CN1220695C - 核苷代谢的抑制剂 - Google Patents
核苷代谢的抑制剂 Download PDFInfo
- Publication number
- CN1220695C CN1220695C CNB988114895A CN98811489A CN1220695C CN 1220695 C CN1220695 C CN 1220695C CN B988114895 A CNB988114895 A CN B988114895A CN 98811489 A CN98811489 A CN 98811489A CN 1220695 C CN1220695 C CN 1220695C
- Authority
- CN
- China
- Prior art keywords
- compound
- group
- imino
- pyrimidin
- formula
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/06—Antimalarials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Immunology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Tropical Medicine & Parasitology (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Transplantation (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
Abstract
Description
ki值(nM) | ||||
酶来源 | 化合物Ia a | 化合物Ib b | 化合物Ic b | 化合物Ia b |
束状短膜(鞭毛(虫属的核苷水解酶 | 42±2nM | 40nM | 7nM | 3nM |
锥虫属布鲁(杆)菌布鲁(杆)菌属的核苷水解酶 | 24±3nM | 108nM | 0.9nM | 23nM |
a多次测定的平均值以及相关误差bki的单次测定值 |
化合物Ib-5’-磷酸酯 | 化合物Ic-5’-磷酸酯 | |||
酶来源 | ki | ki* | ki | ki* |
人类PPRT | 40nM | 3nM | 14nM | 8nM |
疟疾PPRT | 33nM | 3nM | 48nM | 慢发作,没有观察到 |
Claims (24)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US08/949,388 US5985848A (en) | 1997-10-14 | 1997-10-14 | Inhibitors of nucleoside metabolism |
US08/949,388 | 1997-10-14 |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005100920669A Division CN100393722C (zh) | 1997-10-14 | 1998-10-14 | 核苷代谢的抑制剂 |
Publications (2)
Publication Number | Publication Date |
---|---|
CN1279686A CN1279686A (zh) | 2001-01-10 |
CN1220695C true CN1220695C (zh) | 2005-09-28 |
Family
ID=25489007
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005100920669A Expired - Lifetime CN100393722C (zh) | 1997-10-14 | 1998-10-14 | 核苷代谢的抑制剂 |
CNB988114895A Expired - Lifetime CN1220695C (zh) | 1997-10-14 | 1998-10-14 | 核苷代谢的抑制剂 |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CNB2005100920669A Expired - Lifetime CN100393722C (zh) | 1997-10-14 | 1998-10-14 | 核苷代谢的抑制剂 |
Country Status (14)
Country | Link |
---|---|
US (7) | US5985848A (zh) |
EP (1) | EP1023308B1 (zh) |
JP (1) | JP4451983B2 (zh) |
KR (1) | KR100637479B1 (zh) |
CN (2) | CN100393722C (zh) |
AT (1) | ATE304019T1 (zh) |
AU (1) | AU749098B2 (zh) |
CA (1) | CA2305760C (zh) |
DE (1) | DE69831499T2 (zh) |
DK (1) | DK1023308T3 (zh) |
ES (1) | ES2249844T3 (zh) |
HK (1) | HK1089159A1 (zh) |
PT (1) | PT1023308E (zh) |
WO (1) | WO1999019338A1 (zh) |
Families Citing this family (55)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5985848A (en) * | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
FR2790915B1 (fr) * | 1999-03-19 | 2001-06-01 | Commissariat Energie Atomique | Procede de criblage et de selection d'antiparasitaires apicomplexes et/ou d'herbicides et ses applications |
LT2077268T (lt) * | 1999-04-08 | 2017-08-10 | Victoria Link Limited | Nukleozidų metabolizmo inhibitorių gavimo būdas |
US6656915B1 (en) | 1999-09-15 | 2003-12-02 | Biocryst Pharmaceuticals, Inc. | Inhibiting T-cell proliferation |
US6387923B2 (en) * | 2000-03-22 | 2002-05-14 | Biocryst Pharmacueticals, Inc. | Imminoribitol PNP inhibitors, preparation thereof and use thereof |
WO2002018371A1 (en) * | 2000-08-29 | 2002-03-07 | Industrial Research Limited | Nucleoside metabolism inhibitors |
US20040076809A1 (en) * | 2001-09-13 | 2004-04-22 | Spears Ward R. | Composite flywheel rim having commingled layers with macroscopically uniform patterns of fiber arrangement and methods for manufacturing same |
US6660719B2 (en) * | 2001-12-17 | 2003-12-09 | Biocryst Pharmaceuticals Inc. | Inhibiting T-Cell proliferation |
US7098334B2 (en) * | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
ATE478872T1 (de) * | 2002-03-28 | 2010-09-15 | Ustav Ex Botan Av Cr V V I I O | Pyrazoloä4,3-düpyrimidine, verfahren zu ihrer herstellung und therapeutische anwendung |
US20050250728A1 (en) * | 2002-05-23 | 2005-11-10 | Shanta Bantia | Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof |
BRPI0313664B8 (pt) * | 2002-08-21 | 2021-05-25 | Albert Einstein College Medicine Yeshiva Univ | compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos |
NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
AU2004219595A1 (en) * | 2003-03-11 | 2004-09-23 | Qlt Usa Inc. | Formulations for cell- schedule dependent anticancer agents |
US6972331B2 (en) * | 2003-04-23 | 2005-12-06 | Biocryst Pharmaceuticals, Inc. | Carboxy pyrrole, process of preparing and use as precursor |
US7557113B2 (en) | 2003-08-26 | 2009-07-07 | Teijin Pharma Limited | Substituted pyrrolo[3,2-d]pyrimidine derivatives |
TW200519116A (en) * | 2003-08-26 | 2005-06-16 | Teijin Pharma Ltd | Pyrrolopyrimidine derivatives |
US8017634B2 (en) | 2003-12-29 | 2011-09-13 | President And Fellows Of Harvard College | Compositions for treating obesity and insulin resistance disorders |
NZ533360A (en) * | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
EP1844063A4 (en) * | 2005-02-04 | 2009-06-17 | Uti Limited Partnership | PURINNUKLEOSIDANALOGA |
CA2615549A1 (en) * | 2005-07-27 | 2007-02-08 | Albert Einstein College Of Medicine Of Yeshiva University | Transition state structure of 5'-methylthioadenosine/s-adenosylhomocysteine nucleosidases |
NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
WO2007097643A1 (en) * | 2006-02-22 | 2007-08-30 | Industrial Research Limited | Analogues of coformycin and their use for treating protozoan parasite infections |
CA2643056A1 (en) * | 2006-02-24 | 2007-08-30 | Industrial Research Limited | Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases |
US8916571B2 (en) * | 2006-02-24 | 2014-12-23 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase |
CN101094080B (zh) * | 2006-06-22 | 2012-06-20 | 华为技术有限公司 | 一种即按即通系统中的计费方法 |
AU2007293773B2 (en) | 2006-09-07 | 2013-01-31 | Albert Einstein College Of Medicine, Inc. | Acyclic amine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
NZ575365A (en) | 2006-09-07 | 2012-02-24 | Ind Res Ltd | Acyclic amine inhibitors of nucleoside phosphorylases and hydrolases |
AU2007338953A1 (en) * | 2006-12-22 | 2008-07-03 | Albert Einstein College Of Medicine Of Yeshiva University | Azetidine analogues of nucleosidase and phosphorylase inhibitors |
CA2721927C (en) | 2008-04-21 | 2014-01-28 | Otonomy, Inc. | Auris formulations for treating otic diseases and conditions |
US11969501B2 (en) | 2008-04-21 | 2024-04-30 | Dompé Farmaceutici S.P.A. | Auris formulations for treating otic diseases and conditions |
US8784870B2 (en) * | 2008-07-21 | 2014-07-22 | Otonomy, Inc. | Controlled release compositions for modulating free-radical induced damage and methods of use thereof |
UA103195C2 (uk) | 2008-08-11 | 2013-09-25 | Глаксосмитклайн Ллк | Похідні пурину для застосування у лікуванні алергій, запальних та інфекційних захворювань |
EP2348854A4 (en) | 2008-09-22 | 2012-03-14 | Einstein Coll Med | METHOD AND COMPOSITIONS FOR THE TREATMENT OF BACTERIAL INFECTIONS BY INHIBITING THE "QUORUM SENSING |
EP2454263B1 (en) | 2009-07-17 | 2018-06-13 | Albert Einstein College of Medicine, Inc. | 3-hydroxypyrrolidine inhibitors of 5'-methylthioadenosine phosphorylase and nucleosidase |
RS56870B1 (sr) | 2010-10-15 | 2018-04-30 | Biocryst Pharm Inc | Pirolopirimidinski derivati za primenu u lečenju virusnih infekcija |
US9290501B2 (en) * | 2010-11-29 | 2016-03-22 | Albert Einstein College Of Medicine, Inc. | Methods, assays and compounds for treating bacterial infections by inhibiting methylthioinosine phosphorylase |
WO2012106509A1 (en) | 2011-02-02 | 2012-08-09 | The Trustees Of Princeton University | Sirtuin modulators as virus production modulators |
RU2631482C2 (ru) | 2011-07-22 | 2017-09-22 | ГЛАКСОСМИТКЛАЙН ЭлЭлСи | Композиция |
WO2013149258A2 (en) | 2012-03-30 | 2013-10-03 | Charles Drew University of Medicine and Science | Compositions and methods for treating or preventing metabolic syndrome disorders |
AR090699A1 (es) | 2012-04-18 | 2014-12-03 | Biocryst Pharm Inc | Compuestos inhibidores de la actividad de la arn polimerasa viral |
JP6063571B2 (ja) | 2012-08-07 | 2017-01-18 | アルバート アインシュタイン カレッジ オブ メディシン,インコーポレイティド | ヘリコバクター・ピロリ感染の治療 |
CA2880576A1 (en) | 2012-08-24 | 2014-02-27 | Glaxosmithkline Llc | Pyrazolopyrimidine compounds |
PT2922549T (pt) * | 2012-11-20 | 2017-09-01 | Glaxosmithkline Llc | Novos compostos |
BR112015011447A2 (pt) * | 2012-11-20 | 2017-07-11 | Glaxosmithkline Llc | composto da fórmula i, composição farmacêutica e de vacina, e, uso de um composto |
EP2922547B1 (en) * | 2012-11-20 | 2017-03-08 | Glaxosmithkline LLC | Novel compounds |
ES2499965B2 (es) * | 2013-03-27 | 2015-03-31 | Universidad De Alicante | Procedimiento de síntesis de compuestos homólogos de azanucleósidos |
US9452217B2 (en) | 2013-06-22 | 2016-09-27 | Nitor Therapeutics | Methods for potentiating immune response for the treatment of infectious diseases and cancer |
CA2974916C (en) | 2014-02-12 | 2022-05-31 | Victoria Link Limited | Substituted 9-deazaadenine derivates and pharmaceutical compostitions thereof useful in the treatment of h.pylori infection |
US20180258091A1 (en) * | 2015-01-07 | 2018-09-13 | Euro-Celtique S.A | Process for manufacture of forodesine |
WO2017155886A1 (en) | 2016-03-06 | 2017-09-14 | Biocryst Pharmaceuticals, Inc. | Methods and compositions for treatment of zika virus infection |
US10821185B2 (en) | 2016-06-29 | 2020-11-03 | Otonomy Inc. | Triglyceride otic formulations and uses thereof |
US20220054494A1 (en) | 2019-03-13 | 2022-02-24 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Methods for treating bladder and urethra dysfunction and disease |
IL310854A (en) | 2021-08-20 | 2024-04-01 | Shionogi & Co | Nucleoside compounds and their drug derivatives possessing viral growth inhibitory activity |
GB202218782D0 (en) | 2022-12-13 | 2023-01-25 | Mehrling Thomas | Purine nucleoside phosphorylase inhibitor for metabolic syndrome |
Family Cites Families (20)
Publication number | Priority date | Publication date | Assignee | Title |
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US4711955A (en) * | 1981-04-17 | 1987-12-08 | Yale University | Modified nucleotides and methods of preparing and using same |
ATE269870T1 (de) * | 1989-10-24 | 2004-07-15 | Isis Pharmaceuticals Inc | 2'-modifizierte oligonukleotide |
US5506351A (en) * | 1992-07-23 | 1996-04-09 | Isis Pharmaceuticals | Process for the preparation of 2'-O-alkyl guanosine and related compounds |
US5223618A (en) * | 1990-08-13 | 1993-06-29 | Isis Pharmaceuticals, Inc. | 4'-desmethyl nucleoside analog compounds |
AU1739097A (en) * | 1996-02-23 | 1997-09-10 | Albert Einstein College Of Medicine Of Yeshiva University | Enzyme detection/assay method and substrates |
US5985848A (en) | 1997-10-14 | 1999-11-16 | Albert Einstein College Of Medicine Of Yeshiva University | Inhibitors of nucleoside metabolism |
US7022677B1 (en) * | 1999-02-18 | 2006-04-04 | Kaken Pharmaceutical Co., Ltd. | Amide derivatives as growth hormone secretagogues |
LT2077268T (lt) * | 1999-04-08 | 2017-08-10 | Victoria Link Limited | Nukleozidų metabolizmo inhibitorių gavimo būdas |
US6448799B1 (en) * | 1999-09-30 | 2002-09-10 | Hitachi Electronics Engineering Co., Ltd. | Timing adjustment method and apparatus for semiconductor IC tester |
WO2002018371A1 (en) * | 2000-08-29 | 2002-03-07 | Industrial Research Limited | Nucleoside metabolism inhibitors |
US6458799B1 (en) | 2000-08-31 | 2002-10-01 | Biocryst Pharmaceuticals, Inc. | Deazaguanine analog, preparation thereof and use thereof |
US7098334B2 (en) | 2002-03-25 | 2006-08-29 | Industrial Research Limited | 4-amino-5H-pyrrolo[3,2-d]pyrimidine inhibitors of nucleoside phosphorylases and nucleosidases |
BRPI0313664B8 (pt) * | 2002-08-21 | 2021-05-25 | Albert Einstein College Medicine Yeshiva Univ | compostos inibidores de nucleosídeo fosforilase e nucleosidases, suas composições e seus usos |
NZ523970A (en) * | 2003-02-04 | 2005-02-25 | Ind Res Ltd | Process for preparing inhibitors of nucleoside phoshorylases and nucleosidases |
NZ533360A (en) | 2004-06-04 | 2007-02-23 | Ind Res Ltd | Improved method for preparing 3-hydroxy-4-hydroxymethyl-pyrrolidine compounds |
US20090012104A1 (en) | 2004-07-27 | 2009-01-08 | Babu Yarlagadda S | Inhibitors of 5'-Methylthioadenosine Phosphorylase and 5'-Methylthioadenosine/S-Adenosylhomocysteine Nucleosidase |
NZ540160A (en) | 2005-05-20 | 2008-03-28 | Einstein Coll Med | Inhibitors of nucleoside phosphorylases |
NZ544187A (en) | 2005-12-15 | 2008-07-31 | Ind Res Ltd | Deazapurine analogs of 1'-aza-l-nucleosides |
CA2643056A1 (en) | 2006-02-24 | 2007-08-30 | Industrial Research Limited | Methods of treating diseases using inhibitors of nucleoside phosphorylases and nucleosidases |
US8916571B2 (en) | 2006-02-24 | 2014-12-23 | Albert Einstein College Of Medicine Of Yeshiva University | Methods of treating cancer using inhibitors of 5′-methylthioadenosine phosphorylase |
-
1997
- 1997-10-14 US US08/949,388 patent/US5985848A/en not_active Expired - Lifetime
-
1998
- 1998-10-14 AT AT98953516T patent/ATE304019T1/de active
- 1998-10-14 ES ES98953516T patent/ES2249844T3/es not_active Expired - Lifetime
- 1998-10-14 US US09/172,321 patent/US6066722A/en not_active Expired - Lifetime
- 1998-10-14 AU AU10866/99A patent/AU749098B2/en not_active Expired
- 1998-10-14 CN CNB2005100920669A patent/CN100393722C/zh not_active Expired - Lifetime
- 1998-10-14 PT PT98953516T patent/PT1023308E/pt unknown
- 1998-10-14 KR KR1020007003944A patent/KR100637479B1/ko not_active IP Right Cessation
- 1998-10-14 JP JP2000515909A patent/JP4451983B2/ja not_active Expired - Lifetime
- 1998-10-14 DK DK98953516T patent/DK1023308T3/da active
- 1998-10-14 WO PCT/US1998/021717 patent/WO1999019338A1/en active IP Right Grant
- 1998-10-14 CN CNB988114895A patent/CN1220695C/zh not_active Expired - Lifetime
- 1998-10-14 DE DE69831499T patent/DE69831499T2/de not_active Expired - Lifetime
- 1998-10-14 CA CA002305760A patent/CA2305760C/en not_active Expired - Lifetime
- 1998-10-14 EP EP98953516A patent/EP1023308B1/en not_active Expired - Lifetime
-
2000
- 2000-02-03 US US09/496,741 patent/US6228847B1/en not_active Expired - Lifetime
-
2001
- 2001-03-28 US US09/820,276 patent/US6492347B2/en not_active Expired - Lifetime
-
2002
- 2002-10-10 US US10/268,652 patent/US6803455B2/en not_active Expired - Lifetime
-
2004
- 2004-09-02 US US10/932,841 patent/US7211653B2/en not_active Expired - Fee Related
-
2006
- 2006-08-25 HK HK06109456A patent/HK1089159A1/xx not_active IP Right Cessation
-
2007
- 2007-03-26 US US11/728,730 patent/US7390890B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
US20030096830A1 (en) | 2003-05-22 |
ES2249844T3 (es) | 2006-04-01 |
US5985848A (en) | 1999-11-16 |
CN1279686A (zh) | 2001-01-10 |
EP1023308A1 (en) | 2000-08-02 |
US20050026936A1 (en) | 2005-02-03 |
US6066722A (en) | 2000-05-23 |
JP2001519437A (ja) | 2001-10-23 |
US6492347B2 (en) | 2002-12-10 |
WO1999019338A1 (en) | 1999-04-22 |
US7211653B2 (en) | 2007-05-01 |
AU1086699A (en) | 1999-05-03 |
US7390890B2 (en) | 2008-06-24 |
US20070197561A1 (en) | 2007-08-23 |
EP1023308B1 (en) | 2005-09-07 |
ATE304019T1 (de) | 2005-09-15 |
CN100393722C (zh) | 2008-06-11 |
JP4451983B2 (ja) | 2010-04-14 |
EP1023308A4 (en) | 2002-05-29 |
AU749098B2 (en) | 2002-06-20 |
DK1023308T3 (da) | 2006-01-23 |
HK1089159A1 (en) | 2006-11-24 |
US6803455B2 (en) | 2004-10-12 |
KR100637479B1 (ko) | 2006-10-20 |
DE69831499D1 (de) | 2005-10-13 |
US20020061898A1 (en) | 2002-05-23 |
KR20010031082A (ko) | 2001-04-16 |
CA2305760A1 (en) | 1999-04-22 |
CA2305760C (en) | 2008-06-03 |
DE69831499T2 (de) | 2006-06-14 |
PT1023308E (pt) | 2005-11-30 |
US6228847B1 (en) | 2001-05-08 |
CN1757646A (zh) | 2006-04-12 |
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