HK1089159A1 - Inhibitors of nucleoside metabolism - Google Patents

Inhibitors of nucleoside metabolism

Info

Publication number
HK1089159A1
HK1089159A1 HK06109456A HK06109456A HK1089159A1 HK 1089159 A1 HK1089159 A1 HK 1089159A1 HK 06109456 A HK06109456 A HK 06109456A HK 06109456 A HK06109456 A HK 06109456A HK 1089159 A1 HK1089159 A1 HK 1089159A1
Authority
HK
Hong Kong
Prior art keywords
sub
compounds
halogen
chosen
hydroxy
Prior art date
Application number
HK06109456A
Other languages
English (en)
Inventor
Richard Hubert Furneaux
Peter Charles Tyler
Vern L Schramm
Original Assignee
Einstein Coll Med
Ind Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Einstein Coll Med, Ind Res Ltd filed Critical Einstein Coll Med
Publication of HK1089159A1 publication Critical patent/HK1089159A1/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Transplantation (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyrrole Compounds (AREA)
HK06109456A 1997-10-14 2006-08-25 Inhibitors of nucleoside metabolism HK1089159A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/949,388 US5985848A (en) 1997-10-14 1997-10-14 Inhibitors of nucleoside metabolism

Publications (1)

Publication Number Publication Date
HK1089159A1 true HK1089159A1 (en) 2006-11-24

Family

ID=25489007

Family Applications (1)

Application Number Title Priority Date Filing Date
HK06109456A HK1089159A1 (en) 1997-10-14 2006-08-25 Inhibitors of nucleoside metabolism

Country Status (14)

Country Link
US (7) US5985848A (xx)
EP (1) EP1023308B1 (xx)
JP (1) JP4451983B2 (xx)
KR (1) KR100637479B1 (xx)
CN (2) CN100393722C (xx)
AT (1) ATE304019T1 (xx)
AU (1) AU749098B2 (xx)
CA (1) CA2305760C (xx)
DE (1) DE69831499T2 (xx)
DK (1) DK1023308T3 (xx)
ES (1) ES2249844T3 (xx)
HK (1) HK1089159A1 (xx)
PT (1) PT1023308E (xx)
WO (1) WO1999019338A1 (xx)

Families Citing this family (55)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5985848A (en) * 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
FR2790915B1 (fr) * 1999-03-19 2001-06-01 Commissariat Energie Atomique Procede de criblage et de selection d'antiparasitaires apicomplexes et/ou d'herbicides et ses applications
LT2077268T (lt) * 1999-04-08 2017-08-10 Victoria Link Limited Nukleozidų metabolizmo inhibitorių gavimo būdas
US6656915B1 (en) 1999-09-15 2003-12-02 Biocryst Pharmaceuticals, Inc. Inhibiting T-cell proliferation
US6387923B2 (en) * 2000-03-22 2002-05-14 Biocryst Pharmacueticals, Inc. Imminoribitol PNP inhibitors, preparation thereof and use thereof
WO2002018371A1 (en) * 2000-08-29 2002-03-07 Industrial Research Limited Nucleoside metabolism inhibitors
US20040076809A1 (en) * 2001-09-13 2004-04-22 Spears Ward R. Composite flywheel rim having commingled layers with macroscopically uniform patterns of fiber arrangement and methods for manufacturing same
US6660719B2 (en) * 2001-12-17 2003-12-09 Biocryst Pharmaceuticals Inc. Inhibiting T-Cell proliferation
US7098334B2 (en) * 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
ATE478872T1 (de) * 2002-03-28 2010-09-15 Ustav Ex Botan Av Cr V V I I O Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung
US20050250728A1 (en) * 2002-05-23 2005-11-10 Shanta Bantia Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof
BRPI0313664B8 (pt) * 2002-08-21 2021-05-25 Albert Einstein College Medicine Yeshiva Univ compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
AU2004219595A1 (en) * 2003-03-11 2004-09-23 Qlt Usa Inc. Formulations for cell- schedule dependent anticancer agents
US6972331B2 (en) * 2003-04-23 2005-12-06 Biocryst Pharmaceuticals, Inc. Carboxy pyrrole, process of preparing and use as precursor
US7557113B2 (en) 2003-08-26 2009-07-07 Teijin Pharma Limited Substituted pyrrolo[3,2-d]pyrimidine derivatives
TW200519116A (en) * 2003-08-26 2005-06-16 Teijin Pharma Ltd Pyrrolopyrimidine derivatives
US8017634B2 (en) 2003-12-29 2011-09-13 President And Fellows Of Harvard College Compositions for treating obesity and insulin resistance disorders
NZ533360A (en) * 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
EP1844063A4 (en) * 2005-02-04 2009-06-17 Uti Limited Partnership PURINNUKLEOSIDANALOGA
CA2615549A1 (en) * 2005-07-27 2007-02-08 Albert Einstein College Of Medicine Of Yeshiva University Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
WO2007097643A1 (en) * 2006-02-22 2007-08-30 Industrial Research Limited Analogues of coformycin and their use for treating protozoan parasite infections
CA2643056A1 (en) * 2006-02-24 2007-08-30 Industrial Research Limited Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases
US8916571B2 (en) * 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase
CN101094080B (zh) * 2006-06-22 2012-06-20 华为技术有限公司 一种即按即通系统中的计费方法
AU2007293773B2 (en) 2006-09-07 2013-01-31 Albert Einstein College Of Medicine, Inc. Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
NZ575365A (en) 2006-09-07 2012-02-24 Ind Res Ltd Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases
AU2007338953A1 (en) * 2006-12-22 2008-07-03 Albert Einstein College Of Medicine Of Yeshiva University Azetidine analogues of nucleosidase and phosphorylase inhibitors
CA2721927C (en) 2008-04-21 2014-01-28 Otonomy, Inc. Auris formulations for treating otic diseases and conditions
US11969501B2 (en) 2008-04-21 2024-04-30 Dompé Farmaceutici S.P.A. Auris formulations for treating otic diseases and conditions
US8784870B2 (en) * 2008-07-21 2014-07-22 Otonomy, Inc. Controlled release compositions for modulating free-radical induced damage and methods of use thereof
UA103195C2 (uk) 2008-08-11 2013-09-25 Глаксосмитклайн Ллк Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань
EP2348854A4 (en) 2008-09-22 2012-03-14 Einstein Coll Med METHOD AND COMPOSITIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS BY INHIBITING THE "QUORUM SENSING
EP2454263B1 (en) 2009-07-17 2018-06-13 Albert Einstein College of Medicine, Inc. 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase
RS56870B1 (sr) 2010-10-15 2018-04-30 Biocryst Pharm Inc Pirolopirimidinski derivati za primenu u lečenju virusnih infekcija
US9290501B2 (en) * 2010-11-29 2016-03-22 Albert Einstein College Of Medicine, Inc. Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase
WO2012106509A1 (en) 2011-02-02 2012-08-09 The Trustees Of Princeton University Sirtuin modulators as virus production modulators
RU2631482C2 (ru) 2011-07-22 2017-09-22 ГЛАКСОСМИТКЛАЙН ЭлЭлСи Композиция
WO2013149258A2 (en) 2012-03-30 2013-10-03 Charles Drew University of Medicine and Science Compositions and methods for treating or preventing metabolic syndrome disorders
AR090699A1 (es) 2012-04-18 2014-12-03 Biocryst Pharm Inc Compuestos inhibidores de la actividad de la arn polimerasa viral
JP6063571B2 (ja) 2012-08-07 2017-01-18 アルバート アインシュタイン カレッジ オブ メディシン，インコーポレイティド ヘリコバクター・ピロリ感染の治療
CA2880576A1 (en) 2012-08-24 2014-02-27 Glaxosmithkline Llc Pyrazolopyrimidine compounds
PT2922549T (pt) * 2012-11-20 2017-09-01 Glaxosmithkline Llc Novos compostos
BR112015011447A2 (pt) * 2012-11-20 2017-07-11 Glaxosmithkline Llc composto da fórmula i, composição farmacêutica e de vacina, e, uso de um composto
EP2922547B1 (en) * 2012-11-20 2017-03-08 Glaxosmithkline LLC Novel compounds
ES2499965B2 (es) * 2013-03-27 2015-03-31 Universidad De Alicante Procedimiento de síntesis de compuestos homólogos de azanucleósidos
US9452217B2 (en) 2013-06-22 2016-09-27 Nitor Therapeutics Methods for potentiating immune response for the treatment of infectious diseases and cancer
CA2974916C (en) 2014-02-12 2022-05-31 Victoria Link Limited Substituted 9-deazaadenine derivates and pharmaceutical compostitions thereof useful in the treatment of h.pylori infection
US20180258091A1 (en) * 2015-01-07 2018-09-13 Euro-Celtique S.A Process for manufacture of forodesine
WO2017155886A1 (en) 2016-03-06 2017-09-14 Biocryst Pharmaceuticals, Inc. Methods and compositions for treatment of zika virus infection
US10821185B2 (en) 2016-06-29 2020-11-03 Otonomy Inc. Triglyceride otic formulations and uses thereof
US20220054494A1 (en) 2019-03-13 2022-02-24 University Of Pittsburgh - Of The Commonwealth System Of Higher Education Methods for treating bladder and urethra dysfunction and disease
IL310854A (en) 2021-08-20 2024-04-01 Shionogi & Co Nucleoside compounds and their drug derivatives possessing viral growth inhibitory activity
GB202218782D0 (en) 2022-12-13 2023-01-25 Mehrling Thomas Purine nucleoside phosphorylase inhibitor for metabolic syndrome

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4711955A (en) * 1981-04-17 1987-12-08 Yale University Modified nucleotides and methods of preparing and using same
ATE269870T1 (de) * 1989-10-24 2004-07-15 Isis Pharmaceuticals Inc 2'-modifizierte oligonukleotide
US5506351A (en) * 1992-07-23 1996-04-09 Isis Pharmaceuticals Process for the preparation of 2'-O-alkyl guanosine and related compounds
US5223618A (en) * 1990-08-13 1993-06-29 Isis Pharmaceuticals, Inc. 4'-desmethyl nucleoside analog compounds
AU1739097A (en) * 1996-02-23 1997-09-10 Albert Einstein College Of Medicine Of Yeshiva University Enzyme detection/assay method and substrates
US5985848A (en) 1997-10-14 1999-11-16 Albert Einstein College Of Medicine Of Yeshiva University Inhibitors of nucleoside metabolism
US7022677B1 (en) * 1999-02-18 2006-04-04 Kaken Pharmaceutical Co., Ltd. Amide derivatives as growth hormone secretagogues
LT2077268T (lt) * 1999-04-08 2017-08-10 Victoria Link Limited Nukleozidų metabolizmo inhibitorių gavimo būdas
US6448799B1 (en) * 1999-09-30 2002-09-10 Hitachi Electronics Engineering Co., Ltd. Timing adjustment method and apparatus for semiconductor IC tester
WO2002018371A1 (en) * 2000-08-29 2002-03-07 Industrial Research Limited Nucleoside metabolism inhibitors
US6458799B1 (en) 2000-08-31 2002-10-01 Biocryst Pharmaceuticals, Inc. Deazaguanine analog, preparation thereof and use thereof
US7098334B2 (en) 2002-03-25 2006-08-29 Industrial Research Limited 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases
BRPI0313664B8 (pt) * 2002-08-21 2021-05-25 Albert Einstein College Medicine Yeshiva Univ compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos
NZ523970A (en) * 2003-02-04 2005-02-25 Ind Res Ltd Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases
NZ533360A (en) 2004-06-04 2007-02-23 Ind Res Ltd Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds
US20090012104A1 (en) 2004-07-27 2009-01-08 Babu Yarlagadda S Inhibitors of 5'-Methylthioadenosine Phosphorylase and 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase
NZ540160A (en) 2005-05-20 2008-03-28 Einstein Coll Med Inhibitors of nucleoside phosphorylases
NZ544187A (en) 2005-12-15 2008-07-31 Ind Res Ltd Deazapurine analogs of 1'-aza-l-nucleosides
CA2643056A1 (en) 2006-02-24 2007-08-30 Industrial Research Limited Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases
US8916571B2 (en) 2006-02-24 2014-12-23 Albert Einstein College Of Medicine Of Yeshiva University Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase

Also Published As

Publication number Publication date
US20030096830A1 (en) 2003-05-22
ES2249844T3 (es) 2006-04-01
US5985848A (en) 1999-11-16
CN1279686A (zh) 2001-01-10
EP1023308A1 (en) 2000-08-02
US20050026936A1 (en) 2005-02-03
US6066722A (en) 2000-05-23
JP2001519437A (ja) 2001-10-23
CN1220695C (zh) 2005-09-28
US6492347B2 (en) 2002-12-10
WO1999019338A1 (en) 1999-04-22
US7211653B2 (en) 2007-05-01
AU1086699A (en) 1999-05-03
US7390890B2 (en) 2008-06-24
US20070197561A1 (en) 2007-08-23
EP1023308B1 (en) 2005-09-07
ATE304019T1 (de) 2005-09-15
CN100393722C (zh) 2008-06-11
JP4451983B2 (ja) 2010-04-14
EP1023308A4 (en) 2002-05-29
AU749098B2 (en) 2002-06-20
DK1023308T3 (da) 2006-01-23
US6803455B2 (en) 2004-10-12
KR100637479B1 (ko) 2006-10-20
DE69831499D1 (de) 2005-10-13
US20020061898A1 (en) 2002-05-23
KR20010031082A (ko) 2001-04-16
CA2305760A1 (en) 1999-04-22
CA2305760C (en) 2008-06-03
DE69831499T2 (de) 2006-06-14
PT1023308E (pt) 2005-11-30
US6228847B1 (en) 2001-05-08
CN1757646A (zh) 2006-04-12

Similar Documents

Publication Publication Date Title
HK1089159A1 (en) Inhibitors of nucleoside metabolism
EP2308845A3 (en) Caspase inhibitors and uses thereof
ZA976705B (en) Process for the synthesis of protected esters of (S)-3,4-dihydroxybutric acid.
IL133891A0 (en) 2-valproenoic acid amide derivatives, their preparation and pharmaceutical compositions containing them
WO2001009103A3 (en) Imidazole antiproliferative agents
HUP0102471A2 (hu) 4-Benzil-piperidin alkilszulfoxid heterociklusok és használatuk altípus-szelektív NMDA antagonistaként és ezeket tartalmazó gyógyszerkészítmények
MXPA01011517A (es) Nucleosidos de 4'-c-etinil-purina.
TW360652B (en) Acryloyl substituted disstamycin derivatives, process for preparing them, and pharmaceutical composition comprising them
NZ332923A (en) Distamycin derivatives, process for preparing them, and their use as antitumor and antiviral agents
DE69330601D1 (de) Serotoninergische ergolin derivate
AP1518A (en) Novel octahydro-6, 10-dioxo-6h-pyridazino/1,2-a/ /1,2/diazepin-1-carboxylic acid derivatives, preparation method and use for preparing therapeutically active compounds.
CA2266565A1 (en) Azabicyclic rotomase inhibitors
YU28902A (sh) Fenil- i piridil-tetrahidro-piridini koji imaju tnf-inhibitorsku aktivnost
ES2128960A1 (es) Derivados de fluorofenil-triazinas y pirimidinas compuestos farmacologicamente activos en el sistema nervioso central.
IL148590A0 (en) Alkaloid compounds and pharmaceutical compositions containing the same
ES2006336A6 (es) Procedimiento de preparacion de nuevas acetamidas derivadas de la 2,3-dihidro-3-fenil-2-benzofuranona.
ES8608467A1 (es) Procedimiento de preparacion de un derivado 1,1-difenilpro- pan-1-ol
ES8605819A1 (es) Procedimiento de preparacion de nuevos derivados nucleosidos.

Legal Events

Date Code Title Description
PE Patent expired

Effective date: 20181013