ATE304019T1 - Inhibitoren des nukleosid-metabolismus - Google Patents

Inhibitoren des nukleosid-metabolismus

Info

Publication number
ATE304019T1
ATE304019T1 AT98953516T AT98953516T ATE304019T1 AT E304019 T1 ATE304019 T1 AT E304019T1 AT 98953516 T AT98953516 T AT 98953516T AT 98953516 T AT98953516 T AT 98953516T AT E304019 T1 ATE304019 T1 AT E304019T1
Authority
AT
Austria
Prior art keywords
sub
compounds
halogen
chosen
hydroxy
Prior art date
Application number
AT98953516T
Other languages
English (en)
Inventor
Richard Hubert Furneaux
Peter Charles Tyler
Vern L Schramm
Original Assignee
Einstein Coll Med
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med
Application granted granted Critical
Publication of ATE304019T1 publication Critical patent/ATE304019T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pyrrole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
AT98953516T 1997-10-14 1998-10-14 Inhibitoren des nukleosid-metabolismus ATE304019T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/949,388 US5985848A (en) 1997-10-14 1997-10-14 Inhibitors of nucleoside metabolism
PCT/US1998/021717 WO1999019338A1 (en) 1997-10-14 1998-10-14 Inhibitors of nucleoside metabolism

Publications (1)

Publication Number Publication Date
ATE304019T1 true ATE304019T1 (de) 2005-09-15

Family

ID=25489007

Family Applications (1)

Application Number Title Priority Date Filing Date
AT98953516T ATE304019T1 (de) 1997-10-14 1998-10-14 Inhibitoren des nukleosid-metabolismus

Country Status (13)

Country Link
US (7) US5985848A (de)
EP (1) EP1023308B1 (de)
JP (1) JP4451983B2 (de)
KR (1) KR100637479B1 (de)
CN (2) CN100393722C (de)
AT (1) ATE304019T1 (de)
AU (1) AU749098B2 (de)
CA (1) CA2305760C (de)
DE (1) DE69831499T2 (de)
DK (1) DK1023308T3 (de)
ES (1) ES2249844T3 (de)
PT (1) PT1023308E (de)
WO (1) WO1999019338A1 (de)

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US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
FR2790915B1 (fr) * 1999-03-19 2001-06-01 Commissariat Energie Atomique Procede de criblage et de selection d'antiparasitaires apicomplexes et/ou d'herbicides et ses applications
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AU2001284564A1 (en) * 2000-08-29 2002-03-13 Albert Einstein College Of Medicine Of Yeshiva University Nucleoside metabolism inhibitors
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EP1348707B1 (de) * 2002-03-28 2010-08-25 Ustav Experimentalni Botaniky AV CR, v.v.i. (Institute of Experimental Botany Academy of Sciences of the Czech Republic, PRO) Pyrazolo[4,3-d]pyrimidine, Verfahren zu ihrer Herstellung und therapeutische Anwendung
US20050250728A1 (en) * 2002-05-23 2005-11-10 Shanta Bantia Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
PT1539783E (pt) * 2002-08-21 2011-06-01 Einstein Coll Med Inibidores de nucleósido fosforilases e de nucleosidases
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CA2536887C (en) * 2003-08-26 2012-03-06 Teijin Pharma Limited Pyrrolopyrimidinone derivatives
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WO2007016291A2 (en) * 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
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EP1991230A4 (de) * 2006-02-24 2010-12-15 Einstein Coll Med Verfahren zur behandlung von krebs
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
US8383636B2 (en) * 2006-09-07 2013-02-26 Industrial Research Limited Acyclic amine inhibitors of 5-methytioadenosine phosphorylase and nucleosidase
AU2007293774C1 (en) 2006-09-07 2014-12-18 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
CA2674525A1 (en) * 2006-12-22 2008-07-03 Albert Einstein College Of Medicine Of Yeshiva University Azetidine analogues of nucleosidase and phosphorylase inhibitors
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
EP2278999B1 (de) 2008-04-21 2025-01-29 Dompé farmaceutici S.p.A. Ohrbehandlungsformulierungen zur behandlung von ohrenerkrankungen und -leiden
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
US20110190265A1 (en) * 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
EP2454263B1 (de) 2009-07-17 2018-06-13 Albert Einstein College of Medicine, Inc. 3-hydroxypyrrolidinhemmer von 5'-methylthioadenosin-phosphorylase und -nucleosidase
CA2813783C (en) 2010-10-15 2019-01-22 Shanta Bantia Methods and compositions for inhibition of polymerase
US9290501B2 (en) * 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
WO2012106509A1 (en) 2011-02-02 2012-08-09 The Trustees Of Princeton University Sirtuin modulators as virus production modulators
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EP2875359A4 (de) 2012-03-30 2015-08-19 Charles R Drew University Of Medicine And Science Zusammensetzungen und verfahren zur behandlung oder prävention von stoffwechselsyndromerkrankungen
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US11186575B2 (en) 2012-08-07 2021-11-30 Alber Einslein College of Medicine Treatment of helicobacter pylori infections
WO2014031815A1 (en) 2012-08-24 2014-02-27 Glaxosmithkline Llc Pyrazolopyrimidine compounds
RS56233B1 (sr) 2012-11-20 2017-11-30 Glaxosmithkline Llc Nova jedinjenja
AU2013348216B2 (en) * 2012-11-20 2016-10-13 Glaxosmithkline Llc Novel compounds
WO2014081644A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
ES2499965B2 (es) * 2013-03-27 2015-03-31 Universidad De Alicante Procedimiento de síntesis de compuestos homólogos de azanucleósidos
US9616129B2 (en) 2013-06-22 2017-04-11 Nitor Therapeutics Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency
SG11201606595RA (en) 2014-02-12 2016-09-29 Einstein Coll Med Treatment of h. pylori infections using mtan inhibitors
CA2973152A1 (en) * 2015-01-07 2016-07-14 Euro-Celtique S.A. Process for manufacture of forodesine
MX381542B (es) 2016-03-06 2025-03-04 Biocryst Pharm Inc Métodos y composiciones para el tratamiento de la infección por el virus del zika.
AU2017290256A1 (en) 2016-06-29 2019-01-17 Otonomy, Inc. Triglyceride otic formulations and uses thereof
US20220054494A1 (en) 2019-03-13 2022-02-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating bladder and urethra dysfunction and disease
MX2024002116A (es) 2021-08-20 2024-03-06 Shionogi & Co Derivados de nucleosido y profarmacos de los mismos que tienen accion inhibidora del crecimiento viral.
GB202218782D0 (en) 2022-12-13 2023-01-25 Mehrling Thomas Purine nucleoside phosphorylase inhibitor for metabolic syndrome

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PT1539783E (pt) 2002-08-21 2011-06-01 Einstein Coll Med Inibidores de nucleósido fosforilases e de nucleosidases
NZ523970A (en) 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
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WO2007097648A1 (en) 2006-02-24 2007-08-30 Industrial Research Limited Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases

Also Published As

Publication number Publication date
DK1023308T3 (da) 2006-01-23
WO1999019338A1 (en) 1999-04-22
DE69831499D1 (de) 2005-10-13
US20050026936A1 (en) 2005-02-03
US20070197561A1 (en) 2007-08-23
US6803455B2 (en) 2004-10-12
US6228847B1 (en) 2001-05-08
EP1023308A1 (de) 2000-08-02
HK1089159A1 (zh) 2006-11-24
ES2249844T3 (es) 2006-04-01
US5985848A (en) 1999-11-16
AU749098B2 (en) 2002-06-20
US20030096830A1 (en) 2003-05-22
DE69831499T2 (de) 2006-06-14
PT1023308E (pt) 2005-11-30
CA2305760C (en) 2008-06-03
AU1086699A (en) 1999-05-03
EP1023308B1 (de) 2005-09-07
CN1220695C (zh) 2005-09-28
CN100393722C (zh) 2008-06-11
JP2001519437A (ja) 2001-10-23
CA2305760A1 (en) 1999-04-22
US7211653B2 (en) 2007-05-01
KR20010031082A (ko) 2001-04-16
US20020061898A1 (en) 2002-05-23
US6492347B2 (en) 2002-12-10
JP4451983B2 (ja) 2010-04-14
CN1757646A (zh) 2006-04-12
US6066722A (en) 2000-05-23
US7390890B2 (en) 2008-06-24
KR100637479B1 (ko) 2006-10-20
CN1279686A (zh) 2001-01-10
EP1023308A4 (de) 2002-05-29

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