0 (en) 2,5-Substituted aryl pyrroles,compositions containing such compounds and methods of use
PL319070A1 (en) Derivatives of 1,25-dihydroxy-16,22,23-trisdehyrochoecalcifero, method of obtaining them and compositions containing such derivatives

Legal Events

Date Code Title Description
PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

17P Request for examination filed

Effective date: 19980310

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

A4 Supplementary search report drawn up and despatched

Effective date: 19981130

AK Designated contracting states

Kind code of ref document: A4

Designated state(s): AT BE CH DE DK ES FI FR GB GR IE IT LI LU NL PT SE

17Q First examination report despatched

Effective date: 20000904

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAG Despatch of communication of intention to grant

Free format text: ORIGINAL CODE: EPIDOS AGRA

GRAH Despatch of communication of intention to grant a patent

Free format text: ORIGINAL CODE: EPIDOS IGRA

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE APPLICATION IS DEEMED TO BE WITHDRAWN

18D Application deemed to be withdrawn

Effective date: 20020219