HUP0201472A2 - HIV-integráz ellen gátló hatású heteroaromás származékok - Google Patents

HIV-integráz ellen gátló hatású heteroaromás származékok

Info

Publication number
HUP0201472A2
HUP0201472A2 HU0201472A HUP0201472A HUP0201472A2 HU P0201472 A2 HUP0201472 A2 HU P0201472A2 HU 0201472 A HU0201472 A HU 0201472A HU P0201472 A HUP0201472 A HU P0201472A HU P0201472 A2 HUP0201472 A2 HU P0201472A2
Authority
HU
Hungary
Prior art keywords
optionally substituted
group
general formula
aromatic heterocycle
hiv integrase
Prior art date
Application number
HU0201472A
Other languages
English (en)
Inventor
Toshio Fujishita
Akihiko Sato
Tomokazu Yoshinaga
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Publication of HUP0201472A2 publication Critical patent/HUP0201472A2/hu
Publication of HUP0201472A3 publication Critical patent/HUP0201472A3/hu

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Abstract

A találmány tárgyát az általános képletű vegyületek - ahol X hidroxi-,védett hidroxi- vagy adott esetben szubsztituált aminocsoport; Y -COORA általános képletű csoport; amelyben RA hidrogénatom,észtermaradék vagy -CONRBRC általános képletű csoport; amelyben RB ésRC egymástól függetlenül hidrogénatom vagy amidmaradék, adott esetbenszubsztituált aril- vagy adott esetben szubsztituáltheteroarilcsoport; és A1 adott esetben szubsztituáltheteroarilcsoport; azzal a fenntartással, hogy azokat a vegyületeket,amelyekben Y és/vagy A1 jelentése 3-indolil-csoport a találmányoltalmi köréből kizárják -és tautomereik, prodrugjaik,gyógyszerészetileg elfogadható sóik vagy hidrátjaik, ezeket tartalmazógyógyszerkészítmények és előállításuk, továbbá vírusos betegségekelleni alkalmazásuk képezi. Ó
HU0201472A 1998-12-25 1999-12-17 Aromatic heterocycle compounds having hiv integrase inhibiting activities HUP0201472A3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP37127098 1998-12-25
JP24747999 1999-09-01
PCT/JP1999/007101 WO2000039086A1 (fr) 1998-12-25 1999-12-17 Composes heterocycliques aromatiques possedant des activites inhibitrices de l'integrase du vih

Publications (2)

Publication Number Publication Date
HUP0201472A2 true HUP0201472A2 (hu) 2003-10-28
HUP0201472A3 HUP0201472A3 (en) 2006-03-28

Family

ID=26538287

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0201472A HUP0201472A3 (en) 1998-12-25 1999-12-17 Aromatic heterocycle compounds having hiv integrase inhibiting activities

Country Status (22)

Country Link
US (3) US6620841B1 (hu)
EP (1) EP1142872B1 (hu)
JP (1) JP3929244B2 (hu)
KR (1) KR20010089708A (hu)
CN (1) CN1178913C (hu)
AP (1) AP2001002169A0 (hu)
AT (1) ATE411286T1 (hu)
AU (1) AU763040B2 (hu)
BR (1) BR9916583A (hu)
CA (1) CA2353961A1 (hu)
CZ (1) CZ20012160A3 (hu)
DE (1) DE69939749D1 (hu)
HK (1) HK1042701A1 (hu)
HU (1) HUP0201472A3 (hu)
ID (1) ID29027A (hu)
IL (1) IL143958A0 (hu)
NO (1) NO20013179L (hu)
NZ (1) NZ512184A (hu)
PL (1) PL348596A1 (hu)
RU (1) RU2225860C2 (hu)
TR (1) TR200101886T2 (hu)
WO (1) WO2000039086A1 (hu)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
ES2244204T3 (es) 1998-07-27 2005-12-01 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Derivados de dicetoacidos como inhibidores de polimerasas.
GB9816358D0 (en) * 1998-07-27 1998-09-23 Angeletti P Ist Richerche Bio Enzyme inhibitors
CA2376043A1 (en) * 1999-06-02 2000-12-14 Shionogi & Co., Ltd. Novel processes for the preparation of substituted propenone derivatives
CA2370500A1 (en) * 1999-06-25 2001-01-04 Lekhanh O. Tran 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
IL153363A0 (en) * 2000-06-13 2003-07-06 Shionogi & Co Pharmaceutical compositions containing propenone derivatives
EP1297834A4 (en) * 2000-06-14 2007-05-09 Shionogi & Co ENZYME INHIBITOR HAVING TWO DIVALENT METAL IONS AS ACTIVE CENTERS
WO2002038771A1 (fr) * 2000-11-09 2002-05-16 Shionogi & Co., Ltd. Integrases du hiv tolerantes aux medicaments
KR100977701B1 (ko) * 2001-08-10 2010-08-24 시오노기세이야쿠가부시키가이샤 항바이러스제
CN1700918B (zh) * 2001-10-26 2011-06-08 P·安杰莱蒂分子生物学研究所 关于hiv整合酶的n-取代的羟基嘧啶酮甲酰胺抑制剂
TW200407132A (en) * 2001-11-15 2004-05-16 Shionogi & Co Process for producing 1-H-1,2,4-triazole-3-carboxylic acid ester
WO2003047564A1 (fr) * 2001-12-05 2003-06-12 Shionogi & Co., Ltd. Dérivé ayant une activité d'inhibition de l'intégrase du vih
DE60322920D1 (de) 2002-08-13 2008-09-25 Shionogi & Co Heterocyclische verbindungen mit hiv-integrase-hemmender wirkung
WO2004035577A2 (en) 2002-10-16 2004-04-29 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
CN1569803B (zh) * 2003-07-16 2011-04-13 中国科学院上海药物研究所 芳基β－二酮酸的新制备方法
EP1715855A4 (en) * 2004-01-29 2010-06-16 Elixir Pharmaceuticals Inc ANTIVIRAL DRUGS
JP4952943B2 (ja) * 2004-08-25 2012-06-13 アーディア・バイオサイエンシーズ・インコーポレイテッド ＨＩＶ逆転写酵素のインヒビターとしてのＳ−トリアゾリルα−メルカプトアセトアニリド
US7550463B2 (en) 2004-09-15 2009-06-23 Shionogi & Co., Ltd. Carbamoylpyridone derivatives having inhibitory activity against HIV integrase
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
AU2005311714B2 (en) * 2004-12-03 2010-09-30 Merck Sharp & Dohme Corp. Pharmaceutical composition containing an anti-nucleating agent
US7250421B2 (en) * 2005-01-31 2007-07-31 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase
WO2006129134A1 (en) * 2005-06-01 2006-12-07 Bioalliance Pharma Synergic combinations comprising a styrylquinoline compound and other hiv infection therapeutic agents
JP2009537546A (ja) * 2006-05-16 2009-10-29 ギリアード サイエンシーズ， インコーポレイテッド インテグラーゼ阻害剤
AU2007275805A1 (en) * 2006-07-19 2008-01-24 University Of Georgia Research Foundation, Inc. Pyridinone diketo acids: Inhibitors of HIV replication in combination therapy
WO2008041882A1 (fr) * 2006-10-03 2008-04-10 Viktor Veniaminovich Tets Procédé pour agir sur les virus au moyen d'une substance à base de 2,8-dithioxo-1h- pyrano[2,3-d;6,5-d'] dipyrimidine et de leurs analogues 10-aza (et variantes)
MX2010008148A (es) 2008-01-25 2010-10-20 Chimerix Inc Métodos de tratamiento de infecciones virales.
US8664255B2 (en) 2008-10-20 2014-03-04 The Texas A&M University System Inhibitors of mycobacterium tuberculosis malate synthase, methods of making and uses thereof
MX2012006485A (es) 2009-12-07 2012-08-23 Univ Georgia Piridinon hidroxiclicopentil carboxamidas: inhibidores de la integrasa del vih con aplicaciones terapeuticas.
EP3216789A1 (en) 2010-02-12 2017-09-13 Chimerix, Inc. Methods of treating viral infection
WO2011119920A2 (en) 2010-03-25 2011-09-29 Oregon Health & Science University Cmv glycoproteins and recombinant vectors
CN101928258B (zh) * 2010-08-18 2014-10-29 杭州民生药业有限公司 1-(2-取代苯胺基-4-甲基-噻唑-5)-3-取代苯基-丙烯酮衍生物、制备方法及其制药用途
HUE037408T2 (hu) 2011-06-10 2018-08-28 Univ Oregon Health & Science CMV glikoproteinek és rekombináns vektorok
WO2014026033A1 (en) 2012-08-08 2014-02-13 University Of Florida Research Foundation, Inc. Cross-reactive t cell epitopes of hiv, siv, and fiv for vaccines in humans and cats
KR102040007B1 (ko) 2012-12-21 2019-11-05 길리애드 사이언시즈, 인코포레이티드 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도
ES2645192T3 (es) 2013-07-12 2017-12-04 Gilead Sciences, Inc. Compuestos de carbamoilpiridona policíclica y su uso para el tratamiento de infecciones por VIH
NO2865735T3 (hu) 2013-07-12 2018-07-21
TWI677489B (zh) 2014-06-20 2019-11-21 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
NO2717902T3 (hu) 2014-06-20 2018-06-23
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI738321B (zh) 2014-12-23 2021-09-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
EP3736274A1 (en) 2015-04-02 2020-11-11 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
CN106905244B (zh) * 2017-02-27 2019-08-16 武汉工程大学 二芳基嘧啶-二酮酸类杂合型hiv-1抑制剂及其制备方法
AU2020373913B2 (en) * 2019-10-28 2024-04-18 Shanghai Institute Of Materia Medica, Chinese Academy Of Sciences Five-membered heterocyclic oxocarboxylic acid compound and medical use thereof
CN111943899B (zh) * 2020-09-08 2023-04-21 河北凯诺中星科技有限公司 一种5-甲酸乙酯四氮唑的合成方法
CN113683574B (zh) * 2021-09-06 2023-11-17 上海晋鲁医药科技有限公司 一种合成1-甲基-1h-1,2,4-三唑-3-甲酸甲酯的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899508A (en) 1974-04-12 1975-08-12 Lilly Co Eli 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof
US3931247A (en) 1974-12-11 1976-01-06 Morton-Norwich Products, Inc. 5-(Substituted)phenylfurfuryl alcohols
JPS5811878B2 (ja) 1974-12-19 1983-03-04 大正製薬株式会社 フロ （ ３ ２−ｂ ） インド−ルルイノ セイホウ
JPS56100784A (en) 1980-01-16 1981-08-12 Yoshitomi Pharmaceut Ind Ltd Indolizine derivative
US4273776A (en) * 1980-01-30 1981-06-16 E. R. Squibb & Sons, Inc. Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones
US4423063A (en) 1980-12-29 1983-12-27 Merck & Co., Inc. 2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis
US4336397A (en) 1980-12-29 1982-06-22 Merck & Co., Inc. 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis
US4332735A (en) 1981-07-06 1982-06-01 Morton-Norwich Products, Inc. Antifungal compound
US4637829A (en) 1984-04-27 1987-01-20 Ciba-Geigy Corporation Sulfonylureas
JPS61134346A (ja) 1984-12-03 1986-06-21 Shionogi & Co Ltd ４−オキソカルボン酸誘導体および抗潰瘍剤
CA1334975C (en) 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
JPH0238403A (ja) 1988-07-28 1990-02-07 Canon Inc 光重合性組成物および記録媒体
PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
TW224974B (hu) 1991-07-02 1994-06-11 Hoffmann La Roche
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
US5475109A (en) 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
TR199902432T2 (xx) 1997-04-04 2000-01-21 Prizer Products Inc. Nikotinamid t�revleri.
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
RU2217421C2 (ru) 1998-03-26 2003-11-27 Шионоги & Ко., Лтд. Производные индола, обладающие антивирусной активностью
EP1063888A1 (en) 1998-03-27 2001-01-03 The Regents of the University of California Novel hiv integrase inhibitors and hiv therapy based on drug combinations including integrase inhibitors
CA2333771A1 (en) 1998-06-03 1999-12-09 Mark W. Embrey Hiv integrase inhibitors
JP2002516858A (ja) 1998-06-03 2002-06-11 メルク エンド カムパニー インコーポレーテッド Ｈｉｖインテグラーゼ阻害薬
AU4225499A (en) 1998-06-03 1999-12-20 Merck & Co., Inc. Hiv integrase inhibitors
CA2370500A1 (en) 1999-06-25 2001-01-04 Lekhanh O. Tran 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof

Also Published As

Publication number Publication date
EP1142872B1 (en) 2008-10-15
RU2001120016A (ru) 2003-12-10
EP1142872A1 (en) 2001-10-10
RU2225860C2 (ru) 2004-03-20
ID29027A (id) 2001-07-26
TR200101886T2 (tr) 2001-12-21
IL143958A0 (en) 2002-04-21
US20040002485A1 (en) 2004-01-01
CN1335834A (zh) 2002-02-13
US6645956B1 (en) 2003-11-11
EP1142872A4 (en) 2002-04-17
US6620841B1 (en) 2003-09-16
CN1178913C (zh) 2004-12-08
KR20010089708A (ko) 2001-10-08
BR9916583A (pt) 2001-09-25
AU1797900A (en) 2000-07-31
NO20013179D0 (no) 2001-06-22
NO20013179L (no) 2001-08-27
HUP0201472A3 (en) 2006-03-28
US7098201B2 (en) 2006-08-29
CA2353961A1 (en) 2000-07-06
AU763040B2 (en) 2003-07-10
DE69939749D1 (de) 2008-11-27
HK1042701A1 (zh) 2002-08-23
JP3929244B2 (ja) 2007-06-13
NZ512184A (en) 2003-08-29
WO2000039086A1 (fr) 2000-07-06
AP2001002169A0 (en) 2001-06-30
CZ20012160A3 (cs) 2001-10-17
PL348596A1 (en) 2002-06-03
ATE411286T1 (de) 2008-10-15

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