PT1023308E - Inibidores do metabolismo nucleosidico - Google Patents

Inibidores do metabolismo nucleosidico

Info

Publication number
PT1023308E
PT1023308E PT98953516T PT98953516T PT1023308E PT 1023308 E PT1023308 E PT 1023308E PT 98953516 T PT98953516 T PT 98953516T PT 98953516 T PT98953516 T PT 98953516T PT 1023308 E PT1023308 E PT 1023308E
Authority
PT
Portugal
Prior art keywords
sub
compounds
halogen
chosen
hydroxy
Prior art date
Application number
PT98953516T
Other languages
English (en)
Inventor
Richard Hubert Furneaux
Peter Charles Tyler
Vern L Schramm
Original Assignee
Einstein Coll Med
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med
Publication of PT1023308E publication Critical patent/PT1023308E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
PT98953516T 1997-10-14 1998-10-14 Inibidores do metabolismo nucleosidico PT1023308E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/949,388 US5985848A (en) 1997-10-14 1997-10-14 Inhibitors of nucleoside metabolism

Publications (1)

Publication Number Publication Date
PT1023308E true PT1023308E (pt) 2005-11-30

Family

ID=25489007

Family Applications (1)

Application Number Title Priority Date Filing Date
PT98953516T PT1023308E (pt) 1997-10-14 1998-10-14 Inibidores do metabolismo nucleosidico

Country Status (14)

Country Link
US (7) US5985848A (pt)
EP (1) EP1023308B1 (pt)
JP (1) JP4451983B2 (pt)
KR (1) KR100637479B1 (pt)
CN (2) CN100393722C (pt)
AT (1) ATE304019T1 (pt)
AU (1) AU749098B2 (pt)
CA (1) CA2305760C (pt)
DE (1) DE69831499T2 (pt)
DK (1) DK1023308T3 (pt)
ES (1) ES2249844T3 (pt)
HK (1) HK1089159A1 (pt)
PT (1) PT1023308E (pt)
WO (1) WO1999019338A1 (pt)

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CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
KR101433621B1 (ko) 2006-09-07 2014-08-27 알버트 아인슈타인 컬리지 오브 메디신 오브 예쉬바 유니버시티 누클레오시드 포스포릴라아제 및 히드롤라아제의 비고리형 아민 억제제
CA2662626C (en) 2006-09-07 2016-07-26 Industrial Research Limited Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
EP2114925B8 (en) * 2006-12-22 2013-04-10 Industrial Research Limited Azetidine analogues of nucleosidase and phosphorylase inhibitors
KR20190026056A (ko) 2008-04-21 2019-03-12 오토노미, 인코포레이티드 귀 질환 및 병태를 치료하기 위한 귀 조제물
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
US20110190265A1 (en) * 2008-09-22 2011-08-04 Schramm Vern L Methods and compositions for treating bacterial infections by inhibiting quorum sensing
DK2454263T3 (en) 2009-07-17 2018-10-01 Albert Einstein College Medicine Inc 3-HYDROXYPYRROLIDE INHIBITORS OF 5'-METHYLTHIOADENOSINE PHOSPHORYLASE AND - NUCLEOSIDASE
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US9682093B2 (en) 2012-03-30 2017-06-20 Charles R. Drew University Of Medicine And Science Compositions and methods for treating or preventing metabolic syndrome disorders
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CN104780923B (zh) * 2012-11-20 2017-03-15 葛兰素史克有限责任公司 干扰素诱导剂化合物
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BR112015011447A2 (pt) * 2012-11-20 2017-07-11 Glaxosmithkline Llc composto da fórmula i, composição farmacêutica e de vacina, e, uso de um composto
ES2499965B2 (es) * 2013-03-27 2015-03-31 Universidad De Alicante Procedimiento de síntesis de compuestos homólogos de azanucleósidos
EP3010507A4 (en) * 2013-06-22 2017-06-07 Nitor Therapeutics Compositions and methods for potentiating immune response for the treatment of infectious diseases and cancer
WO2015123101A1 (en) 2014-02-12 2015-08-20 Albert Einstein College Of Medicine Of Yeshiva University Treatment of h. pylori infections using mtan inhibitors
KR20170102340A (ko) * 2015-01-07 2017-09-08 유로-셀띠끄 소시에떼 아노님 포로데신의 제조 방법
CN109689027A (zh) 2016-06-29 2019-04-26 奥德纳米有限公司 甘油三酯耳用制剂及其用途
WO2020186187A1 (en) 2019-03-13 2020-09-17 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating bladder and urethra dysfunction and disease
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Also Published As

Publication number Publication date
JP2001519437A (ja) 2001-10-23
EP1023308B1 (en) 2005-09-07
DK1023308T3 (da) 2006-01-23
AU749098B2 (en) 2002-06-20
EP1023308A4 (en) 2002-05-29
US5985848A (en) 1999-11-16
EP1023308A1 (en) 2000-08-02
DE69831499T2 (de) 2006-06-14
AU1086699A (en) 1999-05-03
ES2249844T3 (es) 2006-04-01
CN100393722C (zh) 2008-06-11
US7390890B2 (en) 2008-06-24
CA2305760C (en) 2008-06-03
DE69831499D1 (de) 2005-10-13
JP4451983B2 (ja) 2010-04-14
CN1220695C (zh) 2005-09-28
KR100637479B1 (ko) 2006-10-20
US7211653B2 (en) 2007-05-01
US6492347B2 (en) 2002-12-10
ATE304019T1 (de) 2005-09-15
US6228847B1 (en) 2001-05-08
HK1089159A1 (en) 2006-11-24
US20070197561A1 (en) 2007-08-23
US6803455B2 (en) 2004-10-12
KR20010031082A (ko) 2001-04-16
CA2305760A1 (en) 1999-04-22
CN1279686A (zh) 2001-01-10
US20030096830A1 (en) 2003-05-22
US20050026936A1 (en) 2005-02-03
US20020061898A1 (en) 2002-05-23
WO1999019338A1 (en) 1999-04-22
CN1757646A (zh) 2006-04-12
US6066722A (en) 2000-05-23

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