TR200101886T2 - HIV integrazını önleme aktivitesi olan aromatik heterosikl bileşimleri. - Google Patents

HIV integrazını önleme aktivitesi olan aromatik heterosikl bileşimleri.

Info

Publication number
TR200101886T2
TR200101886T2 TR2001/01886T TR200101886T TR200101886T2 TR 200101886 T2 TR200101886 T2 TR 200101886T2 TR 2001/01886 T TR2001/01886 T TR 2001/01886T TR 200101886 T TR200101886 T TR 200101886T TR 200101886 T2 TR200101886 T2 TR 200101886T2
Authority
TR
Turkey
Prior art keywords
optionally substituted
inhibitory activity
aromatic heterocycle
hiv integrase
integrase inhibitory
Prior art date
Application number
TR2001/01886T
Other languages
English (en)
Inventor
Fujishita Toshio
Yoshinaga Tomokazu
Sato Akihiko
Original Assignee
Shionogi & Co., Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shionogi & Co., Ltd. filed Critical Shionogi & Co., Ltd.
Publication of TR200101886T2 publication Critical patent/TR200101886T2/tr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
    • C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
    • C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
    • C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
    • C07D333/26—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D333/30—Hetero atoms other than halogen
    • C07D333/34—Sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

X'in hidroksi korumali hidroksi veya tercihe göre ester kalani),-CONRBRC (her bir RB ve RB ve RC bagimsiz olarak hidrojen bir amid kalani),tercihe göre ikameli aril veya tercihe göre ikmeli heteroaril; ve A1'in terihe göre ikameli heteroaril oldugu ancak Y ve A1'in tercihe göre ikameli indol-3-yl oldugu durumlarin hariç tutuldugu; intergarz inhibisyon aktiviteleri sergileyen genel; formül bilesimleri, tautomerler, bilesim ve tautomerlerinin ön-ilaçlari veya farmasötik olarak kabul edilir tuzlari veya hidratlari.
TR2001/01886T 1998-12-25 1999-12-17 HIV integrazını önleme aktivitesi olan aromatik heterosikl bileşimleri. TR200101886T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP37127098 1998-12-25
JP24747999 1999-09-01

Publications (1)

Publication Number Publication Date
TR200101886T2 true TR200101886T2 (tr) 2001-12-21

Family

ID=26538287

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2001/01886T TR200101886T2 (tr) 1998-12-25 1999-12-17 HIV integrazını önleme aktivitesi olan aromatik heterosikl bileşimleri.

Country Status (22)

Country Link
US (3) US6620841B1 (tr)
EP (1) EP1142872B1 (tr)
JP (1) JP3929244B2 (tr)
KR (1) KR20010089708A (tr)
CN (1) CN1178913C (tr)
AP (1) AP2001002169A0 (tr)
AT (1) ATE411286T1 (tr)
AU (1) AU763040B2 (tr)
BR (1) BR9916583A (tr)
CA (1) CA2353961A1 (tr)
CZ (1) CZ20012160A3 (tr)
DE (1) DE69939749D1 (tr)
HK (1) HK1042701A1 (tr)
HU (1) HUP0201472A3 (tr)
ID (1) ID29027A (tr)
IL (1) IL143958A0 (tr)
NO (1) NO20013179L (tr)
NZ (1) NZ512184A (tr)
PL (1) PL348596A1 (tr)
RU (1) RU2225860C2 (tr)
TR (1) TR200101886T2 (tr)
WO (1) WO2000039086A1 (tr)

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Also Published As

Publication number Publication date
CA2353961A1 (en) 2000-07-06
ID29027A (id) 2001-07-26
CN1178913C (zh) 2004-12-08
RU2001120016A (ru) 2003-12-10
EP1142872A4 (en) 2002-04-17
IL143958A0 (en) 2002-04-21
CZ20012160A3 (cs) 2001-10-17
KR20010089708A (ko) 2001-10-08
EP1142872B1 (en) 2008-10-15
US7098201B2 (en) 2006-08-29
US6620841B1 (en) 2003-09-16
DE69939749D1 (de) 2008-11-27
EP1142872A1 (en) 2001-10-10
CN1335834A (zh) 2002-02-13
WO2000039086A1 (fr) 2000-07-06
US6645956B1 (en) 2003-11-11
AU1797900A (en) 2000-07-31
RU2225860C2 (ru) 2004-03-20
US20040002485A1 (en) 2004-01-01
NZ512184A (en) 2003-08-29
HK1042701A1 (zh) 2002-08-23
HUP0201472A3 (en) 2006-03-28
HUP0201472A2 (hu) 2003-10-28
JP3929244B2 (ja) 2007-06-13
PL348596A1 (en) 2002-06-03
NO20013179L (no) 2001-08-27
AP2001002169A0 (en) 2001-06-30
NO20013179D0 (no) 2001-06-22
BR9916583A (pt) 2001-09-25
ATE411286T1 (de) 2008-10-15
AU763040B2 (en) 2003-07-10

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