EP0871444A4 - Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation - Google Patents

Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation

Info

Publication number
EP0871444A4
EP0871444A4 EP96928099A EP96928099A EP0871444A4 EP 0871444 A4 EP0871444 A4 EP 0871444A4 EP 96928099 A EP96928099 A EP 96928099A EP 96928099 A EP96928099 A EP 96928099A EP 0871444 A4 EP0871444 A4 EP 0871444A4
Authority
EP
European Patent Office
Prior art keywords
compounds
methods
substituted aryl
compositions containing
aryl pyrroles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Withdrawn
Application number
EP96928099A
Other languages
German (de)
English (en)
Other versions
EP0871444A1 (fr
Inventor
Laszlo Stephen E De
Nathan B Mantlo
Gerald S Ponticello
Harold G Selnick
Nigel J Liverton
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9607253.3A external-priority patent/GB9607253D0/en
Priority claimed from GBGB9608472.8A external-priority patent/GB9608472D0/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of EP0871444A1 publication Critical patent/EP0871444A1/fr
Publication of EP0871444A4 publication Critical patent/EP0871444A4/fr
Withdrawn legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Immunology (AREA)
  • Communicable Diseases (AREA)
  • Cardiology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
EP96928099A 1995-08-10 1996-08-06 Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation Withdrawn EP0871444A4 (fr)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US209495P 1995-08-10 1995-08-10
US2094 1995-08-10
US1418296P 1996-03-26 1996-03-26
US14182 1996-03-26
GB9607253 1996-04-04
GBGB9607253.3A GB9607253D0 (en) 1996-04-04 1996-04-04 2,5-Substituted aryl pyrroles, compositions containing such compounds of use
GB9608472 1996-04-25
GBGB9608472.8A GB9608472D0 (en) 1996-04-25 1996-04-25 2,5-Substituted aryl pyrroles,compositions containing such compounds and methods of use
PCT/US1996/012922 WO1997005878A1 (fr) 1995-08-10 1996-08-06 Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation

Publications (2)

Publication Number Publication Date
EP0871444A1 EP0871444A1 (fr) 1998-10-21
EP0871444A4 true EP0871444A4 (fr) 1999-01-13

Family

ID=27451430

Family Applications (1)

Application Number Title Priority Date Filing Date
EP96928099A Withdrawn EP0871444A4 (fr) 1995-08-10 1996-08-06 Pyrroles d'aryle substitues en position 2 et 5, compositions contenant de tels composes et leurs modes d'utilisation

Country Status (5)

Country Link
EP (1) EP0871444A4 (fr)
JP (1) JPH11510511A (fr)
AU (1) AU699148B2 (fr)
CA (1) CA2228050A1 (fr)
WO (1) WO1997005878A1 (fr)

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US7772432B2 (en) 1991-09-19 2010-08-10 Astrazeneca Ab Amidobenzamide derivatives which are useful as cytokine inhibitors
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
US5916891A (en) 1992-01-13 1999-06-29 Smithkline Beecham Corporation Pyrimidinyl imidazoles
US6046208A (en) * 1996-01-11 2000-04-04 Smithkline Beecham Corporation Substituted imidazole compounds
EP0912548A1 (fr) 1996-07-11 1999-05-06 Pfizer Inc. Composes de pyridylpyrrole utiles comme antagonistes de l'interleukine et du facteur tnf
WO1998047899A1 (fr) * 1997-04-24 1998-10-29 Ortho-Mcneil Corporation, Inc. Pyrrolopyridines substituees utilisees dans le traitement des maladies inflammatoires
CZ9904452A3 (cs) 1997-06-12 2002-02-13 Rhone-Poulenc Rorer Limited Cyklické acetaly imidazolylu, způsob jejich přípravy, jejich pouľití a farmaceutický prostředek, který je obsahuje
US7301021B2 (en) 1997-07-02 2007-11-27 Smithkline Beecham Corporation Substituted imidazole compounds
WO1999015164A1 (fr) 1997-09-23 1999-04-01 Zeneca Limited Derives amide pour le traitement de maladies induites par les cytokines
CN1279682A (zh) * 1997-10-20 2001-01-10 霍夫曼-拉罗奇有限公司 双环激酶抑制剂
US6022884A (en) 1997-11-07 2000-02-08 Amgen Inc. Substituted pyridine compounds and methods of use
AU1053399A (en) * 1997-11-14 1999-06-07 Sankyo Company Limited Pyridylpyrrole derivatives
CA2307111C (fr) 1997-11-19 2009-06-30 Kowa Co., Ltd. Nouveaux derives de pyridazine et medicaments contenant ces composes comme principe actif
AU755421B2 (en) * 1997-12-19 2002-12-12 Amgen, Inc. Substituted pyridine and pyridazine compounds and their pharmaceutical use
AR017219A1 (es) 1997-12-19 2001-08-22 Smithkline Beecham Corp Derivados de imidazol 1,4,5 sustituidos, composiciones que los comprenden, procedimiento para la preparacion de dichos derivados, uso de los derivados parala manufactura de un medicamento
US6174901B1 (en) 1998-12-18 2001-01-16 Amgen Inc. Substituted pyridine and pyridazine compounds and methods of use
PT1077930E (pt) 1998-05-15 2005-03-31 Astrazeneca Ab Derivados de benzamida para o tratamento de doencas mediadas por citocinas
SK286123B6 (sk) 1998-05-15 2008-04-07 Astrazeneca Ab Benzamidové deriváty, spôsob ich prípravy, farmaceutická kompozícia a ich použitie na prípravu liečiva na liečenie chorôb sprostredkovaných cytokínmi
US6858617B2 (en) 1998-05-26 2005-02-22 Smithkline Beecham Corporation Substituted imidazole compounds
JP2002522421A (ja) * 1998-08-04 2002-07-23 アストラゼネカ アクチボラグ サイトカイン産生の阻害剤として有用なアミド誘導体
ID28267A (id) 1998-09-25 2001-05-10 Astrazeneca Ab Turunan benzamida dan penggunaannya sebagai inhibitor sitokina
EP1117653B1 (fr) 1998-10-01 2003-02-05 AstraZeneca AB Derives quinoline et quinazoline et leur utilisation comme inhibiteurs de maladies dans lesquelles la cytokine intervient
EP1119254A4 (fr) 1998-10-07 2004-05-12 Smithkline Beecham Corp Nouveau traitement pour la gestion des accidents vasculaires cerebraux
DE69914357T2 (de) 1998-11-04 2004-11-11 Smithkline Beecham Corp. Pyridin-4-yl oder pyrimidin-4-yl substituierte pyrazine
JP2000247959A (ja) 1999-02-26 2000-09-12 Kowa Co ピリダジン−３−オン誘導体及びこれを含有する医薬
BR0009083B1 (pt) 1999-03-17 2011-11-01 derivado de amida compreendendo um núcleo de quinazolinona, processo para a preparação de um derivado de amida, composição farmacêutica, e, uso de um derivado de amida.
AU4315100A (en) * 1999-04-28 2000-11-17 Sankyo Company Limited Preventive or inhibitory agents for hepatopathy
WO2000069847A1 (fr) * 1999-05-14 2000-11-23 Ortho-Mcneil Pharmaceutical, Inc. 3-pyridyle-4-arylpyrroles substitues et methodes prophylactiques et therapeutiques associees
US7122666B2 (en) 1999-07-21 2006-10-17 Sankyo Company, Limited Heteroaryl-substituted pyrrole derivatives, their preparation and their therapeutic uses
ES2254238T3 (es) * 1999-10-27 2006-06-16 Novartis Ag Compuestos de tiazol e imidazo(4,5-b)piridina y su uso farmaceutico.
US6759410B1 (en) 1999-11-23 2004-07-06 Smithline Beecham Corporation 3,4-dihydro-(1H)-quinazolin-2-ones and their use as CSBP/p38 kinase inhibitors
AU1782301A (en) 1999-11-23 2001-06-04 Smithkline Beecham Corporation 3,4-dihydro-(1h)quinazolin-2-one compounds as csbp/p39 kinase inhibitors
ES2241675T3 (es) 1999-11-23 2005-11-01 Smithkline Beecham Corporation Compuestos de 3,4-dihidro-(1h)quinazolin-2-ona como inhibidores de cspb/p38 quinasa.
US7235551B2 (en) 2000-03-02 2007-06-26 Smithkline Beecham Corporation 1,5-disubstituted-3,4-dihydro-1h-pyrimido[4,5-d]pyrimidin-2-one compounds and their use in treating csbp/p38 kinase mediated diseases
US6664256B1 (en) 2000-07-10 2003-12-16 Kowa Co., Ltd. Phenylpyridazine compounds and medicines containing the same
CA2435141A1 (fr) * 2001-01-18 2002-07-25 Sankyo Company, Limited Compositions destinees a la prevention et au traitement de l'hepatopathie
EG23054A (en) * 2001-01-22 2004-02-29 Sankyo Co Pyrrole derivatives their preparation and their therapeutic uses
WO2002057255A1 (fr) * 2001-01-22 2002-07-25 Sankyo Company, Limited Derives du pyrrole substitues en 4 ou 5
MY130778A (en) 2001-02-09 2007-07-31 Vertex Pharma Heterocyclic inhibitiors of erk2 and uses thereof
GB0112348D0 (en) 2001-05-19 2001-07-11 Smithkline Beecham Plc Compounds
JP2005505562A (ja) 2001-09-05 2005-02-24 スミスクライン　ビーチャム　パブリック　リミテッド　カンパニー Ｒａｆキナーゼ阻害剤としてのピリジルフランおよびピロール
WO2004029040A1 (fr) * 2002-09-27 2004-04-08 Janssen Pharmaceutica N.V. Pyrroles 3,4-disubstitues et utilisation de ceux-ci pour le traitement de maladies inflammatoires
CA2518227A1 (fr) 2003-03-18 2004-09-30 Kowa Co., Ltd Derive de phenylpyridazine soluble dans l'eau et medicament contenant ce derive
GB0324790D0 (en) 2003-10-24 2003-11-26 Astrazeneca Ab Amide derivatives
JO2972B1 (en) 2007-06-08 2016-03-15 جانسين فارماسوتيكا ان. في Piperidine / piperazine derivatives
CA2687912C (fr) 2007-06-08 2015-11-03 Janssen Pharmaceutica N.V. Derives de piperidine/piperazine
AU2008258487B2 (en) 2007-06-08 2012-11-15 Janssen Pharmaceutica N.V. Piperidine/piperazine derivatives
JP5464709B2 (ja) 2007-06-08 2014-04-09 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ ピペリジン／ピペラジン誘導体
AU2009253892B2 (en) 2008-06-05 2015-07-30 Janssen Pharmaceutica Nv Drug combinations comprising a DGAT inhibitor and a PPAR-agonist
EP2319831A4 (fr) * 2008-08-25 2012-10-24 Santen Pharmaceutical Co Ltd Nouveau dérivé de pyrrole ayant, en tant que substituants, un groupe uréide, un groupe aminocarbonyle et un groupe bicyclique qui peut avoir un substituant
SI2716684T1 (sl) * 2011-05-17 2019-11-29 Pharmasyntez Spojine za profilakso in postopek za zdravljenje adhezijskega postopka
CN102863371B (zh) * 2011-07-06 2016-04-13 中国科学院上海有机化学研究所 氟代二氢吡咯或氟代吡咯
CN111662239B (zh) * 2019-03-06 2023-07-28 中国医学科学院药物研究所 1,2,4-三唑类化合物及其制法和药物用途
CN113354616B (zh) * 2020-03-05 2024-03-26 中国医学科学院药物研究所 二芳基-1,2,4-三唑类化合物及其制法和药物用途
CN114394934B (zh) * 2022-01-06 2023-06-13 苏州大学 吡唑苯甲酰胺类化合物及其制备方法和应用

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016441A1 (fr) * 1995-10-31 1997-05-09 Merck & Co., Inc. Pyrroles aryliques de substitution, compositions renfermant de telles composes et methodes d'utilisation de ces substances

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997016441A1 (fr) * 1995-10-31 1997-05-09 Merck & Co., Inc. Pyrroles aryliques de substitution, compositions renfermant de telles composes et methodes d'utilisation de ces substances

Non-Patent Citations (8)

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Title
CHEMICAL ABSTRACTS, vol. 124, no. 19, 6 May 1996, Columbus, Ohio, US; abstract no. 260752x, J. LEHUEDE ET AL: "Preparation of 1H-2,3,4,5-tetraarylpyrroles by oxidation of heterocyclic imine-enamines" page 1241; XP002084087 *
D. BHATTACHARJEE ET AL: "Reissert compound studies. XXXV. Acid-catalyzed condensations of the phthalazine Reissert compound and condensations of phthalazine Reissert compound salt", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 17, 1980, PROVO US, pages 1035 - 1040, XP002084079 *
D. M. PERRINE ET AL: "Four novel phenyldithienoindole isomers from the oxidative photocyclization of dithienylpyrroles", JOURNAL OF ORGANIC CHEMISTRY, vol. 52, no. 11, 1987, EASTON US, pages 2213 - 2216, XP002084077 *
H. STETTER ET AL: "Addition von Aldehyden an aktivierte Doppelbindungen. XV (1. Synthese von gamma-Diketonen mit heterocyclischen Substituenteh und deren Umsetzung zu N-Methylpyrrolen und Chinolizidin bzw. Indolizidin Systemen", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 14, 1977, PROVO US, pages 573 - 581, XP002084080 *
K. T. POTTS ET AL: "The pyrrolo(3,4-c)pyrazole system, a new 10pi-electron heteropentalene", JOURNAL OF ORGANIC CHEMISTRY, vol. 44, no. 4, 1979, EASTON US, pages 622 - 626, XP002084076 *
See also references of WO9705878A1 *
SYNTH. COMMUN., vol. 26, no. 4, 1996, pages 793 - 802 *
V. GIRIDHAR ET AL: "Base and acid-catalyzed condensation reactions of Resissert compounds with vinylpyridines", JOURNAL OF HETEROCYCLIC CHEMISTRY., vol. 8, 1971, PROVO US, pages 121 - 123, XP002084078 *

Also Published As

Publication number Publication date
JPH11510511A (ja) 1999-09-14
WO1997005878A1 (fr) 1997-02-20
AU6769196A (en) 1997-03-05
EP0871444A1 (fr) 1998-10-21
CA2228050A1 (fr) 1997-02-20
AU699148B2 (en) 1998-11-26

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