ES2196332T3 - Derivados de hexahidro-pirido(4,3-b)indol como farmacos antipsicoticos. - Google Patents

Derivados de hexahidro-pirido(4,3-b)indol como farmacos antipsicoticos.

Info

Publication number
ES2196332T3
ES2196332T3 ES97924014T ES97924014T ES2196332T3 ES 2196332 T3 ES2196332 T3 ES 2196332T3 ES 97924014 T ES97924014 T ES 97924014T ES 97924014 T ES97924014 T ES 97924014T ES 2196332 T3 ES2196332 T3 ES 2196332T3
Authority
ES
Spain
Prior art keywords
6alkyl
hydrogen
pct
formula
date nov
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97924014T
Other languages
English (en)
Inventor
Ludo Edmond Josephine Kennis
Josephus Carolus Mertens
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Janssen Pharmaceutica NV
Original Assignee
Janssen Pharmaceutica NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica NV filed Critical Janssen Pharmaceutica NV
Application granted granted Critical
Publication of ES2196332T3 publication Critical patent/ES2196332T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Indole Compounds (AREA)

Abstract

LA INVENCION SE REFIERE A LOS COMPUESTOS DE FORMULA (I), A LAS SALES DE ADICION FARMACEUTICAMENTE ACEPTABLES Y A LAS FORMAS ESTEREOQUIMICAMENTE ISOMERAS DE LOS MISMOS, DONDE ALK ES ALCANODIILO C1-6 ; R1 ES HIDROGENO, ALQUILO C1-6 , RILO O ARILALQUILO C1-6 ; R2 , R3 Y R4 SE SELECCIONAN CADA UNO INDEPENDIENTEMENTE A PARTIR DE HIDROGENO, HALO, HIDROXILO, NITRO, CIANO, ALQUILO C1-6 , ALQUILOXI C1-6 , TRIFLUOROMETILO, ALQUILTIO C1-6 , MERCAPTO, AMINO, MONO - Y DI(ALQUIL C1-6)AMINO, CARBXILO, AL QUILOXICARBONILO C1-6 O ALQUILCARBONILO C1-6 ; R5 ES HIDROGENO, ALQUILO C1-6 , ALQUILOXI C1-6 , A LQUILTIO C1-6 , O UN RADICAL DE FORMULA - NR8 R9 , DONDE R8 Y R9 SE SELECCIONAN CADA UNO INDEPEND IENTEMENTE A PARTIR DE HIROGENO, ALQUILO C 1-6 , FENILO O FENILALQUILO C1-6 ; R7 ES HIDROGENO O ALQUILO C1-6 ; O R6 Y R7 CONJUNTAMENTE PUEDEN FORMAR UN RA DICAL BIVALENTE DE FORMULA - R6-R7 -. DICHOS COMPUESTOS TIENEN ACTIVIDAD ANTAGONISTA CENTRAL DE DOPAMINA Y SEROTONINA. SE DESCRIBE ASIMISMO LA PREPARACION DE DICHOS COMPUESTOS, COMPOSICIONES QUE LOS CONTIENEN Y SU UTILIZACION COMO MEDICINA.
ES97924014T 1996-05-23 1997-05-15 Derivados de hexahidro-pirido(4,3-b)indol como farmacos antipsicoticos. Expired - Lifetime ES2196332T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP96201450 1996-05-23

Publications (1)

Publication Number Publication Date
ES2196332T3 true ES2196332T3 (es) 2003-12-16

Family

ID=8224021

Family Applications (1)

Application Number Title Priority Date Filing Date
ES97924014T Expired - Lifetime ES2196332T3 (es) 1996-05-23 1997-05-15 Derivados de hexahidro-pirido(4,3-b)indol como farmacos antipsicoticos.

Country Status (22)

Country Link
US (1) US6057325A (es)
EP (1) EP0902684B1 (es)
JP (1) JP2000510860A (es)
CN (1) CN1149996C (es)
AT (1) ATE236636T1 (es)
AU (1) AU714113B2 (es)
CA (1) CA2254755C (es)
CY (1) CY2381B1 (es)
CZ (1) CZ287961B6 (es)
DE (1) DE69720715T2 (es)
DK (1) DK0902684T3 (es)
ES (1) ES2196332T3 (es)
IL (1) IL127177A (es)
MY (1) MY125562A (es)
NO (1) NO311724B1 (es)
NZ (1) NZ332310A (es)
PL (1) PL187345B1 (es)
PT (1) PT902684E (es)
SI (1) SI0902684T1 (es)
TW (1) TW470745B (es)
WO (1) WO1997044040A1 (es)
ZA (1) ZA974470B (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1136493A1 (en) * 2000-03-23 2001-09-26 Sanofi-Synthelabo 2-(Thienopyridinyl)pyrimidone, 2-(furopyridinyl)pyrimidone 2-(isoquinolinyl)pyrimidone, 2-(pyridoindolyl)pyrimidone and 2-(benzofuropyridinyl)pyrimidone derivatives
CA2453537A1 (en) * 2001-08-08 2003-02-20 Pharmacia & Upjohn Company Therapeutic 1h-pyrido¬4,3-b|indoles
AU2003303210A1 (en) * 2002-12-19 2004-07-14 Bristol-Myers Squibb Company Substituted tricyclic gamma-carbolines as serotonin receptor agonists and antagonists
KR101168611B1 (ko) 2003-09-17 2012-08-03 얀센 파마슈티카 엔.브이. 세로토닌 수용체 조절자로서의 융합된 헤테로사이클릭 화합물
CN101318962A (zh) * 2003-09-17 2008-12-10 詹森药业有限公司 稠合杂环化合物
EP1944306A1 (en) * 2003-09-17 2008-07-16 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds as serotonin receptor modulators
AU2004283196B2 (en) * 2003-09-17 2011-08-25 Janssen Pharmaceutica, N.V. Fused heterocyclic compounds
RU2338537C2 (ru) * 2006-01-25 2008-11-20 Сергей Олегович Бачурин СРЕДСТВО ДЛЯ ЛЕЧЕНИЯ ШИЗОФРЕНИИ НА ОСНОВЕ ГИДРИРОВАННЫХ ПИРИДО(4,3-b)ИНДОЛОВ (ВАРИАНТЫ), ФАРМАКОЛОГИЧЕСКОЕ СРЕДСТВО НА ЕГО ОСНОВЕ И СПОСОБ ЕГО ПРИМЕНЕНИЯ
BRPI0815850A2 (pt) * 2007-08-01 2014-10-07 Medivation Neurology Inc "método para tratar, retardar a progressão, prevenir ou atrasar o desenvolvimento de esquizofrenia em um individuo, composiçã farmaceuticamente aceitável, kit e método para reforçar uma resposta de um individuo a um antipsicótico"
AU2009308708B2 (en) 2008-10-31 2015-11-19 Medivation Technologies, Inc. Azepino [4, 5-b] indoles and methods of use
US8907097B2 (en) 2008-10-31 2014-12-09 Medivation Technologies, Inc. Pyrido[4,3-b]indoles containing rigid moieties
JP2014505737A (ja) 2011-02-18 2014-03-06 メディベイション テクノロジーズ， インコーポレイテッド 糖尿病を処置する化合物および方法
US20150315188A1 (en) * 2012-08-22 2015-11-05 Medivation Technologies, Inc. Compounds and methods for treatment of hypertension

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR205452A1 (es) * 1973-12-06 1976-05-07 Endo Lab Metodo para preparar nuevos trans-2, 3, 4, 4a, 5, 9b-hexahidro-5-fenil-1h-pirido(4,3-b) indoles
US4337250A (en) * 1979-07-30 1982-06-29 Pfizer Inc. Hexahydro-trans- and tetrahydropyridoindole neuroleptic agents

Also Published As

Publication number Publication date
CA2254755C (en) 2007-01-16
IL127177A0 (en) 1999-09-22
NO311724B1 (no) 2002-01-14
CY2381B1 (en) 2004-06-04
AU2961697A (en) 1997-12-09
NO985389D0 (no) 1998-11-19
CZ377498A3 (cs) 1999-02-17
CN1149996C (zh) 2004-05-19
PL330079A1 (en) 1999-04-26
US6057325A (en) 2000-05-02
TW470745B (en) 2002-01-01
EP0902684B1 (en) 2003-04-09
DE69720715T2 (de) 2004-03-11
AU714113B2 (en) 1999-12-16
IL127177A (en) 2003-10-31
JP2000510860A (ja) 2000-08-22
WO1997044040A1 (en) 1997-11-27
PL187345B1 (pl) 2004-06-30
DE69720715D1 (en) 2003-05-15
NO985389L (no) 1999-01-20
ATE236636T1 (de) 2003-04-15
CA2254755A1 (en) 1997-11-27
EP0902684A1 (en) 1999-03-24
CN1219875A (zh) 1999-06-16
NZ332310A (en) 1999-08-30
ZA974470B (en) 1998-11-23
CZ287961B6 (cs) 2001-03-14
PT902684E (pt) 2003-08-29
SI0902684T1 (en) 2003-10-31
DK0902684T3 (da) 2004-03-29
MY125562A (en) 2006-08-30

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