ATE304019T1 - Inhibitoren des nukleosid-metabolismus - Google Patents

Inhibitoren des nukleosid-metabolismus

Info

Publication number
ATE304019T1
ATE304019T1 AT98953516T AT98953516T ATE304019T1 AT E304019 T1 ATE304019 T1 AT E304019T1 AT 98953516 T AT98953516 T AT 98953516T AT 98953516 T AT98953516 T AT 98953516T AT E304019 T1 ATE304019 T1 AT E304019T1
Authority
AT
Austria
Prior art keywords
sub
compounds
halogen
chosen
hydroxy
Prior art date
Application number
AT98953516T
Other languages
English (en)
Inventor
Richard Hubert Furneaux
Peter Charles Tyler
Vern L Schramm
Original Assignee
Einstein Coll Med
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med
Application granted granted Critical
Publication of ATE304019T1 publication Critical patent/ATE304019T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
AT98953516T 1997-10-14 1998-10-14 Inhibitoren des nukleosid-metabolismus ATE304019T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/949,388 US5985848A (en) 1997-10-14 1997-10-14 Inhibitors of nucleoside metabolism
PCT/US1998/021717 WO1999019338A1 (en) 1997-10-14 1998-10-14 Inhibitors of nucleoside metabolism

Publications (1)

Publication Number Publication Date
ATE304019T1 true ATE304019T1 (de) 2005-09-15

Family

ID=25489007

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98953516T ATE304019T1 (de) 1997-10-14 1998-10-14 Inhibitoren des nukleosid-metabolismus

Country Status (13)

Country Link
US (7) US5985848A (de)
EP (1) EP1023308B1 (de)
JP (1) JP4451983B2 (de)
KR (1) KR100637479B1 (de)
CN (2) CN1220695C (de)
AT (1) ATE304019T1 (de)
AU (1) AU749098B2 (de)
CA (1) CA2305760C (de)
DE (1) DE69831499T2 (de)
DK (1) DK1023308T3 (de)
ES (1) ES2249844T3 (de)
PT (1) PT1023308E (de)
WO (1) WO1999019338A1 (de)

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EP1348707B1 (de) * 2002-03-28 2010-08-25 Ustav Experimentalni Botaniky AV CR, v.v.i. (Institute of Experimental Botany Academy of Sciences of the Czech Republic, PRO) Pyrazolo[4,3-d]pyrimidine, Verfahren zu ihrer Herstellung und therapeutische Anwendung
AU2003233667A1 (en) * 2002-05-23 2003-12-12 Biocryst Pharmaceuticals, Inc. Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
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NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
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NZ544187A (en) * 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
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WO2007097647A1 (en) * 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer
AU2007218334A1 (en) * 2006-02-24 2007-08-30 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
CN101528749B (zh) 2006-09-07 2013-07-31 工业研究有限公司 核苷磷酸化酶和水解酶的无环胺抑制剂
EP2049543B1 (de) 2006-09-07 2014-11-05 Callaghan Innovation Research Limited Acyclische amininhibitoren der 5'-methylthioadenosin phosphorylase und nucleosidase
CA2674525A1 (en) * 2006-12-22 2008-07-03 Albert Einstein College Of Medicine Of Yeshiva University Azetidine analogues of nucleosidase and phosphorylase inhibitors
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
JP2011518195A (ja) 2008-04-21 2011-06-23 オトノミ―，インク． 耳の疾患と疾病を処置するための耳の製剤と関連する応用
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
EP2348854A4 (de) * 2008-09-22 2012-03-14 Einstein Coll Med Verfahren und zusammensetzungen für die behandlung von bakteriellen infektionen durch hemmung des »quorum sensing
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CN103391777A (zh) 2011-02-02 2013-11-13 普林斯顿大学理事会 作为病毒产生调节剂的去乙酰化酶调节剂
PL2734186T3 (pl) 2011-07-22 2019-01-31 Glaxosmithkline Llc Kompozycja
WO2013149258A2 (en) 2012-03-30 2013-10-03 Charles Drew University of Medicine and Science Compositions and methods for treating or preventing metabolic syndrome disorders
AR090699A1 (es) * 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
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BR112015011447A2 (pt) * 2012-11-20 2017-07-11 Glaxosmithkline Llc composto da fórmula i, composição farmacêutica e de vacina, e, uso de um composto
CN104780923B (zh) * 2012-11-20 2017-03-15 葛兰素史克有限责任公司 干扰素诱导剂化合物
KR20150085055A (ko) * 2012-11-20 2015-07-22 글락소스미스클라인 엘엘씨 신규한 화합물
ES2499965B2 (es) * 2013-03-27 2015-03-31 Universidad De Alicante Procedimiento de síntesis de compuestos homólogos de azanucleósidos
US9452217B2 (en) 2013-06-22 2016-09-27 Nitor Therapeutics Methods for potentiating immune response for the treatment of infectious diseases and cancer
WO2015123101A1 (en) 2014-02-12 2015-08-20 Albert Einstein College Of Medicine Of Yeshiva University Treatment of h. pylori infections using mtan inhibitors
US20180258091A1 (en) * 2015-01-07 2018-09-13 Euro-Celtique S.A Process for manufacture of forodesine
CA3016588A1 (en) 2016-03-06 2017-09-14 Biocryst Pharmaceuticals, Inc. Methods and compositions for treatment of zika virus infection
WO2018005830A1 (en) 2016-06-29 2018-01-04 Otonomy, Inc. Triglyceride otic formulations and uses thereof
US20220054494A1 (en) 2019-03-13 2022-02-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating bladder and urethra dysfunction and disease
KR20240050362A (ko) 2021-08-20 2024-04-18 시오노기 앤드 컴파니, 리미티드 바이러스 증식 억제 작용을 갖는 뉴클레오사이드 유도체 및 그들의 프로드러그
GB202218782D0 (en) 2022-12-13 2023-01-25 Mehrling Thomas Purine nucleoside phosphorylase inhibitor for metabolic syndrome

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Also Published As

Publication number Publication date
KR100637479B1 (ko) 2006-10-20
EP1023308A4 (de) 2002-05-29
US6066722A (en) 2000-05-23
US6228847B1 (en) 2001-05-08
CN1279686A (zh) 2001-01-10
KR20010031082A (ko) 2001-04-16
DE69831499T2 (de) 2006-06-14
EP1023308B1 (de) 2005-09-07
CN100393722C (zh) 2008-06-11
CA2305760C (en) 2008-06-03
US7390890B2 (en) 2008-06-24
AU1086699A (en) 1999-05-03
CN1757646A (zh) 2006-04-12
JP2001519437A (ja) 2001-10-23
DE69831499D1 (de) 2005-10-13
JP4451983B2 (ja) 2010-04-14
AU749098B2 (en) 2002-06-20
US7211653B2 (en) 2007-05-01
US6803455B2 (en) 2004-10-12
US20030096830A1 (en) 2003-05-22
DK1023308T3 (da) 2006-01-23
HK1089159A1 (zh) 2006-11-24
PT1023308E (pt) 2005-11-30
ES2249844T3 (es) 2006-04-01
US5985848A (en) 1999-11-16
CA2305760A1 (en) 1999-04-22
WO1999019338A1 (en) 1999-04-22
US6492347B2 (en) 2002-12-10
US20070197561A1 (en) 2007-08-23
EP1023308A1 (de) 2000-08-02
CN1220695C (zh) 2005-09-28
US20050026936A1 (en) 2005-02-03
US20020061898A1 (en) 2002-05-23

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