BR9916583A - Derivados heteroaromáticos tendo uma atividade inibitória contra integrase de hiv - Google Patents

Derivados heteroaromáticos tendo uma atividade inibitória contra integrase de hiv

Info

Publication number
BR9916583A
BR9916583A BR9916583-0A BR9916583A BR9916583A BR 9916583 A BR9916583 A BR 9916583A BR 9916583 A BR9916583 A BR 9916583A BR 9916583 A BR9916583 A BR 9916583A
Authority
BR
Brazil
Prior art keywords
optionally substituted
inhibitory activity
activity against
against hiv
heteroaromatic derivatives
Prior art date
Application number
BR9916583-0A
Other languages
English (en)
Inventor
Toshio Fujishita
Tomokazu Yoshinaga
Akihiko Sato
Original Assignee
Shionogi & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co filed Critical Shionogi & Co
Publication of BR9916583A publication Critical patent/BR9916583A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Virology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Furan Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Patente de Invenção: <B>"DERIVADOS HETEROAROMáTICOS TENDO UMA ATIVIDADE INIBITóRIA CONTRA INTEGRASE DE HIV"<D>. Um composto da fórmula (I): em que X é hidróxi, hidróxi protegido ou amino opcionalmente substituído; Y é -COOR^ A^ em que R^ A^ é hidrogênio ou resíduo éster, -CONR^ B^R^ C^ em que R^ B^ e R^ C^ é cada de modo independente hidrogênio ou resíduo amida, aril opcionalmente substituído ou heteroaril opcionalmente substituído; e A¹ é heteroaril opcionalmente substituído; contanto que seja excluído um composto em que Y e/ou A¹ é indol-3-il opcionalmente substituído, um tautómero, uma pró-droga, um sal ou um hidrato do mesmo farmaceuticamente aceitável tem uma atividade inibitória contra uma integrase.
BR9916583-0A 1998-12-25 1999-12-17 Derivados heteroaromáticos tendo uma atividade inibitória contra integrase de hiv BR9916583A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP37127098 1998-12-25
JP24747999 1999-09-01
PCT/JP1999/007101 WO2000039086A1 (fr) 1998-12-25 1999-12-17 Composes heterocycliques aromatiques possedant des activites inhibitrices de l'integrase du vih

Publications (1)

Publication Number Publication Date
BR9916583A true BR9916583A (pt) 2001-09-25

Family

ID=26538287

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9916583-0A BR9916583A (pt) 1998-12-25 1999-12-17 Derivados heteroaromáticos tendo uma atividade inibitória contra integrase de hiv

Country Status (22)

Country Link
US (3) US6620841B1 (pt)
EP (1) EP1142872B1 (pt)
JP (1) JP3929244B2 (pt)
KR (1) KR20010089708A (pt)
CN (1) CN1178913C (pt)
AP (1) AP2001002169A0 (pt)
AT (1) ATE411286T1 (pt)
AU (1) AU763040B2 (pt)
BR (1) BR9916583A (pt)
CA (1) CA2353961A1 (pt)
CZ (1) CZ20012160A3 (pt)
DE (1) DE69939749D1 (pt)
HK (1) HK1042701A1 (pt)
HU (1) HUP0201472A3 (pt)
ID (1) ID29027A (pt)
IL (1) IL143958A0 (pt)
NO (1) NO20013179L (pt)
NZ (1) NZ512184A (pt)
PL (1) PL348596A1 (pt)
RU (1) RU2225860C2 (pt)
TR (1) TR200101886T2 (pt)
WO (1) WO2000039086A1 (pt)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6306891B1 (en) 1998-06-03 2001-10-23 Merck & Co., Inc. HIV integrase inhibitors
US6262055B1 (en) 1998-06-03 2001-07-17 Merck & Co., Inc. HIV integrase inhibitors
US6380249B1 (en) 1998-06-03 2002-04-30 Merck & Co., Inc. HIV integrase inhibitors
GB9816358D0 (en) * 1998-07-27 1998-09-23 Angeletti P Ist Richerche Bio Enzyme inhibitors
ES2244204T3 (es) 1998-07-27 2005-12-01 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Derivados de dicetoacidos como inhibidores de polimerasas.
EP1186599A4 (en) * 1999-06-02 2003-02-26 Shionogi & Co NOVEL PROCESS FOR THE PREPARATION OF SUBSTITUTED PROPENONE DERIVATIVES
CA2370500A1 (en) * 1999-06-25 2001-01-04 Lekhanh O. Tran 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof
KR20030019423A (ko) * 2000-06-13 2003-03-06 시오노기세이야쿠가부시키가이샤 프로페논 유도체를 함유하는 의약 조성물
US20040039060A1 (en) * 2000-06-14 2004-02-26 Ryuichi Kiyama Inhibitor for enzyme having two divalent metal ions as active centers
AU2002212701A1 (en) * 2000-11-09 2002-05-21 Shionogi And Co., Ltd. Drug-tolerant hiv integrases
EP3042894A1 (en) * 2001-08-10 2016-07-13 Shionogi & Co., Ltd. Antiviral agent
DE122008000016I1 (de) * 2001-10-26 2011-12-01 Angeletti P Ist Richerche Bio N-substituierte hydroxypyrimidinoncarboxamidhemmerder HIV-integrase.
TW200407132A (en) * 2001-11-15 2004-05-16 Shionogi & Co Process for producing 1-H-1,2,4-triazole-3-carboxylic acid ester
AU2002349675A1 (en) * 2001-12-05 2003-06-17 Shionogi And Co., Ltd. Derivative having hiv integrase inhibitory activity
US7358249B2 (en) 2002-08-13 2008-04-15 Shionogi & Co., Ltd. Heterocyclic compounds having inhibitory activity against HIV integrase
AU2003301439A1 (en) 2002-10-16 2004-05-04 Gilead Sciences, Inc. Pre-organized tricyclic integrase inhibitor compounds
CN1569803B (zh) * 2003-07-16 2011-04-13 中国科学院上海药物研究所 芳基β－二酮酸的新制备方法
CA2553670A1 (en) * 2004-01-29 2005-08-11 Elixir Pharmaceuticals, Inc. Anti-viral therapeutics
JP4952943B2 (ja) * 2004-08-25 2012-06-13 アーディア・バイオサイエンシーズ・インコーポレイテッド ＨＩＶ逆転写酵素のインヒビターとしてのＳ−トリアゾリルα−メルカプトアセトアニリド
JP4953297B2 (ja) * 2004-09-15 2012-06-13 塩野義製薬株式会社 Ｈｉｖインテグラーゼ阻害活性を有するカルバモイルピリドン誘導体
CA2588465C (en) * 2004-12-03 2013-10-01 Merck & Co., Inc. Pharmaceutical composition containing an anti-nucleating agent
UA87884C2 (uk) * 2004-12-03 2009-08-25 Мерк Энд Ко., Инк. Безводна кристалічна калієва сіль інгібітора віл-інтегрази
US7250421B2 (en) * 2005-01-31 2007-07-31 University Of Georgia Research Foundation, Inc. Diketo acids with nucleobase scaffolds: anti-HIV replication inhibitors targeted at HIV integrase
WO2006129134A1 (en) * 2005-06-01 2006-12-07 Bioalliance Pharma Synergic combinations comprising a styrylquinoline compound and other hiv infection therapeutic agents
NZ572367A (en) 2006-05-16 2011-09-30 Gilead Sciences Inc Fused cyclic compounds as integrase inhibitors
WO2008010953A2 (en) * 2006-07-19 2008-01-24 University Of Georgia Research Foundation, Inc. Pyridinone diketo acids: inhibitors of hiv replication in combination therapy
WO2008041882A1 (fr) * 2006-10-03 2008-04-10 Viktor Veniaminovich Tets Procédé pour agir sur les virus au moyen d'une substance à base de 2,8-dithioxo-1h- pyrano[2,3-d;6,5-d'] dipyrimidine et de leurs analogues 10-aza (et variantes)
CN105055432A (zh) 2008-01-25 2015-11-18 奇默里克斯公司 治疗病毒感染的方法
WO2010047774A2 (en) * 2008-10-20 2010-04-29 The Texas A & M University System Inhibitors of mycobacterium tuberculosis malate synthase, methods of marking and uses thereof
CA2783540C (en) 2009-12-07 2018-04-24 University Of Georgia Research Foundation, Inc. Pyridinone hydroxycyclopentyl carboxamides: hiv integrase inhibitors with therapeutic applications
HUE032860T2 (en) 2010-02-12 2017-11-28 Chimerix Inc A method for treating a virus infection
ES2625406T3 (es) 2010-03-25 2017-07-19 Oregon Health & Science University Glicoproteínas de CMV y vectores recombinantes
CN101928258B (zh) * 2010-08-18 2014-10-29 杭州民生药业有限公司 1-(2-取代苯胺基-4-甲基-噻唑-5)-3-取代苯基-丙烯酮衍生物、制备方法及其制药用途
AU2012267786B2 (en) 2011-06-10 2017-08-03 Oregon Health & Science University CMV glycoproteins and recombinant vectors
WO2014026033A1 (en) 2012-08-08 2014-02-13 University Of Florida Research Foundation, Inc. Cross-reactive t cell epitopes of hiv, siv, and fiv for vaccines in humans and cats
KR102120875B1 (ko) 2012-12-21 2020-06-09 길리애드 사이언시즈, 인코포레이티드 폴리시클릭-카르바모일피리돈 화합물 및 그의 제약 용도
CA2916993C (en) 2013-07-12 2019-01-15 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
NO2865735T3 (pt) 2013-07-12 2018-07-21
TW201613936A (en) 2014-06-20 2016-04-16 Gilead Sciences Inc Crystalline forms of(2R,5S,13aR)-8-hydroxy-7,9-dioxo-n-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1',2':4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide
TWI744723B (zh) 2014-06-20 2021-11-01 美商基利科學股份有限公司 多環型胺甲醯基吡啶酮化合物之合成
NO2717902T3 (pt) 2014-06-20 2018-06-23
TWI738321B (zh) 2014-12-23 2021-09-01 美商基利科學股份有限公司 多環胺甲醯基吡啶酮化合物及其醫藥用途
EP3277691B1 (en) 2015-04-02 2019-01-30 Gilead Sciences, Inc. Polycyclic-carbamoylpyridone compounds and their pharmaceutical use
CN106905244B (zh) * 2017-02-27 2019-08-16 武汉工程大学 二芳基嘧啶-二酮酸类杂合型hiv-1抑制剂及其制备方法
CN114829357A (zh) * 2019-10-28 2022-07-29 中国科学院上海药物研究所 五元杂环氧代羧酸类化合物及其医药用途
CN111943899B (zh) * 2020-09-08 2023-04-21 河北凯诺中星科技有限公司 一种5-甲酸乙酯四氮唑的合成方法
CN113683574B (zh) * 2021-09-06 2023-11-17 上海晋鲁医药科技有限公司 一种合成1-甲基-1h-1,2,4-三唑-3-甲酸甲酯的方法

Family Cites Families (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3899508A (en) 1974-04-12 1975-08-12 Lilly Co Eli 5-(2-Aminophenyl)pyrazole-3-carboxylic acids and esters thereof
US3931247A (en) * 1974-12-11 1976-01-06 Morton-Norwich Products, Inc. 5-(Substituted)phenylfurfuryl alcohols
JPS5811878B2 (ja) * 1974-12-19 1983-03-04 大正製薬株式会社 フロ （ ３ ２−ｂ ） インド−ルルイノ セイホウ
JPS56100784A (en) 1980-01-16 1981-08-12 Yoshitomi Pharmaceut Ind Ltd Indolizine derivative
US4273776A (en) 1980-01-30 1981-06-16 E. R. Squibb & Sons, Inc. Antibacterial and antifungal derivatives of 3-(1H-imidazol-1-yl)-2-propen-1-ones
US4336397A (en) 1980-12-29 1982-06-22 Merck & Co., Inc. 2,4-Dioxo-4-substituted-1-butanoic acid derivatives useful in treating urinary tract calcium oxalate lithiasis
US4423063A (en) 1980-12-29 1983-12-27 Merck & Co., Inc. 2,4-Dioxo-4-substituted-1-butaoic acid derivatives useful in treating urinary track calcium oxalate lithiasis
US4332735A (en) * 1981-07-06 1982-06-01 Morton-Norwich Products, Inc. Antifungal compound
US4637829A (en) * 1984-04-27 1987-01-20 Ciba-Geigy Corporation Sulfonylureas
JPS61134346A (ja) 1984-12-03 1986-06-21 Shionogi & Co Ltd ４−オキソカルボン酸誘導体および抗潰瘍剤
CA1334975C (en) 1987-11-13 1995-03-28 James H. Holms Furan and pyrrole containing lipoxygenase inhibiting compounds
JPH0238403A (ja) 1988-07-28 1990-02-07 Canon Inc 光重合性組成物および記録媒体
PH27357A (en) 1989-09-22 1993-06-21 Fujisawa Pharmaceutical Co Pyrazole derivatives and pharmaceutical compositions comprising the same
US5192773A (en) * 1990-07-02 1993-03-09 Vertex Pharmaceuticals, Inc. Immunosuppressive compounds
TW224974B (pt) 1991-07-02 1994-06-11 Hoffmann La Roche
EP0658559A1 (de) * 1993-12-14 1995-06-21 Chemisch Pharmazeutische Forschungsgesellschaft m.b.H. Thienothiazinderivate, Verfahren zu ihrer Herstellung und ihre Verwendung als 5-dipoxygenase und Cyclooxygenaseinhibitoren
US5475109A (en) 1994-10-17 1995-12-12 Merck & Co., Inc. Dioxobutanoic acid derivatives as inhibitors of influenza endonuclease
US5693804A (en) * 1994-11-17 1997-12-02 Molecular Geriatrics Corporation Substituted 1-aryl-3-piperazin-1'-yl propanones
SK132899A3 (en) 1997-04-04 2000-09-12 Pfizer Prod Inc NICOTINAMIDE DERIVATIVES AND PHARMACEUTICAL COMPOSITIONì (54) COMPRISING THEM
IL122591A0 (en) 1997-12-14 1998-06-15 Arad Dorit Pharmaceutical compositions comprising cystein protease inhibitors
EP1069111A4 (en) 1998-03-26 2001-06-06 Shionogi & Co INDOLE DERIVATIVES EXER ANT ANTIVIRAL ACTIVITY
AU3366899A (en) 1998-03-27 1999-10-18 Regents Of The University Of California, The Novel hiv integrase inhibitors and hiv therapy based on drug combinations including integrase inhibitors
WO1999062520A1 (en) 1998-06-03 1999-12-09 Merck & Co., Inc. Hiv integrase inhibitors
CA2333771A1 (en) 1998-06-03 1999-12-09 Mark W. Embrey Hiv integrase inhibitors
CA2329134A1 (en) 1998-06-03 1999-12-09 David L. Clark Hiv integrase inhibitors
CA2370500A1 (en) 1999-06-25 2001-01-04 Lekhanh O. Tran 1-(aromatic- or heteroaromatic-substituted)-3-(heteroaromatic substituted)-1,3-propanediones and uses thereof

Also Published As

Publication number Publication date
US6645956B1 (en) 2003-11-11
RU2225860C2 (ru) 2004-03-20
HK1042701A1 (zh) 2002-08-23
HUP0201472A3 (en) 2006-03-28
NO20013179D0 (no) 2001-06-22
EP1142872A1 (en) 2001-10-10
DE69939749D1 (de) 2008-11-27
RU2001120016A (ru) 2003-12-10
CZ20012160A3 (cs) 2001-10-17
KR20010089708A (ko) 2001-10-08
IL143958A0 (en) 2002-04-21
US20040002485A1 (en) 2004-01-01
CN1178913C (zh) 2004-12-08
NZ512184A (en) 2003-08-29
CN1335834A (zh) 2002-02-13
US6620841B1 (en) 2003-09-16
WO2000039086A1 (fr) 2000-07-06
TR200101886T2 (tr) 2001-12-21
JP3929244B2 (ja) 2007-06-13
AU1797900A (en) 2000-07-31
EP1142872B1 (en) 2008-10-15
HUP0201472A2 (hu) 2003-10-28
AP2001002169A0 (en) 2001-06-30
ID29027A (id) 2001-07-26
US7098201B2 (en) 2006-08-29
CA2353961A1 (en) 2000-07-06
AU763040B2 (en) 2003-07-10
NO20013179L (no) 2001-08-27
EP1142872A4 (en) 2002-04-17
PL348596A1 (en) 2002-06-03
ATE411286T1 (de) 2008-10-15

Similar Documents

Publication Publication Date Title
BR9916583A (pt) Derivados heteroaromáticos tendo uma atividade inibitória contra integrase de hiv
ES2182852T3 (es) Derivados de prolinamida.
MY133473A (en) Haterocyclic glycyl beta-alanine derivatives.
BR9913097B1 (pt) Derivado heterocíclico de carboxamida contendo nitrogênio ou um sal do mesmo
MY141661A (en) 17b-hydroxysteroid dehydrogenase type 3 inhibitors for the treatment of androgen dependent diseases
JO2372B1 (en) Source drugs of 4-phenylpyridine derivatives
AU6645998A (en) Oxygen or sulfur containing heteroaromatics as factor xa inhibitors
AU3851199A (en) Heterocyclic indole derivatives and mono- or diazaindole derivatives
CA2469592A1 (en) Hiv integrase inhibitors
AU2001274806A1 (en) Sulfonamide derivatives
MXPA04003611A (es) Piperidina- y piperazinacetaminas como inhibidores de la 17 beta-hidroxiesteroide deshidrogenasa tipo 3 para el tratamiento de enfermedades androgeno-dependientes.
AU699728B2 (en) Cancerous metastasis inhibitors containing uracil derivatives
IL136100A0 (en) Biphenylamidine derivatives, prodrugs thereof and pharmaceutical compositions containing the same
NO983444L (no) Benzo(c)kinolizin derivater, deres fremstilling og anvendelse som 5&lt;alfa&gt;-reduktaseinhibitorer
AU3785897A (en) Neuraminic acid compound
BR0110871A (pt) Derivados de sulfonamida
EP1613328B8 (en) Use of carbamazepine derivatives for the treatment of agitation in dementia patients
HUP0302255A2 (hu) Szulfonamidszármazékok, ezeket tartalmazó gyógyszerkészítmények és alkalmazásuk
AU3285000A (en) 22r-hydroxycholesta-8,14-diene derivatives for the inhibition of meiosis
ES2196174T3 (es) `derivados de sesquiterpeno de actividad antiviral.
TW375525B (en) Inhibitors for morphine-like drug induced emesis containing active components (R)-1-ethyl-4-methyl hexahydro-1H-1,4-diazepine derivatives
CA2270026A1 (en) Substituted bicyclic derivatives for treating central nervous system disorders
BR9908948A (pt) Composição farmacêutica contendo um inibidor de protease cisteìna para profilaxia e terapia de dano ao tecido cerebral
MY139844A (en) 1,2,4-triaminobenzene derivatives and their uses thereof for the prevention, treatment and/or inhibition of disorders of the central nervous system

Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 6O E 7O ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO 8.6 PUBLICADO NA RPI 1913 DE 04/09/2007.