PT1023308E - Inibidores do metabolismo nucleosidico - Google Patents

Inibidores do metabolismo nucleosidico

Info

Publication number
PT1023308E
PT1023308E PT98953516T PT98953516T PT1023308E PT 1023308 E PT1023308 E PT 1023308E PT 98953516 T PT98953516 T PT 98953516T PT 98953516 T PT98953516 T PT 98953516T PT 1023308 E PT1023308 E PT 1023308E
Authority
PT
Portugal
Prior art keywords
sub
compounds
halogen
chosen
hydroxy
Prior art date
Application number
PT98953516T
Other languages
English (en)
Inventor
Richard Hubert Furneaux
Peter Charles Tyler
Vern L Schramm
Original Assignee
Einstein Coll Med
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med
Publication of PT1023308E publication Critical patent/PT1023308E/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D487/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04Ortho-condensed systems
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00Antiparasitic agents
    • A61P33/02Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06Antimalarials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
PT98953516T 1997-10-14 1998-10-14 Inibidores do metabolismo nucleosidico PT1023308E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/949,388 US5985848A (en) 1997-10-14 1997-10-14 Inhibitors of nucleoside metabolism

Publications (1)

Publication Number Publication Date
PT1023308E true PT1023308E (pt) 2005-11-30

Family

ID=25489007

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98953516T PT1023308E (pt) 1997-10-14 1998-10-14 Inibidores do metabolismo nucleosidico

Country Status (14)

Country Link
US (7) US5985848A (pt)
EP (1) EP1023308B1 (pt)
JP (1) JP4451983B2 (pt)
KR (1) KR100637479B1 (pt)
CN (2) CN1220695C (pt)
AT (1) ATE304019T1 (pt)
AU (1) AU749098B2 (pt)
CA (1) CA2305760C (pt)
DE (1) DE69831499T2 (pt)
DK (1) DK1023308T3 (pt)
ES (1) ES2249844T3 (pt)
HK (1) HK1089159A1 (pt)
PT (1) PT1023308E (pt)
WO (1) WO1999019338A1 (pt)

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ATE478872T1 (de) * 2002-03-28 2010-09-15 Ustav Ex Botan Av Cr V V I I O Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
WO2003100009A2 (en) * 2002-05-23 2003-12-04 Biocryst Pharmaceuticals, Inc. Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
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US8916571B2 (en) * 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
WO2007097648A1 (en) * 2006-02-24 2007-08-30 Industrial Research Limited Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
CA2662626C (en) 2006-09-07 2016-07-26 Industrial Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
AU2007293774C1 (en) 2006-09-07 2014-12-18 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
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KR20210107137A (ko) 2008-04-21 2021-08-31 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
US8784870B2 (en) 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
WO2010033236A2 (en) 2008-09-22 2010-03-25 Albert Einstein College Of Medicine Of Yeshiva University Methods and compositions for treating bacterial infections by inhibiting quorum sensing
US9493465B2 (en) 2009-07-17 2016-11-15 Victoria Link Limited 3-hydroxypyrrolidine inhibitors of 5′-methylthioadenosine phosphorylase and nucleosidase
ES2536831T3 (es) 2010-10-15 2015-05-29 Biocryst Pharmaceuticals, Inc. Métodos y composiciones para inhibición de polimerasa
WO2012074912A1 (en) * 2010-11-29 2012-06-07 Albert Einstein College Of Medicine Of Yeshiva University Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
US20130338178A1 (en) 2011-02-02 2013-12-19 The Trustees Of Princeton University Sirtuin modulators as inhibitors of cytomegalovirus
KR101916928B1 (ko) 2011-07-22 2018-11-08 글락소스미스클라인 엘엘씨 조성물
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AR090699A1 (es) 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
JP6063571B2 (ja) 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン,インコーポレイティド ヘリコバクター・ピロリ感染の治療
TWI625331B (zh) 2012-08-24 2018-06-01 葛蘭素史密斯克藍有限責任公司 可作為干擾素誘導物之化合物及其組合物及用途
WO2014081645A1 (en) 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
CA2890198A1 (en) * 2012-11-20 2014-05-30 Diane Mary Coe Novel compounds
WO2014081644A1 (en) * 2012-11-20 2014-05-30 Glaxosmithkline Llc Novel compounds
ES2499965B2 (es) * 2013-03-27 2015-03-31 Universidad De Alicante Procedimiento de síntesis de compuestos homólogos de azanucleósidos
US9616129B2 (en) 2013-06-22 2017-04-11 Nitor Therapeutics Compositions and methods for potentiating immune response, enhancing immunotherapy, and increasing vaccine potency
SG11201606595RA (en) 2014-02-12 2016-09-29 Einstein Coll Med Treatment of h. pylori infections using mtan inhibitors
CA2973152A1 (en) * 2015-01-07 2016-07-14 Euro-Celtique S.A. Process for manufacture of forodesine
MA43812A (fr) 2016-03-06 2018-11-28 Biocryst Pharm Inc Procédés et compositions pour le traitement d'une infection par le virus zika
CA3029281A1 (en) 2016-06-29 2018-01-04 Otonomy, Inc. Triglyceride otic formulations and uses thereof
WO2020186187A1 (en) 2019-03-13 2020-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating bladder and urethra dysfunction and disease
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NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
JP2008508287A (ja) 2004-07-27 2008-03-21 バイオクリスト・フアーマシユーテイカルズ・インコーポレイテツド 5’−メチルチオアデノシンホスホリラーゼ及び5’メチルチオアデノシン/s−アデノシルホモシステインヌクレオシダーゼの阻害剤
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NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
US8916571B2 (en) 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
WO2007097648A1 (en) 2006-02-24 2007-08-30 Industrial Research Limited Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases

Also Published As

Publication number Publication date
AU1086699A (en) 1999-05-03
CN100393722C (zh) 2008-06-11
US6492347B2 (en) 2002-12-10
US20020061898A1 (en) 2002-05-23
EP1023308B1 (en) 2005-09-07
DE69831499T2 (de) 2006-06-14
US6803455B2 (en) 2004-10-12
US6228847B1 (en) 2001-05-08
US20050026936A1 (en) 2005-02-03
US5985848A (en) 1999-11-16
EP1023308A4 (en) 2002-05-29
US7211653B2 (en) 2007-05-01
WO1999019338A1 (en) 1999-04-22
DK1023308T3 (da) 2006-01-23
ATE304019T1 (de) 2005-09-15
ES2249844T3 (es) 2006-04-01
CN1220695C (zh) 2005-09-28
CA2305760C (en) 2008-06-03
EP1023308A1 (en) 2000-08-02
CN1279686A (zh) 2001-01-10
KR20010031082A (ko) 2001-04-16
DE69831499D1 (de) 2005-10-13
KR100637479B1 (ko) 2006-10-20
CN1757646A (zh) 2006-04-12
HK1089159A1 (en) 2006-11-24
US20070197561A1 (en) 2007-08-23
CA2305760A1 (en) 1999-04-22
JP4451983B2 (ja) 2010-04-14
US20030096830A1 (en) 2003-05-22
AU749098B2 (en) 2002-06-20
US6066722A (en) 2000-05-23
JP2001519437A (ja) 2001-10-23
US7390890B2 (en) 2008-06-24

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